Colon Cancer Clinical Trial

Irinotecan Hydrochloride and Cetuximab With or Without Ramucirumab in Treating Patients With Advanced Colorectal Cancer With Progressive Disease After Treatment With Bevacizumab-Containing Chemotherapy

Summary

RATIONALE: Drugs used in chemotherapy, such as irinotecan hydrochloride, work in different ways to stop the growth of tumor cells, either by killing the cells or by stopping them from dividing. Monoclonal antibodies, such as cetuximab and ramucirumab, can block tumor growth in different ways. Some block the ability of tumor cells to grow and spread. Others find tumor cells and help kill them or carry tumor-killing substances to them. Cetuximab and ramucirumab may also stop the growth of colorectal cancer by blocking blood flow to the tumor. It is not yet know whether giving cetuximab and irinotecan hydrochloride together is more effective with or without ramucirumab in treating colorectal cancer.

PURPOSE: This randomized phase II trial is studying the side effects and how well giving cetuximab and irinotecan hydrochloride with or without ramucirumab work in treating patients with advanced colorectal cancer with progressive disease after treatment with bevacizumab-containing chemotherapy.

View Full Description

Full Description

OBJECTIVES:

To evaluate the progression-free survival of patients with advanced K-ras wild-type colorectal cancer, following progression on bevacizumab-contained chemotherapy, treated with irinotecan hydrochloride and cetuximab with versus without ramucirumab as second-line therapy.
To evaluate the response rate in patients treated with these regimens.
To evaluate the grade 3-4 toxicity rates of these regimens in these patients.
To evaluate the overall survival of patients treated with these regimens.

OUTLINE: This is a multicenter, randomized study. Patients are stratified according to performance status (0 vs 1), discontinuation of oxaliplatin before disease progression (yes vs no), and time to disease progression since last treatment (≤ 6 months vs > 6 months). Patients are randomized to 1 of 2 treatment arms.

Arm A: Patients receive cetuximab IV over 60-120 minutes and irinotecan hydrochloride over 60-90 minutes on day 1.
Arm B: Patients receive ramucirumab IV over 60 minutes on day 1 and cetuximab and irinotecan hydrochloride as in arm A. Arm B was closed early due to excessive toxicities and Arm C was then added to the study with reduced dose of protocol drugs.
Arm C: Patients receive reduced dose of ramucirumab, cetuximab and irinotecan hydrochloride as in arm B.

In all arms, courses repeat every 14 days in the absence of disease progression or unacceptable toxicity.

After completion of study therapy, patients are followed up periodically for 5 years.

View Eligibility Criteria

Eligibility Criteria

Inclusion Criteria:

Measurable disease
Histologically confirmed adenocarcinoma of the colon or rectum
K-ras wild type based on either primary or metastatic tumor
Must have received prior first-line therapy comprising oxaliplatin-based fluoropyrimidine-containing chemotherapy and bevacizumab for metastatic colorectal cancer
Registration within 42 days since confirmed disease progression
Performance status 0-1
ANC ≥ 1,500/μL
Platelet count ≥ 75,000/μL
Hemoglobin ≥ 9 g/dL
Serum creatinine ≤ 1.5 times upper limit of normal (ULN) OR creatinine clearance ≥ 40 mL/min
Urine protein ≤ 1+ on dipstick or routine urinalysis (if ≥ 2+, a 24-hour urine collection must demonstrate < 1,000 mg of protein)
Total bilirubin ≤ 2.0 mg/dL
AST and ALT ≤ 3.0 times ULN (5.0 times ULN for patients with liver metastases)
INR ≤ 1.6 (≤ 3.0 for patients on warfarin and no active bleeding [i.e., no bleeding within the past 14 days])
Negative pregnancy test
Fertile patients must use effective contraception during and for 3 months after completion of study therapy
At least 28 days and no more than 90 days since prior bevacizumab
Concurrent stable dose of oral anticoagulant or low-molecular weight heparin allowed

Exclusion Criteria:

Brain or CNS metastases
Pregnant or nursing
Prior therapy with drugs other than oxaliplatin and a fluoropyrimidine plus bevacizumab for colorectal cancer
Clinically significant (equivalent to NCI CTCAE grade 3-4) bleeding episodes within the past 3 months
Active infection
Symptomatic congestive heart failure
Unstable angina pectoris
Symptomatic or poorly controlled cardiac arrhythmia
Uncontrolled thrombotic or hemorrhagic disorder
Uncontrolled or poorly controlled hypertension despite standard medical management (e.g., consistently systolic BP > 160 mm Hg and diastolic BP > 90 mm Hg)
Acute arterial thrombotic events within the past 6 months, including cerebrovascular accident, transient ischemic attack, myocardial infarction, or unstable angina
Other cancer requiring therapy within the past 3 years except in situ carcinoma or nonmelanoma skin cancer
Acute or subacute intestinal obstruction
History of inflammatory bowel disease requiring pharmacological and/or surgical intervention within the past 12 months
Known allergy to any of the treatment components
Major surgery within the past 28 days
Subcutaneous venous access device placement within the past 7 days

Study is for people with:

Colon Cancer

Phase:

Phase 2

Estimated Enrollment:

136

Study ID:

NCT01079780

Recruitment Status:

Completed

Sponsor:

Eastern Cooperative Oncology Group

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There are 221 Locations for this study

