Colon Cancer Clinical Trial

Five or Ten Year Colonoscopy for 1-2 Non-Advanced Adenomatous Polyps

Summary

This trial examines colorectal cancer incidence in participants with 1 to 2 non-advanced adenomas randomized to surveillance colonoscopy at 10 years compared to participants randomized to surveillance colonoscopy at 5 and 10 years.

View Full Description

Full Description

Colorectal cancer (CRC) is the fourth most common cancer and the second leading cause of cancer death among men and women in the United States (US). The lifetime risk of colorectal cancer in both men and women in the US is approximately 6%. About 93% of colorectal cancer (CRC) diagnoses are in patients older than 50 years (Siegel 2014). Randomized controlled trials show that screening for CRC significantly decreases CRC incidence and mortality (Schoen 2012, Atkin 2010, Mandel 1999, Mandel 2000). CRC screening has received a Grade A recommendation from the US Preventive Services Task Force.

In the U.S., colonoscopy is the most utilized screening modality for CRC. On a population basis, screening rates, which were around 40-50%, have now increased to 65%, and a goal to increase to 80% compliance is being promoted (CDC 2011, CDC 2013, Meester 2015).

Adenomatous polyps are the acknowledged precursors of colorectal cancer. Identification and removal of adenomas is the mechanism by which screening is effective in reducing CRC incidence and subsequent mortality. "Advanced" adenomas are adenomas which are greater than or equal to 1 cm, or have a "villous" component (tubulovillous or villous), or have foci of high grade dysplasia. Advanced adenomas are associated with increased long-term risk of cancer, even years after colonoscopy (Click 2018). The prevalence of advanced adenomas at screening colonoscopy is 5-10% (Ferlitsch 2011, Imperiale 2014). Non-advanced adenomas are adenomas greater than 1 cm with neither villous components nor high grade dysplasia. Non-advanced adenomas are much more common than advanced adenomas, present in around 30% of colonoscopy exams (Ferlitsch 2011, Imperiale 2014).

After detection of adenomas, patients are advised to return periodically for surveillance colonoscopy. Patients with 1-2 non-advanced adenomas are recommended by guidelines to return in 5 - 10 years for follow-up surveillance colonoscopy (Lieberman 2012). However, there are no guidelines on how to triage individuals to 5 as opposed to 10 years. Furthermore, there is limited evidence supporting the effectiveness of surveillance colonoscopy in reducing CRC incidence. A retrospective study in patients with advanced adenomas demonstrated benefit (Atkin 2017), but the study was not randomized and did not include patients with 1-2 non-advanced adenomas. The only randomized trial of surveillance colonoscopy was reported in the early 1990's, when participants were randomized to 3 vs. 1- and 3- year surveillance (Winawer 1993). No difference in advanced adenoma detection was observed when comparing participants examined at the two screening intervals, and as a result, guidelines were modified with participants advised to return every 3 years after adenomatous polyp detection. The recommended interval for non-advanced adenomas was gradually lengthened to the current standard, but there is no randomized, controlled data to support that interval. Furthermore, observational data of surveillance colonoscopy practice in the U.S. demonstrate that recommended intervals are often not adhered to, and individuals return for repeat testing well ahead of guideline recommendations (Schoen 2010, Lieberman 2014).

Furthermore, if anything, retrospective, natural history studies of non-advanced adenomas do not support the association of non-advanced adenoma with a higher risk of subsequent colorectal cancer (Atkin 1992, Spencer 1984, Loberg 2014). For example, in a classic study from the United Kingdom, patients with small rectosigmoid adenomas, even if multiple, did not have an increased risk of CRC compared to the general population, over a 14-year mean follow-up time (Atkin 1992). In a recent observational study from Norway, participants with a low-risk adenoma followed over a median of 7.7 years (maximum 19 years) without subsequent surveillance colonoscopy, had a lower CRC mortality than the general population (Loberg 2014), implying that although the initial colonoscopy may be protective, subsequent follow-up colonoscopy was not required. More recently, several studies have reported that individuals with non-advanced adenomas do not have an increased risk of colorectal cancer compared to those with no adenomas (Click 2018, Lieberman 2019, Lee 2019).

Another recent major development affecting screening is that practitioners of colonoscopy are now recommended to monitor and insure their adenoma detection rates are high. Data from Poland (Kaminski 2010) and Kaiser Permanente in California (Corley 2014) have demonstrated that a higher adenoma detection rate (ADR) is associated with a lower long-term risk of interval CRC, or cancer occurring after colonoscopy. Our understanding of these observations is premised on the notion that leaving pre-neoplastic tissue (adenomas) in situ, (such as what occurs with a lower ADR), increases the chance that an adenoma left behind will subsequently transform into cancer. The concern over interval cancers has stimulated quality concerns about the practice of colonoscopy. Guidelines for a recommended ADR at screening colonoscopy are rising, from the initial targets of 15% in women and 25% in men (Lieberman 2012) to 20% in women and 30% in men or 25% overall. ADRs in clinical studies are now commonly over 30% and some practitioners report rates exceeding 50%. However, adenomas that are detected when the ADR is high or as it increases over time are generally small, non-advanced adenomas.

