Colon Cancer Clinical Trial

Testing the Use of BRAF-Targeted Therapy After Surgery and Usual Chemotherapy for BRAF-Mutated Colon Cancer

Summary

This phase II/III trial compares treatment with encorafenib and cetuximab to usual care (patient observation) for reducing the chance of cancer recurrence after standard surgery and chemotherapy in patients with BRAF-mutated stage IIB-III colon cancer. Encorafenib may stop the growth of tumor cells by blocking some of the enzymes needed for cell growth. Cetuximab is in a class of medications called monoclonal antibodies. It binds to a protein called EGFR, which is found on some types of tumor cells. This may help keep tumor cells from growing. Giving encorafenib and cetuximab after standard surgery and chemotherapy may be more effective at reducing the chance of cancer recurrence compared to the usual patient observation.

View Full Description

Full Description

The primary and secondary objectives of the study:

PRIMARY OBJECTIVES:

I. To evaluate and compare 6 month circulating tumor deoxyribonucleic acid (ctDNA) clearance rate in study patients with detectable ctDNA prior to randomization to targeted BRAF therapy versus usual care after standard adjuvant chemotherapy. (Phase II) II. To evaluate and compare 6 month ctDNA recurrence-free survival (ctDNA-RFS) rate in study patients with undetectable ctDNA prior to randomization to targeted BRAF therapy versus usual care after standard adjuvant chemotherapy. (Phase II) III. To evaluate and compare disease-free survival (DFS) (measured from randomization) in patients with resected stage III or high-risk (pT4) stage II mismatch repair protein (MMR) proficient BRAF V600E colon cancer treated with targeted BRAF therapy versus usual care after standard adjuvant chemotherapy. (Phase III)

SECONDARY OBJECTIVES:

I. To evaluate and compare overall survival (OS) between the two treatment arms.

II. To evaluate and compare the toxicity profile between the two treatment arms.

III. To evaluate and compare the alternative DFS endpoint (measured from date of primary tumor resection) between the two treatment arms.

IV. To evaluate and compare DFS in the subset of patients with detectable ctDNA prior to randomization between the two treatment arms.

EXPLORATORY OBJECTIVE:

I. To evaluate and compare patient-reported outcomes for symptoms of rash, diarrhea, and fatigue according to Patient Reported Outcomes Version of Common Terminology Criteria for Adverse Events (PRO-CTCAE) between the two treatment arms.

OUTLINE: Patients are randomized to 1 of 2 arms.

ARM I: Patients receive encorafenib orally (PO) and cetuximab intravenously (IV) on study. Patients also undergo collection of blood samples throughout the study and computed tomography (CT) or magnetic resonance imaging (MRI) during screening and follow-up.

ARM II: Patients undergo observation per usual care on study. Patients also undergo collection of blood samples throughout the study and CT or MRI during screening and follow-up.

View Eligibility Criteria

Eligibility Criteria

Inclusion Criteria:

PRE-REGISTRATION (STEP 0) ELIGIBILITY CRITERIA:
BRAF V600 mutational status may be determined either locally or by central testing. This testing is mandatory prior to registration to determine eligibility. Tissue submission should be initiated as soon after surgery as possible. For tumors evaluated at local laboratories, formalin-fixed paraffin-embedded (FFPE) tumor tissue must still be submitted for central confirmation of BRAF status
REGISTRATION (STEP 1) ELIGIBILITY CRITERIA:
Histologically-proven stage III (any T [Tx, T1, T2, T3, or T4], N1-2M0; includes N1C) or high-risk (pT4) stage II colon adenocarcinoma. Tumors must be deemed to originate in the colon including tumors that extend into/involve the small bowel (e.g. those at the ileocecal valve) and must have been completely resected
BRAF V600E mutation
MMR proficient (pMMR) or microsatellite stable (MSS) tumor
Histologic documentation: adenocarcinoma
Stage: III (any T [Tx, T1, T2, T3, or T4], N1-2M0; includes N1C) or high-risk II (pT4)
Tumor site: colon
Patients must have received at least 3 months of adjuvant chemotherapy with either leucovorin calcium, fluorouracil, and oxaliplatin (FOLFOX) (minimum of 5 cycles) or capecitabine and oxaliplatin (CAPOX) (minimum of 3 cycles)
Adjuvant therapy must be completed at most 8 weeks prior to registration
No other prior medical therapy (chemotherapy, immunotherapy, biologic, or targeted therapy) or radiation therapy for the current colon cancer is permitted
Not pregnant and not nursing, because this study involves an agent that has known genotoxic, mutagenic and teratogenic effects. Therefore, for women of childbearing potential only, a negative pregnancy test done =< 7 days prior to registration is required
Age >= 18 years
Eastern Cooperative Oncology Group (ECOG) performance status: 0-2
Absolute neutrophil count (ANC) >= 1.0 x 10^9/L
Platelet count >= 75 x 10^9/L
Hemoglobin > 9.0 g/dL
Total bilirubin =< 1.5 x upper limit of normal (ULN)
Aspartate aminotransferase (AST)/alanine aminotransferase (ALT) =< 3.0 x ULN
Corrected QT (QTc) Interval =< 480 msec
Creatinine = calculated (calc.) creatinine clearance >= 40 mL/min
Human immunodeficiency virus (HIV)-infected patients on effective anti-retroviral therapy with undetectable viral load within 6 months are eligible for this trial
No medical condition such as uncontrolled infection, uncontrolled diabetes mellitus, or cardiac disease which, in the opinion of the treating physician, would make this protocol unreasonably hazardous for the patient
Patients with known history or current symptoms of cardiac disease or history of treatment with cardiotoxic agents in the last 12 months, should have a clinical risk assessment of cardiac function using the New York Heart Association Functional Classification. To be eligible for this trial, patients should be class 2B or better
No uncontrolled or poorly-controlled hypertension (> 180 mmHg systolic or > 130 mmHg diastolic)
No history of allergic reactions attributed to compounds of chemical or biologic composition similar to those of cetuximab