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UAB Comprehensive Cancer Center
Birmingham Alabama, 35294, United States
Aurora Presbyterian Hospital
Aurora Colorado, 80012, United States
Boulder Community Hospital
Boulder Colorado, 80301, United States
Penrose Cancer Center at Penrose Hospital
Colorado Springs Colorado, 80933, United States
St. Anthony Central Hospital
Denver Colorado, 80204, United States
Porter Adventist Hospital
Denver Colorado, 80210, United States
Presbyterian - St. Luke's Medical Center
Denver Colorado, 80218, United States
St. Joseph Hospital
Denver Colorado, 80218, United States
Rose Medical Center
Denver Colorado, 80220, United States
CCOP - Colorado Cancer Research Program
Denver Colorado, 80224, United States
Swedish Medical Center
Englewood Colorado, 80110, United States
Poudre Valley Hospital
Fort Collins Colorado, 80524, United States
Front Range Cancer Specialists
Fort Collins Colorado, 80528, United States
St. Mary's Regional Cancer Center at St. Mary's Hospital and Medical Center
Grand Junction Colorado, 81502, United States
North Colorado Medical Center
Greeley Colorado, 80631, United States
Littleton Adventist Hospital
Littleton Colorado, 80122, United States
Sky Ridge Medical Center
Lone Tree Colorado, 80124, United States
Hope Cancer Care Center at Longmont United Hospital
Longmont Colorado, 80501, United States
McKee Medical Center
Loveland Colorado, 80539, United States
Parker Adventist Hospital
Parker Colorado, 80138, United States
St. Mary - Corwin Regional Medical Center
Pueblo Colorado, 81004, United States
North Suburban Medical Center
Thornton Colorado, 80229, United States
Exempla Lutheran Medical Center
Wheat Ridge Colorado, 80033, United States
Saint Francis/Mount Sinai Regional Cancer Center at Saint Francis Hospital and Medical Center
Hartford Connecticut, 06105, United States
Yale Cancer Center
New Haven Connecticut, 06520, United States
Veterans Affairs Medical Center - Atlanta (Decatur)
Decatur Georgia, 30033, United States
Nancy N. and J. C. Lewis Cancer and Research Pavilion at St. Joseph's/Candler
Savannah Georgia, 31405, United States
Rush-Copley Cancer Care Center
Aurora Illinois, 60504, United States
St. Joseph Medical Center
Bloomington Illinois, 61701, United States
Graham Hospital
Canton Illinois, 61520, United States
Memorial Hospital
Carthage Illinois, 62321, United States
Robert H. Lurie Comprehensive Cancer Center at Northwestern University
Chicago Illinois, 60611, United States
Hematology and Oncology Associates
Chicago Illinois, 60611, United States
John H. Stroger, Jr. Hospital of Cook County
Chicago Illinois, 60612, United States
Decatur Memorial Hospital Cancer Care Institute
Decatur Illinois, 62526, United States
Eureka Community Hospital
Eureka Illinois, 61530, United States
Galesburg Clinic, PC
Galesburg Illinois, 61401, United States
Mason District Hospital
Havana Illinois, 62644, United States
Kellogg Cancer Care Center
Highland Park Illinois, 60035, United States
Hinsdale Hematology Oncology Associates
Hinsdale Illinois, 60521, United States
Provena St. Mary's Regional Cancer Center - Kankakee
Kankakee Illinois, 60901, United States
North Shore Oncology and Hematology Associates, Limited - Libertyville
Libertyville Illinois, 60048, United States
McDonough District Hospital
Macomb Illinois, 61455, United States
Trinity Cancer Center at Trinity Medical Center - 7th Street Campus
Moline Illinois, 61265, United States
Cancer Care and Hematology Specialists of Chicagoland - Niles
Niles Illinois, 60714, United States
BroMenn Regional Medical Center
Normal Illinois, 61761, United States
Community Cancer Center
Normal Illinois, 61761, United States
Advocate Christ Medical Center
Oak Lawn Illinois, 60453, United States
Community Hospital of Ottawa
Ottawa Illinois, 61350, United States
Cancer Treatment Center at Pekin Hospital
Pekin Illinois, 61554, United States
Proctor Hospital
Peoria Illinois, 61614, United States
CCOP - Illinois Oncology Research Association
Peoria Illinois, 61615, United States
Oncology Hematology Associates of Central Illinois, PC - Peoria
Peoria Illinois, 61615, United States
