Esophageal Cancer Clinical Trial

Bemarituzumab Plus Chemotherapy and Nivolumab Versus Chemotherapy and Nivolumab for FGFR2b Overexpressed Untreated Advanced Gastric and Gastroesophageal Junction Cancer

Summary

The main objective of Part 1 is to evaluate the safety and tolerability of bemarituzumab plus 5-fluorouracil, leucovorin, and oxaliplatin (mFOLFOX6) and nivolumab.

The main objective Part 2 is to compare efficacy of bemarituzumab plus mFOLFOX6 and nivolumab to placebo plus mFOLFOX6 and nivolumab as assessed by overall survival.

View Eligibility Criteria

Eligibility Criteria

Inclusion Criteria Part 1 and Part 2:

Adult with unresectable, locally advanced or metastatic (not amenable to curative therapy) histologically documented gastric or gastroesophageal junction adenocarcinoma
Eastern Cooperative Oncology Group (ECOG) performance status of 0 to 1
Measurable disease or non-measurable, but evaluable disease, according to Response Evaluation Criteria in Solid Tumours version 1.1 (RECIST v1.1)
Participant has no contraindications to nivolumab and either mFOLFOX6 or CAPOX chemotherapy as per local prescribing information. Participants in Part 1 must have no contraindications to mFOLFOX6. Participants in Part 2 with contraindications to mFOLFOX6 are permitted and may be administered the CAPOX regimen, if no contraindications for this regimen exist. Participants in Part 2 with contraindications to CAPOX are permitted and may be administered the mFOLFOX6 regimen, if no contraindications for this regimen exist

Adequate organ function as follows:

Absolute neutrophil count ≥ 1.5 x 10^9/L
Platelet count ≥ 100 x 10^9/L
Hemoglobin ≥ 9 g/dL without red blood cell (RBC) transfusion within 7 days prior to the first dose of study treatment
Aspartate aminotransaminase (AST) and Alanine aminotransaminase (ALT) <3 x upper limit of normal (ULN) (or < 5 x ULN if liver involvement)
Total bilirubin <1.5 x ULN (or < 2 x ULN if liver involvement or Gilbert's disease)
Part 1 only: Calculated or measured creatinine clearance (CrCl) of ≥ 50 mL/minute calculated using the formula of Cockcroft and Gault ([140 - Age] × Mass [kg]/[72 × Creatinine mg/dL]) (x 0.85 if female).
Part 2 only: Calculated or measured creatinine clearance (CrCl) of ≥ 30 mL/minute calculated using the formula of Cockcroft and Gault ([140 - Age] × Mass [kg]/[72 × Creatinine mg/dL]) (x 0.85 if female).
INR or prothrombin time (PT) < 1.5 × ULN except for participants receiving anticoagulation, who must be on a stable dose of anticoagulant therapy for 6 weeks prior to enrollment

Additional Inclusion Criteria Part 2:

No prior treatment for metastatic or unresectable disease except for a maximum of

1 dose of chemotherapy with or without nivolumab; prior adjuvant, neo-adjuvant, and peri-operative therapy is allowed, provided it has been completed more than 6 months prior to the first dose of study treatment

Fibroblast growth factor receptor 2b (FGFR2b) ≥ 10% 2+/3+ tumor cells (TC) as determined by centrally performed immunohistochemistry (IHC) testing, based on tumor sample either archival (obtained within 6 months/180 days prior to signing pre-screening informed consent) or a fresh biopsy.