No "currently active" second malignancy other than non-melanoma skin cancers or cervical carcinoma in situ. Patients are not considered to have a "currently active" malignancy if they have completed therapy and are free of disease for >= 3 years

Patients are not considered to have a "currently active" malignancy if they had a gastric or bowel carcinoid < 1 cm, ductal carcinoma in situ (DCIS)/lobular carcinoma in situ (LCIS) of the breast without invasive cancer, or endometrial dysplasia/carcinoma in situ
Patients are not considered to have a "currently active" malignancy if they had a sebaceous neoplasm (sebaceous adenoma, sebaceous epithelioma, sebaceous adenocarcinoma, keratoacanthoma, and squamous cell carcinoma) that was noninvasive
No known medical condition causing an inability to swallow oral formulations of agents
No residual Common Terminology Criteria for Adverse Events (CTCAE) version (v) 5.0 grade >= 2 toxicity from prior chemotherapy, with the exception of grade 2 alopecia or neuropathy
Drugs that prolong the QTc interval should be avoided if possible, as encorafenib can prolong the QTc interval. Drugs that are generally accepted to have a risk of causing Torsades de Pointes should be discontinued or replaced with drugs that do not carry this risk if at all possible. Patients who receive potential QTc-prolonging medications should be monitored closely
Chronic concomitant treatment with strong inhibitors of CYP3A4 is not allowed during treatment on this study. Patients on strong CYP3A4 inhibitors must discontinue the drug for 14 days prior to registration on the study
Chronic concomitant treatment with strong CYP3A4 inducers is not allowed during treatment on this study. Patients must discontinue the drug 14 days prior to registration on the study

Exclusion Criteria: N/A

Study is for people with:

Colon Cancer

Phase:

Phase 2

Estimated Enrollment:

394

Study ID:

NCT05710406

Recruitment Status:

Recruiting

Sponsor:

Alliance for Clinical Trials in Oncology

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There are 164 Locations for this study

