Acute Myeloid Leukemia Clinical Trial
The Pediatric Acute Leukemia (PedAL) Screening Trial – A Study to Test Bone Marrow and Blood in Children With Leukemia That Has Come Back After Treatment or Is Difficult to Treat – A Leukemia & Lymphoma Society and Children’s Oncology Group Study
Summary
This study aims to use clinical and biological characteristics of acute leukemias to screen for patient eligibility for available pediatric leukemia sub-trials. Testing bone marrow and blood from patients with leukemia that has come back after treatment or is difficult to treat may provide information about the patient's leukemia that is important when deciding how to best treat it, and may help doctors find better ways to diagnose and treat leukemia in children, adolescents, and young adults.
Full Description
PRIMARY OBJECTIVES:
I. To utilize clinical and biological characteristics of acute leukemias to screen for patient eligibility for available phase I/II Pediatric Acute Leukemia (PedAL) sub-trials.
II. To maintain a longitudinal and comprehensive registry from relapse in children and young adults with recurrent and refractory leukemia.
OUTLINE:
Patients undergo collection of blood and/or bone marrow samples at baseline, end of treatment cycle(s), and at relapse/refractory disease status (if applicable).
After completion of study, patients are followed up every 3 months for 2 years, and then every 6 months for 3 years.
Eligibility Criteria
Inclusion Criteria:
Patients must be less than 22 years of age at the time of study enrollment
Patient must have one of the following:
Patient has known or suspected relapsed/refractory (including primary refractory) AML
This includes isolated myeloid sarcoma
Patient has known or suspected relapsed/refractory (including primary refractory) myeloid leukemia of Down syndrome
Patient has known or suspected relapsed ALL that meets one of the following criteria:
Second or greater B-ALL medullary relapse, excluding KMT2Ar.
Any first or greater B-ALL medullary relapse involving KMT2Ar.
Any first or greater T-ALL medullary relapse with or without KMT2Ar.
Patient has known or suspected relapsed/refractory (including primary refractory) mixed phenotype acute leukemia
Patient has known or suspected de novo or relapsed/refractory (including primary refractory) treatment related AML
All patients and/or their parents or legal guardians must sign a written informed consent
All institutional, Food and Drug Administration (FDA), and National Cancer Institute (NCI) requirements for human studies must be met
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There are 147 Locations for this study
Birmingham Alabama, 35233, United States
Mobile Alabama, 36604, United States
Anchorage Alaska, 99508, United States
Mesa Arizona, 85202, United States
Phoenix Arizona, 85016, United States More Info
Principal Investigator
Tucson Arizona, 85719, United States
Little Rock Arkansas, 72202, United States
Downey California, 90242, United States More Info
Principal Investigator
Los Angeles California, 90027, United States
Madera California, 93636, United States
Oakland California, 94609, United States
Oakland California, 94611, United States
Orange California, 92868, United States
Palo Alto California, 94304, United States
San Diego California, 92123, United States
San Francisco California, 94158, United States
Aurora Colorado, 80045, United States More Info
Principal Investigator
Denver Colorado, 80218, United States
Hartford Connecticut, 06106, United States
Wilmington Delaware, 19803, United States
Washington District of Columbia, 20010, United States
Fort Lauderdale Florida, 33316, United States
Fort Myers Florida, 33908, United States
Gainesville Florida, 32610, United States
Hollywood Florida, 33021, United States
Jacksonville Florida, 32207, United States More Info
Principal Investigator
Miami Florida, 33155, United States
Orlando Florida, 32827, United States
Pensacola Florida, 32504, United States More Info
Principal Investigator
Tampa Florida, 33607, United States
West Palm Beach Florida, 33407, United States More Info
Principal Investigator
Atlanta Georgia, 30322, United States
Honolulu Hawaii, 96826, United States
Boise Idaho, 83712, United States
Chicago Illinois, 60611, United States More Info
Principal Investigator
Chicago Illinois, 60612, United States
Maywood Illinois, 60153, United States
Peoria Illinois, 61637, United States
Indianapolis Indiana, 46202, United States More Info
Principal Investigator
Des Moines Iowa, 50309, United States
Iowa City Iowa, 52242, United States More Info
Principal Investigator
Louisville Kentucky, 40202, United States
New Orleans Louisiana, 70118, United States
New Orleans Louisiana, 70121, United States More Info
Principal Investigator
Scarborough Maine, 04074, United States
Baltimore Maryland, 21215, United States
Baltimore Maryland, 21287, United States
Bethesda Maryland, 20889, United States
Boston Massachusetts, 02215, United States
