Lung Cancer Clinical Trial

Study to Compare AMG 510 “Proposed INN Sotorasib” With Docetaxel in Non Small Cell Lung Cancer (NSCLC) (CodeBreak 200).

Summary

A Phase 3 Study to Compare AMG 510 with Docetaxel in Non Small Cell Lung Cancer (NSCLC) subjects with KRAS p. G12c mutation

View Eligibility Criteria

Eligibility Criteria

Inclusion Criteria:

Men or women greater than or equal to 18 years old.
ECOG ≤ 1
Pathologically documented, previously treated, locally-advanced and unresectable or metastatic NSCLC with KRAS p.G12C mutation confirmed through central testing or have documentation of KRAS p.G12C mutation through Amgen Study 20190294 prior to enrollment

Exclusion Criteria:

Active brain metastases
Myocardial infarction within 6 months of study day 1
Gastrointestinal (GI) tract disease causing the inability to take oral medication

Study is for people with:

Lung Cancer

Phase:

Phase 3

Estimated Enrollment:

345

Study ID:

NCT04303780

Recruitment Status:

Active, not recruiting

Sponsor:

Amgen

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There are 269 Locations for this study

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Pacific Cancer Medical Center Inc
Anaheim California, 92801, United States
City of Hope National Medical Center
Duarte California, 91010, United States
Pacific Shores Medical Group Long Beach
Long Beach California, 90813, United States
University of California Los Angeles
Los Angeles California, 90095, United States
University of California Los Angeles
Los Angeles California, 90095, United States
University of California at Davis Medical Center
Sacramento California, 95817, United States
Ridley Tree Cancer Center
Santa Barbara California, 93105, United States
University of California San Francisco Mission Hall
Stanford California, 94305, United States
Harbor University of California Los Angeles Medical Center
Torrance California, 90502, United States
Rocky Mountain Cancer Centers
Denver Colorado, 80218, United States
Danbury Hospital
Norwalk Connecticut, 06856, United States
Medical Oncology Hematology Consultants Helen F Graham Cancer Center
Newark Delaware, 19713, United States
Washington Cancer Institute at MedStar Washington Hospital
Washington District of Columbia, 20010, United States
Florida Cancer Specialists - Fort Myers
Fort Myers Florida, 33901, United States
Memorial Regional Hospital
Hollywood Florida, 33021, United States
Florida Cancer Specialists Research North
Saint Petersburg Florida, 33705, United States
Florida Cancer Specialists Research Panhandle
Tallahassee Florida, 32308, United States
Emory University
Atlanta Georgia, 30332, United States
Northside Hospital, Incorporated
Atlanta Georgia, 30341, United States
Affiliated Oncologists, LLC
North Chicago Illinois, 60064, United States
Fort Wayne Medical Oncology and Hematology
Fort Wayne Indiana, 46804, United States
Willis Knighton Cancer Center
Shreveport Louisiana, 71103, United States
Maryland Oncology Hematology PA
Clinton Maryland, 20735, United States
New York Cancer and Blood Specialists
Lowell Massachusetts, 01854, United States
University of Michigan
Ann Arbor Michigan, 48109, United States
Center for Oncology Clinical Trials
Grand Rapids Michigan, 49503, United States
Minnesota Oncology Hematology PA
Minneapolis Minnesota, 55404, United States
HCA Midwest Health Kansas City
Kansas City Missouri, 64132, United States
Comprehensive Cancer Centers of Nevada
Las Vegas Nevada, 89169, United States