See Locations Near You

Beebe South Coastal Health Campus
Frankford Delaware, 19945, United States More Info
Site Public Contact
Contact
302-291-6730
[email protected]
Gregory A. Masters
Principal Investigator
Helen F Graham Cancer Center
Newark Delaware, 19713, United States More Info
Site Public Contact
Contact
302-623-4450
[email protected]
Gregory A. Masters
Principal Investigator
Medical Oncology Hematology Consultants PA
Newark Delaware, 19713, United States More Info
Site Public Contact
Contact
302-623-4450
[email protected]
Gregory A. Masters
Principal Investigator
Beebe Health Campus
Rehoboth Beach Delaware, 19971, United States More Info
Site Public Contact
Contact
302-291-6730
[email protected]
Gregory A. Masters
Principal Investigator
Emory University Hospital Midtown
Atlanta Georgia, 30308, United States More Info
Site Public Contact
Contact
888-946-7447
Olatunji B. Alese
Principal Investigator
Emory University Hospital/Winship Cancer Institute
Atlanta Georgia, 30322, United States More Info
Site Public Contact
Contact
404-778-1868
Olatunji B. Alese
Principal Investigator
Emory Saint Joseph's Hospital
Atlanta Georgia, 30342, United States More Info
Site Public Contact
Contact
404-851-7115
Olatunji B. Alese
Principal Investigator
Hawaii Cancer Care - Westridge
'Aiea Hawaii, 96701, United States More Info
Site Public Contact
Contact
808-539-2273
[email protected]
Jared D. Acoba
Principal Investigator
Pali Momi Medical Center
'Aiea Hawaii, 96701, United States More Info
Site Public Contact
Contact
808-486-6000
Jared D. Acoba
Principal Investigator
Hawaii Cancer Care Inc - Waterfront Plaza
Honolulu Hawaii, 96813, United States More Info
Site Public Contact
Contact
808-524-6115
[email protected]
Jared D. Acoba
Principal Investigator
Queen's Cancer Cenrer - POB I
Honolulu Hawaii, 96813, United States More Info
Site Public Contact
Contact
808-532-0315
Jared D. Acoba
Principal Investigator
Queen's Medical Center
Honolulu Hawaii, 96813, United States More Info
Site Public Contact
Contact
808-545-8548
Jared D. Acoba
Principal Investigator
Straub Clinic and Hospital
Honolulu Hawaii, 96813, United States More Info
Site Public Contact
Contact
808-522-4333
Jared D. Acoba
Principal Investigator
Queen's Cancer Center - Kuakini
Honolulu Hawaii, 96817, United States More Info
Site Public Contact
Contact
808-531-8521
Jared D. Acoba
Principal Investigator
Saint Alphonsus Cancer Care Center-Boise
Boise Idaho, 83706, United States More Info
Site Public Contact
Contact
734-712-3671
[email protected]
John M. Schallenkamp
Principal Investigator
Saint Luke's Cancer Institute - Boise
Boise Idaho, 83712, United States More Info
Site Public Contact
Contact
208-381-2774
[email protected]
Alison K. Conlin
Principal Investigator
Saint Alphonsus Cancer Care Center-Caldwell
Caldwell Idaho, 83605, United States More Info
Site Public Contact
Contact
734-712-3671
[email protected]
John M. Schallenkamp
Principal Investigator
Kootenai Health - Coeur d'Alene
Coeur d'Alene Idaho, 83814, United States More Info
Site Public Contact
Contact
406-969-6060
[email protected]
John M. Schallenkamp
Principal Investigator
Saint Luke's Cancer Institute - Fruitland
Fruitland Idaho, 83619, United States More Info
Site Public Contact
Contact
208-381-2774
[email protected]
Alison K. Conlin
Principal Investigator
Saint Luke's Cancer Institute - Meridian
Meridian Idaho, 83642, United States More Info
Site Public Contact
Contact
208-381-2774
[email protected]
Alison K. Conlin
Principal Investigator
Saint Luke's Cancer Institute - Nampa
Nampa Idaho, 83686, United States More Info
Site Public Contact
Contact
208-381-2774
[email protected]
Alison K. Conlin
Principal Investigator
Saint Alphonsus Cancer Care Center-Nampa
Nampa Idaho, 83687, United States More Info
Site Public Contact
Contact
406-969-6060
[email protected]
John M. Schallenkamp
Principal Investigator
Kootenai Clinic Cancer Services - Post Falls
Post Falls Idaho, 83854, United States More Info
Site Public Contact
Contact
406-969-6060
[email protected]
John M. Schallenkamp
Principal Investigator
Kootenai Cancer Clinic
Sandpoint Idaho, 83864, United States More Info
Site Public Contact
Contact
406-969-6060
[email protected]
John M. Schallenkamp
Principal Investigator
Saint Luke's Cancer Institute - Twin Falls
Twin Falls Idaho, 83301, United States More Info
Site Public Contact
Contact
208-381-2774
[email protected]
Alison K. Conlin
Principal Investigator
Illinois CancerCare-Bloomington
Bloomington Illinois, 61704, United States More Info
Site Public Contact
Contact
309-243-3605
[email protected]
Bryan A. Faller
Principal Investigator
Illinois CancerCare-Canton
Canton Illinois, 61520, United States More Info
Site Public Contact
Contact
309-243-3605
[email protected]
Bryan A. Faller
Principal Investigator
Illinois CancerCare-Carthage
Carthage Illinois, 62321, United States More Info
Site Public Contact
Contact
309-243-3605
[email protected]
Bryan A. Faller
Principal Investigator
Northwestern University
Chicago Illinois, 60611, United States More Info
Site Public Contact
Contact
312-695-1301
[email protected]
Chengwei Peng
Principal Investigator
University of Chicago Comprehensive Cancer Center
Chicago Illinois, 60637, United States More Info
Site Public Contact
Contact
773-702-8222
[email protected]
Ardaman Shergill
Principal Investigator
Carle at The Riverfront
Danville Illinois, 61832, United States More Info
Site Public Contact
Contact
800-446-5532
[email protected]
Prem Sobti
Principal Investigator
Cancer Care Specialists of Illinois - Decatur
Decatur Illinois, 62526, United States More Info
Site Public Contact