Current clinical practice favoring colonoscopy-based screening with increased emphasis on detection of adenomas, most of which will turn out to be small, non-advanced adenomas, will greatly increase demand for utilization of surveillance colonoscopy exams in the coming decades. Yet, the evidence for determining the benefit, optimal timing, and recommended frequency of surveillance colonoscopy is unknown. A randomized, clinical trial to demonstrate the difference in yield between 5- or 10-year surveillance for participants with non-advanced adenoma is needed to guide clinical practice. Only a randomized trial will be authoritative enough to define good clinical practice and directly influence clinical care.

View Eligibility Criteria

Eligibility Criteria

Inclusion Criteria:

• The participant must have signed and dated an IRB-approved consent form that conforms to federal and institutional guidelines.

Participants with a first-time diagnosis of 1-2 non-advanced tubular adenomas (less than 10 mm without tubulovillous or villous changes or high grade or severe dysplasia) from the qualifying colonoscopy within 4 years prior to randomization.
Sessile serrated polyps/adenomas, as long as they do not meet the criteria for advanced adenomas, will be considered as non-advanced adenomas.
Qualifying colonoscopy must be a complete colonoscopy with visualization of the cecum and with adequate cleansing within 4 years prior to randomization.
Complete excision of all observed polyps in qualifying colonoscopy
Participants must be able to read or understand English or Spanish.

Exclusion Criteria:

• Prior history of colorectal cancer or colorectal adenomas including sessile serrated polyps/adenomas excluding those found on the qualifying colonoscopy.

Prior history of a hyperplastic polyp measuring greater than or equal to 1 cm in size.
Traditional serrated adenomas found on the qualifying colonoscopy.
Hyperplastic polyp measuring greater than or equal to 1 cm in size found on the qualifying colonoscopy.
Previous malignancies unless the patient has been disease-free for 5 or more years prior to randomization and is deemed by the physician to be at low risk for recurrence. Patients with the following cancers are eligible if diagnosed and treated within the past 5 years: all in situ cancers and basal cell and squamous cell carcinoma of the skin.
Colonoscopy performed after the qualifying colonoscopy but prior to randomization.
Incomplete qualifying colonoscopy (e.g., cecum not visualized).
Incomplete endoscopic excision of adenomatous polyps based on colonoscopist impression at qualifying colonoscopy. (Excision of all hyperplastic rectosigmoid polyps is not required.)
Sub-total colectomy or total proctocolectomy. (Segmental resections are allowed.)
Family history of CRC diagnosed at greater than or equal to 60 years of age in a first degree relative (mother, father, child, sibling) or in two first degree relatives with CRC at any age.
Participants with a clinical diagnosis of a significant heritable risk for colorectal cancer (Familial Adenomatous Polyposis, Hereditary Nonpolyposis Colorectal Cancer [Lynch Syndrome]).
Participants tested positive for a Familial Adenomatous Polyposis, Hereditary Nonpolyposis Colorectal Cancer [Lynch Syndrome] genetic mutation that increases risk of colorectal cancer.
Inflammatory bowel disease (e.g., Crohn's Disease, ulcerative colitis).
Life expectancy less than 10 years due to comorbid conditions in the opinion of the investigator.
Other comorbid conditions that would prevent the participant from having colonoscopies or would prevent required follow-up.

Study is for people with:

Colon Cancer

Estimated Enrollment:

9500

Study ID:

NCT05080673

Recruitment Status:

Recruiting

Sponsor:

NRG Oncology

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There are 142 Locations for this study

