Acute Myeloid Leukemia Clinical Trial

The Pediatric Acute Leukemia (PedAL) Screening Trial – A Study to Test Bone Marrow and Blood in Children With Leukemia That Has Come Back After Treatment or Is Difficult to Treat – A Leukemia & Lymphoma Society and Children’s Oncology Group Study

Summary

This study aims to use clinical and biological characteristics of acute leukemias to screen for patient eligibility for available pediatric leukemia sub-trials. Testing bone marrow and blood from patients with leukemia that has come back after treatment or is difficult to treat may provide information about the patient's leukemia that is important when deciding how to best treat it, and may help doctors find better ways to diagnose and treat leukemia in children, adolescents, and young adults.

View Full Description

Full Description

PRIMARY OBJECTIVES:

I. To utilize clinical and biological characteristics of acute leukemias to screen for patient eligibility for available phase I/II Pediatric Acute Leukemia (PedAL) sub-trials.

II. To maintain a longitudinal and comprehensive registry from relapse in children and young adults with recurrent and refractory leukemia.

OUTLINE:

Patients undergo collection of blood and/or bone marrow samples at baseline, end of treatment cycle(s), and at relapse/refractory disease status (if applicable).

After completion of study, patients are followed up every 3 months for 2 years, and then every 6 months for 3 years.

View Eligibility Criteria

Eligibility Criteria

Inclusion Criteria:

Patients must be less than 22 years of age at the time of study enrollment

Patient must have one of the following:

Patient has known or suspected relapsed/refractory (including primary refractory) AML

This includes isolated myeloid sarcoma
Patient has known or suspected relapsed/refractory (including primary refractory) myeloid leukemia of Down syndrome

Patient has known or suspected relapsed ALL that meets one of the following criteria:

Second or greater B-ALL medullary relapse, excluding KMT2Ar.
Any first or greater B-ALL medullary relapse involving KMT2Ar.
Any first or greater T-ALL medullary relapse with or without KMT2Ar.
Patient has known or suspected relapsed/refractory (including primary refractory) mixed phenotype acute leukemia
Patient has known or suspected de novo or relapsed/refractory (including primary refractory) treatment related AML
All patients and/or their parents or legal guardians must sign a written informed consent
All institutional, Food and Drug Administration (FDA), and National Cancer Institute (NCI) requirements for human studies must be met

Study is for people with:

Acute Myeloid Leukemia

Estimated Enrollment:

960

Study ID:

NCT04726241

Recruitment Status:

Recruiting

Sponsor:

LLS PedAL Initiative, LLC

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There are 88 Locations for this study