Contact
217-876-4762
[email protected]
Bryan A. Faller
Principal Investigator
Decatur Memorial Hospital
Decatur Illinois, 62526, United States More Info
Site Public Contact
Contact
217-876-4762
[email protected]
Bryan A. Faller
Principal Investigator
Northwestern Medicine Cancer Center Kishwaukee
DeKalb Illinois, 60115, United States More Info
Site Public Contact
Contact
630-352-5360
[email protected]
Chengwei Peng
Principal Investigator
Illinois CancerCare-Dixon
Dixon Illinois, 61021, United States More Info
Site Public Contact
Contact
815-285-7800
Bryan A. Faller
Principal Investigator
Carle Physician Group-Effingham
Effingham Illinois, 62401, United States More Info
Site Public Contact
Contact
800-446-5532
[email protected]
Prem Sobti
Principal Investigator
Crossroads Cancer Center
Effingham Illinois, 62401, United States More Info
Site Public Contact
Contact
217-876-4762
[email protected]
Bryan A. Faller
Principal Investigator
Illinois CancerCare-Eureka
Eureka Illinois, 61530, United States More Info
Site Public Contact
Contact
309-243-3605
[email protected]
Bryan A. Faller
Principal Investigator
Illinois CancerCare-Galesburg
Galesburg Illinois, 61401, United States More Info
Site Public Contact
Contact
309-243-3605
[email protected]
Bryan A. Faller
Principal Investigator
Northwestern Medicine Cancer Center Delnor
Geneva Illinois, 60134, United States More Info
Site Public Contact
Contact
630-352-5360
[email protected]
Chengwei Peng
Principal Investigator
Northwestern Medicine Glenview Outpatient Center
Glenview Illinois, 60026, United States More Info
Site Public Contact
Contact
312-695-1102
Chengwei Peng
Principal Investigator
Northwestern Medicine Grayslake Outpatient Center
Grayslake Illinois, 60030, United States More Info
Site Public Contact
Contact
312-695-1102
Chengwei Peng
Principal Investigator
Illinois CancerCare-Kewanee Clinic
Kewanee Illinois, 61443, United States More Info
Site Public Contact
Contact
309-243-3605
[email protected]
Bryan A. Faller
Principal Investigator
Northwestern Medicine Lake Forest Hospital
Lake Forest Illinois, 60045, United States More Info
Site Public Contact
Contact
[email protected]
Chengwei Peng
Principal Investigator
Illinois CancerCare-Macomb
Macomb Illinois, 61455, United States More Info
Site Public Contact
Contact
309-243-3605
[email protected]
Bryan A. Faller
Principal Investigator
Carle Physician Group-Mattoon/Charleston
Mattoon Illinois, 61938, United States More Info
Site Public Contact
Contact
800-446-5532
[email protected]
Prem Sobti
Principal Investigator
UC Comprehensive Cancer Center at Silver Cross
New Lenox Illinois, 60451, United States More Info
Site Public Contact
Contact
773-702-8222
[email protected]
Ardaman Shergill
Principal Investigator
Cancer Care Center of O'Fallon
O'Fallon Illinois, 62269, United States More Info
Site Public Contact
Contact
217-876-4762
[email protected]
Bryan A. Faller
Principal Investigator
Northwestern Medicine Orland Park
Orland Park Illinois, 60462, United States More Info
Site Public Contact
Contact
[email protected]
Chengwei Peng
Principal Investigator
University of Chicago Medicine-Orland Park
Orland Park Illinois, 60462, United States More Info
Site Public Contact
Contact
773-702-8222
[email protected]
Ardaman Shergill
Principal Investigator
Illinois CancerCare-Ottawa Clinic
Ottawa Illinois, 61350, United States More Info
Site Public Contact
Contact
309-243-3605
[email protected]
Bryan A. Faller
Principal Investigator
Illinois CancerCare-Pekin
Pekin Illinois, 61554, United States More Info
Site Public Contact
Contact
309-243-3605
[email protected]
Bryan A. Faller
Principal Investigator
Illinois CancerCare-Peoria
Peoria Illinois, 61615, United States More Info
Site Public Contact
Contact
309-243-3605
[email protected]
Bryan A. Faller
Principal Investigator
Illinois CancerCare-Peru
Peru Illinois, 61354, United States More Info
Site Public Contact
Contact
309-243-3605
[email protected]
Bryan A. Faller
Principal Investigator
Illinois CancerCare-Princeton
Princeton Illinois, 61356, United States More Info
Site Public Contact
Contact
309-243-3605
[email protected]
Bryan A. Faller
Principal Investigator
Southern Illinois University School of Medicine
Springfield Illinois, 62702, United States More Info
Site Public Contact
Contact
217-545-7929
Bryan A. Faller
Principal Investigator
Springfield Clinic
Springfield Illinois, 62702, United States More Info
Site Public Contact
Contact
800-444-7541
Bryan A. Faller
Principal Investigator
Memorial Medical Center
Springfield Illinois, 62781, United States More Info
Site Public Contact
Contact
217-528-7541
[email protected]
Bryan A. Faller
Principal Investigator
Carle Cancer Center
Urbana Illinois, 61801, United States More Info
Site Public Contact
Contact
800-446-5532
[email protected]
Prem Sobti
Principal Investigator
Northwestern Medicine Cancer Center Warrenville
Warrenville Illinois, 60555, United States More Info
Site Public Contact
Contact
630-352-5360
[email protected]
Chengwei Peng
Principal Investigator
Illinois CancerCare - Washington
Washington Illinois, 61571, United States More Info
Site Public Contact
Contact
309-243-3605
[email protected]
Bryan A. Faller
Principal Investigator
Northwest Cancer Center - Main Campus
Crown Point Indiana, 46307, United States More Info
Site Public Contact
Contact
219-310-2550
Prem Sobti
Principal Investigator
Northwest Oncology LLC
Dyer Indiana, 46311, United States More Info
Site Public Contact
Contact
219-924-8178
Prem Sobti
Principal Investigator
Northwest Cancer Center - Hobart
Hobart Indiana, 46342, United States More Info
Site Public Contact