Summit Medical Group
Florham Park New Jersey, 07932, United States
New York Oncology Hematology, PC
Albany New York, 12208, United States
United States Oncology Regulatory Affairs Corporate Office
Albany New York, 12208, United States
Montefiore Einstein Center for Cancer Care
Bronx New York, 10461, United States
James J Peters VA Medical Center
Bronx New York, 10468, United States
Northwell Health Monter Cancer Center
Lake Success New York, 11042, United States
Wake Forest Baptist Health
Winston-Salem North Carolina, 27157, United States
Oncology Hematology Care Inc
Cincinnati Ohio, 45219, United States
Northwest Cancer Specialists - Vancouver
Portland Oregon, 97227, United States
Charleston Oncology
Charleston South Carolina, 29414, United States
Saint Francis Hospital, Inc
Greenville South Carolina, 29607, United States
Tennessee Oncology PLLC
Chattanooga Tennessee, 37404, United States
Tennessee Cancer Specialists
Knoxville Tennessee, 37909, United States
Tennessee Oncology
Nashville Tennessee, 37203, United States
Texas Oncology-Bedford
Bedford Texas, 76022, United States
Texas Oncology Baylor
Dallas Texas, 75246, United States
UT Southwestern Medical Center
Dallas Texas, 75390, United States
The Center for Cancer and Blood Disorders
Fort Worth Texas, 76104, United States
Valley Cancer Associates
Harlingen Texas, 78550, United States
University of Texas MD Anderson Cancer Center
Houston Texas, 77030, United States
US Oncology Research Investigational Products Center
Irving Texas, 75063, United States
Hope Cancer Center
Tyler Texas, 75701, United States
Intermountain Medical Center
Murray Utah, 84107, United States
Virginia Cancer Specialists, PC
Fairfax Virginia, 22031, United States
Virginia Oncology Associates
Norfolk Virginia, 23502, United States
Blacktown Hospital
Blacktown New South Wales, 2148, Australia
Chris OBrien Lifehouse
Camperdown New South Wales, 2050, Australia
St George Hospital
Kogarah New South Wales, 2217, Australia
Liverpool Hospital
Liverpool New South Wales, 2170, Australia
Prince Charles Hospital
Chermside Queensland, 4032, Australia
Princess Alexandra Hospital
Woolloongabba Queensland, 4102, Australia
The Queen Elizabeth Hospital
Woodville South South Australia, 5011, Australia
Monash Medical Centre
Clayton Victoria, 3168, Australia
Peter MacCallum Cancer Centre
Melbourne Victoria, 3000, Australia
St John of God Healthcare
Subiaco Western Australia, 6008, Australia
Institute Jules Bordet
Brussels , 1000, Belgium
Universite Catholique de Louvain Cliniques Universitaires Saint Luc
Bruxelles , 1200, Belgium
Grand Hopital de Charleroi
Charleroi , 6000, Belgium
Universitair Ziekenhuis Antwerpen
Edegem , 2650, Belgium
Universitair Ziekenhuis Gent
Gent , 9000, Belgium
Universitair Ziekenhuis Leuven - Campus Gasthuisberg
Leuven , 3000, Belgium
Centre Hospitalier Universitaire de Liege
Liege , 4000, Belgium
AZ Delta Campus Rumbeke
Roeselare , 8800, Belgium
Algemeen Ziekenhuis Nikolaas Campus Sint Niklaas
Sint-Niklaas , 9100, Belgium
Hospital de Caridade de Ijui
Ijui Rio Grande Do Sul, 98700, Brazil
Hospital Sao Lucas da Pontificia Universidade Catolica do Rio Grande do Sul
Porto Alegre Rio Grande Do Sul, 90610, Brazil
Sociedade Beneficente de Senhoras Hospital Sirio Libanes
Sao Paulo São Paulo, 01308, Brazil
Beneficencia Portuguesa de Sao Paulo
Sao Paulo São Paulo, 01321, Brazil
Oncologia Rede D´Or
Sao Paulo São Paulo, 04501, Brazil
Hospital Israelita Albert Einstein
Sao Paulo São Paulo, 05652, Brazil