Ann Arbor Michigan, 48109, United States
Detroit Michigan, 48201, United States
East Lansing Michigan, 48824, United States
Grand Rapids Michigan, 49503, United States
Kalamazoo Michigan, 49007, United States
Royal Oak Michigan, 48073, United States
Minneapolis Minnesota, 55404, United States More Info
Principal Investigator
Minneapolis Minnesota, 55455, United States
Rochester Minnesota, 55905, United States
Jackson Mississippi, 39216, United States
Columbia Missouri, 65201, United States More Info
Principal Investigator
Kansas City Missouri, 64108, United States
Saint Louis Missouri, 63104, United States
Saint Louis Missouri, 63110, United States
Saint Louis Missouri, 63141, United States
Omaha Nebraska, 68114, United States
Omaha Nebraska, 68198, United States
Las Vegas Nevada, 89135, United States More Info
Principal Investigator
Las Vegas Nevada, 89144, United States More Info
Principal Investigator
Lebanon New Hampshire, 03756, United States More Info
Principal Investigator
Hackensack New Jersey, 07601, United States
Morristown New Jersey, 07960, United States
New Brunswick New Jersey, 08901, United States
New Brunswick New Jersey, 08903, United States
Paterson New Jersey, 07503, United States
Albany New York, 12208, United States
Bronx New York, 10467, United States More Info
Principal Investigator
Brooklyn New York, 11219, United States
Mineola New York, 11501, United States
New Hyde Park New York, 11040, United States
New York New York, 10016, United States More Info
Principal Investigator
New York New York, 10032, United States
New York New York, 10065, United States More Info
Principal Investigator
Rochester New York, 14642, United States
Stony Brook New York, 11794, United States More Info
Principal Investigator
Syracuse New York, 13210, United States More Info
Principal Investigator
Valhalla New York, 10595, United States More Info
Principal Investigator
Charlotte North Carolina, 28203, United States
Durham North Carolina, 27710, United States
Greenville North Carolina, 27834, United States
Winston-Salem North Carolina, 27157, United States
Fargo North Dakota, 58122, United States More Info
Principal Investigator
Cleveland Ohio, 44106, United States
Cleveland Ohio, 44195, United States More Info
Principal Investigator
Columbus Ohio, 43205, United States
Dayton Ohio, 45404, United States
Toledo Ohio, 43606, United States More Info
Principal Investigator
Oklahoma City Oklahoma, 73104, United States More Info
Principal Investigator
Portland Oregon, 97227, United States
Portland Oregon, 97239, United States
Allentown Pennsylvania, 18103, United States
Danville Pennsylvania, 17822, United States More Info
Principal Investigator
Philadelphia Pennsylvania, 19104, United States
Philadelphia Pennsylvania, 19134, United States More Info
Principal Investigator
Pittsburgh Pennsylvania, 15224, United States
Providence Rhode Island, 02903, United States
Charleston South Carolina, 29425, United States
Columbia South Carolina, 29203, United States
Greenville South Carolina, 29605, United States
Sioux Falls South Dakota, 57117, United States
Knoxville Tennessee, 37916, United States
Memphis Tennessee, 38105, United States More Info
Principal Investigator
Nashville Tennessee, 37203, United States
Nashville Tennessee, 37232, United States More Info
Principal Investigator
Austin Texas, 78723, United States
Dallas Texas, 75230, United States
Dallas Texas, 75390, United States
El Paso Texas, 79905, United States More Info
Principal Investigator
Houston Texas, 77030, United States
Houston Texas, 77030, United States More Info
Principal Investigator
San Antonio Texas, 78207, United States More Info
Principal Investigator
San Antonio Texas, 78229, United States
San Antonio Texas, 78229, United States
Salt Lake City Utah, 84113, United States
Falls Church Virginia, 22042, United States More Info
Principal Investigator
Norfolk Virginia, 23507, United States
Richmond Virginia, 23298, United States More Info
Principal Investigator
Roanoke Virginia, 24014, United States
Seattle Washington, 98105, United States
Spokane Washington, 99204, United States
Tacoma Washington, 98405, United States
Tacoma Washington, 98431, United States More Info
Principal Investigator
Morgantown West Virginia, 26506, United States More Info
Principal Investigator
Madison Wisconsin, 53792, United States More Info
Principal Investigator
Marshfield Wisconsin, 54449, United States
Westmead New South Wales, 2145, Australia More Info
Principal Investigator
Parkville Victoria, 3052, Australia
Perth Western Australia, 6009, Australia
Calgary Alberta, T3B 6, Canada
Edmonton Alberta, T6G 2, Canada
Winnipeg Manitoba, R3E 0, Canada
London Ontario, N6A 5, Canada
Ottawa Ontario, K1H 8, Canada
Toronto Ontario, M5G 1, Canada
Montreal Quebec, H3H 1, Canada
Montreal Quebec, H3T 1, Canada
Grafton Auckland, 1145, New Zealand
Christchurch , 8011, New Zealand
Caguas , 00726, Puerto Rico
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