Contact
219-947-1795
Prem Sobti
Principal Investigator
Saint Mary Medical Center
Hobart Indiana, 46342, United States More Info
Site Public Contact
Contact
219-836-6875
[email protected]
Prem Sobti
Principal Investigator
Saint Catherine Hospital
Indianapolis Indiana, 46312, United States More Info
Site Public Contact
Contact
773-702-9171
[email protected]
Prem Sobti
Principal Investigator
The Community Hospital
Munster Indiana, 46321, United States More Info
Site Public Contact
Contact
219-836-3349
Prem Sobti
Principal Investigator
Women's Diagnostic Center - Munster
Munster Indiana, 46321, United States More Info
Site Public Contact
Contact
219-934-8869
[email protected]
Prem Sobti
Principal Investigator
Northwest Cancer Center - Valparaiso
Valparaiso Indiana, 46383, United States More Info
Site Public Contact
Contact
219-836-6875
[email protected]
Prem Sobti
Principal Investigator
Mission Cancer and Blood - Ankeny
Ankeny Iowa, 50023, United States More Info
Site Public Contact
Contact
515-282-2921
Joshua Lukenbill
Principal Investigator
Mercy Hospital
Cedar Rapids Iowa, 52403, United States More Info
Site Public Contact
Contact
319-365-4673
Deborah W. Wilbur
Principal Investigator
Oncology Associates at Mercy Medical Center
Cedar Rapids Iowa, 52403, United States More Info
Site Public Contact
Contact
319-363-2690
Deborah W. Wilbur
Principal Investigator
Mission Cancer and Blood - Des Moines
Des Moines Iowa, 50309, United States More Info
Site Public Contact
Contact
515-241-3305
Joshua Lukenbill
Principal Investigator
Trinity Health Saint Joseph Mercy Hospital Ann Arbor
Ann Arbor Michigan, 48106, United States More Info
Site Public Contact
Contact
734-712-7251
[email protected]
Elie G. Dib
Principal Investigator
Trinity Health IHA Medical Group Hematology Oncology - Brighton
Brighton Michigan, 48114, United States More Info
Site Public Contact
Contact
734-712-7251
[email protected]
Elie G. Dib
Principal Investigator
Trinity Health Medical Center - Brighton
Brighton Michigan, 48114, United States More Info
Site Public Contact
Contact
734-712-7251
[email protected]
Elie G. Dib
Principal Investigator
Trinity Health IHA Medical Group Hematology Oncology - Canton
Canton Michigan, 48188, United States More Info
Site Public Contact
Contact
734-712-7251
[email protected]
Elie G. Dib
Principal Investigator
Trinity Health Medical Center - Canton
Canton Michigan, 48188, United States More Info
Site Public Contact
Contact
734-712-7251
[email protected]
Elie G. Dib
Principal Investigator
Saint Joseph Mercy Chelsea
Chelsea Michigan, 48118, United States More Info
Site Public Contact
Contact
734-712-7251
[email protected]
Elie G. Dib
Principal Investigator
Trinity Health IHA Medical Group Hematology Oncology - Chelsea Hospital
Chelsea Michigan, 48118, United States More Info
Site Public Contact
Contact
734-712-7251
[email protected]
Elie G. Dib
Principal Investigator
Genesee Cancer and Blood Disease Treatment Center
Flint Michigan, 48503, United States More Info
Site Public Contact
Contact
810-762-8038
[email protected]
Elie G. Dib
Principal Investigator
Genesee Hematology Oncology PC
Flint Michigan, 48503, United States More Info
Site Public Contact
Contact
810-762-8038
[email protected]
Elie G. Dib
Principal Investigator
Genesys Hurley Cancer Institute
Flint Michigan, 48503, United States More Info
Site Public Contact
Contact
810-762-8038
[email protected]
Elie G. Dib
Principal Investigator
Hurley Medical Center
Flint Michigan, 48503, United States More Info
Site Public Contact
Contact
810-762-8038
[email protected]
Elie G. Dib
Principal Investigator
Trinity Health Saint Mary Mercy Livonia Hospital
Livonia Michigan, 48154, United States More Info
Site Public Contact
Contact
734-712-7251
[email protected]
Elie G. Dib
Principal Investigator
Great Lakes Cancer Management Specialists-Macomb Medical Campus
Macomb Michigan, 48044, United States More Info
Site Public Contact
Contact
313-343-3166
[email protected]
Elie G. Dib
Principal Investigator
Huron Gastroenterology PC
Ypsilanti Michigan, 48106, United States More Info
Site Public Contact
Contact
734-712-7251
[email protected]
Elie G. Dib
Principal Investigator
Trinity Health IHA Medical Group Hematology Oncology Ann Arbor Campus
Ypsilanti Michigan, 48197, United States More Info
Site Public Contact
Contact
734-712-7251
[email protected]
Elie G. Dib
Principal Investigator
Sanford Joe Lueken Cancer Center
Bemidji Minnesota, 56601, United States More Info
Site Public Contact
Contact
218-333-5000
[email protected]
Daniel Almquist
Principal Investigator
Mercy Hospital
Coon Rapids Minnesota, 55433, United States More Info
Site Public Contact
Contact
952-993-1517
[email protected]
Daniel M. Anderson
Principal Investigator
Abbott-Northwestern Hospital
Minneapolis Minnesota, 55407, United States More Info
Site Public Contact
Contact
952-993-1517
[email protected]
Daniel M. Anderson
Principal Investigator
United Hospital
Saint Paul Minnesota, 55102, United States More Info
Site Public Contact
Contact
952-993-1517
[email protected]
Daniel M. Anderson
Principal Investigator
Saint Francis Medical Center
Cape Girardeau Missouri, 63703, United States More Info
Site Public Contact
Contact
573-334-2230
[email protected]
Bryan A. Faller
Principal Investigator
Community Hospital of Anaconda
Anaconda Montana, 59711, United States More Info
Site Public Contact
Contact
406-969-6060
[email protected]
John M. Schallenkamp
Principal Investigator
Billings Clinic Cancer Center
Billings Montana, 59101, United States More Info
Site Public Contact
Contact
800-996-2663
[email protected]
John M. Schallenkamp
