Melanoma Clinical Trial

An Investigational Immuno-therapy Study of BMS-986205 Given in Combination With Nivolumab and in Combination With Both Nivolumab and Ipilimumab in Cancers That Are Advanced or Have Spread

Summary

The purpose of the study is to determine safety and effectiveness of experimental medication BMS-986205 when combined with Nivolumab and in combination with both Nivolumab and Ipilimumab in patients with cancers that are advanced or have spread. Pharmacokinetics and pharmacodynamics of BMS-986205 when combined with Nivolumab and in combination with Nivolumab and Ipilimumab in this patient population will also be assessed.

View Eligibility Criteria

Eligibility Criteria

For more information regarding Bristol-Myers Squibb (BMS) Clinical Trial participation, please visit www.BMSStudyConnect.com

Inclusion Criteria:

During dose escalation, subjects with advanced solid tumors that have progressed following at least one standard regimen
During cohort expansion, subjects with advanced cancer that either have received at least one prior therapy or are treatment naive, depending on the specified tumor type
Subjects must have measurable disease
Subject must consent to provide previously collected tumor tissue and a tumor biopsy during screening.
At least 4 weeks since any previous treatment for cancer
Must be able to swallow pills or capsules
Eastern Cooperative Oncology Group(ECOG) Performance Status 0-1

Exclusion Criteria:

Active or chronic autoimmune diseases
Uncontrolled or significant cardiovascular disease
History of any chronic Hepatitis, active Hepatitis B or C, human immunodeficiency virus (HIV), or acquired immune deficiency syndrome (AIDS)
Chronic hepatitis: Positive test for Hepatitis B virus surface antigen or Hepatitis C antibody (except for subjects with hepatocellular carcinoma)
Active central nervous system (CNS) metastases and CNS metastases as the only sites of disease
Active infection

Other protocol defined inclusion/exclusion criteria could apply

Study is for people with:

Melanoma

Phase:

Phase 1

Estimated Enrollment:

627

Study ID:

NCT02658890

Recruitment Status:

Completed

Sponsor:

Bristol-Myers Squibb

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There are 47 Locations for this study

See Locations Near You

Local Institution - 0028
Tucson Arizona, 85724, United States
Local Institution - 0026
La Jolla California, 92093, United States
Local Institution - 0035
Tampa Florida, 33612, United States
Local Institution - 0005
Atlanta Georgia, 30322, United States
Local Institution - 0048
Atlanta Georgia, 30342, United States
Local Institution - 0027
Chicago Illinois, 60637, United States
Local Institution - 0051
Lutherville Maryland, 21093, United States
Local Institution - 0049
Detroit Michigan, 48201, United States
Local Institution - 0006
Saint Louis Missouri, 63110, United States
Local Institution - 0033
Hackensack New Jersey, 07601, United States
Local Institution - 0041
New York New York, 10016, United States
Local Institution - 0030
Cleveland Ohio, 44195, United States
Local Institution - 0034
Philadelphia Pennsylvania, 19111, United States
Local Institution - 0057
Pittsburgh Pennsylvania, 15232, United States
Local Institution - 0043
Nashville Tennessee, 37232, United States
Local Institution - 0045
North Sydney New South Wales, 2146, Australia
Local Institution - 0029
Sydney New South Wales, 2010, Australia
Local Institution - 0046
Westmead New South Wales, 2145, Australia
Local Institution - 0044
Brisbane Queensland, 4102, Australia
Local Institution - 0008
Clayton Victoria, 3168, Australia
Local Institution - 0004
Melbourne Victoria, 3000, Australia
Local Institution - 0047
Nedlands Western Australia, 6009, Australia
Local Institution - 0003
Edmonton Alberta, T6G 1, Canada
Local Institution - 0002
Vancouver British Columbia, V5Z 4, Canada
Local Institution - 0001
Toronto Ontario, M5G 1, Canada
Local Institution
Greenfield Park Quebec, J4V 2, Canada
Local Institution - 0036
Montreal Quebec, H3T 1, Canada
Local Institution - 0059
Helsinki , 00180, Finland
Local Institution - 0040
Lille CEDEX , 59037, France
Local Institution - 0024
Lyon Cedex 08 , 69373, France
Local Institution - 0053
Marseille Cedex 5 , 13385, France
Local Institution - 0052
Nantes Cedex 01 , 44093, France
Local Institution - 0025
Paris , 75005, France
Local Institution - 0023
Toulouse , 31100, France
Local Institution - 0022
Villejuif , 94800, France
Local Institution - 0019
Essen , 45147, Germany
Local Institution - 0013
Heilbronn , 74078, Germany
Local Institution - 0010
Milano , 20132, Italy
Local Institution - 0011
Milano , 20133, Italy
Local Institution - 0012
Milano , 20141, Italy
Local Institution - 0009
Rozzano MI , 20089, Italy
Local Institution - 0054
Oslo , 0424, Norway
Local Institution - 0042
Warszawa Mazowieckie, 02-78, Poland
Local Institution - 0017
Barcelona , 08035, Spain
Local Institution - 0016
Madrid , 28040, Spain
Local Institution - 0018
Madrid , 28050, Spain
Local Institution - 0055
Solna , 171 6, Sweden

How clear is this clinincal trial information?

Study is for people with:

Melanoma

Phase:

Phase 1

Estimated Enrollment:

627

Study ID:

NCT02658890

Recruitment Status:

Completed

Sponsor:


Bristol-Myers Squibb

How clear is this clinincal trial information?

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