Melanoma Clinical Trial

Ipilimumab With or Without Sargramostim in Treating Patients With Stage III or Stage IV Melanoma That Cannot Be Removed by Surgery

Summary

This randomized phase II trial is studying how well giving ipilimumab with or without sargramostim (GM-CSF) works in treating patients with stage III or stage IV melanoma that cannot be removed by surgery (unresectable). Ipilimumab works by activating the patient's immune system to fight cancer. Colony-stimulating factors, such as sargramostim, may increase the number of immune cells found in bone marrow or peripheral blood and may help the immune system recover from the side effects of treatment. It is not yet known whether giving ipilimumab together with sargramostim is more effective than ipilimumab alone in treating melanoma.

View Full Description

Full Description

PRIMARY OBJECTIVES:

I. To evaluate the overall survival for the combination of sargramostim (GM-CSF) plus ipilimumab and ipilimumab alone in patients with advanced melanoma.

SECONDARY OBJECTIVES:

I. To evaluate the progression-free survival, response rate, safety and tolerability for the combination of GM-CSF plus ipilimumab and ipilimumab alone in patients with advanced melanoma.

II. To explore the utility of immune related response criteria (irRC) prospectively in patients receiving ipilimumab.

OUTLINE: Patients are randomized to 1 of 2 treatment arms.

ARM A: Patients receive induction therapy comprising ipilimumab intravenously (IV) over 90 minutes on day 1 and sargramostim subcutaneously (SC) once daily on days 1-14. Treatment repeats every 21 days for 4 cycles. After 12 weeks of induction treatment, anti-tumor response is assessed and patients then receive maintenance therapy comprising ipilimumab IV over 90 minutes on day 1 and sargramostim SC once daily on days 1-14. Treatment with ipilimumab repeats every 12 weeks and treatment with sargramostim repeats every 21 days. After 12 weeks of maintenance therapy, anti-tumor response is reassessed and patients with responsive or stable disease then continue maintenance therapy until disease progression or unacceptable toxicity.

ARM B: Patients receive induction therapy comprising ipilimumab IV over 90 minutes on day 1. Treatment repeats every 21 days for 4 cycles. After 12 weeks of induction treatment, anti-tumor response is assessed and patients then receive maintenance therapy of ipilimumab IV over 90 minutes on day 1. Treatment with ipilimumab repeats every 12 weeks. After 12 weeks of maintenance therapy, anti-tumor response is reassessed and cycles repeat every 12 weeks in the absence of disease progression or unacceptable toxicity.

After completion of study therapy, patients are followed up every 3 months for 2 years and then every 6 months for 3 years.

View Eligibility Criteria

Eligibility Criteria

Inclusion Criteria:

All sites of disease must be evaluated within 4 weeks prior to randomization; patients must have measurable disease as defined by Response Evaluation Criteria in Solid Tumors (RECIST)
No more than one prior systemic therapeutic regimen for unresectable stage III or stage IV melanoma; this includes chemotherapy, biologic therapy, biochemotherapy, or investigational treatment; this does not include any therapies given in the adjuvant setting
Histologic diagnosis of metastatic melanoma; for unknown primary disease, diagnosis of metastatic disease by cytology fine needle aspiration (FNA) is not acceptable
Women must not be pregnant or breast-feeding due to unknown effects of ipilimumab and GM-CSF on the unborn fetus; all women of childbearing potential must have a blood test within 72 hours prior to randomization to rule out pregnancy; women of childbearing potential and sexually active males must be strongly advised to use an accepted and effective method of contraception; women of childbearing potential (WOCBP) must be using an adequate method of contraception to avoid pregnancy throughout the study and for up to 12 weeks after the last dose of investigational product, in such a manner that the risk of pregnancy is minimized; sexually mature females who have not undergone a hysterectomy or who have not been postmenopausal naturally for at least 24 consecutive months (i.e., who have had menses at some time in the preceding 24 consecutive months) are considered to be of childbearing potential; women who are using oral contraceptives, other hormonal contraceptives (vaginal products, skin patches, or implanted or injectable products), or mechanical products such as an intrauterine device or barrier methods (diaphragm, condoms, spermicides) to prevent pregnancy, or are practicing abstinence or where their partner is sterile (e.g., vasectomy) should be considered to be of childbearing potential
White blood cells (WBC) >= 2000/uL (obtained =< 4 weeks prior to randomization)
Absolute neutrophil count (ANC) >= 1500/mcL (obtained =< 4 weeks prior to randomization)
Platelets >= 100,000/mcL (obtained =< 4 weeks prior to randomization)
Hemoglobin >= 8 g/dL (obtained =< 4 weeks prior to randomization)
Creatinine =< 3.0 x upper limit of normal (ULN) (obtained =< 4 weeks prior to randomization)
Aspartate aminotransferase (AST) and alanine aminotransferase (ALT) =< 2.5 x ULN (obtained =< 4 weeks prior to randomization)
Bilirubin =< 3.0 x ULN, (except patients with Gilbert's syndrome, who must have a total bilirubin less than 3.0 mg/dL) (obtained =< 4 weeks prior to randomization)
No concomitant therapy with any of the following: interleukin (IL) 2, interferon, or other non-study immunotherapy regimens; cytotoxic chemotherapy; immunosuppressive agents; other investigation therapies; or chronic use of systemic corticosteroids; must have been discontinued >= 4 weeks
No infection with human immunodeficiency virus (HIV); due to the mechanism of action of ipilimumab and GM-CSF, activity and side effects in an immune compromised patient are unknown
No active infection with hepatitis B
No active or chronic infection with hepatitis C
Eastern Cooperative Oncology Group (ECOG) performance status 0 or 1

Exclusion Criteria:

Patients with any history of central nervous system (CNS) metastases are excluded
Patients are excluded if they have a history of any other malignancy from which the patient has been disease-free for less than 2 years, with the exception of adequately treated and cured basal or squamous cell skin cancer, superficial bladder cancer or carcinoma in situ of the cervix
Patients are excluded if they have a history of any autoimmune disease; patients with a history of autoimmune thyroiditis are eligible if their current thyroid disorder is treated and stable with replacement or other medical therapy
Patients are excluded for any underlying medical or psychiatric condition, which in the opinion of the investigator, will make the administration of study drug hazardous or obscure the interpretation of adverse events, such as a condition associated with frequent diarrhea
Patients are excluded for receiving any non-oncology vaccine therapy used for prevention of infectious diseases for up to four weeks (28 days) prior to or after any dose of ipilimumab
Patients are excluded if they have a history of prior treatment with ipilimumab or prior cluster of differentiation (CD)137 agonist or cytotoxic T-lymphocyte antigen 4 (CTLA-4) inhibitor or agonist
Any concurrent medical condition requiring the use of systemic steroids is not permitted (the use of inhaled or topical steroids is permitted)

Study is for people with:

Melanoma

Phase:

Phase 2

Estimated Enrollment:

245

Study ID:

NCT01134614

Recruitment Status:

Active, not recruiting

Sponsor:

National Cancer Institute (NCI)

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There are 232 Locations for this study