Principal Investigator
Bozeman Health Deaconess Hospital
Bozeman Montana, 59715, United States More Info
Site Public Contact
Contact
406-969-6060
[email protected]
John M. Schallenkamp
Principal Investigator
Benefis Sletten Cancer Institute
Great Falls Montana, 59405, United States More Info
Site Public Contact
Contact
406-969-6060
[email protected]
John M. Schallenkamp
Principal Investigator
Community Medical Center
Missoula Montana, 59804, United States More Info
Site Public Contact
Contact
406-969-6060
[email protected]
John M. Schallenkamp
Principal Investigator
Memorial Sloan Kettering Basking Ridge
Basking Ridge New Jersey, 07920, United States More Info
Site Public Contact
Contact
212-639-7592
Rona D. Yaeger
Principal Investigator
Memorial Sloan Kettering Monmouth
Middletown New Jersey, 07748, United States More Info
Site Public Contact
Contact
212-639-7592
Rona D. Yaeger
Principal Investigator
Memorial Sloan Kettering Bergen
Montvale New Jersey, 07645, United States More Info
Site Public Contact
Contact
212-639-7592
Rona D. Yaeger
Principal Investigator
Roswell Park Cancer Institute
Buffalo New York, 14263, United States More Info
Site Public Contact
Contact
800-767-9355
[email protected]
Anuradha Krishnamurthy
Principal Investigator
Memorial Sloan Kettering Commack
Commack New York, 11725, United States More Info
Site Public Contact
Contact
212-639-7592
Rona D. Yaeger
Principal Investigator
Glens Falls Hospital
Glens Falls New York, 12801, United States More Info
Site Public Contact
Contact
518-926-6700
Charles Yun
Principal Investigator
Memorial Sloan Kettering Westchester
Harrison New York, 10604, United States More Info
Site Public Contact
Contact
212-639-7592
Rona D. Yaeger
Principal Investigator
Memorial Sloan Kettering Cancer Center
New York New York, 10065, United States More Info
Site Public Contact
Contact
212-639-7592
Rona D. Yaeger
Principal Investigator
Upstate Cancer Center at Oswego
Oswego New York, 13126, United States More Info
Site Public Contact
Contact
315-464-8230
[email protected]
Rahul Seth
Principal Investigator
State University of New York Upstate Medical University
Syracuse New York, 13210, United States More Info
Site Public Contact
Contact
315-464-5476
Rahul Seth
Principal Investigator
SUNY Upstate Medical Center-Community Campus
Syracuse New York, 13215, United States More Info
Site Public Contact
Contact
315-464-5476
Rahul Seth
Principal Investigator
Memorial Sloan Kettering Nassau
Uniondale New York, 11553, United States More Info
Site Public Contact
Contact
212-639-7592
Rona D. Yaeger
Principal Investigator
Upstate Cancer Center at Verona
Verona New York, 13478, United States More Info
Site Public Contact
Contact
315-464-8230
[email protected]
Rahul Seth
Principal Investigator
Southeastern Medical Oncology Center-Clinton
Clinton North Carolina, 28328, United States More Info
Site Public Contact
Contact
919-587-9084
[email protected]
Samer S. Kasbari
Principal Investigator
Southeastern Medical Oncology Center-Goldsboro
Goldsboro North Carolina, 27534, United States More Info
Site Public Contact
Contact
919-587-9084
[email protected]
Samer S. Kasbari
Principal Investigator
Southeastern Medical Oncology Center-Jacksonville
Jacksonville North Carolina, 28546, United States More Info
Site Public Contact
Contact
910-587-9084
[email protected]
Samer S. Kasbari
Principal Investigator
Sanford Bismarck Medical Center
Bismarck North Dakota, 58501, United States More Info
Site Public Contact
Contact
701-323-5760
[email protected]
Daniel Almquist
Principal Investigator
Sanford Broadway Medical Center
Fargo North Dakota, 58122, United States More Info
Site Public Contact
Contact
701-323-5760
[email protected]
Daniel Almquist
Principal Investigator
Sanford Roger Maris Cancer Center
Fargo North Dakota, 58122, United States More Info
Site Public Contact
Contact
701-234-6161
[email protected]
Daniel Almquist
Principal Investigator
Aultman Health Foundation
Canton Ohio, 44710, United States More Info
Site Public Contact
Contact
330-363-7274
[email protected]
Adarsh Vennepureddy
Principal Investigator
Miami Valley Hospital South
Centerville Ohio, 45459, United States More Info
Site Public Contact
Contact
937-528-2900
[email protected]
Tarek M. Sabagh
Principal Investigator
Cleveland Clinic Cancer Center/Fairview Hospital
Cleveland Ohio, 44111, United States More Info
Site Public Contact
Contact
866-223-8100
[email protected]
Smitha S. Krishnamurthi
Principal Investigator
Cleveland Clinic Foundation
Cleveland Ohio, 44195, United States More Info
Site Public Contact
Contact
866-223-8100
[email protected]
Smitha S. Krishnamurthi
Principal Investigator
Miami Valley Hospital
Dayton Ohio, 45409, United States More Info
Site Public Contact
Contact
937-528-2900
[email protected]
Tarek M. Sabagh
Principal Investigator
Premier Blood and Cancer Center
Dayton Ohio, 45409, United States More Info
Site Public Contact
Contact
937-276-8320
Tarek M. Sabagh
Principal Investigator
Miami Valley Hospital North
Dayton Ohio, 45415, United States More Info
Site Public Contact
Contact
937-528-2900
[email protected]
Tarek M. Sabagh
Principal Investigator
Atrium Medical Center-Middletown Regional Hospital
Franklin Ohio, 45005, United States More Info
Site Public Contact
Contact
937-528-2900
[email protected]
Tarek M. Sabagh
Principal Investigator
Miami Valley Cancer Care and Infusion
Greenville Ohio, 45331, United States More Info
Site Public Contact
Contact
937-569-7515
Tarek M. Sabagh
Principal Investigator
Cleveland Clinic Cancer Center Independence
Independence Ohio, 44131, United States More Info
Site Public Contact
