Hypertrophic Cardiomyopathy Clinical Trial
Treating Nocturnal Hypertension and Nocturia in African American Men
Summary
This is a protocol to obtain pilot data to submit a new NIH grant on Nocturnal Hypertension and Nocturia. In the diversity supplement to Dr. Victor's current NIH grant (Cut Your Pressure Too: The Los Angeles Barbershop Blood Pressure Study) the results show that uncontrolled systolic hypertension is an independent determinant of nocturia in African American men.
the investigators now want to pursue this correlation by designing a new NIH grant proposal to determine whether replacing short acting with long acting drugs and dosing them at bedtime rather than in the morning will: A. Lower systolic blood pressure during sleep B. Improve nocturia and result in better sleep quality
Full Description
Aims and Significance of pilot data
Determine:
The feasibility of the Southern California Healthy Heart and Blood Pressure registry as an effective method to recruit African American men to participate in a new research program
If participants are willing to comply with the study procedures including wearing an activity monitor, sleep study device, and ambulatory blood pressure monitor
The within subject variation for repeated measures of nocturnal blood pressure by ambulatory blood pressure and activity monitoring
If nocturnal systolic blood pressure is higher in men with self-reported nocturia ≥2 than in men with 0-1 nocturia
If use of long-acting antihypertensive medication as well as nighttime dosing of medication can lower nocturnal systolic blood pressure and reduce nocturia
Purpose:
Obtain key pilot data to show feasibility and document the reproducibility of the proposed measurements.
Eligibility Criteria
Inclusion Criteria:
African American Men
Age 35 to 59 years-old
Able to give informed consent
Willing to wear the activity monitor, ambulatory blood pressure monitoring (ABPM), and sleep study device
Uncontrolled hypertension: both a sleeping average systolic blood pressure of ≥ 125 mm Hg and an awake average systolic blood pressure of ≥ 135 mm Hg
Exclusion Criteria:
Severe Sleep Apnea (Apnea Hypopnea Index (AHI) of > 30 on home sleep study) or history of sleep apnea diagnosis and use of Continuous Positive Airway Pressure therapy
Uncontrolled Diabetes Mellitus (a random glucose of ≥ 200 mg/dL)
History of diagnosis or symptoms of either prostate disease or overactive bladder (urinary urgency or frequency during the daytime)
Chronic kidney disease (Glomerular filtration rate of < 60 mL/min/1.73 m2 based on the MDRD equation)
Renal transplant recipient
Loop diuretic use
Night shift work
On chemotherapy for cancer
Orthostatic hypotension
o After 2 minutes of standing: a drop in blood pressure of > 20/10 mm Hg, a standing systolic blood pressure of < 100 mm Hg, or tachycardia with an increased heart rate of > 20 beats/minute
Other reasons deemed unsafe for study participation by Principle Investigator
Check Your Eligibility
Let’s see if you might be eligible for this study.
What is your age and gender ?
There is 1 Location for this study
Los Angeles California, 90048, United States
How clear is this clinincal trial information?
Please confirm you are a US based health care provider:
Yes, I am a health care Provider No, I am not a health care providerSign Up Now.
Take Control of Your Disease Journey.
Sign up now for expert patient guides, personalized treatment options, and cutting-edge insights that can help you push for the best care plan.