Methodist Medical Center of Illinois
Peoria Illinois, 61636, United States
OSF St. Francis Medical Center
Peoria Illinois, 61637, United States
Illinois Valley Community Hospital
Peru Illinois, 61354, United States
Perry Memorial Hospital
Princeton Illinois, 61356, United States
West Suburban Center for Cancer Care
River Forest Illinois, 60305, United States
Swedish-American Regional Cancer Center
Rockford Illinois, 61104, United States
Hematology Oncology Associates - Skokie
Skokie Illinois, 60076, United States
Regional Cancer Center at Memorial Medical Center
Springfield Illinois, 62781, United States
CCOP - Carle Cancer Center
Urbana Illinois, 61801, United States
Indiana University Melvin and Bren Simon Cancer Center
Indianapolis Indiana, 46202, United States
William N. Wishard Memorial Hospital
Indianapolis Indiana, 46202, United States
Clarian Arnett Cancer Care
Lafayette Indiana, 47904, United States
Saint Anthony Memorial Health Centers
Michigan City Indiana, 46360, United States
McFarland Clinic, PC
Ames Iowa, 50010, United States
Cedar Rapids Oncology Associates
Cedar Rapids Iowa, 52403, United States
Mercy Regional Cancer Center at Mercy Medical Center
Cedar Rapids Iowa, 52403, United States
Medical Oncology and Hematology Associates - West Des Moines
Clive Iowa, 50325, United States
CCOP - Iowa Oncology Research Association
Des Moines Iowa, 50309, United States
John Stoddard Cancer Center at Iowa Methodist Medical Center
Des Moines Iowa, 50309, United States
Medical Oncology and Hematology Associates at John Stoddard Cancer Center
Des Moines Iowa, 50309, United States
Medical Oncology and Hematology Associates at Mercy Cancer Center
Des Moines Iowa, 50314, United States
Mercy Cancer Center at Mercy Medical Center - Des Moines
Des Moines Iowa, 50314, United States
John Stoddard Cancer Center at Iowa Lutheran Hospital
Des Moines Iowa, 50316, United States
Mercy Cancer Center at Mercy Medical Center - North Iowa
Mason City Iowa, 50401, United States
McCreery Cancer Center at Ottumwa Regional
Ottumwa Iowa, 52501, United States
Siouxland Hematology-Oncology Associates, LLP
Sioux City Iowa, 51101, United States
Mercy Medical Center - Sioux City
Sioux City Iowa, 51102, United States
St. Luke's Regional Medical Center
Sioux City Iowa, 51104, United States
Cancer Center of Kansas, PA - Chanute
Chanute Kansas, 66720, United States
Cancer Center of Kansas, PA - Dodge City
Dodge City Kansas, 67801, United States
Cancer Center of Kansas, PA - El Dorado
El Dorado Kansas, 67042, United States
Cancer Center of Kansas - Fort Scott
Fort Scott Kansas, 66701, United States
Cancer Center of Kansas-Independence
Independence Kansas, 67301, United States
Cancer Center of Kansas, PA - Kingman
Kingman Kansas, 67068, United States
Lawrence Memorial Hospital
Lawrence Kansas, 66044, United States
Cancer Center of Kansas, PA - Liberal
Liberal Kansas, 67901, United States
Cancer Center of Kansas, PA - McPherson
McPherson Kansas, 67460, United States
Cancer Center of Kansas, PA - Newton
Newton Kansas, 67114, United States
Cancer Center of Kansas, PA - Parsons
Parsons Kansas, 67357, United States
Cancer Center of Kansas, PA - Pratt
Pratt Kansas, 67124, United States
Cancer Center of Kansas, PA - Salina
Salina Kansas, 67401, United States
Cancer Center of Kansas, PA - Wellington
Wellington Kansas, 67152, United States
Associates in Womens Health, PA - North Review
Wichita Kansas, 67208, United States
Cancer Center of Kansas, PA - Medical Arts Tower
Wichita Kansas, 67208, United States
Cancer Center of Kansas, PA - Wichita
Wichita Kansas, 67214, United States
CCOP - Wichita
Wichita Kansas, 67214, United States
Via Christi Cancer Center at Via Christi Regional Medical Center
Wichita Kansas, 67214, United States
Cancer Center of Kansas, PA - Winfield
Winfield Kansas, 67156, United States
Mary Bird Perkins Cancer Center - Baton Rouge
Baton Rouge Louisiana, 70809, United States
Ochsner Health Center - Bluebonnet
Baton Rouge Louisiana, 70809, United States
Ochsner Health Center - Covington
Covington Louisiana, 70433, United States
MBCCOP - LSU Health Sciences Center