See Locations Near You

Children's Hospital of Alabama
Birmingham Alabama, 35233, United States More Info
Site Public Contact
Contact
205-638-9285
[email protected]
Matthew A. Kutny
Principal Investigator
USA Health Strada Patient Care Center
Mobile Alabama, 36604, United States More Info
Site Public Contact
Contact
800-388-8721
Hamayun Imran
Principal Investigator
Banner University Medical Center - Tucson
Tucson Arizona, 85719, United States More Info
Site Public Contact
Contact
[email protected]
Holly E. Pariury
Principal Investigator
Arkansas Children's Hospital
Little Rock Arkansas, 72202, United States More Info
Site Public Contact
Contact
501-364-7373
David L. Becton
Principal Investigator
Kaiser Permanente-Oakland
Oakland California, 94611, United States More Info
Site Public Contact
Contact
877-642-4691
[email protected]
Aarati V. Rao
Principal Investigator
Children's Hospital of Orange County
Orange California, 92868, United States More Info
Site Public Contact
Contact
714-509-8646
[email protected]
Elyssa M. Rubin
Principal Investigator
UCSF Medical Center-Mission Bay
San Francisco California, 94158, United States More Info
Site Public Contact
Contact
877-827-3222
[email protected]
Elliot Stieglitz
Principal Investigator
Rocky Mountain Hospital for Children-Presbyterian Saint Luke's Medical Center
Denver Colorado, 80218, United States More Info
Site Public Contact
Contact
303-839-6000
Jennifer J. Clark
Principal Investigator
Connecticut Children's Medical Center
Hartford Connecticut, 06106, United States More Info
Site Public Contact
Contact
860-545-9981
Michael S. Isakoff
Principal Investigator
Alfred I duPont Hospital for Children
Wilmington Delaware, 19803, United States More Info
Site Public Contact
Contact
302-651-5572
[email protected]
Scott M. Bradfield
Principal Investigator
Children's National Medical Center
Washington District of Columbia, 20010, United States More Info
Site Public Contact
Contact
202-884-2549
Jeffrey S. Dome
Principal Investigator
Broward Health Medical Center
Fort Lauderdale Florida, 33316, United States More Info
Site Public Contact
Contact
302-651-5572
[email protected]
Hector M. Rodriguez-Cortes
Principal Investigator
University of Florida Health Science Center - Gainesville
Gainesville Florida, 32610, United States More Info
Site Public Contact
Contact
352-273-8010
[email protected]
William B. Slayton
Principal Investigator
Memorial Regional Hospital/Joe DiMaggio Children's Hospital
Hollywood Florida, 33021, United States More Info
Site Public Contact
Contact
954-265-1847
[email protected]
Iftikhar Hanif
Principal Investigator
Nemours Children's Clinic-Jacksonville
Jacksonville Florida, 32207, United States More Info
Site Public Contact
Contact
302-651-5572
[email protected]
Scott M. Bradfield
Principal Investigator
Nemours Children's Hospital
Orlando Florida, 32827, United States More Info
Site Public Contact
Contact
302-651-5572
[email protected]
Scott M. Bradfield
Principal Investigator
Sacred Heart Hospital
Pensacola Florida, 32504, United States More Info
Site Public Contact
Contact
850-416-4611
[email protected]
Erlyn C. Smith
Principal Investigator
Saint Joseph's Hospital/Children's Hospital-Tampa
Tampa Florida, 33607, United States More Info
Site Public Contact
Contact
813-357-0849
[email protected]
Don E. Eslin
Principal Investigator
Kapiolani Medical Center for Women and Children
Honolulu Hawaii, 96826, United States More Info
Site Public Contact
Contact
808-983-6090
Wade T. Kyono
Principal Investigator
Saint Luke's Cancer Institute - Boise
Boise Idaho, 83712, United States More Info
Site Public Contact
Contact
208-381-2774
[email protected]
Eugenia Chang
Principal Investigator
Lurie Children's Hospital-Chicago
Chicago Illinois, 60611, United States More Info
Site Public Contact
Contact
773-880-4562
Jenna Rossoff
Principal Investigator
Saint Jude Midwest Affiliate
Peoria Illinois, 61637, United States More Info
Site Public Contact
Contact
888-226-4343
Jaime M. Libes
Principal Investigator
Riley Hospital for Children