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University of Alabama at Birmingham Cancer Center
Birmingham Alabama, 35233, United States
Stanford Cancer Institute Palo Alto
Palo Alto California, 94304, United States
VA Palo Alto Health Care System
Palo Alto California, 94304, United States
Eisenhower Medical Center
Rancho Mirage California, 92270, United States
The Medical Center of Aurora
Aurora Colorado, 80012, United States
Boulder Community Hospital
Boulder Colorado, 80301, United States
Penrose-Saint Francis Healthcare
Colorado Springs Colorado, 80907, United States
Porter Adventist Hospital
Denver Colorado, 80210, United States
Presbyterian - Saint Lukes Medical Center - Health One
Denver Colorado, 80218, United States
SCL Health Saint Joseph Hospital
Denver Colorado, 80218, United States
Rose Medical Center
Denver Colorado, 80220, United States
Western States Cancer Research NCORP
Denver Colorado, 80222, United States
Swedish Medical Center
Englewood Colorado, 80113, United States
Poudre Valley Hospital
Fort Collins Colorado, 80524, United States
Saint Mary's Hospital and Regional Medical Center
Grand Junction Colorado, 81501, United States
North Colorado Medical Center
Greeley Colorado, 80631, United States
Saint Anthony Hospital
Lakewood Colorado, 80228, United States
Sky Ridge Medical Center
Lone Tree Colorado, 80124, United States
Longmont United Hospital
Longmont Colorado, 80501, United States
McKee Medical Center
Loveland Colorado, 80539, United States
Saint Mary Corwin Medical Center
Pueblo Colorado, 81004, United States
North Suburban Medical Center
Thornton Colorado, 80229, United States
SCL Health Lutheran Medical Center
Wheat Ridge Colorado, 80033, United States
Smilow Cancer Hospital Care Center at Saint Francis
Hartford Connecticut, 06105, United States
Manchester Memorial Hospital
Manchester Connecticut, 06040, United States
The Hospital of Central Connecticut
New Britain Connecticut, 06050, United States
Yale University
New Haven Connecticut, 06520, United States
Eastern Connecticut Hematology and Oncology Associates
Norwich Connecticut, 06360, United States
Beebe Medical Center
Lewes Delaware, 19958, United States
Christiana Care Health System-Christiana Hospital
Newark Delaware, 19718, United States
Boca Raton Regional Hospital
Boca Raton Florida, 33486, United States
Lakeland Regional Health Hollis Cancer Center
Lakeland Florida, 33805, United States
21st Century Oncology-Orange Park
Orange Park Florida, 32073, United States
University Cancer and Blood Center LLC
Athens Georgia, 30607, United States
Emory University Hospital/Winship Cancer Institute
Atlanta Georgia, 30322, United States
Augusta University Medical Center
Augusta Georgia, 30912, United States
Lewis Cancer and Research Pavilion at Saint Joseph's/Candler
Savannah Georgia, 31405, United States
Rush - Copley Medical Center
Aurora Illinois, 60504, United States
MacNeal Hospital and Cancer Center
Berwyn Illinois, 60402, United States
Saint Joseph Medical Center
Bloomington Illinois, 61701, United States
Graham Hospital Association
Canton Illinois, 61520, United States
Memorial Hospital
Carthage Illinois, 62321, United States
Hematology and Oncology Associates
Chicago Illinois, 60611, United States
Northwestern University
Chicago Illinois, 60611, United States
Rush University Medical Center
Chicago Illinois, 60612, United States
Decatur Memorial Hospital
Decatur Illinois, 62526, United States
Heartland Cancer Research NCORP
Decatur Illinois, 62526, United States
Eureka Hospital
Eureka Illinois, 61530, United States
Illinois CancerCare-Galesburg
Galesburg Illinois, 61401, United States
Mason District Hospital
Havana Illinois, 62644, United States
Hematology Oncology Associates of Illinois-Highland Park
Highland Park Illinois, 60035, United States
Hinsdale Hematology Oncology Associates Incorporated
Hinsdale Illinois, 60521, United States
Duly Health and Care Joliet