Exclusion Criteria:

Prior treatment with any selective inhibitor of the fibroblast growth factor (FGF)-FGFR pathway
Known positive human epidermal growth factor receptor 2 (HER2) status
Untreated or symptomatic central nervous system disease metastases and leptomeningeal disease
Peripheral sensory neuropathy grade 2 or higher
Clinically significant cardiac disease
Other malignancy within the last 2 years (exceptions for definitively treated disease)
Chronic or systemic ophthalmologic disorders
Major surgery or other investigational study within 28 days prior to randomization
Palliative radiotherapy within 14 days prior to randomization
Abnormalities of the cornea that may pose an increased risk of developing a corneal ulcer
Active autoimmune disease that has required systemic treatment (except replacement therapy) within the past 2 years or any other diseases requiring immunosuppressive therapy while on study

Study is for people with:

Esophageal Cancer

Phase:

Phase 3

Estimated Enrollment:

528

Study ID:

NCT05111626

Recruitment Status:

Recruiting

Sponsor:

Amgen

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There are 280 Locations for this study

See Locations Near You

Mayo Clinic - Arizona
Phoenix Arizona, 85054, United States
The Oncology Institute Clinical Research
Cerritos California, 90703, United States
Cancer and Blood Specialty Clinic
Downey California, 90241, United States
City of Hope National Medical Center
Duarte California, 91010, United States
University of California Los Angeles
Los Angeles California, 90095, United States
University of California Irvine
Orange California, 92868, United States
Torrance Memorial Physician Network
Redondo Beach California, 90277, United States
Translational Research in Oncology - US Inc
Santa Monica California, 90404, United States
Translational Research in Oncology US Inc, Trio Central Pharmacy
Santa Monica California, 90404, United States
Olive View-University of California in Los Angeles Medical Center
Sylmar California, 91342, United States
Presbyterian Intercommunity Hospital Health Whitter Hospital
Whittier California, 90602, United States
Yale New Haven Hospital Yale Cancer Center
New Haven Connecticut, 06520, United States
Florida Cancer Specialists - Fort Myers
Fort Myers Florida, 33901, United States
Mayo Clinic Florida
Jacksonville Florida, 32224, United States
Adventist Health System/Sunbelt, Inc d/b/a AdventHealth Orlando
Orlando Florida, 32804, United States
Orlando Health Cancer Institute
Orlando Florida, 32806, United States
University of Illinois Hospital and Health Sciences System
Chicago Illinois, 60612, United States
Greater Baltimore Medical Center
Baltimore Maryland, 21204, United States
Henry Ford Health System
Detroit Michigan, 48202, United States
Mayo Clinic Rochester
Rochester Minnesota, 55905, United States
Summit Medical Group
Florham Park New Jersey, 07932, United States
Memorial Sloan Kettering Cancer Center
New York New York, 10022, United States
Stony Brook University Medical Center
Stony Brook New York, 11794, United States
FirstHealth Cancer Center
Pinehurst North Carolina, 28374, United States
Gabrail Cancer Center, LLC
Canton Ohio, 44718, United States
