Kidney Cancer Clinical Trial

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Study of BMS-986315 Alone and in Combination With Nivolumab or Cetuximab in Participants With Advanced Solid Tumors

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Summary

The purpose of this study is to evaluate BMS-986315 alone and in combination with nivolumab or cetuximab in participants with advanced solid tumors.

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Eligibility Criteria

Inclusion Criteria:

Participants must have histologic confirmation of advanced (metastatic, recurrent, and/or unresectable) squamous cell carcinoma of the head and neck (SCCHN), nonsmall cell lung cancer (NSCLC), or renal cell cancer (RCC) with measurable disease per RECIST 1.1
Participants expected to have received standard of care therapies including an available PD-(L)1 inhibitor
Eastern cooperative oncology group performance status of 0 or 1
Women of childbearing potential must agree to follow methods of contraception

Exclusion Criteria:

Participants with active, known or suspected autoimmune disease
Participants with a condition requiring systemic treatment with either corticosteroids or other immunosuppressive medications
Uncontrolled or significant cardiovascular disease
History of or with active interstitial lung disease or pulmonary fibrosis
Prior participation in anti-natural killer cell receptor (anti-NKG2A) clinical study
History of allergy or hypersensitivity to study drug components

Other protocol-defined inclusion/exclusion criteria apply

Study is for people with:

Kidney Cancer

Phase:

Phase 1

Estimated Enrollment:

308

Study ID:

NCT04349267

Recruitment Status:

Active, not recruiting

Sponsor:

Bristol-Myers Squibb

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There are 8 Locations for this study

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Local Institution - 0028
Sioux Falls South Dakota, 57104, United States
Local Institution - 0001
Germantown Tennessee, 38138, United States
Local Institution - 0014
Edmonton Alberta, T6X 1, Canada
Local Institution - 0011
Vancouver British Columbia, V5Z 4, Canada
Local Institution - 0004
Toronto Ontario, M5G 2, Canada
Local Institution - 0005
Montreal Quebec, H2X 3, Canada
Local Institution - 0013
Ottawa , K1H 8, Canada
Local Institution
Mexico city Distrito Federal, 06100, Mexico
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How clear is this clinincal trial information?

Study is for people with:

Kidney Cancer

Phase:

Phase 1

Estimated Enrollment:

308

Study ID:

NCT04349267

Recruitment Status:

Active, not recruiting

Sponsor:


Bristol-Myers Squibb

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