Joliet Illinois, 60435, United States
Presence Saint Mary's Hospital
Kankakee Illinois, 60901, United States
AMG Libertyville - Oncology
Libertyville Illinois, 60048, United States
Mcdonough District Hospital
Macomb Illinois, 61455, United States
Trinity Medical Center
Moline Illinois, 61265, United States
DuPage Medical Group-Ogden
Naperville Illinois, 60563, United States
Illinois Cancer Specialists-Niles
Niles Illinois, 60714, United States
Bromenn Regional Medical Center
Normal Illinois, 61761, United States
Carle Cancer Institute Normal
Normal Illinois, 61761, United States
Ottawa Regional Hospital and Healthcare Center
Ottawa Illinois, 61350, United States
OSF Saint Francis Radiation Oncology at Pekin Cancer Treatment Center
Pekin Illinois, 61554, United States
Proctor Hospital
Peoria Illinois, 61614, United States
Illinois CancerCare-Peoria
Peoria Illinois, 61615, United States
Methodist Medical Center of Illinois
Peoria Illinois, 61636, United States
OSF Saint Francis Medical Center
Peoria Illinois, 61637, United States
Illinois Valley Hospital
Peru Illinois, 61354, United States
Perry Memorial Hospital
Princeton Illinois, 61356, United States
Swedish American Hospital
Rockford Illinois, 61104, United States
SwedishAmerican Regional Cancer Center/ACT
Rockford Illinois, 61114, United States
Hematology Oncology Associates of Illinois - Skokie
Skokie Illinois, 60076, United States
Memorial Medical Center
Springfield Illinois, 62781, United States
Carle Cancer Center
Urbana Illinois, 61801, United States
Elkhart General Hospital
Elkhart Indiana, 46515, United States
Indiana University/Melvin and Bren Simon Cancer Center
Indianapolis Indiana, 46202, United States
Community Howard Regional Health
Kokomo Indiana, 46904, United States
IU Health La Porte Hospital
La Porte Indiana, 46350, United States
Franciscan Saint Anthony Health-Michigan City
Michigan City Indiana, 46360, United States
Saint Joseph Regional Medical Center-Mishawaka
Mishawaka Indiana, 46545, United States
IU Health Ball Memorial Hospital
Muncie Indiana, 47303, United States
Memorial Hospital of South Bend
South Bend Indiana, 46601, United States
Northern Indiana Cancer Research Consortium
South Bend Indiana, 46628, United States
McFarland Clinic PC - Ames
Ames Iowa, 50010, United States
Mercy Hospital
Cedar Rapids Iowa, 52403, United States
Oncology Associates at Mercy Medical Center
Cedar Rapids Iowa, 52403, United States
Medical Oncology and Hematology Associates-West Des Moines
Clive Iowa, 50325, United States
Iowa Methodist Medical Center
Des Moines Iowa, 50309, United States
Iowa-Wide Oncology Research Coalition NCORP
Des Moines Iowa, 50309, United States
Medical Oncology and Hematology Associates-Des Moines
Des Moines Iowa, 50309, United States
Mercy Medical Center - Des Moines
Des Moines Iowa, 50314, United States
Mission Cancer and Blood - Laurel
Des Moines Iowa, 50314, United States
Iowa Lutheran Hospital
Des Moines Iowa, 50316, United States
Mercy Medical Center - North Iowa
Mason City Iowa, 50401, United States
Siouxland Regional Cancer Center
Sioux City Iowa, 51101, United States
Mercy Medical Center-Sioux City
Sioux City Iowa, 51102, United States
Saint Luke's Regional Medical Center
Sioux City Iowa, 51104, United States
Cancer Center of Kansas - Chanute
Chanute Kansas, 66720, United States
Cancer Center of Kansas - Dodge City
Dodge City Kansas, 67801, United States
Cancer Center of Kansas - El Dorado
El Dorado Kansas, 67042, United States
Cancer Center of Kansas-Kingman
Kingman Kansas, 67068, United States
Lawrence Memorial Hospital
Lawrence Kansas, 66044, United States
Cancer Center of Kansas-Liberal
Liberal Kansas, 67905, United States
Cancer Center of Kansas - Newton
Newton Kansas, 67114, United States
Cancer Center of Kansas - Parsons
Parsons Kansas, 67357, United States
Cancer Center of Kansas - Pratt
Pratt Kansas, 67124, United States
Cancer Center of Kansas - Salina