Providence Portland Medical Center
Portland Oregon, 97213, United States
Saint Lukes University Health Network
Allentown Pennsylvania, 18104, United States
Medical University of South Carolina, Hollings Cancer Center
Charleston South Carolina, 29425, United States
The West Clinic, PLLC
Germantown Tennessee, 38138, United States
Sarah Cannon Research Institute
Nashville Tennessee, 37203, United States
Texas Oncology - Austin Midtown
Austin Texas, 78705, United States
University of Texas MD Anderson Cancer Center
Houston Texas, 77030, United States
United States Oncology Regulatory Affairs Corporate Office
The Woodlands Texas, 77380, United States
US Oncology Research Investigational Products Center
The Woodlands Texas, 77380, United States
Virginia Oncology Associates
Norfolk Virginia, 23502, United States
Northwest Cancer Specialists - Vancouver
Vancouver Washington, 98684, United States
Aurora Health Care Metro Inc
Milwaukee Wisconsin, 53215, United States
Cemic
Ciudad Autonoma de Buenos Aires Buenos Aires, C1431, Argentina
Hospital Italiano de La Plata
La Plata Buenos Aires, 1900, Argentina
Centro Medico Austral
Ciudad Autónoma de Buenos Aires Distrito Federal, C1019, Argentina
Fundacion Ars Medica
San Salvador de Jujuy Jujuy, 4600, Argentina
Clinica Viedma
Viedma Río Negro, 8500, Argentina
Exelsus Oncologia Clinica
San Miguel de Tucuman Tucuman, 4000, Argentina
Fundacion Respirar
Buenos Aires , C1426, Argentina
Hospital Italiano
Capital Federal , C1199, Argentina
Sanatorio Allende
Córdoba , X5000, Argentina
Hospital Privado Universitario de Cordoba
Córdoba , X5016, Argentina
Centro Oncologico Riojano Integral
La Rioja , F5300, Argentina
GenesisCare -North Shore Oncology
St Leonards New South Wales, 2065, Australia
Calvary Mater Newcastle Hospital
Waratah New South Wales, 2298, Australia
The Queen Elizabeth Hospital
Woodville South South Australia, 5011, Australia
Ballarat Health Services
Ballarat Victoria, 3350, Australia
Austin Health, Austin Hospital
Heidelberg Victoria, 3084, Australia
Medizinische Universitaet Graz
Graz , 8036, Austria
Medizinische Universitaet Innsbruck
Innsbruck , 6020, Austria
Landeskrankenhaus Feldkirch
Rankweil , 6830, Austria
Landeskrankenhaus Salzburg
Salzburg , 5020, Austria
Krankenhaus Wiener Neustadt
Wiener Neustadt , 2700, Austria
Universitaetsklinikum Allgemeines Krankenhaus Wien
Wien , 1090, Austria
Universite Catholique de Louvain Cliniques Universitaires Saint Luc
Bruxelles , 1200, Belgium
Grand Hopital de Charleroi
Charleroi , 5530, Belgium
Universitair Ziekenhuis Antwerpen
Edegem , 2650, Belgium
Universitair Ziekenhuis Gent
Gent , 9000, Belgium
Universitair Ziekenhuis Brussel
Jette , 1090, Belgium
Universitair Ziekenhuis Leuven - Campus Gasthuisberg
Leuven , 3000, Belgium
Hopital De Libramont
Libramont , 6800, Belgium
Centre Hospitalier Universitaire de Liege - Sart Tilman
Liege , 4000, Belgium
Algemeen Ziekenhuis Turnhout Campus Sint-Jozef
Turnhout , 2300, Belgium
Hospital Haroldo Juacaba - Instituto do Cancer do Ceara
Fortaleza Ceará, 60430, Brazil
Hospital Sirio Libanes
Brasilia Distrito Federal, 70200, Brazil
Hospital Evangelico de Cachoeiro de Itapemirim
Cachoeiro de Itapemirim Espírito Santo, 29308, Brazil