Indianapolis Indiana, 46202, United States More Info
Site Public Contact
Contact
800-248-1199
Sandeep Batra
Principal Investigator
University of Iowa/Holden Comprehensive Cancer Center
Iowa City Iowa, 52242, United States More Info
Site Public Contact
Contact
800-237-1225
David S. Dickens
Principal Investigator
Norton Children's Hospital
Louisville Kentucky, 40202, United States More Info
Site Public Contact
Contact
502-629-5500
[email protected]
Ashok B. Raj
Principal Investigator
Ochsner Medical Center Jefferson
New Orleans Louisiana, 70121, United States More Info
Site Public Contact
Contact
504-842-8084
[email protected]
Craig Lotterman
Principal Investigator
Maine Children's Cancer Program
Scarborough Maine, 04074, United States More Info
Site Public Contact
Contact
207-396-7581
[email protected]
Sei-Gyung K. Sze
Principal Investigator
Sinai Hospital of Baltimore
Baltimore Maryland, 21215, United States More Info
Site Public Contact
Contact
410-601-6120
[email protected]
Jason M. Fixler
Principal Investigator
Michigan State University Clinical Center
East Lansing Michigan, 48824, United States More Info
Site Public Contact
Contact
517-975-9547
Laura E. Agresta
Principal Investigator
Helen DeVos Children's Hospital at Spectrum Health
Grand Rapids Michigan, 49503, United States More Info
Site Public Contact
Contact
616-391-1230
[email protected]
Kathleen J. Yost
Principal Investigator
University of Minnesota/Masonic Cancer Center
Minneapolis Minnesota, 55455, United States More Info
Site Public Contact
Contact
612-624-2620
Emily G. Greengard
Principal Investigator
University of Mississippi Medical Center
Jackson Mississippi, 39216, United States More Info
Site Public Contact
Contact
601-815-6700
Anderson (Andy) B. Collier
Principal Investigator
Children's Mercy Hospitals and Clinics
Kansas City Missouri, 64108, United States More Info
Site Public Contact
Contact
816-302-6808
[email protected]
Kevin F. Ginn
Principal Investigator
Cardinal Glennon Children's Medical Center
Saint Louis Missouri, 63104, United States More Info
Site Public Contact
Contact
314-268-4000
William S. Ferguson
Principal Investigator
Washington University School of Medicine
Saint Louis Missouri, 63110, United States More Info
Site Public Contact
Contact
800-600-3606
[email protected]
Robert J. Hayashi
Principal Investigator
Alliance for Childhood Diseases/Cure 4 the Kids Foundation
Las Vegas Nevada, 89135, United States More Info
Site Public Contact
Contact
702-384-0013
[email protected]
Alan K. Ikeda
Principal Investigator
Summerlin Hospital Medical Center
Las Vegas Nevada, 89144, United States More Info
Site Public Contact
Contact
702-384-0013
[email protected]
Alan K. Ikeda
Principal Investigator
Dartmouth Hitchcock Medical Center
Lebanon New Hampshire, 03756, United States More Info
Site Public Contact
Contact
800-639-6918
[email protected]
Julie Kim
Principal Investigator
Hackensack University Medical Center
Hackensack New Jersey, 07601, United States More Info
Site Public Contact
Contact
201-996-2879
Jing Chen
Principal Investigator
Morristown Medical Center
Morristown New Jersey, 07960, United States More Info
Site Public Contact
Contact
973-971-5900
Kathryn L. Laurie
Principal Investigator
Rutgers Cancer Institute of New Jersey-Robert Wood Johnson University Hospital
New Brunswick New Jersey, 08903, United States More Info
Site Public Contact
Contact
732-235-8675
Richard A. Drachtman
Principal Investigator
Saint Joseph's Regional Medical Center
Paterson New Jersey, 07503, United States More Info
Site Public Contact
Contact
973-754-2207
[email protected]
Alissa Kahn
Principal Investigator
Albany Medical Center
Albany New York, 12208, United States More Info
Site Public Contact
Contact
518-262-5513
Lauren R. Weintraub
Principal Investigator
Montefiore Medical Center - Moses Campus
Bronx New York, 10467, United States More Info
Site Public Contact
Contact
718-379-6866
[email protected]
Lisa Gennarini
Principal Investigator
NYU Winthrop Hospital
Mineola New York, 11501, United States More Info
Site Public Contact
Contact
212-263-4432