Salina Kansas, 67401, United States
Cancer Center of Kansas - Wellington
Wellington Kansas, 67152, United States
Associates In Womens Health
Wichita Kansas, 67208, United States
Cancer Center of Kansas-Wichita Medical Arts Tower
Wichita Kansas, 67208, United States
Ascension Via Christi Hospitals Wichita
Wichita Kansas, 67214, United States
Cancer Center of Kansas - Wichita
Wichita Kansas, 67214, United States
Wichita NCI Community Oncology Research Program
Wichita Kansas, 67214, United States
Cancer Center of Kansas - Winfield
Winfield Kansas, 67156, United States
Owensboro Health Mitchell Memorial Cancer Center
Owensboro Kentucky, 42303, United States
Ochsner Health Center-Summa
Baton Rouge Louisiana, 70809, United States
Ochsner Health Center-Covington
Covington Louisiana, 70433, United States
Ochsner Medical Center Jefferson
New Orleans Louisiana, 70121, United States
Greater Baltimore Medical Center
Baltimore Maryland, 21204, United States
Johns Hopkins University/Sidney Kimmel Cancer Center
Baltimore Maryland, 21287, United States
Christiana Care - Union Hospital
Elkton Maryland, 21921, United States
Massachusetts General Hospital Cancer Center
Boston Massachusetts, 02114, United States
Beth Israel Deaconess Medical Center
Boston Massachusetts, 02215, United States
Dana-Farber Cancer Institute
Boston Massachusetts, 02215, United States
Baystate Medical Center
Springfield Massachusetts, 01199, United States
Michigan Cancer Research Consortium NCORP
Ann Arbor Michigan, 48106, United States
Saint Joseph Mercy Hospital
Ann Arbor Michigan, 48106, United States
Beaumont Hospital - Dearborn
Dearborn Michigan, 48124, United States
Ascension Saint John Hospital
Detroit Michigan, 48236, United States
Hurley Medical Center
Flint Michigan, 48503, United States
Genesys Regional Medical Center-West Flint Campus
Flint Michigan, 48532, United States
Allegiance Health
Jackson Michigan, 49201, United States
Bronson Methodist Hospital
Kalamazoo Michigan, 49007, United States
West Michigan Cancer Center
Kalamazoo Michigan, 49007, United States
Borgess Medical Center
Kalamazoo Michigan, 49048, United States
Sparrow Hospital
Lansing Michigan, 48912, United States
Trinity Health Saint Mary Mercy Livonia Hospital
Livonia Michigan, 48154, United States
Saint Joseph Mercy Oakland
Pontiac Michigan, 48341, United States
Lake Huron Medical Center
Port Huron Michigan, 48060, United States
Ascension Saint Mary's Hospital
Saginaw Michigan, 48601, United States
Lakeland Medical Center Saint Joseph
Saint Joseph Michigan, 49085, United States
Marie Yeager Cancer Center
Saint Joseph Michigan, 49085, United States
Saint John Macomb-Oakland Hospital
Warren Michigan, 48093, United States
Fairview Ridges Hospital
Burnsville Minnesota, 55337, United States
Mercy Hospital
Coon Rapids Minnesota, 55433, United States
Essentia Health Cancer Center
Duluth Minnesota, 55805, United States
Essentia Health Saint Mary's Medical Center
Duluth Minnesota, 55805, United States
Miller-Dwan Hospital
Duluth Minnesota, 55805, United States
Fairview Southdale Hospital
Edina Minnesota, 55435, United States
Unity Hospital
Fridley Minnesota, 55432, United States
Hutchinson Area Health Care
Hutchinson Minnesota, 55350, United States
Minnesota Oncology Hematology PA-Maplewood
Maplewood Minnesota, 55109, United States
Saint John's Hospital - Healtheast
Maplewood Minnesota, 55109, United States
Abbott-Northwestern Hospital
Minneapolis Minnesota, 55407, United States
Hennepin County Medical Center
Minneapolis Minnesota, 55415, United States
North Memorial Medical Health Center
Robbinsdale Minnesota, 55422, United States
Metro Minnesota Community Oncology Research Consortium
Saint Louis Park Minnesota, 55416, United States
Park Nicollet Clinic - Saint Louis Park
Saint Louis Park Minnesota, 55416, United States
Regions Hospital
Saint Paul Minnesota, 55101, United States
United Hospital
Saint Paul Minnesota, 55102, United States
