Stereotactic Body Radiation Therapy in Treating Patients With Prostate Cancer After Undergoing Surgery

Inclusion Criteria:

History of diagnosis of prostate cancer after undergoing prostatectomy
No evidence of regional nodal or distant metastases based on computed tomography (CT) abdomen and pelvis and whole body bone scan within 120 days prior to study entry; nodes less than 1.5 cm will be considered reactive and biopsy is not required; nodes 1.5 cm or larger are required to undergo biopsy and be negative prior to study registration; bone scan findings in the absence of blastic or lytic lesion correlates on CT imaging will also be deemed non-neoplastic
Eastern Cooperative Oncology Group (ECOG) performance scale 0-2
Child bearing potential: In this patient population, this pertains to the ability to conceive a child; eligible patients already have received prostatectomy, and therefore this risk is not applicable
Prostate specific antigen (PSA) value can be undetectable up to a value of 2.0 within 30 days prior to study entry
PSA value that is undetectable can be enrolled if pathology from prostatectomy demonstrates one or more of the following: positive margin, extracapsular extension, or seminal vesicle invasion
All subjects must have the ability to understand and the willingness to sign a written informed consent

Exclusion Criteria:

Patients should not have any uncontrolled illness including ongoing or active infection
Patients may not be receiving any other investigational agents, or concurrent biological chemotherapy
Patients with history of prior malignancies (with exception to non-melanoma skin cancer) are ineligible for this study, unless they are documented to be disease-free for at least 5 years

Study-specific exclusions:

History of prior radiation to the pelvis
History of uncontrolled inflammatory bowel disease
Unable to comply with radiation therapy procedures
Subjects, who in the opinion of the investigator, may not be able to comply with the safety monitoring requirements of the study