Contact
866-223-8100
[email protected]
Smitha S. Krishnamurthi
Principal Investigator
Cleveland Clinic Cancer Center Mansfield
Mansfield Ohio, 44906, United States More Info
Site Public Contact
Contact
866-223-8100
[email protected]
Smitha S. Krishnamurthi
Principal Investigator
Hillcrest Hospital Cancer Center
Mayfield Heights Ohio, 44124, United States More Info
Site Public Contact
Contact
866-223-8100
[email protected]
Smitha S. Krishnamurthi
Principal Investigator
North Coast Cancer Care
Sandusky Ohio, 44870, United States More Info
Site Public Contact
Contact
866-223-8100
[email protected]
Smitha S. Krishnamurthi
Principal Investigator
Cleveland Clinic Cancer Center Strongsville
Strongsville Ohio, 44136, United States More Info
Site Public Contact
Contact
866-223-8100
[email protected]
Smitha S. Krishnamurthi
Principal Investigator
Toledo Clinic Cancer Centers-Toledo
Toledo Ohio, 43623, United States More Info
Site Public Contact
Contact
800-444-3561
Rex B. Mowat
Principal Investigator
Upper Valley Medical Center
Troy Ohio, 45373, United States More Info
Site Public Contact
Contact
937-528-2900
[email protected]
Tarek M. Sabagh
Principal Investigator
South Pointe Hospital
Warrensville Heights Ohio, 44122, United States More Info
Site Public Contact
Contact
866-223-8100
[email protected]
Smitha S. Krishnamurthi
Principal Investigator
Cleveland Clinic Wooster Family Health and Surgery Center
Wooster Ohio, 44691, United States More Info
Site Public Contact
Contact
866-223-8100
[email protected]
Smitha S. Krishnamurthi
Principal Investigator
University of Oklahoma Health Sciences Center
Oklahoma City Oklahoma, 73104, United States More Info
Site Public Contact
Contact
405-271-8777
[email protected]
Sagila George
Principal Investigator
Saint Alphonsus Medical Center-Ontario
Ontario Oregon, 97914, United States More Info
Site Public Contact
Contact
406-969-6060
[email protected]
John M. Schallenkamp
Principal Investigator
Providence Portland Medical Center
Portland Oregon, 97213, United States More Info
Site Public Contact
Contact
503-215-2614
[email protected]
Alison K. Conlin
Principal Investigator
Providence Saint Vincent Medical Center
Portland Oregon, 97225, United States More Info
Site Public Contact
Contact
503-215-2614
[email protected]
Alison K. Conlin
Principal Investigator
Lehigh Valley Hospital-Cedar Crest
Allentown Pennsylvania, 18103, United States More Info
Site Public Contact
Contact
610-402-9543
[email protected]
Elie G. Dib
Principal Investigator
Lehigh Valley Hospital - Muhlenberg
Bethlehem Pennsylvania, 18017, United States More Info
Site Public Contact
Contact
610-402-9543
[email protected]
Elie G. Dib
Principal Investigator
Geisinger Medical Center
Danville Pennsylvania, 17822, United States More Info
Site Public Contact
Contact
570-271-5251
[email protected]
Ahmad Hanif
Principal Investigator
Pocono Medical Center
East Stroudsburg Pennsylvania, 18301, United States More Info
Site Public Contact
Contact
610-402-9543
[email protected]
Elie G. Dib
Principal Investigator
Geisinger Medical Center-Cancer Center Hazleton
Hazleton Pennsylvania, 18201, United States More Info
Site Public Contact
Contact
570-459-2901
[email protected]
Ahmad Hanif
Principal Investigator
Geisinger Medical Oncology-Lewisburg
Lewisburg Pennsylvania, 17837, United States More Info
Site Public Contact
Contact
570-374-8555
[email protected]
Ahmad Hanif
Principal Investigator
Geisinger Cancer Services-Pottsville
Pottsville Pennsylvania, 17901, United States More Info
Site Public Contact
Contact
800-275-6401
[email protected]
Ahmad Hanif
Principal Investigator
Community Medical Center
Scranton Pennsylvania, 18510, United States More Info
Site Public Contact
Contact
570-703-4768
[email protected]
Ahmad Hanif
Principal Investigator
Geisinger Wyoming Valley/Henry Cancer Center
Wilkes-Barre Pennsylvania, 18711, United States More Info
Site Public Contact
Contact
570-271-5251
[email protected]
Ahmad Hanif
Principal Investigator
Prisma Health Cancer Institute - Spartanburg
Boiling Springs South Carolina, 29316, United States More Info
Site Public Contact
Contact
864-241-6251
Ki Y. Chung
Principal Investigator
Prisma Health Cancer Institute - Easley
Easley South Carolina, 29640, United States More Info
Site Public Contact
Contact
864-522-2066
[email protected]
Ki Y. Chung
Principal Investigator
Gibbs Cancer Center-Gaffney
Gaffney South Carolina, 29341, United States More Info
Site Public Contact
Contact
864-560-6104
[email protected]
Samuel G. Adediran
Principal Investigator
Prisma Health Cancer Institute - Butternut
Greenville South Carolina, 29605, United States More Info
Site Public Contact
Contact
864-241-6251
Ki Y. Chung
Principal Investigator
Prisma Health Cancer Institute - Faris
Greenville South Carolina, 29605, United States More Info
Site Public Contact
Contact
864-241-6251
Ki Y. Chung
Principal Investigator
Prisma Health Cancer Institute - Eastside
Greenville South Carolina, 29615, United States More Info
Site Public Contact
Contact
864-241-6251
Ki Y. Chung
Principal Investigator
Prisma Health Cancer Institute - Greer
Greer South Carolina, 29650, United States More Info
Site Public Contact
Contact
864-241-6251
Ki Y. Chung
Principal Investigator
Gibbs Cancer Center-Pelham
Greer South Carolina, 29651, United States More Info
Site Public Contact
Contact
864-560-6104
[email protected]
Samuel G. Adediran
Principal Investigator
Prisma Health Cancer Institute - Seneca
Seneca South Carolina, 29672, United States More Info
Site Public Contact
Contact
864-241-6251
Ki Y. Chung
Principal Investigator
Spartanburg Medical Center