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Cancer Center at Saint Joseph's
Phoenix Arizona, 85004, United States More Info
Site Public Contact
Contact
602-406-0777
[email protected]
Richard L. Deming
Principal Investigator
CHI Saint Vincent Cancer Center Hot Springs
Hot Springs Arkansas, 71913, United States More Info
Site Public Contact
Contact
855-313-2409
[email protected]
Richard L. Deming
Principal Investigator
Mission Hope Medical Oncology - Arroyo Grande
Arroyo Grande California, 93420, United States More Info
Site Public Contact
Contact
805-219-4673
[email protected]
Richard L. Deming
Principal Investigator
Epic Care-Dublin
Dublin California, 94568, United States More Info
Site Public Contact
Contact
925-875-1677
Lisa Bailey
Principal Investigator
Bay Area Breast Surgeons Inc
Emeryville California, 94608, United States More Info
Site Public Contact
Contact
510-835-9900
Lisa Bailey
Principal Investigator
Epic Care Partners in Cancer Care
Emeryville California, 94608, United States More Info
Site Public Contact
Contact
510-629-6682
Lisa Bailey
Principal Investigator
UCLA / Jonsson Comprehensive Cancer Center
Los Angeles California, 90095, United States More Info
Site Public Contact
Contact
888-798-0719
Folasade P. May
Principal Investigator
Contra Costa Regional Medical Center
Martinez California, 94553, United States More Info
Site Public Contact
Contact
925-957-5400
Lisa Bailey
Principal Investigator
Alta Bates Summit Medical Center - Summit Campus
Oakland California, 94609, United States
Bay Area Tumor Institute
Oakland California, 94609, United States More Info
Site Public Contact
Contact
510-465-2242
[email protected]
Lisa Bailey
Principal Investigator
Pacific Central Coast Health Center-San Luis Obispo
San Luis Obispo California, 93401, United States More Info
Site Public Contact
Contact
805-219-4673
[email protected]
Richard L. Deming
Principal Investigator
Mission Hope Medical Oncology - Santa Maria
Santa Maria California, 93444, United States More Info
Site Public Contact
Contact
805-219-4673
[email protected]
Richard L. Deming
Principal Investigator
Kaiser Permanente-Vallejo
Vallejo California, 94589, United States More Info
Site Public Contact
Contact
877-642-4691
[email protected]
Douglas A. Corley
Principal Investigator
Epic Care Cyberknife Center
Walnut Creek California, 94597, United States More Info
Site Public Contact
Contact
510-465-8016
[email protected]
Lisa Bailey
Principal Investigator
Penrose-Saint Francis Healthcare
Colorado Springs Colorado, 80907, United States More Info
Site Public Contact
Contact
719-776-6550
[email protected]
Richard L. Deming
Principal Investigator
Rocky Mountain Cancer Centers-Penrose
Colorado Springs Colorado, 80907, United States More Info
Site Public Contact
Contact
719-776-6550
[email protected]
Richard L. Deming
Principal Investigator
Saint Francis Cancer Center
Colorado Springs Colorado, 80923, United States More Info
Site Public Contact
Contact
719-776-6550
[email protected]
Richard L. Deming
Principal Investigator
Porter Adventist Hospital
Denver Colorado, 80210, United States More Info
Site Public Contact
Contact
719-776-6550
[email protected]
Richard L. Deming
Principal Investigator
Mercy Medical Center
Durango Colorado, 81301, United States More Info
Site Public Contact
Contact
719-776-6550
[email protected]
Richard L. Deming
Principal Investigator
Southwest Oncology PC
Durango Colorado, 81301, United States More Info
Site Public Contact
Contact
719-776-6550
[email protected]
Richard L. Deming
Principal Investigator
Saint Anthony Hospital
Lakewood Colorado, 80228, United States More Info
Site Public Contact
Contact
719-776-6550
[email protected]
Richard L. Deming
Principal Investigator
Littleton Adventist Hospital
Littleton Colorado, 80122, United States More Info
Site Public Contact
Contact
719-776-6550
[email protected]
Richard L. Deming
Principal Investigator
Longmont United Hospital
Longmont Colorado, 80501, United States More Info
Site Public Contact
Contact
719-776-6550
[email protected]
Richard L. Deming
Principal Investigator
Rocky Mountain Cancer Centers-Longmont
Longmont Colorado, 80501, United States More Info
Site Public Contact
Contact
719-776-6550
[email protected]
Richard L. Deming
Principal Investigator
Parker Adventist Hospital
Parker Colorado, 80138, United States More Info
Site Public Contact
Contact
719-776-6550
[email protected]
Richard L. Deming
Principal Investigator
Saint Mary Corwin Medical Center
Pueblo Colorado, 81004, United States More Info
Site Public Contact
Contact
719-776-6550
[email protected]
Richard L. Deming
Principal Investigator
Rush - Copley Medical Center
Aurora Illinois, 60504, United States
John H Stroger Jr Hospital of Cook County
Chicago Illinois, 60612, United States More Info
Site Public Contact
Contact
312-864-5204
Thomas E. Lad
Principal Investigator
Rush University Medical Center
Chicago Illinois, 60612, United States More Info
