Inclusion Criteria:

Patients with select advanced hematologic malignancies who are refractory, resistant or intolerant to prior therapies. They may be newly diagnosed and previously untreated, but not eligible for standard treatment options, or for whom standard therapies are not anticipated to result in a durable response.
ECOG performance status 0 to 2
Adequate organ function

Exclusion Criteria:

Patients with active CNS disease
Patient with active malignancy with the exception of basal cell carcinoma, non melanoma skin cancer, carcinoma in situ cervical or skin cancer
Active GVHD other than Grade 1 skin involvement
Known malabsorption syndrome
Patient has an active, life threatening or clinically significant uncontrolled systemic infection