Acute Myeloid Leukemia Clinical Trial

A Study Of PF-04449913 In Select Hematologic Malignancies

Summary

This study examines the effect of a small molecule inhibitor to the Sonic Hedgehog pathway on select hematologic malignancies.

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Eligibility Criteria

Inclusion Criteria:

Patients with select advanced hematologic malignancies who are refractory, resistant or intolerant to prior therapies. They may be newly diagnosed and previously untreated, but not eligible for standard treatment options, or for whom standard therapies are not anticipated to result in a durable response.
ECOG performance status 0 to 2
Adequate organ function

Exclusion Criteria:

Patients with active CNS disease
Patient with active malignancy with the exception of basal cell carcinoma, non melanoma skin cancer, carcinoma in situ cervical or skin cancer
Active GVHD other than Grade 1 skin involvement
Known malabsorption syndrome
Patient has an active, life threatening or clinically significant uncontrolled systemic infection

Study is for people with:

Acute Myeloid Leukemia

Phase:

Phase 1

Estimated Enrollment:

47

Study ID:

NCT00953758

Recruitment Status:

Completed

Sponsor:

Pfizer

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There are 6 Locations for this study

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UCSD Medical Center - La Jolla
La Jolla California, 92037, United States
Moores UCSD Cancer Center
La Jolla California, 92093, United States
UCSD Medical Center - Hillcrest
San Diego California, 92103, United States
The University of Texas M.D. Anderson Cancer Center
Houston Texas, 77030, United States
University of Washington Medical Center, Seattle Cancer Care Alliance
Seattle Washington, 98109, United States
U.O. di Ematologia
Bologna , 40138, Italy

How clear is this clinincal trial information?

Study is for people with:

Acute Myeloid Leukemia

Phase:

Phase 1

Estimated Enrollment:

47

Study ID:

NCT00953758

Recruitment Status:

Completed

Sponsor:


Pfizer

How clear is this clinincal trial information?

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