Site Public Contact
Contact
312-942-5498
[email protected]
Joshua E. Melson
Principal Investigator
Carle on Vermilion
Danville Illinois, 61832, United States
Carle Physician Group-Effingham
Effingham Illinois, 62401, United States
Carle Physician Group-Mattoon/Charleston
Mattoon Illinois, 61938, United States
Carle Cancer Center
Urbana Illinois, 61801, United States
The Carle Foundation Hospital
Urbana Illinois, 61801, United States
Rush-Copley Healthcare Center
Yorkville Illinois, 60560, United States
Medical Oncology and Hematology Associates-West Des Moines
Clive Iowa, 50325, United States More Info
Site Public Contact
Contact
515-643-2196
[email protected]
Richard L. Deming
Principal Investigator
Mercy Cancer Center-West Lakes
Clive Iowa, 50325, United States More Info
Site Public Contact
Contact
515-643-2196
[email protected]
Richard L. Deming
Principal Investigator
Alegent Health Mercy Hospital
Council Bluffs Iowa, 51503, United States More Info
Site Public Contact
Contact
402-717-1510
[email protected]
Richard L. Deming
Principal Investigator
Greater Regional Medical Center
Creston Iowa, 50801, United States More Info
Site Public Contact
Contact
515-643-2196
[email protected]
Richard L. Deming
Principal Investigator
Medical Oncology and Hematology Associates-Laurel
Des Moines Iowa, 50314, United States More Info
Site Public Contact
Contact
515-643-2196
[email protected]
Richard L. Deming
Principal Investigator
Mercy Medical Center - Des Moines
Des Moines Iowa, 50314, United States More Info
Site Public Contact
Contact
515-358-6613
[email protected]
Richard L. Deming
Principal Investigator
Mercy Medical Center-West Lakes
West Des Moines Iowa, 50266, United States More Info
Site Public Contact
Contact
515-643-2196
[email protected]
Richard L. Deming
Principal Investigator
Flaget Memorial Hospital
Bardstown Kentucky, 40004, United States More Info
Site Public Contact
Contact
859-629-7169
[email protected]
Richard L. Deming
Principal Investigator
Commonwealth Cancer Center-Corbin
Corbin Kentucky, 40701, United States More Info
Site Public Contact
Contact
859-629-7169
[email protected]
Richard L. Deming
Principal Investigator
Saint Joseph Radiation Oncology Resource Center
Lexington Kentucky, 40504, United States More Info
Site Public Contact
Contact
859-629-7169
[email protected]
Richard L. Deming
Principal Investigator
Saint Joseph Hospital East
Lexington Kentucky, 40509, United States More Info
Site Public Contact
Contact
859-629-7169
[email protected]
Richard L. Deming
Principal Investigator
Saint Joseph London
London Kentucky, 40741, United States More Info
Site Public Contact
Contact
859-629-7169
[email protected]
Richard L. Deming
Principal Investigator
Jewish Hospital
Louisville Kentucky, 40202, United States More Info
Site Public Contact
Contact
859-629-7169
[email protected]
Richard L. Deming
Principal Investigator
Saints Mary and Elizabeth Hospital
Louisville Kentucky, 40215, United States More Info
Site Public Contact
Contact
859-629-7169
[email protected]
Richard L. Deming
Principal Investigator
UofL Health Medical Center Northeast
Louisville Kentucky, 40245, United States More Info
Site Public Contact
Contact
502-852-2755
[email protected]
Richard L. Deming
Principal Investigator
Jewish Hospital Medical Center South
Shepherdsville Kentucky, 40165, United States More Info
Site Public Contact
Contact
859-629-7169
[email protected]
Richard L. Deming
Principal Investigator
Bronson Battle Creek
Battle Creek Michigan, 49017, United States More Info
Site Public Contact
Contact
616-391-1230
[email protected]
Kathleen J. Yost
Principal Investigator
Helen DeVos Children's Hospital at Spectrum Health
Grand Rapids Michigan, 49503, United States More Info
Site Public Contact
Contact
616-391-1230
[email protected]
Kathleen J. Yost
Principal Investigator
Mercy Health Saint Mary's
Grand Rapids Michigan, 49503, United States More Info
Site Public Contact
Contact
616-391-1230
[email protected]
Kathleen J. Yost
Principal Investigator
Spectrum Health at Butterworth Campus
Grand Rapids Michigan, 49503, United States More Info
Site Public Contact
Contact
616-391-1230
[email protected]
Kathleen J. Yost
Principal Investigator
Bronson Methodist Hospital
Kalamazoo Michigan, 49007, United States More Info
Site Public Contact
Contact
616-391-1230
[email protected]
Kathleen J. Yost
Principal Investigator
West Michigan Cancer Center
Kalamazoo Michigan, 49007, United States More Info
Site Public Contact
Contact
616-391-1230
[email protected]
Kathleen J. Yost
Principal Investigator
Ascension Borgess Cancer Center
Kalamazoo Michigan, 49009, United States More Info
Site Public Contact
Contact
616-391-1230
[email protected]
Kathleen J. Yost
Principal Investigator
Borgess Medical Center
Kalamazoo Michigan, 49048, United States More Info
Site Public Contact
Contact
616-391-1230
[email protected]
Kathleen J. Yost
Principal Investigator
