Myeloproliferative Neoplasms Clinical Trial

Stopping Tyrosine Kinase Inhibitors in Affecting Treatment-Free Remission in Patients With Chronic Phase Chronic Myeloid Leukemia

Summary

This phase II trial studies how stopping tyrosine kinase inhibitors will affect treatment-free remission in patients with chronic myeloid leukemia in chronic phase. When the level of disease is very low, it's called molecular remission. TKIs are a type of medication that help keep this level low. However, after being in molecular remission for a specific amount of time, it may not be necessary to take tyrosine kinase inhibitors. It is not yet known whether stopping tyrosine kinase inhibitors will help patients with chronic myeloid leukemia in chronic phase continue or re-achieve molecular remission.

View Full Description

Full Description

PRIMARY OBJECTIVES:

I. To determine the 2-year treatment free remission (TFR) rate of children, adolescents, and young adults with chronic myeloid leukemia - chronic phase (CML-CP) following discontinuation tyrosine kinase inhibitor (TKI).

II. To estimate the re-induction rate and maintenance of molecular remission (BCR-ABL1 =< 0.1%) at 1 year after restarting TKI for children, adolescents, and young adults.

SECONDARY OBJECTIVE:

I. To describe clinical factors and laboratory correlates affecting the persistence of major molecular remission (MMR) and re-initiation of treatment after stopping TKI (e.g. patient demographics, duration and level of prior molecular remission, duration and type of TKI, clinical presentation at diagnosis and immune studies).

EXPLORATORY OBJECTIVES:

I. To describe change in height standard deviation score over time in patients who are able to discontinue their TKI.

II. To describe the long-term health outcomes including but not limited to gonadal function, endocrine function, and bone metabolism in patients who are able to discontinue TKI as well as those that need to restart TKIs.

III. To describe differences in patient-reported health status after stopping TKIs, including those who need to resume TKI after stopping.

IV. To describe the incidence and characteristics of TKI withdrawal syndrome in children.

V. To evaluate changes in neurocognitive outcomes of patients enrolled on this study using a patient-completed, performance-based, computerized measure of neuropsychological functioning and a parent-report/self-report questionnaire.

OUTLINE:

Patients stop taking TKI medication within 10 days after enrollment. Patients undergo peripheral blood collection to monitor loss of MMR every 4 weeks in year 1, every 6 weeks in year 2, and every 12 weeks in year 3. Patients who lose their molecular remission may restart TKI medication and are monitored every 4 weeks in year 1, every 6 weeks in year 2, and every 12 weeks in year 3.

After completion of study treatment, patients are followed up annually.

View Eligibility Criteria

Eligibility Criteria

Inclusion Criteria:

Patient must have been diagnosed with CML-CP at < 18 years of age.
Patient must have histologic verification of CML-CP at original diagnosis

Patient must be in molecular remission (MR) with a BCR-ABL1 level of =< 0.01% BCR-ABL1 as measured using the International Scale (IS) by RQ-PCR for >= 2 consecutive years at the time of enrollment

Please note: The lab evaluating disease status and molecular response for this study must be College of American Pathology (CAP) and/or Clinical Laboratory Improvement Amendments (CLIA) certified (United States [US] only), sites in other countries must be certified by their accredited authorities. All labs must use the International Scale guidelines with a sensitivity of detection assay =< 0.01% BCR-ABL1 and be able to report results in =< 2 weeks
Patient must have received any TKI for a minimum of 3 consecutive years at time of enrollment
Patient agrees to discontinue TKI therapy
REGULATORY REQUIREMENTS
All patients and/or their parents or legal guardians must sign a written informed consent
All institutional, Food and Drug Administration (FDA), and National Cancer Institute (NCI) requirements for human studies must be met
ELIGIBILITY FOR PATIENT-REPORTED OUTCOMES (PROs):
Age >= 8 years at the time of enrollment
Ability to understand English or Spanish
Cognitive ability to complete instruments according to the primary team
ELIGIBILITY FOR AAML18P1 NEUROCOGNITIVE STUDY:
Patient must be 5 years or older at the time of enrollment
English-, French- or Spanish-speaking
No known history of neurodevelopmental disorder prior to diagnosis of CML (e.g., Down syndrome, Fragile X, William syndrome, mental retardation)
No significant visual or motor impairment that would prevent computer use or recognition of visual test stimuli

Exclusion Criteria:

Known T3151 mutation
Additional clonal chromosomal abnormalities in Philadelphia chromosome (Ph) positive (+) cells at any time prior to enrollment that include "major route" abnormalities (second Ph, trisomy 8, isochromosome 17q, trisomy 19), complex karyotype or abnormalities of 3q26.2
History of accelerated phase or blast crisis CML
Female patients who are pregnant
Lactating females are not eligible unless they have agreed not to breastfeed their infants
Female patients of childbearing potential are not eligible unless a negative pregnancy test result has been obtained

