Ultrafiltration Versus IV Diuretics in Worsening Heart Failure

Inclusion Criteria:

18 years or older
Man, or non-pregnant woman
Admitted to the hospital with a diagnosis of acute decompensated heart failure
On regularly prescribed oral loop diuretics, Sodium-glucose Cotransporter-2 (SGLT2) Inhibitors or a Mineralcorticoid Receptor Antagonists (MRA) prior to admission
Fluid overload manifested by at least three clinical indications (e.g., edema, an excess of at least 10 pounds of fluid, etc.)
Provide written informed consent

Exclusion Criteria:

New diagnosis of heart failure
Acute coronary syndromes
Creatinine ≥ 3.0 mg/dl or planned renal replacement therapies at the time of enrollment
Contraindications to systemic anticoagulation
Severe concomitant disease expected to prolong hospitalization or cause death in less than 90 days
Sepsis or ongoing systemic infection
Active myocarditis
Constrictive pericarditis or restrictive cardiomyopathy
Severe aortic stenosis
Any condition in the opinion of the investigator that would prevent the patient from follow-up/survival