Mercy Health Mercy Campus
Muskegon Michigan, 49444, United States More Info
Site Public Contact
Contact
616-391-1230
[email protected]
Kathleen J. Yost
Principal Investigator
Lakeland Hospital Niles
Niles Michigan, 49120, United States More Info
Site Public Contact
Contact
616-391-1230
Kathleen J. Yost
Principal Investigator
Cancer and Hematology Centers of Western Michigan - Norton Shores
Norton Shores Michigan, 49444, United States More Info
Site Public Contact
Contact
616-391-1230
[email protected]
Kathleen J. Yost
Principal Investigator
Spectrum Health Reed City Hospital
Reed City Michigan, 49677, United States More Info
Site Public Contact
Contact
616-391-1230
[email protected]
Kathleen J. Yost
Principal Investigator
Lakeland Medical Center Saint Joseph
Saint Joseph Michigan, 49085, United States More Info
Site Public Contact
Contact
616-391-1230
[email protected]
Kathleen J. Yost
Principal Investigator
Marie Yeager Cancer Center
Saint Joseph Michigan, 49085, United States More Info
Site Public Contact
Contact
616-391-1230
[email protected]
Kathleen J. Yost
Principal Investigator
Munson Medical Center
Traverse City Michigan, 49684, United States More Info
Site Public Contact
Contact
616-391-1230
[email protected]
Kathleen J. Yost
Principal Investigator
Metro Health Hospital
Wyoming Michigan, 49519, United States More Info
Site Public Contact
Contact
616-391-1230
[email protected]
Kathleen J. Yost
Principal Investigator
Riverwood Healthcare Center
Aitkin Minnesota, 56431, United States More Info
Site Public Contact
Contact
218-786-3308
[email protected]
Bret E. Friday
Principal Investigator
Sanford Joe Lueken Cancer Center
Bemidji Minnesota, 56601, United States More Info
Site Public Contact
Contact
218-333-5000
[email protected]
Preston D. Steen
Principal Investigator
Essentia Health Saint Joseph's Medical Center
Brainerd Minnesota, 56401, United States More Info
Site Public Contact
Contact
218-786-3308
[email protected]
Bret E. Friday
Principal Investigator
Fairview Ridges Hospital
Burnsville Minnesota, 55337, United States More Info
Site Public Contact
Contact
952-993-1517
[email protected]
Daniel M. Anderson
Principal Investigator
Minnesota Oncology - Burnsville
Burnsville Minnesota, 55337, United States More Info
Site Public Contact
Contact
952-993-1517
[email protected]
Daniel M. Anderson
Principal Investigator
Cambridge Medical Center
Cambridge Minnesota, 55008, United States More Info
Site Public Contact
Contact
952-993-1517
[email protected]
Daniel M. Anderson
Principal Investigator
Mercy Hospital
Coon Rapids Minnesota, 55433, United States More Info
Site Public Contact
Contact
952-993-1517
[email protected]
Daniel M. Anderson
Principal Investigator
Essentia Health - Deer River Clinic
Deer River Minnesota, 56636, United States More Info
Site Public Contact
Contact
218-786-3308
[email protected]
Bret E. Friday
Principal Investigator
Essentia Health Saint Mary's - Detroit Lakes Clinic
Detroit Lakes Minnesota, 56501, United States More Info
Site Public Contact
Contact
218-786-3308
[email protected]
Bret E. Friday
Principal Investigator
Essentia Health Cancer Center
Duluth Minnesota, 55805, United States More Info
Site Public Contact
Contact
218-786-3308
[email protected]
Bret E. Friday
Principal Investigator
Essentia Health Saint Mary's Medical Center
Duluth Minnesota, 55805, United States More Info
Site Public Contact
Contact
218-786-3308
[email protected]
Bret E. Friday
Principal Investigator
Miller-Dwan Hospital
Duluth Minnesota, 55805, United States More Info
Site Public Contact
Contact
218-786-3308
[email protected]
Bret E. Friday
Principal Investigator
Fairview Southdale Hospital
Edina Minnesota, 55435, United States More Info
Site Public Contact
Contact
952-993-1517
[email protected]
Daniel M. Anderson
Principal Investigator
Lake Region Healthcare Corporation-Cancer Care
Fergus Falls Minnesota, 56537, United States More Info
Site Public Contact
Contact
218-786-3308
[email protected]
Bret E. Friday
Principal Investigator
Essentia Health - Fosston
Fosston Minnesota, 56542, United States More Info
Site Public Contact
Contact
218-786-3308
[email protected]
Bret E. Friday
Principal Investigator
Unity Hospital
Fridley Minnesota, 55432, United States More Info
Site Public Contact
Contact
952-993-1517
[email protected]
Daniel M. Anderson
Principal Investigator
Essentia Health Hibbing Clinic
Hibbing Minnesota, 55746, United States More Info
Site Public Contact
Contact
218-786-3308
Bret E. Friday
Principal Investigator
Fairview Clinics and Surgery Center Maple Grove
Maple Grove Minnesota, 55369, United States More Info
Site Public Contact
Contact
952-993-1517
[email protected]
Daniel M. Anderson
Principal Investigator
Minnesota Oncology Hematology PA-Maplewood
Maplewood Minnesota, 55109, United States More Info
Site Public Contact
Contact
952-993-1517
[email protected]
Daniel M. Anderson
Principal Investigator