[email protected]
Chana L. Glasser
Principal Investigator
The Steven and Alexandra Cohen Children's Medical Center of New York
New Hyde Park New York, 11040, United States More Info
Site Public Contact
Contact
718-470-3460
Arlene S. Redner
Principal Investigator
NYP/Columbia University Medical Center/Herbert Irving Comprehensive Cancer Center
New York New York, 10032, United States More Info
Site Public Contact
Contact
212-305-6361
[email protected]
Luca Szalontay
Principal Investigator
Memorial Sloan Kettering Cancer Center
New York New York, 10065, United States More Info
Site Public Contact
Contact
212-639-7592
Maria Luisa Sulis
Principal Investigator
University of Rochester
Rochester New York, 14642, United States More Info
Site Public Contact
Contact
585-275-5830
Craig A. Mullen
Principal Investigator
State University of New York Upstate Medical University
Syracuse New York, 13210, United States More Info
Site Public Contact
Contact
315-464-5476
Philip M. Monteleone
Principal Investigator
New York Medical College
Valhalla New York, 10595, United States More Info
Site Public Contact
Contact
914-594-3794
Jessica C. Hochberg
Principal Investigator
Carolinas Medical Center/Levine Cancer Institute
Charlotte North Carolina, 28203, United States More Info
Site Public Contact
Contact
800-804-9376
Joel A. Kaplan
Principal Investigator
Wake Forest University Health Sciences
Winston-Salem North Carolina, 27157, United States More Info
Site Public Contact
Contact
336-713-6771
Thomas W. McLean
Principal Investigator
Rainbow Babies and Childrens Hospital
Cleveland Ohio, 44106, United States More Info
Site Public Contact
Contact
216-844-5437
Duncan S. Stearns
Principal Investigator
Nationwide Children's Hospital
Columbus Ohio, 43205, United States More Info
Site Public Contact
Contact
614-722-6039
[email protected]
Mark A. Ranalli
Principal Investigator
Dayton Children's Hospital
Dayton Ohio, 45404, United States More Info
Site Public Contact
Contact
800-228-4055
Mukund G. Dole
Principal Investigator
ProMedica Toledo Hospital/Russell J Ebeid Children's Hospital
Toledo Ohio, 43606, United States More Info
Site Public Contact
Contact
419-824-1842
[email protected]
Jamie L. Dargart
Principal Investigator
University of Oklahoma Health Sciences Center
Oklahoma City Oklahoma, 73104, United States More Info
Site Public Contact
Contact
405-271-8777
[email protected]
Rene Y. McNall-Knapp
Principal Investigator
Lehigh Valley Hospital-Cedar Crest
Allentown Pennsylvania, 18103, United States More Info
Site Public Contact
Contact
610-402-9543
[email protected]
Jacob A. Troutman
Principal Investigator
Geisinger Medical Center
Danville Pennsylvania, 17822, United States More Info
Site Public Contact
Contact
570-271-5251
[email protected]
Jagadeesh Ramdas
Principal Investigator
Saint Christopher's Hospital for Children
Philadelphia Pennsylvania, 19134, United States More Info
Site Public Contact
Contact
215-427-8991
Gregory E. Halligan
Principal Investigator
Children's Hospital of Pittsburgh of UPMC
Pittsburgh Pennsylvania, 15224, United States More Info
Site Public Contact
Contact
412-692-8570
[email protected]
Erika Friehling
Principal Investigator
Rhode Island Hospital
Providence Rhode Island, 02903, United States More Info
Site Public Contact
Contact
401-444-1488
Jennifer J. Welch
Principal Investigator
Medical University of South Carolina
Charleston South Carolina, 29425, United States More Info
Site Public Contact
Contact
843-792-9321
[email protected]
Jacqueline M. Kraveka
Principal Investigator
Prisma Health Richland Hospital
Columbia South Carolina, 29203, United States More Info
Site Public Contact
Contact
864-241-6251
Stuart L. Cramer
Principal Investigator
BI-LO Charities Children's Cancer Center
Greenville South Carolina, 29605, United States More Info
Site Public Contact
Contact
864-241-6251
Aniket Saha
Principal Investigator
East Tennessee Childrens Hospital
Knoxville Tennessee, 37916, United States More Info
Site Public Contact
Contact
865-541-8266
Susan E. Spiller
Principal Investigator
Saint Jude Children's Research Hospital