Hospital de Base de Sao Jose do Rio Preto
São José Do Rio Preto São Paulo, 15090, Brazil
Centro de Tratamento de Tumores Botafogo
Rio de Janeiro , 22250, Brazil
Instituto Coi
Rio de Janeiro , 22793, Brazil
Fundacao Antonio Prudente - Hospital A C Camargo
São Paulo , 01509, Brazil
Tom Baker Cancer Centre
Calgary Alberta, T2N 4, Canada
Cross Cancer Institute
Edmonton Alberta, T6G 1, Canada
Juravinski Cancer Centre
Hamilton Ontario, L8V 5, Canada
London Health Sciences Centre
London Ontario, N6A 5, Canada
The Ottawa Hospital Cancer Centre
Ottawa Ontario, K1H 8, Canada
Princess Margaret Cancer Centre
Toronto Ontario, M5G 2, Canada
Centre Hospitalier de L'Universite de Montreal Hopital Notre-Dame
Montreal Quebec, H2X 3, Canada
Herlev og Gentofte Hospital
Herlev , 2730, Denmark
Rigshospitalet
København , 2100, Denmark
Odense Universitetshospital
Odense C , 5000, Denmark
Docrates Syopasairaala
Helsinki , 00180, Finland
Helsingin Yliopistollinen Keskussairaala
Helsinki , 00290, Finland
Oulu University Hospital
Oulu , 90220, Finland
Turku University Hospital
Turku , 20520, Finland
Centre Hospitalier Regional Universitaire - Hopital Morvan
Brest , 29609, France
Centre Hospitalier Intercommunal de Créteil
Créteil , 94010, France
Centre Hospitalier Universitaire de Grenoble - Hopital Nord Michallon
Grenoble , 38700, France
Centre Hospitalier Universitaire Régional de Lille - Hôpital Albert Calmette
Lille Cedex , 59037, France
Centre Hospitalier Universitaire de Limoges - Hopital Dupuytren
Limoges Cedex , 87042, France
Centre Leon Berard
Lyon , 69008, France
Centre Hospitalier Universitaire Nord
Marseille Cedex 20 , 13915, France
Hôpital Tenon
Paris Cedex 20 , 75020, France
Institut Curie
Paris , 75005, France
Hopital Cochin
Paris , 75014, France
Hopital Bichat Claude Bernard
Paris , 75018, France
Centre Hospitalier Universitaire de Bordeaux - Hopital Haut Leveque
Pessac Cedex , 33604, France
Centre Hospitalier Lyon Sud
Pierre-Benite cedex , 69495, France
Centre Hospitalier Universitaire de Rennes - Hopital Pontchaillou
Rennes , 35033, France
Centre Hospitalier de Nantes - Hôpital Nord LaÃ"nnec
Saint Herblain , 44800, France
Centre Hospitalier Universitaire de Strasbourg - Nouvel Hopital Civil
Strasbourg cedex , 67091, France
Centre Hospitalier Universitaire de Toulouse - Hopital Larrey
Toulouse Cedex 9 , 31059, France
Gustave Roussy
Villejuif , 94805, France
Evangelische Lungenklinik
Berlin , 13125, Germany
Charite Universitätsmedizin Berlin, Charité Campus Virchow-Klinikum
Berlin , 13353, Germany
Universitaetsklinikum Carl Gustav Carus
Dresden , 01307, Germany
Universitätsklinikum Essen
Essen , 45147, Germany
Klinikum Esslingen GmbH
Esslingen am Neckar , 73730, Germany
Universitätsklinikum Frankfurt/Main
Frankfurt am Main , 60590, Germany
Asklepios - Fachkliniken München-Gauting
Gauting , 82130, Germany
LungenClinic Grosshansdorf GmbH
Grosshansdorf , 22927, Germany
Studiengesellschaft Hämato Onkologie Hamburg Prof Laack und Partner
Hamburg , 20251, Germany
Universitaetsklinikum Heidelberg
Heidelberg , 69126, Germany
Klinikverbund Allgäu
Immenstadt , 87509, Germany
Universitatsklinikum Koln
Köln , 50937, Germany
Pneumologisch/onkologisch/internistisches Studienzentrum
Leipzig , 04357, Germany
Bethanien Krankenhaus
Moers , 47441, Germany
Pius-Hospital Oldenburg
Oldenburg , 26121, Germany
Agios Savvas Anticancer Hospital
Athens , 115 2, Greece
Henry Dunant Hospital Center
Athens , 11526, Greece
Sotiria General Hospital