Saint John's Hospital - Healtheast
Maplewood Minnesota, 55109, United States More Info
Site Public Contact
Contact
952-993-1517
[email protected]
Daniel M. Anderson
Principal Investigator
Abbott-Northwestern Hospital
Minneapolis Minnesota, 55407, United States More Info
Site Public Contact
Contact
952-993-1517
[email protected]
Daniel M. Anderson
Principal Investigator
Hennepin County Medical Center
Minneapolis Minnesota, 55415, United States More Info
Site Public Contact
Contact
952-993-1517
[email protected]
Daniel M. Anderson
Principal Investigator
Health Partners Inc
Minneapolis Minnesota, 55454, United States More Info
Site Public Contact
Contact
952-993-1517
[email protected]
Daniel M. Anderson
Principal Investigator
Monticello Cancer Center
Monticello Minnesota, 55362, United States More Info
Site Public Contact
Contact
952-993-1517
[email protected]
Daniel M. Anderson
Principal Investigator
New Ulm Medical Center
New Ulm Minnesota, 56073, United States More Info
Site Public Contact
Contact
952-993-1517
[email protected]
Daniel M. Anderson
Principal Investigator
Essentia Health - Park Rapids
Park Rapids Minnesota, 56470, United States More Info
Site Public Contact
Contact
218-786-3308
[email protected]
Bret E. Friday
Principal Investigator
Fairview Northland Medical Center
Princeton Minnesota, 55371, United States More Info
Site Public Contact
Contact
952-993-1517
[email protected]
Daniel M. Anderson
Principal Investigator
North Memorial Medical Health Center
Robbinsdale Minnesota, 55422, United States More Info
Site Public Contact
Contact
952-993-1517
[email protected]
Daniel M. Anderson
Principal Investigator
Park Nicollet Clinic - Saint Louis Park
Saint Louis Park Minnesota, 55416, United States More Info
Site Public Contact
Contact
952-993-1517
[email protected]
Daniel M. Anderson
Principal Investigator
Regions Hospital
Saint Paul Minnesota, 55101, United States More Info
Site Public Contact
Contact
952-993-1517
[email protected]
Daniel M. Anderson
Principal Investigator
United Hospital
Saint Paul Minnesota, 55102, United States More Info
Site Public Contact
Contact
952-993-1517
[email protected]
Daniel M. Anderson
Principal Investigator
Essentia Health Sandstone
Sandstone Minnesota, 55072, United States More Info
Site Public Contact
Contact
218-786-3308
[email protected]
Bret E. Friday
Principal Investigator
Saint Francis Regional Medical Center
Shakopee Minnesota, 55379, United States More Info
Site Public Contact
Contact
952-993-1517
[email protected]
Daniel M. Anderson
Principal Investigator
Lakeview Hospital
Stillwater Minnesota, 55082, United States More Info
Site Public Contact
Contact
952-993-1517
[email protected]
Daniel M. Anderson
Principal Investigator
Sanford Thief River Falls Medical Center
Thief River Falls Minnesota, 56701, United States More Info
Site Public Contact
Contact
605-312-3320
Preston D. Steen
Principal Investigator
Essentia Health Virginia Clinic
Virginia Minnesota, 55792, United States More Info
Site Public Contact
Contact
218-786-3308
[email protected]
Bret E. Friday
Principal Investigator
Ridgeview Medical Center
Waconia Minnesota, 55387, United States More Info
Site Public Contact
Contact
952-993-1517
[email protected]
Daniel M. Anderson
Principal Investigator
Rice Memorial Hospital
Willmar Minnesota, 56201, United States More Info
Site Public Contact
Contact
952-993-1517
[email protected]
Daniel M. Anderson
Principal Investigator
Minnesota Oncology Hematology PA-Woodbury
Woodbury Minnesota, 55125, United States More Info
Site Public Contact
Contact
952-993-1517
[email protected]
Daniel M. Anderson
Principal Investigator
Sanford Cancer Center Worthington
Worthington Minnesota, 56187, United States More Info
Site Public Contact
Contact
605-312-3320
Preston D. Steen
Principal Investigator
Fairview Lakes Medical Center
Wyoming Minnesota, 55092, United States More Info
Site Public Contact
Contact
952-993-1517
[email protected]
Daniel M. Anderson
Principal Investigator
CHI Health Saint Francis
Grand Island Nebraska, 68803, United States More Info
Site Public Contact
Contact
855-313-2409
[email protected]
Richard L. Deming
Principal Investigator
CHI Health Good Samaritan
Kearney Nebraska, 68847, United States More Info
Site Public Contact
Contact
308-865-7963
[email protected]
Richard L. Deming
Principal Investigator
Saint Elizabeth Regional Medical Center
Lincoln Nebraska, 68510, United States More Info
Site Public Contact
Contact
855-313-2409
[email protected]
Richard L. Deming
Principal Investigator
Alegent Health Immanuel Medical Center
Omaha Nebraska, 68122, United States More Info
Site Public Contact
Contact
402-717-1510
[email protected]
Richard L. Deming
Principal Investigator
Alegent Health Bergan Mercy Medical Center
Omaha Nebraska, 68124, United States More Info
Site Public Contact
Contact
402-717-1510
[email protected]
Richard L. Deming
Principal Investigator
Alegent Health Lakeside Hospital
