Acute Myeloid Leukemia Clinical Trial
The Pediatric Acute Leukemia (PedAL) Screening Trial – A Study to Test Bone Marrow and Blood in Children With Leukemia That Has Come Back After Treatment or Is Difficult to Treat – A Leukemia & Lymphoma Society and Children’s Oncology Group Study
Summary
This study aims to use clinical and biological characteristics of acute leukemias to screen for patient eligibility for available pediatric leukemia sub-trials. Testing bone marrow and blood from patients with leukemia that has come back after treatment or is difficult to treat may provide information about the patient's leukemia that is important when deciding how to best treat it, and may help doctors find better ways to diagnose and treat leukemia in children, adolescents, and young adults.
Full Description
PRIMARY OBJECTIVES:
I. To utilize clinical and biological characteristics of acute leukemias to screen for patient eligibility for available phase I/II Pediatric Acute Leukemia (PedAL) sub-trials.
II. To maintain a longitudinal and comprehensive registry from relapse in children and young adults with recurrent and refractory leukemia.
OUTLINE:
Patients undergo collection of blood and/or bone marrow samples at baseline, end of treatment cycle(s), and at relapse/refractory disease status (if applicable).
After completion of study, patients are followed up every 3 months for 2 years, and then every 6 months for 3 years.
Eligibility Criteria
Inclusion Criteria:
Patients must be less than 22 years of age at the time of study enrollment
Patient must have one of the following:
Patient has known or suspected relapsed/refractory (including primary refractory) AML
This includes isolated myeloid sarcoma
Patient has known or suspected relapsed/refractory (including primary refractory) myeloid leukemia of Down syndrome
Patient has known or suspected relapsed ALL that meets one of the following criteria:
Second or greater B-ALL medullary relapse, excluding KMT2Ar.
Any first or greater B-ALL medullary relapse involving KMT2Ar.
Any first or greater T-ALL medullary relapse with or without KMT2Ar.
Patient has known or suspected relapsed/refractory (including primary refractory) mixed phenotype acute leukemia
Patient has known or suspected de novo or relapsed/refractory (including primary refractory) treatment related AML
All patients and/or their parents or legal guardians must sign a written informed consent
All institutional, Food and Drug Administration (FDA), and National Cancer Institute (NCI) requirements for human studies must be met
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There are 155 Locations for this study
Birmingham Alabama, 35233, United States More Info
Principal Investigator
Mobile Alabama, 36604, United States More Info
Principal Investigator
Anchorage Alaska, 99508, United States More Info
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Mesa Arizona, 85202, United States More Info
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Phoenix Arizona, 85016, United States More Info
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Tucson Arizona, 85719, United States
Little Rock Arkansas, 72202, United States More Info
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Downey California, 90242, United States More Info
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Long Beach California, 90806, United States More Info
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Los Angeles California, 90027, United States More Info
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Madera California, 93636, United States More Info
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Oakland California, 94609, United States More Info
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Oakland California, 94611, United States More Info
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Orange California, 92868, United States More Info
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Palo Alto California, 94304, United States More Info
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San Diego California, 92123, United States More Info
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San Francisco California, 94158, United States More Info
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Aurora Colorado, 80045, United States More Info
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Denver Colorado, 80218, United States More Info
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Hartford Connecticut, 06106, United States More Info
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Wilmington Delaware, 19803, United States More Info
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Washington District of Columbia, 20010, United States More Info
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Fort Lauderdale Florida, 33316, United States More Info
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Fort Myers Florida, 33908, United States More Info
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Gainesville Florida, 32610, United States More Info
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Hollywood Florida, 33021, United States More Info
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Jacksonville Florida, 32207, United States More Info
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Miami Florida, 33155, United States More Info
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Orlando Florida, 32827, United States More Info
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Pensacola Florida, 32504, United States More Info
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Tampa Florida, 33607, United States More Info
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West Palm Beach Florida, 33407, United States More Info
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Atlanta Georgia, 30322, United States More Info
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Honolulu Hawaii, 96826, United States More Info
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Boise Idaho, 83712, United States More Info
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Chicago Illinois, 60611, United States More Info
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Chicago Illinois, 60612, United States More Info
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Maywood Illinois, 60153, United States More Info
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Peoria Illinois, 61637, United States More Info
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Indianapolis Indiana, 46202, United States More Info
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Des Moines Iowa, 50309, United States
Iowa City Iowa, 52242, United States More Info
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Lexington Kentucky, 40536, United States More Info
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Louisville Kentucky, 40202, United States More Info
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New Orleans Louisiana, 70118, United States More Info
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New Orleans Louisiana, 70121, United States More Info
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Scarborough Maine, 04074, United States More Info
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Baltimore Maryland, 21215, United States More Info
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Baltimore Maryland, 21287, United States More Info
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Bethesda Maryland, 20889, United States
Boston Massachusetts, 02215, United States More Info
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Ann Arbor Michigan, 48109, United States More Info
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Detroit Michigan, 48201, United States More Info
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East Lansing Michigan, 48824, United States More Info
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Grand Rapids Michigan, 49503, United States More Info
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Kalamazoo Michigan, 49007, United States More Info
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Royal Oak Michigan, 48073, United States More Info
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Minneapolis Minnesota, 55404, United States More Info
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Minneapolis Minnesota, 55455, United States More Info
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Rochester Minnesota, 55905, United States
Jackson Mississippi, 39216, United States More Info
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Columbia Missouri, 65201, United States More Info
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Kansas City Missouri, 64108, United States More Info
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Saint Louis Missouri, 63104, United States More Info
