Multiple Sclerosis Clinical Trial

Long-Term Effects of Torso-Weighting

Summary

The goal of this pilot study is to test the protocol for investigating the longer-term effects of torso weighting on physical activity, number of falls, and muscle activation (when muscles turn on and off and how intensely) in five volunteers with multiple sclerosis. The hypotheses of this study include: torso weighting will (1) increase physical activity, (2) decrease the number of falls, and (3) improve the timing and coordination of muscle activation during balance perturbations.

View Full Description

Full Description

Torso weighting, using the balance-based torso-weighting (BBTW) method, is an intervention that addresses balance by first challenging stability in standing using a series of perturbations (nudges) and resisted rotations to people. Challenging stability allows the assessor to determine directional instability. Once the direction of instability is determined, small weights are placed on a vest-like garment and retesting of balance occurs. In this study, participants will be tested with no weights (NW), with sham weights (SW), and with BBTW weighting (WT). Following non-weighted baseline assessment, participants will be randomly allocated into the sham weight condition or BBTW weight condition in a cross-over design. The initial condition (NW) will last four weeks and the final two conditions (SW,WT) will last two weeks each. Following each condition, outcome measures will be reassessed. Throughout the study, participants will be asked to wear a commercially-available remote monitoring device (e.g., Fitbit Flex) and keep a daily log of physical activity and number of falls. During the SW and WT conditions, participants will wear the assigned garment for 2-4 hours daily.

View Eligibility Criteria

Eligibility Criteria

Inclusion Criteria:

Self-reported a diagnosis of multiple sclerosis
Self-reported mild or moderate gait or balance difficulties
Living in the community rather than in a care facility
Able to walk independently for at least one minute at a time with or without an assistive device
No exacerbations within the past 2 months
Able to get to the testing area and tolerate 2-3 hours of testing for each assessment occasion
Willing to be nudged by a researcher when standing

Exclusion Criteria:

Unable to comprehend and follow instructions in English
Current diagnosis of other neurological disorders such as head injury, stroke, Parkinson disease, or other conditions that affect gait or balance (self-reported)
Experiencing pain that could be exacerbated by external perturbation while standing
History of skin reaction to adhesives

Study is for people with:

Multiple Sclerosis

Estimated Enrollment:

5

Study ID:

NCT02743312

Recruitment Status:

Completed

Sponsor:

San Francisco State University

Check Your Eligibility

Let’s see if you might be eligible for this study.

What is your age and gender ?

Submit

There is 1 Location for this study

See Locations Near You

Samuel Merritt University, Motion Analysis Research Center
Oakland California, 94609, United States

How clear is this clinincal trial information?

Study is for people with:

Multiple Sclerosis

Estimated Enrollment:

5

Study ID:

NCT02743312

Recruitment Status:

Completed

Sponsor:


San Francisco State University

How clear is this clinincal trial information?

×

Introducing, the Journey Bar

Use this bar to access information about the steps in your cancer journey.

Please confirm you are a US based health care provider:

Yes, I am a health care Provider No, I am not a health care provider