Purpose of this study is to assess the intra-rater and inter-rater reliability of a hand-held dynamometer (HHD) in the assessment of lower limb strength in patients with Multiple Sclerosis.
Also to establish a standardized strength testing procedure for key lower limb muscle groups using a HHD fo research and clinical purposes in Multiple Sclerosis.
Stable patients with clinically definite Multiple Sclerosis No Multiple Sclerosis exacerbation 30 days prior to screening No change in disease modifying therapy for 30 day prior to screening
Exclusion Criteria:
Inflammatory myopathy Endocarditis, pericarditis o rother unstable heart disease Cardiac surgery or myocardial infarction in the last 3 months Decompensated congestive heart failure Severe aortic stenosis Severe pulmonary hypertension Pulmonary embolus or infarction in the last 6 months Uncontrolled hypertension by history or by screening or baseline diastolic blood pressure >170 or systolic blood pressure >105 Concomitant neurodegenerative neurological disease such as Amyotrophic Lateral Sclerosis (ALS) Parkinsons or hemiplegic stroke females who are pregnant Cognitive deficits that would interfere with the subjects's ability to give informed consent or preform study testing Painful orthopedic condition affecting the lower limbs Any other serious and/or unstable medical condition