Memphis Tennessee, 38105, United States More Info
Site Public Contact
Contact
888-226-4343
[email protected]
Seth E. Karol
Principal Investigator
Vanderbilt University/Ingram Cancer Center
Nashville Tennessee, 37232, United States More Info
Site Public Contact
Contact
800-811-8480
Sara Zarnegar-Lumley
Principal Investigator
Dell Children's Medical Center of Central Texas
Austin Texas, 78723, United States More Info
Site Public Contact
Contact
512-628-1902
[email protected]
Shannon M. Cohn
Principal Investigator
UT Southwestern/Simmons Cancer Center-Dallas
Dallas Texas, 75390, United States More Info
Site Public Contact
Contact
214-648-7097
[email protected]
Kathleen (Wiertel) Ludwig
Principal Investigator
El Paso Children's Hospital
El Paso Texas, 79905, United States More Info
Site Public Contact
Contact
915-298-5444
[email protected]
Ranjan Bista
Principal Investigator
Baylor College of Medicine/Dan L Duncan Comprehensive Cancer Center
Houston Texas, 77030, United States More Info
Site Public Contact
Contact
713-798-1354
[email protected]
Michele S. Redell
Principal Investigator
Children's Hospital of San Antonio
San Antonio Texas, 78207, United States More Info
Site Public Contact
Contact
210-704-2894
[email protected]
Timothy C. Griffin
Principal Investigator
Methodist Children's Hospital of South Texas
San Antonio Texas, 78229, United States More Info
Site Public Contact
Contact
210-575-6240
[email protected]
Jose M. Esquilin
Principal Investigator
Primary Children's Hospital
Salt Lake City Utah, 84113, United States More Info
Site Public Contact
Contact
801-585-5270
Luke D. Maese
Principal Investigator
Inova Fairfax Hospital
Falls Church Virginia, 22042, United States More Info
Site Public Contact
Contact
703-208-6650
[email protected]
Robin Y. Dulman
Principal Investigator
Children's Hospital of The King's Daughters
Norfolk Virginia, 23507, United States More Info
Site Public Contact
Contact
757-668-7243
[email protected]
Eric J. Lowe
Principal Investigator
Mary Bridge Children's Hospital and Health Center
Tacoma Washington, 98405, United States More Info
Site Public Contact
Contact
253-403-1461
[email protected]
Robert G. Irwin
Principal Investigator
Madigan Army Medical Center
Tacoma Washington, 98431, United States More Info
Site Public Contact
Contact
253-968-6144
[email protected]
Melissa A. Forouhar
Principal Investigator
University of Wisconsin Carbone Cancer Center
Madison Wisconsin, 53792, United States More Info
Kenneth B. De Santes
Contact
608-263-6200
[email protected]
Kenneth B. De Santes
Principal Investigator
Marshfield Medical Center-Marshfield
Marshfield Wisconsin, 54449, United States More Info
Site Public Contact
Contact
800-782-8581
[email protected]
Michelle A. Manalang
Principal Investigator
University of Alberta Hospital
Edmonton Alberta, T6G 2, Canada More Info
Site Public Contact
Contact
780-407-8798
[email protected]
Sarah J. McKillop
Principal Investigator
CancerCare Manitoba
Winnipeg Manitoba, R3E 0, Canada More Info
Site Public Contact
Contact
866-561-1026
[email protected]
Ashley Chopek
Principal Investigator
IWK Health Centre
Halifax Nova Scotia, B3K 6, Canada More Info
Site Public Contact
Contact
902-470-8520
[email protected]
Craig Erker
Principal Investigator
Children's Hospital
London Ontario, N6A 5, Canada More Info
Site Public Contact
Contact
519-685-8306
Shayna M. Zelcer
Principal Investigator
Children's Hospital of Eastern Ontario
Ottawa Ontario, K1H 8, Canada More Info
Site Public Contact
Contact
613-737-7600
Donna L. Johnston
Principal Investigator
Hospital for Sick Children
Toronto Ontario, M5G 1, Canada More Info
Site Public Contact
Contact
416-813-7654
[email protected]
Johann Hitzler
Principal Investigator

How clear is this clinincal trial information?

Study is for people with:

Acute Myeloid Leukemia

Estimated Enrollment:

960

Study ID:

NCT04726241

Recruitment Status:

Recruiting

Sponsor:


LLS PedAL Initiative, LLC

How clear is this clinincal trial information?

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