Athens , 11527, Greece
General Oncology Hospital of Kifissia Agioi Anargyroi
Athens , 14564, Greece
Metropolitan Hospital
Athens , 18547, Greece
University Hospital of Heraklion
Heraklion - Crete , 71110, Greece
University Hospital of Larissa
Larissa , 41110, Greece
University Hospital of Patras
Patra , 26504, Greece
Theagenion Cancer Hospital
Thessaloniki , 54007, Greece
Bioclinic of Thessaloniki
Thessaloniki , 54622, Greece
Euromedica General Clinic of Thessaloniki
Thessaloniki , 54645, Greece
Agios Loukas Clinic
Thessaloniki , 55236, Greece
Semmelweis Egyetem
Budapest , 1083, Hungary
Orszagos Koranyi Pulmonologiai Intezet
Budapest , 1121, Hungary
Veszprem Megyei Tudogyogyintezet
Farkasgyepu , 8582, Hungary
Bekes Megyei Kozponti Korhaz Pandy Kalman Tagkorhaz
Gyula , 5700, Hungary
Somogy Megyei Kaposi Mor Oktato Korhaz
Kaposvar , 7400, Hungary
Borsod-Abauj-Zemplen Megyei Kozponti Korhaz es Egyetemi Oktatokorhaz
Miskolc , 3529, Hungary
Fejer Megyei Szent Gyorgy Egyetemi Oktato Korhaz
Szekesfehervar , 8000, Hungary
Szent Borbala Korhaz
Tatabanya , 2800, Hungary
Tudogyogyintezet Torokbalint
Torokbalint , 2045, Hungary
Azienda Ospedaliera di Rilievo Nazionale San Giuseppe Moscati
Avellino , 83100, Italy
IRCCS Istituto Tumori Giovanni Paolo II
Bari , 70124, Italy
Azienda Ospedaliera Universitaria di Bologna Policlinico S Orsola Malpighi
Bologna , 40138, Italy
Azienda Ospedaliera Universitaria Policlinico Vittorio Emanuele Presidio Ospedaliero G Rodolico
Catania , 95123, Italy
Azienda Ospedaliero Universitaria Careggi
Firenze , 50134, Italy
Fondazione IRCCS Ca Granda Ospedale Maggiore Policlinico
Milano , 20122, Italy
IRCCS Ospedale San Raffaele
Milano , 20132, Italy
Fondazione IRCCS Istituto Nazionale dei Tumori
Milano , 20133, Italy
Azienda Ospedaliero Universitaria di Cagliari Policlinico Duilio Casula
Monserrato CA , 09042, Italy
Azienda Socio Sanitaria Territoriale di Monza Ospedale San Gerardo
Monza (MB) , 20900, Italy
Azienda Ospedaliera di Rilievo Nazionale Specialistica dei Colli Monaldi
Napoli , 80131, Italy
Azienda Ospedaliera Universitaria San Luigi Gonzaga
Orbassano (TO) , 10043, Italy
Istituto Oncologico Veneto IRCCS
Padova , 35128, Italy
Azienda Unità Sanitaria Locale della Romagna Presidio ospedaliero di Ravenna
Ravenna , 48100, Italy
Azienda Ospedaliera Policlinico Umberto I
Roma , 00161, Italy
Policlinico Universitario Agostino Gemelli
Roma , 00168, Italy
Aichi Cancer Center Hospital
Nagoya-shi Aichi, 464-8, Japan
Nagoya University Hospital
Nagoya-shi Aichi, 466-8, Japan
Chiba Cancer Center
Chiba-shi Chiba, 260-8, Japan
National Cancer Center Hospital East
Kashiwa-shi Chiba, 277-8, Japan
National Hospital Organization Shikoku Cancer Center
Matsuyama-shi Ehime, 791-0, Japan
National Hospital Organization Kyushu Cancer Center
Fukuoka-shi Fukuoka, 811-1, Japan
Kyushu University Hospital
Fukuoka-shi Fukuoka, 812-8, Japan
Hospital of the University of Occupational and Environmental Health
Kitakyushu-shi Fukuoka, 807-8, Japan
Chugoku Central Hospital of Japan Mutual Aid Association of Public School Teachers
Fukuyama-shi Hiroshima, 720-0, Japan
Hiroshima University Hospital
Hiroshima-shi Hiroshima, 734-8, Japan
National Hospital Organization Hokkaido Cancer Center
Sapporo-shi Hokkaido, 003-0, Japan
Hyogo Cancer Center
Akashi-shi Hyogo, 673-8, Japan
National Hospital Organization Himeji Medical Center
Himeji-shi Hyogo, 670-8, Japan
Itami City Hospital
Itami-shi Hyogo, 664-8, Japan