Personal Oncologia de Precisao e Personalizada
Belo Horizonte Minas Gerais, 30130, Brazil
Liga Norte-Riograndense Contra O Cancer
Natal Rio Grande Do Norte, 59075, Brazil
Hospital das Clinicas de Porto Alegre
Porto Alegre Rio Grande Do Sul, 90035, Brazil
Centro Gaucho Integrado de Oncologia, Hematologia, Ensino e Pesquisa - Hospital Mae de Deus
Porto Alegre Rio Grande Do Sul, 90110, Brazil
Fundacao Pio 12 Hospital de Amor de Barretos
Barretos São Paulo, 14784, Brazil
Instituto do Cancer Arnaldo Vieira de Carvalho
Sao Paulo São Paulo, 01221, Brazil
Sociedade Beneficente de Senhoras Hospital Sirio Libanes
Sao Paulo São Paulo, 01308, Brazil
Fundacao Antonio Prudente AC Camargo Cancer Center
Sao Paulo São Paulo, 01508, Brazil
Fundacao Faculdade Regional de Medicina de Sao Jose do Rio Preto
São José do Rio Preto São Paulo, 15090, Brazil
Instituto Coi
Rio de Janeiro , 22793, Brazil
Instituto do Cancer do Estado de Sao Paulo Octavio Frias de Oliveira Icesp
São Paulo , 04501, Brazil
Complex Oncology Center - Burgas
Burgas , 8000, Bulgaria
Specialized Hospital for Active Treatment of Oncology - Haskovo EOOD
Haskovo , 6300, Bulgaria
Multiprofile Hospital for Active Treatment - Uni Hospital OOD
Panagyurishte , 4500, Bulgaria
Multiprofile Hospital for Active Treatment Central Onco Hospital OOD
Plovdiv , 4000, Bulgaria
Military Medical Academy Multiprofile Hospital for Active Treatment - Sofia
Sofia , 1606, Bulgaria
Multiprofile Hospital for Active Treatment Serdika EOOD
Sofia , 1632, Bulgaria
London Health Sciences Centre
London Ontario, N6A 5, Canada
Princess Margaret Cancer Centre
Toronto Ontario, M4G 2, Canada
Sunnybrook Research Institute Sunnybrook Health Sciences Centre
Toronto Ontario, M4N 3, Canada
Jewish General Hospital
Montreal Quebec, H3T 1, Canada
Centre Hospitalier de L Universite de Montreal
Montréal Quebec, H2X 3, Canada
CHU de Quebec Hopital de l Enfant Jesus
Quebec , G1J 1, Canada
Centro De Estudios Clínicos Suecia SpA
Santiago de Chile Santiago, 75100, Chile
Oncocentro Apys
Viña del Mar Valparaíso, 25205, Chile
IC La Serena Research
La Serena , 17204, Chile
Centro de Estudios Clinicos SAGA Spa
Santiago , 75006, Chile
Oncovida
Santiago , 75100, Chile
Icegclinic
Santiago , 82414, Chile
Centro de Estudios Clinicos e Investigaciones Medicas CeCim
Santiago , 83303, Chile
Peking Union Medical College Hospital, Chinese Academy of Medical Sciences
Beijing Beijing, 10003, China
The First Affiliated Hospital of Chongqing Medical University
Chongqing Chongqing, 40004, China
Gansu Provincial Cancer Hospital
Lanzhou Gansu, 73005, China
Gansu Wuwei Tumour Hospital
Wuwei Gansu, 73300, China
The first people's Hospital of Foshan
Foshan Guangdong, 52800, China
Sun Yat-sen University Cancer Center
Guangzhou Guangdong, 51003, China
Guangdong Provincial Peoples Hospital
Guangzhou Guangdong, 51018, China
Cancer Hospital of Shantou University Medical College
Shantou Guangdong, 51503, China
Guangxi Medical University Cancer Hospital
Nanning Guangxi, 53002, China
The First Affiliated Hospital of Henan University of science and Technology
Luoyang Henan, 47100, China
The Cancer Center Union Hospital Tongji Medical College Huazhong University of Science and Tech