Omaha Nebraska, 68130, United States More Info
Site Public Contact
Contact
402-717-1510
[email protected]
Richard L. Deming
Principal Investigator
Creighton University Medical Center
Omaha Nebraska, 68131, United States More Info
Site Public Contact
Contact
402-717-1510
[email protected]
Richard L. Deming
Principal Investigator
Midlands Community Hospital
Papillion Nebraska, 68046, United States More Info
Site Public Contact
Contact
402-717-1510
[email protected]
Richard L. Deming
Principal Investigator
Morristown Medical Center
Morristown New Jersey, 07960, United States More Info
Site Public Contact
Contact
973-971-5900
Henry S. Dinneen
Principal Investigator
Sanford Bismarck Medical Center
Bismarck North Dakota, 58501, United States More Info
Site Public Contact
Contact
701-323-5760
[email protected]
Preston D. Steen
Principal Investigator
Essentia Health Cancer Center-South University Clinic
Fargo North Dakota, 58103, United States More Info
Site Public Contact
Contact
218-786-3308
[email protected]
Bret E. Friday
Principal Investigator
Sanford South University Medical Center
Fargo North Dakota, 58103, United States More Info
Site Public Contact
Contact
701-234-6161
Preston D. Steen
Principal Investigator
Southpointe-Sanford Medical Center Fargo
Fargo North Dakota, 58103, United States More Info
Site Public Contact
Contact
605-312-3320
Preston D. Steen
Principal Investigator
Sanford Medical Center Fargo
Fargo North Dakota, 58104, United States More Info
Site Public Contact
Contact
800-437-4010
Preston D. Steen
Principal Investigator
Sanford Broadway Medical Center
Fargo North Dakota, 58122, United States More Info
Site Public Contact
Contact
701-323-5760
[email protected]
Preston D. Steen
Principal Investigator
Sanford Roger Maris Cancer Center
Fargo North Dakota, 58122, United States More Info
Site Public Contact
Contact
701-234-6161
[email protected]
Preston D. Steen
Principal Investigator
Essentia Health - Jamestown Clinic
Jamestown North Dakota, 58401, United States More Info
Site Public Contact
Contact
218-786-3308
[email protected]
Bret E. Friday
Principal Investigator
Good Samaritan Hospital - Cincinnati
Cincinnati Ohio, 45220, United States More Info
Site Public Contact
Contact
513-853-1300
[email protected]
Richard L. Deming
Principal Investigator
Bethesda North Hospital
Cincinnati Ohio, 45242, United States More Info
Site Public Contact
Contact
513-853-1300
[email protected]
Richard L. Deming
Principal Investigator
TriHealth Cancer Institute-Westside
Cincinnati Ohio, 45247, United States More Info
Site Public Contact
Contact
513-853-1300
[email protected]
Richard L. Deming
Principal Investigator
TriHealth Cancer Institute-Anderson
Cincinnati Ohio, 45255, United States More Info
Site Public Contact
Contact
513-853-1300
[email protected]
Richard L. Deming
Principal Investigator
UPMC-Presbyterian Hospital
Pittsburgh Pennsylvania, 15213, United States More Info
Site Public Contact
Contact
412-647-2811
Robert E. Schoen
Principal Investigator
Ralph H Johnson VA Medical Center
Charleston South Carolina, 29401, United States More Info
Site Public Contact
Contact
843-789-7020
[email protected]
Oleksandra Lupak
Principal Investigator
Prisma Health Greenville Memorial Hospital
Greenville South Carolina, 29605, United States More Info
Site Public Contact
Contact
864-241-6251
Ki Y. Chung
Principal Investigator
Sanford Cancer Center Oncology Clinic
Sioux Falls South Dakota, 57104, United States More Info
Site Public Contact
Contact
605-312-3320
[email protected]
Preston D. Steen
Principal Investigator
Sanford USD Medical Center - Sioux Falls
Sioux Falls South Dakota, 57117, United States More Info
Site Public Contact
Contact
605-312-3320
[email protected]
Preston D. Steen
Principal Investigator
Saint Joseph Regional Cancer Center
Bryan Texas, 77802, United States More Info
Site Public Contact
Contact
855-313-2409
[email protected]
Richard L. Deming
Principal Investigator
Harrison Medical Center
Bremerton Washington, 98310, United States More Info
Site Public Contact
Contact
253-426-6882
[email protected]
Richard L. Deming
Principal Investigator
Highline Medical Center-Main Campus
Burien Washington, 98166, United States More Info
Site Public Contact
Contact
253-426-6882
[email protected]
Richard L. Deming
Principal Investigator
Saint Elizabeth Hospital
Enumclaw Washington, 98022, United States More Info
Site Public Contact
Contact
253-426-6882
[email protected]
Richard L. Deming
Principal Investigator
Saint Francis Hospital
Federal Way Washington, 98003, United States More Info
Site Public Contact
Contact
253-426-6882
[email protected]
Richard L. Deming
Principal Investigator
Saint Clare Hospital
Lakewood Washington, 98499, United States More Info
Site Public Contact
Contact
253-426-6882
[email protected]
Richard L. Deming
Principal Investigator
Franciscan Research Center-Northwest Medical Plaza
Tacoma Washington, 98405, United States More Info
