PRE-ProstAtectomy MRI-GuidEd Stereotactic Body RadioTherapy for High-Risk Prostate Cancer Trial (PREPARE SBRT)

Inclusion Criteria:

Men aged greater than equal to18 with histologically confirmed primary prostate cancer.
KPS greater than equal to 70
Patient with a negative staging bone scan.
Patient can undergo an MRI.
Patient with negative staging CT or MRI of pelvis. Suspicious evidence of nodal involvement on staging CT or MRI of pelvis is defined as greater than 1 cm on short axis. Documented negative biopsy of suspicious node required.
Patient is medically fit to undergo prostatectomy.
Patient has either Gleason Score greater than equal to 8 on biopsy and/or clinical/radiographic evidence of T3 disease.

Exclusion Criteria:

Prior history of receiving pelvic radiotherapy.
Patient is unwilling to undergo prostatectomy.
Patient with active inflammatory bowel disease defined as currently receiving therapy for IBD.