Wuhan Hubei, 43000, China
The Second Xiangya Hospital of Central South Universiy
Changsha Hunan, 41000, China
Hunan Cancer Hospital
Changsha Hunan, 41000, China
Hunan Cancer Hospital
Changsha Hunan, 41001, China
Inner Mongolia Autonomous Region Peoples Hospital
Hohhot Inner Mongolia, 01001, China
The First People's Hospital of Changzhou
Changzhou Jiangsu, 21300, China
Nanjing Drum Tower Hospital
Nanjing Jiangsu, 21000, China
Zhongda Hospital Southeast University
Nanjing Jiangsu, 21000, China
Affiliated Hospital of Yangzhou University
Yangzhou Jiangsu, 22500, China
Northern Jiangsu Peoples Hospital
Yangzhou Jiangsu, 22500, China
The First Affiliated Hospital of Nanchang University
Nanchang Jiangxi, 33000, China
General Hospital of Ningxia Medical University
Yinchuan Ningxia, 75000, China
Shaanxi Provincial Peoples Hospital
Xian Shaanxi, 71006, China
Qilu Hospital of Shandong University
Jinan Shandong, 25001, China
The Affiliated Cancer Hospital of Shandong First Medical University
Jinan Shandong, 25011, China
Affiliated Hospital of Jining Medical University
Jining Shandong, 27200, China
Ruijin Hospital Shanghai Jiao Tong University School of Medicine
Shanghai Shanghai, 20002, China
Zhongshan Hospital Fudan University
Shanghai Shanghai, 20003, China
Changzhi Peoples Hospital
Changzhi Shanxi, 04600, China
West China Hospital of Sichuan University
Chengdu Sichuan, 61004, China
The Affiliated Hospital of Southwest Medical University
Luzhou Sichuan, 64600, China
Yunnan Cancer Hospital
Kunming Yunnan, 65010, China
Fakultni nemocnice Hradec Kralove
Hradec Kralove , 500 0, Czechia
Fakultni nemocnice Olomouc
Olomouc , 779 0, Czechia
Fakultni nemocnice Kralovske Vinohrady
Praha 10 , 100 3, Czechia
Vseobecna fakultni nemocnice v Praze
Praha 2 , 128 0, Czechia
Fakultni Thomayerova nemocnice
Praha 4 , 140 5, Czechia
Centre Hospitalier Universitaire Amiens Picardie - Hopital Sud
Amiens Cedex 1 , 80054, France
Centre Hospitalier Régional Universitaire de Besançon, Hôpital Jean Minjoz
Besançon , 25030, France
Institut Bergonie
Bordeaux , 33000, France
Centre Hospitalier Universitaire de Brest - Cavale Blanche
Brest , 29200, France
Centre Hospitalier Universitaire de Clermont Ferrand, Hôpital Estaing
Clermont-Ferrand cedex 1 , 63003, France
Centre Hospitalier Régional Universitaire de Lille - Hôpital Claude Huriez
Lille , 59037, France
Centre Hospitalier Universitaire de Limoges - Hopital Dupuytren
Limoges Cedex , 87042, France
Centre Leon Berard
Lyon cedex 8 , 69373, France
Centre Antoine Lacassagne
Nice , 06189, France
Hôpital Saint Louis
Paris Cedex 10 , 75475, France
Institut Mutualiste Montsouris
Paris Cedex 14 , 75674, France
Hôpital Européen Georges Pompidou
Paris , 75015, France
Centre Hospitalier Universitaire de Rouen
Rouen Cedex , 76031, France
Centre Rene Gauducheau - Institut de Cancerologie de l Ouest
Saint Herblain , 44800, France
Centre Hospitalier Universitaire Nord de Saint Etienne - Hôpital Nord
Saint Priest en Jarez , 42270, France
Institut de cancerologie Strasbourg Europe
Strasbourg cedex , 67065, France
Centre Hospitalier Universitaire de Toulouse - Hopital Rangueil
Toulouse Cedex 9 , 31059, France
Institut Gustave Roussy