New Orleans Louisiana, 70112, United States
Medical Center of Louisiana - New Orleans
New Orleans Louisiana, 70112, United States
Ochsner Cancer Institute at Ochsner Clinic Foundation
New Orleans Louisiana, 70121, United States
Greater Baltimore Medical Center Cancer Center
Baltimore Maryland, 21204, United States
Baystate Regional Cancer Program at D'Amour Center for Cancer Care
Springfield Massachusetts, 01199, United States
Hickman Cancer Center at Bixby Medical Center
Adrian Michigan, 49221, United States
Saint Joseph Mercy Cancer Center
Ann Arbor Michigan, 48106, United States
CCOP - Michigan Cancer Research Consortium
Ann Arbor Michigan, 48106, United States
Oakwood Cancer Center at Oakwood Hospital and Medical Center
Dearborn Michigan, 48123, United States
Genesys Hurley Cancer Institute
Flint Michigan, 48503, United States
Hurley Medical Center
Flint Michigan, 48503, United States
Van Elslander Cancer Center at St. John Hospital and Medical Center
Grosse Pointe Woods Michigan, 48236, United States
Foote Memorial Hospital
Jackson Michigan, 49201, United States
Borgess Medical Center
Kalamazoo Michigan, 49001, United States
West Michigan Cancer Center
Kalamazoo Michigan, 49007, United States
Bronson Methodist Hospital
Kalamazoo Michigan, 49007, United States
Sparrow Regional Cancer Center
Lansing Michigan, 48912, United States
St. Mary Mercy Hospital
Livonia Michigan, 48154, United States
Community Cancer Center of Monroe
Monroe Michigan, 48162, United States
Mercy Memorial Hospital - Monroe
Monroe Michigan, 48162, United States
St. Joseph Mercy Oakland
Pontiac Michigan, 48341, United States
Mercy Regional Cancer Center at Mercy Hospital
Port Huron Michigan, 48060, United States
Seton Cancer Institute at Saint Mary's - Saginaw
Saginaw Michigan, 48601, United States
St. John Macomb Hospital
Warren Michigan, 48093, United States
MeritCare Bemidji
Bemidji Minnesota, 56601, United States
Fairview Ridges Hospital
Burnsville Minnesota, 55337, United States
Mercy and Unity Cancer Center at Mercy Hospital
Coon Rapids Minnesota, 55433, United States
Duluth Clinic Cancer Center - Duluth
Duluth Minnesota, 55805, United States
CCOP - Duluth
Duluth Minnesota, 55805, United States
Miller - Dwan Medical Center
Duluth Minnesota, 55805, United States
Fairview Southdale Hospital
Edina Minnesota, 55435, United States
Mercy and Unity Cancer Center at Unity Hospital
Fridley Minnesota, 55432, United States
Hutchinson Area Health Care
Hutchinson Minnesota, 55350, United States
HealthEast Cancer Care at St. John's Hospital
Maplewood Minnesota, 55109, United States
Minnesota Oncology - Maplewood
Maplewood Minnesota, 55109, United States
Virginia Piper Cancer Institute at Abbott - Northwestern Hospital
Minneapolis Minnesota, 55407, United States
Hennepin County Medical Center - Minneapolis
Minneapolis Minnesota, 55415, United States
New Ulm Medical Center
New Ulm Minnesota, 56073, United States
Humphrey Cancer Center at North Memorial Outpatient Center
Robbinsdale Minnesota, 55422, United States
CCOP - Metro-Minnesota
Saint Louis Park Minnesota, 55416, United States
Park Nicollet Cancer Center
Saint Louis Park Minnesota, 55416, United States
Regions Hospital Cancer Care Center
Saint Paul Minnesota, 55101, United States
United Hospital
Saint Paul Minnesota, 55102, United States
St. Francis Cancer Center at St. Francis Medical Center
Shakopee Minnesota, 55379, United States
Lakeview Hospital
Stillwater Minnesota, 55082, United States
Ridgeview Medical Center
Waconia Minnesota, 55387, United States
Willmar Cancer Center at Rice Memorial Hospital
Willmar Minnesota, 56201, United States
Minnesota Oncology - Woodbury
Woodbury Minnesota, 55125, United States
Cancer Resource Center - Lincoln
Lincoln Nebraska, 68510, United States
CCOP - Missouri Valley Cancer Consortium
Omaha Nebraska, 68106, United States
Immanuel Medical Center
Omaha Nebraska, 68122, United States
Alegant Health Cancer Center at Bergan Mercy Medical Center
Omaha Nebraska, 68124, United States
Lakeside Hospital
Omaha Nebraska, 68130, United States
Creighton University Medical Center
Omaha Nebraska, 68131, United States