Kobe City Medical Center General Hospital
Kobe-shi Hyogo, 650-0, Japan
Kanazawa University Hospital
Kanazawa-shi Ishikawa, 920-8, Japan
St Marianna University School of Medicine Hospital
Kawasaki-shi Kanagawa, 216-8, Japan
Kitasato University Hospital
Sagamihara-shi Kanagawa, 252-0, Japan
Kanagawa Prefectural Hospital Organization Kanagawa Cancer Center
Yokohama-shi Kanagawa, 241-8, Japan
Kyoto University Hospital
Kyoto-shi Kyoto, 606-8, Japan
Miyagi Cancer Center
Natori-shi Miyagi, 981-1, Japan
Sendai Kousei Hospital
Sendai-shi Miyagi, 980-0, Japan
Niigata Cancer Center Hospital
Niigata-shi Niigata, 951-8, Japan
Okayama University Hospital
Okayama-shi Okayama, 700-8, Japan
Osaka Habikino Medical Center
Habikino-shi Osaka, 583-8, Japan
Kansai Medical University Hospital
Hirakata-shi Osaka, 573-1, Japan
Osaka City General Hospital
Osaka-shi Osaka, 534-0, Japan
Osaka International Cancer Institute
Osaka-shi Osaka, 541-8, Japan
Kindai University Hospital
Osakasayama-shi Osaka, 589-8, Japan
National Hospital Organization Kinki-chuo Chest Medical Center
Sakai-shi Osaka, 591-8, Japan
Saga-ken Medical Centre Koseikan
Saga-shi Saga, 840-8, Japan
Saitama Cancer Center
Kitaadachi-gun Saitama, 362-0, Japan
Shiga University of Medical Science Hospital
Otsu-shi Shiga, 520-2, Japan
Juntendo University Hospital
Bunkyo-ku Tokyo, 113-8, Japan
National Cancer Center Hospital
Chuo-ku Tokyo, 104-0, Japan
Cancer Institute Hospital of Japanese Foundation for Cancer Research
Koto-ku Tokyo, 135-8, Japan
Tottori University Hospital
Yonago-shi Tottori, 683-8, Japan
Wakayama Medical University Hospital
Wakayama-shi Wakayama, 641-8, Japan
National Hospital Organization Iwakuni Clinical Center
Iwakuni-shi Yamaguchi, 740-8, Japan
National Hospital Organization Yamaguchi Ube Medical Center
Ube-shi Yamaguchi, 755-0, Japan
Chungbuk National University Hospital
Cheongju-si, Chungcheongbuk-do , 28644, Korea, Republic of
National Cancer Center
Goyang-si Gyeonggi-do , 10408, Korea, Republic of
Cha Bundang Medical Center, Cha University
Seongnam-si, Gyeonggi-do , 13496, Korea, Republic of
Seoul National University Bundang Hospital
Seongnam-si, Gyeonggi-do , 13620, Korea, Republic of
Seoul National University Hospital
Seoul , 03080, Korea, Republic of
Kangbuk Samsung Hospital
Seoul , 03181, Korea, Republic of
Severance Hospital Yonsei University Health System
Seoul , 03722, Korea, Republic of
Asan Medical Center
Seoul , 05505, Korea, Republic of
Samsung medical center
Seoul , 06351, Korea, Republic of
The Catholic University of Korea Seoul St Marys Hospital
Seoul , 06591, Korea, Republic of
Ulsan University Hospital
Ulsan , 44033, Korea, Republic of
Nederlands Kanker Instituut Antoni van Leeuwenhoekziekenhuis
Amsterdam , 1066 , Netherlands
Universitair Medisch Centrum Groningen
Groningen , 9713 , Netherlands
Radboudumc
Nijmegen , 6525 , Netherlands
Erasmus Medisch Centrum
Rotterdam , 3015 , Netherlands
Universitair Medisch Centrum Utrecht
Utrecht , 3584 , Netherlands
Uniwersyteckie Centrum Kliniczne
Gdansk , 80-21, Poland
Instytut Genetyki i Immunologii GENIM Spzoo
Lublin , 20-60, Poland
Szpital Kliniczny Przemienienia Panskiego Uniwersytetu Medycznego im K Marcinkowskiego w Poznaniu
Poznan , 60-56, Poland
Centrum Onkologii Instytut im Marii Sklodowskiej-Curie
Warszawa , 02-78, Poland
Dolnoslaskie Centrum Onkologii we Wroclawiu
Wroclaw , 53-41, Poland
Centro Hospitalar Universitario de Lisboa Norte EPE - Hospital Pulido Valente
Lisboa , 1769-, Portugal