Villejuif , 94805, France
Charite - Universitaetsmedizin Berlin, Campus Virchow
Berlin , 13353, Germany
Universitaetsklinikum Dresden
Dresden , 01307, Germany
Krankenhaus Nordwest GmbH
Frankfurt am Main , 60488, Germany
Haematologisch Onkologische Praxis Eppendorf
Hamburg , 20249, Germany
Medizinische Hochschule Hannover
Hannover , 30625, Germany
Universitaetsklinikum Schleswig-Holstein
Kiel , 24105, Germany
Universitaetsklinikum Leipzig
Leipzig , 04103, Germany
Regional Kliniken Holding Klinikum Ludwigsburg
Ludwigsburg , 71640, Germany
Johannes Gutenberg Universitaet Mainz
Mainz , 55131, Germany
Universitaetsmedizin Mannheim
Mannheim , 68167, Germany
Klinikum der LMU Muenchen
Muenchen , 81377, Germany
Klinikum rechts der Isar der TUM
Muenchen , 81675, Germany
Universitaetsklinikum der Eberhard Karls Universitaet Tuebingen
Tuebingen , 72076, Germany
Universitaetsklinikum Ulm
Ulm , 89081, Germany
Klinikum der Stadt Wolfsburg
Wolfsburg , 38440, Germany
Prince of Wales Hospital
Shatin, New Territories , , Hong Kong
Semmelweis Egyetem
Budapest , 1082, Hungary
Del-pesti Centrumkorhaz - Orszagos Hematologiai es Infektologiai Intezet
Budapest , 1097, Hungary
Orszagos Onkologiai Intezet
Budapest , 1122, Hungary
Debreceni Egyetem Klinikai Kozpont
Debrecen , 4032, Hungary
Szabolcs-Szatmar-Bereg Varmegyei Oktatokorhaz Nyiregyhazi Josa Andras Tagkorhaz
Nyiregyhaza , 4400, Hungary
Tolna Varmegyei Balassa Janos Korhaz
Szekszard , 7100, Hungary
Jasz-Nagykun-Szolnok Varmegyei Hetenyi Geza Korhaz-Rendelointezet
Szolnok , 5000, Hungary
Komarom-Esztergom Varmegyei Szent Borbala Korhaz
Tatabanya , 2800, Hungary
Rambam Health Care Campus
Haifa , 31096, Israel
Shaare Zedek Medical Center
Jerusalem , 91031, Israel
Hadassah Ein-Kerem Medical Center
Jerusalem , 91120, Israel
Sheba Medical Center
Ramat Gan , 52620, Israel
Tel-Aviv Sourasky Medical Center
Tel Aviv , 64239, Israel
Azienda Ospedaliero Universitaria Ospedali Riuniti di Ancona
Ancona , 60126, Italy
Azienda Socio Sanitaria Territoriale Papa Giovanni xxiii
Bergamo , 24127, Italy
Ente Ospedaliero IRCCS Saverio De Bellis
Castellana Grotte , 70013, Italy
Azienda Socio Sanitaria Territoriale di Cremona
Cremona , 26100, Italy
Azienda Ospedaliero Universitaria Careggi
Firenze , 50134, Italy
Ospedale Policlinico San Martino IRCCS
Genova , 16132, Italy
IRCCS Ospedale San Raffaele
Milano , 20132, Italy
Fondazione IRCCS Istituto Nazionale dei Tumori
Milano , 20133, Italy
Azienda Ospedaliero Universitaria Luigi Vanvitelli
Napoli , 80131, Italy
Istituto Oncologico Veneto IRCCS
Padova , 35128, Italy
Azienda Ospedaliera Universitaria Pisana Ospedale Santa Chiara
Pisa , 56126, Italy
Nagoya University Hospital
Nagoya-shi Aichi, 466-8, Japan
Chiba Cancer Center
Chiba-shi Chiba, 260-8, Japan
National Cancer Center Hospital East
Kashiwa-shi Chiba, 277-8, Japan
National Hospital Organization Shikoku Cancer Center
Matsuyama-shi Ehime, 791-0, Japan
National Hospital Organization Kyushu Cancer Center
Fukuoka-shi Fukuoka, 811-1, Japan
Gifu University Hospital
Gifu-shi Gifu, 501-1, Japan
Hokkaido University Hospital
Sapporo Hokkaido, 060-8, Japan
Hyogo Cancer Center
Akashi-shi Hyogo, 673-8, Japan
Kobe City Medical Center General Hospital