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Saint Louis Missouri, 63110, United States More Info
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Saint Louis Missouri, 63141, United States More Info
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Omaha Nebraska, 68114, United States
Omaha Nebraska, 68198, United States
Las Vegas Nevada, 89135, United States More Info
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Las Vegas Nevada, 89144, United States More Info
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Lebanon New Hampshire, 03756, United States More Info
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Hackensack New Jersey, 07601, United States More Info
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Morristown New Jersey, 07960, United States More Info
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New Brunswick New Jersey, 08901, United States
New Brunswick New Jersey, 08903, United States
Paterson New Jersey, 07503, United States More Info
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Albany New York, 12208, United States More Info
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Bronx New York, 10467, United States More Info
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Brooklyn New York, 11219, United States
Mineola New York, 11501, United States More Info
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New Hyde Park New York, 11040, United States More Info
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New York New York, 10016, United States More Info
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New York New York, 10032, United States
New York New York, 10065, United States More Info
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Rochester New York, 14642, United States More Info
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Stony Brook New York, 11794, United States More Info
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Syracuse New York, 13210, United States More Info
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Valhalla New York, 10595, United States More Info
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Asheville North Carolina, 28801, United States More Info
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Chapel Hill North Carolina, 27599, United States More Info
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Charlotte North Carolina, 28203, United States More Info
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Durham North Carolina, 27710, United States More Info
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Greenville North Carolina, 27834, United States More Info
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Winston-Salem North Carolina, 27157, United States More Info
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Fargo North Dakota, 58122, United States More Info
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Cincinnati Ohio, 45229, United States More Info
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Cleveland Ohio, 44106, United States More Info
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Cleveland Ohio, 44195, United States More Info
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Columbus Ohio, 43205, United States More Info
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Dayton Ohio, 45404, United States More Info
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Toledo Ohio, 43606, United States More Info
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Oklahoma City Oklahoma, 73104, United States More Info
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Portland Oregon, 97227, United States More Info
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Portland Oregon, 97239, United States More Info
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Allentown Pennsylvania, 18103, United States More Info
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Danville Pennsylvania, 17822, United States More Info
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Philadelphia Pennsylvania, 19104, United States More Info
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Philadelphia Pennsylvania, 19134, United States More Info
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Pittsburgh Pennsylvania, 15224, United States More Info
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Providence Rhode Island, 02903, United States More Info
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Charleston South Carolina, 29425, United States
Columbia South Carolina, 29203, United States More Info
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Greenville South Carolina, 29605, United States More Info
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Sioux Falls South Dakota, 57117, United States More Info
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Knoxville Tennessee, 37916, United States More Info
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Memphis Tennessee, 38105, United States More Info
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Nashville Tennessee, 37203, United States More Info
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Nashville Tennessee, 37232, United States More Info
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Austin Texas, 78723, United States More Info
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Dallas Texas, 75230, United States More Info
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Dallas Texas, 75390, United States More Info
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El Paso Texas, 79905, United States More Info
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Houston Texas, 77030, United States More Info
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Houston Texas, 77030, United States More Info
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Lubbock Texas, 79410, United States More Info
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San Antonio Texas, 78207, United States More Info
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San Antonio Texas, 78229, United States More Info
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San Antonio Texas, 78229, United States More Info
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Salt Lake City Utah, 84113, United States More Info
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Charlottesville Virginia, 22908, United States More Info
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Falls Church Virginia, 22042, United States More Info
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Norfolk Virginia, 23507, United States More Info
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Richmond Virginia, 23298, United States More Info
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Roanoke Virginia, 24014, United States More Info
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Seattle Washington, 98105, United States More Info
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Spokane Washington, 99204, United States
Tacoma Washington, 98405, United States More Info
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Tacoma Washington, 98431, United States More Info
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Morgantown West Virginia, 26506, United States More Info
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Madison Wisconsin, 53792, United States More Info
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Marshfield Wisconsin, 54449, United States More Info
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Westmead New South Wales, 2145, Australia More Info
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Parkville Victoria, 3052, Australia More Info
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Perth Western Australia, 6009, Australia More Info
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Calgary Alberta, T3B 6, Canada More Info
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Edmonton Alberta, T6G 2, Canada More Info
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Winnipeg Manitoba, R3E 0, Canada More Info
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London Ontario, N6A 5, Canada
Ottawa Ontario, K1H 8, Canada More Info
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Toronto Ontario, M5G 1, Canada More Info
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Montreal Quebec, H3H 1, Canada
Montreal Quebec, H3T 1, Canada More Info
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Quebec , G1V 4, Canada More Info
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Grafton Auckland, 1145, New Zealand More Info
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Christchurch , 8011, New Zealand More Info
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Caguas , 00726, Puerto Rico
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