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(Neo)Adjuvant IDE196 (Darovasertib) in Patients With Localized Ocular Melanoma Summary Neoadjuvant/adjuvant IDE196 (darovasertib) in patients with primary uveal melanoma
View Full Description Full Description Phase 2 multi-center open-label IDE196 study in patients with primary uveal melanoma requiring either enucleation or plaque brachytherapy. Patients will be treated in neoadjuvant setting up to 6 months (or maximum benefit) followed by primary local therapy. An additional 6 months of adjuvant treatment to follow with long term follow-up (up to 3 years) to assess visual outcome, disease recurrence , and development of metastatic disease.
View Eligibility Criteria Eligibility Criteria Inclusion Criteria:
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There are 22 Locations for this study
HonorHealth Research Institute Scottsdale Arizona, 85258, United States
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UCLA Medical Center Los Angeles California, 90024, United States
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Stanford Cancer Institute Palo Alto California, 94305, United States
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Sarah Cannon Research Institute Denver Colorado, 80218, United States
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University of Miami Miami Florida, 33146, United States
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The Cancer and Hematology Centers Grand Rapids Michigan, 49546, United States
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Northwell Manhasset New York, 11030, United States
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Duke University Health System Durham North Carolina, 27710, United States
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Thomas Jefferson University Philadelphia Pennsylvania, 19107, United States
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Sarah Cannon Research Institute Nashville Tennessee, 37203, United States
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University of Texas Southwestern Medical Center Dallas Texas, 75390, United States
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St. Vincent's Health Sydney Sydney New South Wales, 2010, Australia
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Alfred Health Melbourne Victoria, 3004, Australia
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Princess Margaret Cancer Centre Toronto Ontario, M5G2M, Canada
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Institute Curie
Charite Comprehensive Cancer Center
University Hospital Essen - West German Cancer Center
Instituto Nazionale Tumori di Milano
Instituto Nazionale Tumori IRCCS - Fondazione Pascale
Fondazione Policlinico Universitario Agostino Gemelli IRCCS
Leiden University Medical Center
The Clatterbridge Cancer Centre NHS FT
University College London Hospital - NHS Foundation Trust
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