Veterans Affairs Medical Center - East Orange
East Orange New Jersey, 07018, United States
Hunterdon Regional Cancer Center at Hunterdon Medical Center
Flemington New Jersey, 08822, United States
CentraState Medical Center
Freehold New Jersey, 07728, United States
Hematology Oncology Associates, PC
Albuquerque New Mexico, 87106, United States
Presbyterian Cancer Treatment Center at Presbyterian Kaseman Hospital
Albuquerque New Mexico, 87110, United States
University of New Mexico Cancer Center
Albuquerque New Mexico, 87131, United States
New Mexico Cancer Care Associates
Santa Fe New Mexico, 87505, United States
NYU Cancer Institute at New York University Medical Center
New York New York, 10016, United States
CCOP - MeritCare Hospital
Fargo North Dakota, 58122, United States
Roger Maris Cancer Center at MeritCare Hospital
Fargo North Dakota, 58122, United States
Summa Center for Cancer Care at Akron City Hospital
Akron Ohio, 44309, United States
Wood County Oncology Center
Bowling Green Ohio, 43402, United States
Adena Regional Medical Center
Chillicothe Ohio, 45601, United States
Case Comprehensive Cancer Center
Cleveland Ohio, 44106, United States
MetroHealth Cancer Care Center at MetroHealth Medical Center
Cleveland Ohio, 44109, United States
Riverside Methodist Hospital Cancer Care
Columbus Ohio, 43214, United States
CCOP - Columbus
Columbus Ohio, 43215, United States
Grant Medical Center Cancer Care
Columbus Ohio, 43215, United States
Mount Carmel Health - West Hospital
Columbus Ohio, 43222, United States
Doctors Hospital at Ohio Health
Columbus Ohio, 43228, United States
Grady Memorial Hospital
Delaware Ohio, 43015, United States
Community Cancer Center
Elyria Ohio, 44035, United States
Hematology Oncology Center
Elyria Ohio, 44035, United States
Fairfield Medical Center
Lancaster Ohio, 43130, United States
St. Rita's Medical Center
Lima Ohio, 45801, United States
Lima Memorial Hospital
Lima Ohio, 45804, United States
Strecker Cancer Center at Marietta Memorial Hospital
Marietta Ohio, 45750, United States
Northwest Ohio Oncology Center
Maumee Ohio, 43537, United States
Knox Community Hospital
Mount Vernon Ohio, 43050, United States
Licking Memorial Cancer Care Program at Licking Memorial Hospital
Newark Ohio, 43055, United States
St. Charles Mercy Hospital
Oregon Ohio, 43616, United States
Toledo Clinic - Oregon
Oregon Ohio, 43616, United States
North Coast Cancer Care, Incorporated
Sandusky Ohio, 44870, United States
Community Hospital of Springfield and Clark County
Springfield Ohio, 45505, United States
Flower Hospital Cancer Center
Sylvania Ohio, 43560, United States
Mercy Hospital of Tiffin
Tiffin Ohio, 44883, United States
Toledo Hospital
Toledo Ohio, 43606, United States
St. Vincent Mercy Medical Center
Toledo Ohio, 43608, United States
Medical University of Ohio Cancer Center
Toledo Ohio, 43614, United States
CCOP - Toledo Community Hospital
Toledo Ohio, 43617, United States
St. Anne Mercy Hospital
Toledo Ohio, 43623, United States
Toledo Clinic, Incorporated - Main Clinic
Toledo Ohio, 43623, United States
Fulton County Health Center
Wauseon Ohio, 43567, United States
Mount Carmel St. Ann's Cancer Center
Westerville Ohio, 43081, United States
Genesis - Good Samaritan Hospital
Zanesville Ohio, 43701, United States
Natalie Warren Bryant Cancer Center at St. Francis Hospital
Tulsa Oklahoma, 74136, United States
St. Luke's Cancer Network at St. Luke's Hospital
Bethlehem Pennsylvania, 18015, United States
Bryn Mawr Hospital
Bryn Mawr Pennsylvania, 19010, United States
Geisinger Cancer Institute at Geisinger Health
Danville Pennsylvania, 17822, United States
Doylestown Hospital Cancer Center
Doylestown Pennsylvania, 18901, United States
PinnacleHealth Regional Cancer Center at Polyclinic Hospital
Harrisburg Pennsylvania, 17110, United States
Geisinger Hazleton Cancer Center
Hazleton Pennsylvania, 18201, United States
Cancer Center of Paoli Memorial Hospital
Paoli Pennsylvania, 19301, United States
Abramson Cancer Center of the University of Pennsylvania
Philadelphia Pennsylvania, 19104, United States
Kimmel Cancer Center at Thomas Jefferson University - Philadelphia