Unidade Local de Saude de Matosinhos, EPE - Hospital Pedro Hispano
Matosinhos , 4464-, Portugal
Centro Hospitalar Universitario do Porto EPE - Hospital de Santo Antonio
Porto , 4099-, Portugal
Instituto Portugues de Oncologia do Porto Francisco Gentil, EPE
Porto , 4200-, Portugal
Centro Hospitalar Universitario de Sao Joao EPE - Hospital Sao Joao
Porto , 4200-, Portugal
Clinical hospital 2, Group of companies medsi
Moscow , 12528, Russian Federation
LLC Tonus
Nizhniy Novgorod , 60308, Russian Federation
Omsk Regional Clinical Oncology Dispensary
Omsk , 64401, Russian Federation
FSBI Scientific and Research Oncology Institute named after N N Petrov
Saint-Petersburg , 19775, Russian Federation
Saint Petersburg scientifical practical center of specialized kinds of medical care oncological
Saint-Petersburg , 19775, Russian Federation
Hospital Regional Universitario de Malaga
Malaga AndalucÃ-a, 29011, Spain
Hospital Universitario Insular de Gran Canaria
Las Palmas de Gran Canaria Canarias, 35016, Spain
Hospital Universitari Vall d Hebron
Barcelona Cataluña, 08035, Spain
Hospital Clinic i Provincial de Barcelona
Barcelona Cataluña, 08036, Spain
Hospital de la Santa Creu i Sant Pau
Barcelona Cataluña, 08041, Spain
Instituto Catalan de Oncologia Hospital Duran i Reynals
Hospitalet de Llobregat Cataluña, 08907, Spain
Hospital Clinico Universitario de Valencia
Valencia Comunidad Valenciana, 46010, Spain
Complexo Hospitalario Universitario A Coruña Hospital Teresa Herrera
A Coruña Galicia, 15006, Spain
Hospital Universitario Puerta de Hierro Majadahonda
Majadahonda Madrid, 28222, Spain
Hospital Universitario Ramon y Cajal
Madrid , 28034, Spain
Hospital Universitario 12 de Octubre
Madrid , 28041, Spain
Hospital Universitario La Paz
Madrid , 28046, Spain
Gavle Sjukhus
Gavle , 801 8, Sweden
Sahlgrenska Universitetssjukhuset
Goteborg , 413 4, Sweden
Universitetssjukhuset i Linkoping
Linkoping , 581 8, Sweden
Skanes Universitetssjukhus
Lund , 221 8, Sweden
Karolinska Universitetssjukhuset Solna
Stockholm , 171 6, Sweden
Norrlands Universitetssjukhus
Umea , 901 8, Sweden
Universitaetsspital Basel
Basel , 4031, Switzerland
Inselspital Bern
Bern , 3010, Switzerland
Hopitaux Universitaires de Geneve
Geneve , 1205, Switzerland
Centre Hospitalier Universitaire Vaudois
Lausanne , 1011, Switzerland
Kantonsspital Winterthur
Winterthur , 8401, Switzerland
Universitaetsspital Zuerich
Zurich , 8091, Switzerland
China Medical University Hospital
Taichung , 40447, Taiwan
Veterans General Hospital - Taichung
Taichung , 40705, Taiwan
National Cheng Kung University Hospital
Tainan , 70403, Taiwan
National Taiwan University Hospital
Taipei , 10002, Taiwan
Addenbrookes Hospital, Cambridge University Hospitals NHS Foundation Trust
Cambridge , CB2 0, United Kingdom
Western General Hospital
Edinburgh , EH4 2, United Kingdom
Royal Marsden Hospital
London , SW3 6, United Kingdom
Sarah Cannon Research Institute UK
London , W1G 6, United Kingdom
Christie Hospital
Manchester , M20 4, United Kingdom
Nottingham City Hospital
Nottingham , NG5 1, United Kingdom
Churchill Hospital
Oxford , OX3 7, United Kingdom
Royal Marsden Hospital
Sutton , SM2 5, United Kingdom

How clear is this clinincal trial information?

Study is for people with:

Lung Cancer

Phase:

Phase 3

Estimated Enrollment:

345

Study ID:

NCT04303780

Recruitment Status:

Active, not recruiting

Sponsor:


Amgen

How clear is this clinincal trial information?

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