Saint Francis Regional Medical Center
Shakopee Minnesota, 55379, United States
Lakeview Hospital
Stillwater Minnesota, 55082, United States
Ridgeview Medical Center
Waconia Minnesota, 55387, United States
Rice Memorial Hospital
Willmar Minnesota, 56201, United States
Minnesota Oncology Hematology PA-Woodbury
Woodbury Minnesota, 55125, United States
Nebraska Cancer Research Center
Lincoln Nebraska, 68510, United States
Alegent Health Immanuel Medical Center
Omaha Nebraska, 68122, United States
Alegent Health Bergan Mercy Medical Center
Omaha Nebraska, 68124, United States
Creighton University Medical Center
Omaha Nebraska, 68131, United States
Nevada Cancer Institute-Summerlin Campus
Las Vegas Nevada, 89135, United States
Nevada Cancer Research Foundation NCORP
Las Vegas Nevada, 89169, United States
Cooper Hospital University Medical Center
Camden New Jersey, 08103, United States
Hunterdon Medical Center
Flemington New Jersey, 08822, United States
Hackensack University Medical Center
Hackensack New Jersey, 07601, United States
Morristown Medical Center
Morristown New Jersey, 07960, United States
Virtua Memorial
Mount Holly New Jersey, 08060, United States
Rutgers Cancer Institute of New Jersey
New Brunswick New Jersey, 08903, United States
Overlook Hospital
Summit New Jersey, 07902, United States
University of New Mexico Cancer Center
Albuquerque New Mexico, 87102, United States
Presbyterian Kaseman Hospital
Albuquerque New Mexico, 87110, United States
San Juan Oncology Associates
Farmington New Mexico, 87401, United States
New York Oncology Hematology PC - Albany Medical Center
Albany New York, 12208, United States
Mary Imogene Bassett Hospital
Cooperstown New York, 13326, United States
Laura and Isaac Perlmutter Cancer Center at NYU Langone
New York New York, 10016, United States
Stony Brook University Medical Center
Stony Brook New York, 11794, United States
Sanford Broadway Medical Center
Fargo North Dakota, 58122, United States
Summa Health System - Akron Campus
Akron Ohio, 44304, United States
Cleveland Clinic Mercy Hospital
Canton Ohio, 44708, United States
Aultman Health Foundation
Canton Ohio, 44710, United States
The Christ Hospital
Cincinnati Ohio, 45219, United States
Case Western Reserve University
Cleveland Ohio, 44106, United States
MetroHealth Medical Center
Cleveland Ohio, 44109, United States
Cleveland Clinic Foundation
Cleveland Ohio, 44195, United States
Saint Rita's Medical Center
Lima Ohio, 45801, United States
Saint Charles Hospital
Oregon Ohio, 43616, United States
ProMedica Flower Hospital
Sylvania Ohio, 43560, United States
ProMedica Toledo Hospital/Russell J Ebeid Children's Hospital
Toledo Ohio, 43606, United States
Saint Vincent Mercy Medical Center
Toledo Ohio, 43608, United States
Jefferson Abington Hospital
Abington Pennsylvania, 19001, United States
Lehigh Valley Hospital-Cedar Crest
Allentown Pennsylvania, 18103, United States
Saint Luke's University Hospital-Bethlehem Campus
Bethlehem Pennsylvania, 18015, United States
Bryn Mawr Hospital
Bryn Mawr Pennsylvania, 19010, United States
Geisinger Medical Center
Danville Pennsylvania, 17822, United States
Doylestown Hospital
Doylestown Pennsylvania, 18901, United States
Geisinger Medical Center-Cancer Center Hazleton
Hazleton Pennsylvania, 18201, United States
Saint Mary Medical and Regional Cancer Center
Langhorne Pennsylvania, 19047, United States
Paoli Memorial Hospital
Paoli Pennsylvania, 19301, United States
Thomas Jefferson University Hospital
Philadelphia Pennsylvania, 19107, United States
University of Pittsburgh Cancer Institute (UPCI)
Pittsburgh Pennsylvania, 15232, United States
Pottstown Hospital
Pottstown Pennsylvania, 19464, United States
Guthrie Medical Group PC-Robert Packer Hospital
Sayre Pennsylvania, 18840, United States
Hematology and Oncology Associates of North East Pennsylvania
Scranton Pennsylvania, 18508, United States
Reading Hospital
West Reading Pennsylvania, 19611, United States