Philadelphia Pennsylvania, 19107, United States
Joan Karnell Cancer Center at Pennsylvania Hospital
Philadelphia Pennsylvania, 19107, United States
Fox Chase Cancer Center - Philadelphia
Philadelphia Pennsylvania, 19111, United States
Pottstown Memorial Regional Cancer Center
Pottstown Pennsylvania, 19464, United States
McGlinn Family Regional Cancer Center at Reading Hospital and Medical Center
Reading Pennsylvania, 19612, United States
Hematology and Oncology Associates of Northeastern Pennsylvania
Scranton Pennsylvania, 18508, United States
Grand View Hospital
Sellersville Pennsylvania, 18960, United States
Geisinger Medical Group - Scenery Park
State College Pennsylvania, 16801, United States
Chester County Hospital
West Chester Pennsylvania, 19380, United States
Frank M. and Dorothea Henry Cancer Center at Geisinger Wyoming Valley Medical Center
Wilkes-Barre Pennsylvania, 18711, United States
CCOP - Main Line Health
Wynnewood Pennsylvania, 19096, United States
Lankenau Cancer Center at Lankenau Hospital
Wynnewood Pennsylvania, 19096, United States
Sanford Cancer Center at Sanford USD Medical Center
Sioux Falls South Dakota, 57117, United States
Parkland Memorial Hospital
Dallas Texas, 75235, United States
Simmons Comprehensive Cancer Center at University of Texas Southwestern Medical Center - Dallas
Dallas Texas, 75390, United States
CCOP - Scott and White Hospital
Temple Texas, 76508, United States
Fredericksburg Oncology, Incorporated
Fredericksburg Virginia, 22401, United States
West Virginia University Health Sciences Center - Charleston
Charleston West Virginia, 25304, United States
Langlade Memorial Hospital
Antigo Wisconsin, 54409, United States
Marshfield Clinic Cancer Care at Regional Cancer Center
Eau Claire Wisconsin, 54701, United States
St. Vincent Hospital Regional Cancer Center
Green Bay Wisconsin, 54307, United States
Vince Lombardi Cancer Clinic - Green Bay at Aurora BayCare Medical Center
Green Bay Wisconsin, 54311, United States
UW Cancer Center Johnson Creek
Johnson Creek Wisconsin, 53038, United States
University of Wisconsin Paul P. Carbone Comprehensive Cancer Center
Madison Wisconsin, 53792, United States
Holy Family Memorial Medical Center Cancer Care Center
Manitowoc Wisconsin, 54221, United States
Bay Area Cancer Care Center at Bay Area Medical Center
Marinette Wisconsin, 54143, United States
Vince Lombardi Cancer Clinic - Marinette
Marinette Wisconsin, 54143, United States
Marshfield Clinic - Marshfield Center
Marshfield Wisconsin, 54449, United States
Marshfield Clinic - Lakeland Center
Minocqua Wisconsin, 54548, United States
Regional Cancer Center at Oconomowoc Memorial Hospital
Oconomowoc Wisconsin, 53066, United States
Ministry Medical Group at Saint Mary's Hospital
Rhinelander Wisconsin, 54501, United States
Marshfield Clinic - Indianhead Center
Rice Lake Wisconsin, 54868, United States
St. Nicholas Hospital
Sheboygan Wisconsin, 53081, United States
Vince Lombardi Cancer Clinic - Sheboygan
Sheboygan Wisconsin, 53081, United States
Marshfield Clinic at Saint Michael's Hospital
Stevens Point Wisconsin, 54481, United States
Aurora Medical Center
Summit Wisconsin, 53066, United States
Vince Lombardi Cancer Clinic - Two Rivers
Two Rivers Wisconsin, 54241, United States
Waukesha Memorial Hospital Regional Cancer Center
Waukesha Wisconsin, 53188, United States
University of Wisconcin Cancer Center at Aspirus Wausau Hospital
Wausau Wisconsin, 54401, United States
Diagnostic and Treatment Center
Weston Wisconsin, 54476, United States
Marshfield Clinic - Weston Center
Weston Wisconsin, 54476, United States
Marshfield Clinic - Wisconsin Rapids Center
Wisconsin Rapids Wisconsin, 54494, United States
Riverview UW Cancer Center at Riverview Hospital
Wisconsin Rapids Wisconsin, 54494, United States

How clear is this clinincal trial information?

Study is for people with:

Colon Cancer

Phase:

Phase 2

Estimated Enrollment:

136

Study ID:

NCT01079780

Recruitment Status:

Completed

Sponsor:


Eastern Cooperative Oncology Group

How clear is this clinincal trial information?

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