Kobe-shi Hyogo, 650-0, Japan
Yokohama City University Medical Center
Yokohama-shi Kanagawa, 232-0, Japan
Kanagawa Prefectural Hospital Organization Kanagawa Cancer Center
Yokohama-shi Kanagawa, 241-8, Japan
Niigata Cancer Center Hospital
Niigata-shi Niigata, 951-8, Japan
Kansai Medical University Hospital
Hirakata-shi Osaka, 573-1, Japan
Osaka International Cancer Institute
Osaka-shi Osaka, 541-8, Japan
Kindai University Hospital
Osakasayama-shi Osaka, 589-8, Japan
Osaka University Hospital
Suita-shi Osaka, 565-0, Japan
Saitama Cancer Center
Kitaadachi-gun Saitama, 362-0, Japan
Shizuoka Cancer Center
Sunto-gun Shizuoka, 411-8, Japan
National Cancer Center Hospital
Chuo-ku Tokyo, 104-0, Japan
The Cancer Institute Hospital of Japanese Foundation for Cancer Research
Koto-ku Tokyo, 135-8, Japan
Kyungpook National University Chilgok Hospital
Daegu , 41404, Korea, Republic of
Chungnam National University Hospital
Daejeon , 35015, Korea, Republic of
National Cancer Center
Goyang-si Gyeonggi-do , 10408, Korea, Republic of
Jeonbuk National University Hospital
Jeonju-si, Jeollabuk-do , 54907, Korea, Republic of
Seoul National University Bundang Hospital
Seongnam-si, Gyeonggi-do , 13620, Korea, Republic of
Korea University Anam Hospital
Seoul , 02841, Korea, Republic of
Seoul National University Hospital
Seoul , 03080, Korea, Republic of
Kangbuk Samsung Hospital
Seoul , 03181, Korea, Republic of
Severance Hospital Yonsei University Health System
Seoul , 03722, Korea, Republic of
Asan Medical Center
Seoul , 05505, Korea, Republic of
Samsung Medical Center
Seoul , 06351, Korea, Republic of
The Catholic University of Korea Seoul St Marys Hospital
Seoul , 06591, Korea, Republic of
Korea University Guro Hospital
Seoul , 08308, Korea, Republic of
Beskidzkie Centrum Onkologii Szpital Miejski imienia Jana Pawla Drugiego
Bielsko-Biala , 43-30, Poland
Narodowy Instytut Onkologii im M Sklodowskiej-Curie Panstwowy Instytut Badawczy Oddzial w Gliwicach
Gliwice , 44-10, Poland
Przychodnia Lekarska Komed Roman Karaszewski
Konin , 62-50, Poland
Samodzielny Publiczny Szpital Kliniczny Nr 1
Lublin , 20-08, Poland
Szpital Kliniczny Ministerstwa Spraw Wewnetrznych i Administracji
Olsztyn , 10-22, Poland
Mazowiecki Szpital Wojewodzki im Sw Jana Pawla II w Siedlcach spzoo
Siedlce , 08-11, Poland
Centrum Medyczne Pratia Poznan
Skorzewo , 60-18, Poland
Samodzielny Publiczny Szpital Kliniczny Nr 1 Pomorskiego Uniwersytetu Medycznego w Szczecinie
Szczecin , 71-25, Poland
Lux med onkologia sp zoo szpital szamocka
Warszawa , 01-74, Poland
Narodowy Instytut Onkologii im Marii Sklodowskiej-Curie Panstwowy Instytut Badawczy
Warszawa , 02-03, Poland
MTZ Clinical Research powered by Pratia
Warszawa , 02-17, Poland
Uniwersytecki Szpital Kliniczny im Jana Mikulicza-Radeckiego we Wroclawiu
Wroclaw , 50-55, Poland
Unidade Local de Saude de Braga, EPE
Braga , 4710-, Portugal
Unidade Local de Saude do Alto Ave, EPE
Guimaraes , 4835-, Portugal
Hospital da Luz, SA
Lisboa , 1500-, Portugal
Unidade Local de Saude de Santa Maria, EPE - Hospital de Santa Maria
Lisboa , 1649-, Portugal
Unidade Local de Saude de Matosinhos, EPE - Hospital Pedro Hispano
Matosinhos , 4464-, Portugal
Hospital Cuf porto
