Lung Cancer Clinical Trial

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Lung Cancer Biomarkers and Screening

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Summary

RATIONALE: Screening tests that use biomarkers may help doctors find tumor cells early and plan effective treatment for lung cancer.

PURPOSE: This clinical trial is studying biomarkers in screening participants for lung cancer.

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Full Description

OBJECTIVES:

Identify and validate biomarkers for the early detection of lung cancer in individuals at low- or high-risk for smoking-related cancers.
Identify preneoplastic cellular changes and lesions in these patients.

OUTLINE: Participants are stratified according to lung cancer risk status (with or without increased risk).

Group 1 (screening cohort): Participants complete a questionnaire and undergo pulmonary function testing, multidetector chest CT scan, sputum induction, and phlebotomy.

Group 2 (rule-out lung cancer): Participants complete the same questionnaire and undergo the same tests and scans as in group 1. Some participants may undergo fiberoptic bronchoscopy based upon CT scan results with transbronchial or endobronchial biopsies. Some participants may undergo lung resection. Tissue samples are collected from surgery or biopsy.

PROJECTED ACCRUAL: A total of participants will be accrued for this study.

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Eligibility Criteria

DISEASE CHARACTERISTICS:

Screening Cohort

At high- or low-risk for lung cancer

Smoking history ≥ 20 pack years*

With or without workplace exposure to asbestos
NOTE: * Participants with < 20 pack years of smoking are eligible if 50 years of age or older

Rule-Out Lung cancer group

Referred for evaluation of suspicious nodules with 1 of the following diagnoses:

Lung cancer
Nonmalignant nodules (control group)

PATIENT CHARACTERISTICS:

Not pregnant
No prior malignancy except nonmelanoma skin cancer

PRIOR CONCURRENT THERAPY:

Not specified

Study is for people with:

Lung Cancer

Estimated Enrollment:

6860

Study ID:

NCT00301119

Recruitment Status:

Recruiting

Sponsor:

NYU Langone Health

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There is 1 Location for this study

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NYU Cancer Institute at New York University Medical Center
New York New York, 10016, United States More Info
James J. Tsay, MD, MSc
Contact
212-598-6351
[email protected]

How clear is this clinincal trial information?

Study is for people with:

Lung Cancer

Estimated Enrollment:

6860

Study ID:

NCT00301119

Recruitment Status:

Recruiting

Sponsor:


NYU Langone Health

How clear is this clinincal trial information?

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