Spartanburg South Carolina, 29303, United States More Info
Site Public Contact
Contact
864-560-6104
[email protected]
Samuel G. Adediran
Principal Investigator
MGC Hematology Oncology-Union
Union South Carolina, 29379, United States More Info
Site Public Contact
Contact
864-560-6104
[email protected]
Samuel G. Adediran
Principal Investigator
Sanford Cancer Center Oncology Clinic
Sioux Falls South Dakota, 57104, United States More Info
Site Public Contact
Contact
605-312-3320
[email protected]
Daniel Almquist
Principal Investigator
Sanford USD Medical Center - Sioux Falls
Sioux Falls South Dakota, 57117, United States More Info
Site Public Contact
Contact
605-312-3320
[email protected]
Daniel Almquist
Principal Investigator
Parkland Memorial Hospital
Dallas Texas, 75235, United States More Info
Site Public Contact
Contact
214-590-5582
[email protected]
Syed M. Kazmi
Principal Investigator
UT Southwestern Simmons Cancer Center - RedBird
Dallas Texas, 75237, United States More Info
Site Public Contact
Contact
214-648-7097
[email protected]
Syed M. Kazmi
Principal Investigator
UT Southwestern/Simmons Cancer Center-Dallas
Dallas Texas, 75390, United States More Info
Site Public Contact
Contact
214-648-7097
[email protected]
Syed M. Kazmi
Principal Investigator
UT Southwestern/Simmons Cancer Center-Fort Worth
Fort Worth Texas, 76104, United States More Info
Site Public Contact
Contact
214-648-7097
[email protected]
Syed M. Kazmi
Principal Investigator
UT Southwestern Clinical Center at Richardson/Plano
Richardson Texas, 75080, United States More Info
Site Public Contact
Contact
972-669-7044
[email protected]
Syed M. Kazmi
Principal Investigator
University of Virginia Cancer Center
Charlottesville Virginia, 22908, United States More Info
Site Public Contact
Contact
434-243-6303
[email protected]
Muneeb Rehman
Principal Investigator
Swedish Cancer Institute-Edmonds
Edmonds Washington, 98026, United States More Info
Site Public Contact
Contact
206-215-3086
[email protected]
Alison K. Conlin
Principal Investigator
Swedish Cancer Institute-Issaquah
Issaquah Washington, 98029, United States More Info
Site Public Contact
Contact
206-215-3086
[email protected]
Alison K. Conlin
Principal Investigator
Swedish Medical Center-First Hill
Seattle Washington, 98122, United States More Info
Site Public Contact
Contact
206-215-3086
[email protected]
Alison K. Conlin
Principal Investigator
West Virginia University Charleston Division
Charleston West Virginia, 25304, United States More Info
Site Public Contact
Contact
304-388-9944
Ahmed A. Khalid
Principal Investigator
Langlade Hospital and Cancer Center
Antigo Wisconsin, 54409, United States More Info
Site Public Contact
Contact
715-623-9869
[email protected]
Andrew J. Huang
Principal Investigator
ThedaCare Regional Cancer Center
Appleton Wisconsin, 54911, United States More Info
Site Public Contact
Contact
920-364-3604
[email protected]
Matthias Weiss
Principal Investigator
ThedaCare Cancer Care - Berlin
Berlin Wisconsin, 54923, United States More Info
Site Public Contact
Contact
920-364-3605
[email protected]
Matthias Weiss
Principal Investigator
Aspirus Medford Hospital
Medford Wisconsin, 54451, United States More Info
Site Public Contact
Contact
715-847-2353
[email protected]
Andrew J. Huang
Principal Investigator
ProHealth D N Greenwald Center
Mukwonago Wisconsin, 53149, United States More Info
Site Public Contact
Contact
[email protected]
Timothy R. Wassenaar
Principal Investigator
ThedaCare Regional Medical Center - Neenah
Neenah Wisconsin, 54956, United States More Info
Site Public Contact
Contact
920-364-3605
[email protected]
Matthias Weiss
Principal Investigator
Cancer Center of Western Wisconsin
New Richmond Wisconsin, 54017, United States More Info
Site Public Contact
Contact
952-993-1517
[email protected]
Daniel M. Anderson
Principal Investigator
ProHealth Oconomowoc Memorial Hospital
Oconomowoc Wisconsin, 53066, United States More Info
Site Public Contact
Contact
262-928-7878
Timothy R. Wassenaar
Principal Investigator
Ascension Saint Mary's Hospital
Rhinelander Wisconsin, 54501, United States More Info
Site Public Contact
Contact
715-847-2353
[email protected]
Andrew J. Huang
Principal Investigator
ThedaCare Cancer Care - Shawano
Shawano Wisconsin, 54166, United States More Info
Site Public Contact
Contact
920-364-3605
[email protected]
Matthias Weiss
Principal Investigator
Ascension Saint Michael's Hospital
Stevens Point Wisconsin, 54481, United States More Info
Site Public Contact
Contact
715-847-2353
[email protected]
Andrew J. Huang
Principal Investigator
UW Cancer Center at ProHealth Care
Waukesha Wisconsin, 53188, United States More Info
Site Public Contact
Contact
262-928-5539
[email protected]
Timothy R. Wassenaar
Principal Investigator
ThedaCare Cancer Care - Waupaca
Waupaca Wisconsin, 54981, United States More Info
Site Public Contact
Contact
920-364-3605
[email protected]
Matthias Weiss
Principal Investigator
Aspirus Regional Cancer Center
Wausau Wisconsin, 54401, United States More Info
Site Public Contact
Contact
877-405-6866
Andrew J. Huang
Principal Investigator
Aspirus Cancer Care - Wisconsin Rapids
Wisconsin Rapids Wisconsin, 54494, United States More Info
Site Public Contact
Contact
715-422-7718
Andrew J. Huang
Principal Investigator

How clear is this clinincal trial information?

Study is for people with:

Colon Cancer

Phase:

Phase 2

Estimated Enrollment:

394

Study ID:

NCT05710406

Recruitment Status:

Recruiting

Sponsor:


Alliance for Clinical Trials in Oncology

How clear is this clinincal trial information?

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