Geisinger Wyoming Valley/Henry Cancer Center
Wilkes-Barre Pennsylvania, 18711, United States
Lankenau Medical Center
Wynnewood Pennsylvania, 19096, United States
Sanford Cancer Center Oncology Clinic
Sioux Falls South Dakota, 57104, United States
Avera Cancer Institute
Sioux Falls South Dakota, 57105, United States
Medical X-Ray Center
Sioux Falls South Dakota, 57105, United States
Avera McKennan Hospital and University Health Center
Sioux Falls South Dakota, 57117, United States
Sanford USD Medical Center - Sioux Falls
Sioux Falls South Dakota, 57117, United States
Erlanger Medical Center
Chattanooga Tennessee, 37403, United States
Jackson-Madison County General Hospital
Jackson Tennessee, 38301, United States
Vanderbilt University/Ingram Cancer Center
Nashville Tennessee, 37232, United States
Parkland Memorial Hospital
Dallas Texas, 75235, United States
UT Southwestern/Simmons Cancer Center-Dallas
Dallas Texas, 75390, United States
University of Virginia Cancer Center
Charlottesville Virginia, 22908, United States
West Virginia University Charleston Division
Charleston West Virginia, 25304, United States
West Virginia University Healthcare
Morgantown West Virginia, 26506, United States
Wheeling Hospital/Schiffler Cancer Center
Wheeling West Virginia, 26003, United States
Langlade Hospital and Cancer Center
Antigo Wisconsin, 54409, United States
ThedaCare Regional Cancer Center
Appleton Wisconsin, 54911, United States
Marshfield Clinic-Chippewa Center
Chippewa Falls Wisconsin, 54729, United States
Marshfield Clinic Cancer Center at Sacred Heart
Eau Claire Wisconsin, 54701, United States
Saint Vincent Hospital Cancer Center Green Bay
Green Bay Wisconsin, 54301, United States
Aurora BayCare Medical Center
Green Bay Wisconsin, 54311, United States
Mercyhealth Hospital and Cancer Center - Janesville
Janesville Wisconsin, 53548, United States
UW Cancer Center Johnson Creek
Johnson Creek Wisconsin, 53038, United States
Gundersen Lutheran Medical Center
La Crosse Wisconsin, 54601, United States
Dean Hematology and Oncology Clinic
Madison Wisconsin, 53717, United States
University of Wisconsin Carbone Cancer Center
Madison Wisconsin, 53792, United States
Holy Family Memorial Hospital
Manitowoc Wisconsin, 54221, United States
Aurora Bay Area Medical Group-Marinette
Marinette Wisconsin, 54143, United States
Bay Area Medical Center
Marinette Wisconsin, 54143, United States
Marshfield Medical Center-Marshfield
Marshfield Wisconsin, 54449, United States
Marshfield Clinic-Minocqua Center
Minocqua Wisconsin, 54548, United States
ProHealth Oconomowoc Memorial Hospital
Oconomowoc Wisconsin, 53066, United States
Ascension Saint Mary's Hospital
Rhinelander Wisconsin, 54501, United States
Marshfield Medical Center-Rice Lake
Rice Lake Wisconsin, 54868, United States
HSHS Saint Nicholas Hospital
Sheboygan Wisconsin, 53081, United States
Vince Lombardi Cancer Clinic-Sheboygan
Sheboygan Wisconsin, 53081, United States
Ascension Saint Michael's Hospital
Stevens Point Wisconsin, 54481, United States
Aurora Medical Center in Summit
Summit Wisconsin, 53066, United States
Vince Lombardi Cancer Clinic-Two Rivers
Two Rivers Wisconsin, 54241, United States
ProHealth Waukesha Memorial Hospital
Waukesha Wisconsin, 53188, United States
Aspirus Regional Cancer Center
Wausau Wisconsin, 54401, United States
Marshfield Clinic-Wausau Center
Wausau Wisconsin, 54401, United States
Marshfield Medical Center - Weston
Weston Wisconsin, 54476, United States
Marshfield Clinic - Wisconsin Rapids Center
Wisconsin Rapids Wisconsin, 54494, United States

How clear is this clinincal trial information?

Study is for people with:

Melanoma

Phase:

Phase 2

Estimated Enrollment:

245

Study ID:

NCT01134614

Recruitment Status:

Active, not recruiting

Sponsor:


National Cancer Institute (NCI)

How clear is this clinincal trial information?

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