Site Public Contact
Contact
253-426-6882
[email protected]
Richard L. Deming
Principal Investigator
Ascension Saint Elizabeth Hospital
Appleton Wisconsin, 54915, United States More Info
Site Public Contact
Contact
414-635-6420
[email protected]
Shannon Offerman
Principal Investigator
Duluth Clinic Ashland
Ashland Wisconsin, 54806, United States More Info
Site Public Contact
Contact
218-786-3308
[email protected]
Bret E. Friday
Principal Investigator
Northwest Wisconsin Cancer Center
Ashland Wisconsin, 54806, United States More Info
Site Public Contact
Contact
218-786-3308
[email protected]
Bret E. Friday
Principal Investigator
Ascension Southeast Wisconsin Hospital - Elmbrook Campus
Brookfield Wisconsin, 53045, United States More Info
Site Public Contact
Contact
414-635-6420
[email protected]
Shannon Offerman
Principal Investigator
Ascension Calumet Hospital
Chilton Wisconsin, 53014, United States More Info
Site Public Contact
Contact
414-635-6420
[email protected]
Shannon Offerman
Principal Investigator
Marshfield Medical Center-EC Cancer Center
Eau Claire Wisconsin, 54701, United States More Info
Site Public Contact
Contact
800-782-8581
[email protected]
Sabo B. Tanimu
Principal Investigator
Ascension Saint Francis - Reiman Cancer Center
Franklin Wisconsin, 53132, United States More Info
Site Public Contact
Contact
414-635-6420
[email protected]
Shannon Offerman
Principal Investigator
Ascension Southeast Wisconsin Hospital - Franklin
Franklin Wisconsin, 53132, United States More Info
Site Public Contact
Contact
414-635-6420
[email protected]
Shannon Offerman
Principal Investigator
Essentia Health-Hayward Clinic
Hayward Wisconsin, 54843, United States More Info
Site Public Contact
Contact
218-786-3308
[email protected]
Bret E. Friday
Principal Investigator
Marshfield Medical Center-Marshfield
Marshfield Wisconsin, 54449, United States More Info
Site Public Contact
Contact
800-782-8581
[email protected]
Sabo B. Tanimu
Principal Investigator
Ascension Columbia Saint Mary's Hospital Ozaukee
Mequon Wisconsin, 53097, United States More Info
Site Public Contact
Contact
414-635-6420
[email protected]
Shannon Offerman
Principal Investigator
Ascension Southeast Wisconsin Hospital - Saint Joseph Campus
Milwaukee Wisconsin, 53210, United States More Info
Site Public Contact
Contact
414-635-6420
[email protected]
Shannon Offerman
Principal Investigator
Ascension Columbia Saint Mary's Hospital - Milwaukee
Milwaukee Wisconsin, 53211, United States More Info
Site Public Contact
Contact
414-635-6420
[email protected]
Shannon Offerman
Principal Investigator
Ascension Saint Francis Hospital
Milwaukee Wisconsin, 53215, United States More Info
Site Public Contact
Contact
414-635-6420
[email protected]
Shannon Offerman
Principal Investigator
Marshfield Clinic-Minocqua Center
Minocqua Wisconsin, 54548, United States More Info
Site Public Contact
Contact
800-782-8581
[email protected]
Sabo B. Tanimu
Principal Investigator
Cancer Center of Western Wisconsin
New Richmond Wisconsin, 54017, United States More Info
Site Public Contact
Contact
952-993-1517
[email protected]
Daniel M. Anderson
Principal Investigator
Ascension Mercy Hospital
Oshkosh Wisconsin, 54904, United States More Info
Site Public Contact
Contact
920-831-8900
[email protected]
Shannon Offerman
Principal Investigator
Ascension All Saints Hospital
Racine Wisconsin, 53405, United States More Info
Site Public Contact
Contact
414-635-6420
[email protected]
Shannon Offerman
Principal Investigator
Marshfield Medical Center-Rice Lake
Rice Lake Wisconsin, 54868, United States More Info
Site Public Contact
Contact
800-782-8581
[email protected]
Sabo B. Tanimu
Principal Investigator
Essentia Health-Spooner Clinic
Spooner Wisconsin, 54801, United States More Info
Site Public Contact
Contact
218-786-3308
[email protected]
Bret E. Friday
Principal Investigator
Marshfield Clinic Stevens Point Center
Stevens Point Wisconsin, 54482, United States More Info
Site Public Contact
Contact
800-782-8581
[email protected]
Sabo B. Tanimu
Principal Investigator
Essentia Health Saint Mary's Hospital - Superior
Superior Wisconsin, 54880, United States More Info
Site Public Contact
Contact
701-364-6272
Bret E. Friday
Principal Investigator
Ascension Medical Group Southeast Wisconsin - Mayfair Road
Wauwatosa Wisconsin, 53226, United States More Info
Site Public Contact
Contact
414-635-6420
[email protected]
Shannon Offerman
Principal Investigator
Marshfield Medical Center - Weston
Weston Wisconsin, 54476, United States More Info
Site Public Contact
Contact
800-782-8581
[email protected]
Sabo B. Tanimu
Principal Investigator

How clear is this clinincal trial information?

Study is for people with:

Colon Cancer

Estimated Enrollment:

9500

Study ID:

NCT05080673

Recruitment Status:

Recruiting

Sponsor:


NRG Oncology

How clear is this clinincal trial information?

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