Porto , 4100-, Portugal
Unidade Local de Saude de Sao Joao, EPE - Hospital de Sao Joao
Porto , 4200-, Portugal
Institutul Clinic Fundeni
Bucharest , 02232, Romania
Institutul Oncologic Prof Dr Ion Chiricuta Cluj-Napoca
Cluj Napoca , 40001, Romania
Institutul Regional de Gastroenterologie si Hepatologie Prof Dr Octavian Fodor
Cluj-Napoca , 40000, Romania
Centrul de Oncologie Sf Nectarie SRL
Craiova , 20054, Romania
Institutul Regional de Oncologie Iasi
Iasi , 70048, Romania
SC Oncomed SRL
Timisoara , 30023, Romania
National University Hospital
Singapore , 11907, Singapore
National Cancer Centre Singapore
Singapore , 16858, Singapore
Hospital Universitario Virgen del Rocio
Sevilla Andalucía, 41013, Spain
Hospital Universitario Central de Asturias
Oviedo Asturias, 33011, Spain
Hospital Universitario Marques de Valdecilla
Santander Cantabria, 39008, Spain
Hospital del Mar
Barcelona Cataluña, 08003, Spain
Hospital Universitari Vall d Hebron
Barcelona Cataluña, 08035, Spain
Institut Catala d Oncologia Hospitalet Hospital Duran i Reynals
Hospitalet de Llobregat Cataluña, 08908, Spain
Hospital General Universitario de Elche
Elche Comunidad Valenciana, 03203, Spain
Hospital Clinico Universitario de Valencia
Valencia Comunidad Valenciana, 46010, Spain
Complexo Hospitalario Universitario A Coruña Hospital Teresa Herrera
A Coruña Galicia, 15006, Spain
Hospital Universitario de Navarra
Pamplona Navarra, 31008, Spain
Hospital Universitario Ramon y Cajal
Madrid , 28034, Spain
Hospital Clinico San Carlos
Madrid , 28040, Spain
Hospital Universitario 12 de Octubre
Madrid , 28041, Spain
Universitaetsspital Basel
Basel , 4031, Switzerland
Inselspital Bern
Bern , 3010, Switzerland
Kantonsspital Graubuenden
Chur , 7000, Switzerland
Hopitaux Universitaires de Geneve
Geneve , 1205, Switzerland
Onkozentrum Zuerich
Zurich , 8038, Switzerland
Universitaetsspital Zuerich
Zurich , 8091, Switzerland
Kaohsiung Medical University Chung-Ho Memorial Hospital
Kaohsiung , 80756, Taiwan
China Medical University Hospital
Taichung , 40447, Taiwan
National Cheng Kung University Hospital
Tainan , 70403, Taiwan
Taipei Veterans General Hospital
Taipei , 11217, Taiwan
Tri-Service General Hospital
Taipei , 11490, Taiwan
Chulabhorn Hospital
Bangkok , 10210, Thailand
Siriraj Hospital
Bangkok , 10700, Thailand
Maharaj Nakorn Chiang Mai Hospital
Chiang Mai , 50200, Thailand
Chiangrai Prachanukroh Hospital
Chiang Rai , 57000, Thailand
Prince of Songkla Hospital
Songkhla , 90110, Thailand
Addenbrookes Hospital
Cambridge , CB2 0, United Kingdom
University Hospital Coventry
Coventry , CV2 2, United Kingdom
Ninewells Hospital and Medical School
Dundee , DD1 9, United Kingdom
Guys Hospital
London , SE1 9, United Kingdom
Christie Hospital
Manchester , M20 4, United Kingdom
Mount Vernon Cancer Centre
Northwood , HA6 2, United Kingdom
Torbay Hospital
Torquay , TQ2 7, United Kingdom

How clear is this clinincal trial information?

Study is for people with:

Esophageal Cancer

Phase:

Phase 3

Estimated Enrollment:

528

Study ID:

NCT05111626

Recruitment Status:

Recruiting

Sponsor:


Amgen

How clear is this clinincal trial information?

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