Study is for people with:

Myeloproliferative Neoplasms

Phase:

Phase 2

Estimated Enrollment:

110

Study ID:

NCT03817398

Recruitment Status:

Recruiting

Sponsor:

Children's Oncology Group

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There are 166 Locations for this study

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Children's Hospital of Alabama
Birmingham Alabama, 35233, United States More Info
Site Public Contact
Contact
205-638-9285
[email protected]
Matthew A. Kutny
Principal Investigator
USA Health Strada Patient Care Center
Mobile Alabama, 36604, United States More Info
Site Public Contact
Contact
800-388-8721
Hamayun Imran
Principal Investigator
Banner Children's at Desert
Mesa Arizona, 85202, United States More Info
Site Public Contact
Contact
480-412-3100
Joseph C. Torkildson
Principal Investigator
Banner University Medical Center - Tucson
Tucson Arizona, 85719, United States More Info
Site Public Contact
Contact
[email protected]
Holly E. Pariury
Principal Investigator
Arkansas Children's Hospital
Little Rock Arkansas, 72202, United States More Info
Site Public Contact
Contact
501-364-7373
David L. Becton
Principal Investigator
Kaiser Permanente Downey Medical Center
Downey California, 90242, United States More Info
Site Public Contact
Contact
626-564-3455
Robert M. Cooper
Principal Investigator
Miller Children's and Women's Hospital Long Beach
Long Beach California, 90806, United States More Info
Site Public Contact
Contact
562-933-5600
Jacqueline N. Casillas
Principal Investigator
Children's Hospital Los Angeles
Los Angeles California, 90027, United States More Info
Site Public Contact
Contact
323-361-4110
Leo Mascarenhas
Principal Investigator
Mattel Children's Hospital UCLA
Los Angeles California, 90095, United States More Info
Site Public Contact
Contact
310-825-6708
Theodore B. Moore
Principal Investigator
Valley Children's Hospital
Madera California, 93636, United States More Info
Site Public Contact
Contact
559-353-3000
[email protected]
Karen S. Fernandez
Principal Investigator
UCSF Benioff Children's Hospital Oakland
Oakland California, 94609, United States More Info
Site Public Contact
Contact
510-428-3324
[email protected]
Carla B. Golden
Principal Investigator
Kaiser Permanente-Oakland
Oakland California, 94611, United States More Info
Site Public Contact
Contact
877-642-4691
[email protected]
Aarati V. Rao
Principal Investigator
Children's Hospital of Orange County
Orange California, 92868, United States More Info
Site Public Contact
Contact
714-509-8646
[email protected]
Elyssa M. Rubin
Principal Investigator
Lucile Packard Children's Hospital Stanford University
Palo Alto California, 94304, United States More Info
Site Public Contact
Contact
800-694-0012
[email protected]
Jay Michael S. Balagtas
Principal Investigator
University of California Davis Comprehensive Cancer Center
Sacramento California, 95817, United States More Info
Site Public Contact
Contact
916-734-3089
Marcio H. Malogolowkin
Principal Investigator
Rady Children's Hospital - San Diego
San Diego California, 92123, United States More Info
Site Public Contact
Contact
858-966-5934
William D. Roberts
Principal Investigator
Children's Hospital Colorado
Aurora Colorado, 80045, United States More Info
Site Public Contact
Contact
303-764-5056
[email protected]
Kelly W. Maloney
Principal Investigator
Rocky Mountain Hospital for Children-Presbyterian Saint Luke's Medical Center
Denver Colorado, 80218, United States More Info
Site Public Contact
Contact
303-839-6000
Jennifer J. Clark
Principal Investigator
Connecticut Children's Medical Center
Hartford Connecticut, 06106, United States More Info
Site Public Contact
Contact
860-545-9981
Michael S. Isakoff
Principal Investigator
Alfred I duPont Hospital for Children
Wilmington Delaware, 19803, United States More Info
Site Public Contact
Contact
302-651-5572
[email protected]
Scott M. Bradfield
Principal Investigator
MedStar Georgetown University Hospital
Washington District of Columbia, 20007, United States More Info
Site Public Contact
Contact
202-444-2223
Nina S. Kadan-Lottick
Principal Investigator
Children's National Medical Center
Washington District of Columbia, 20010, United States More Info
Site Public Contact
Contact
202-884-2549
Jeffrey S. Dome
Principal Investigator
Golisano Children's Hospital of Southwest Florida
Fort Myers Florida, 33908, United States More Info
Site Public Contact
Contact
239-343-5333
[email protected]
Emad K. Salman
Principal Investigator
University of Florida Health Science Center - Gainesville
Gainesville Florida, 32610, United States More Info
Site Public Contact
Contact
352-273-8010
[email protected]
William B. Slayton
Principal Investigator
Memorial Regional Hospital/Joe DiMaggio Children's Hospital
Hollywood Florida, 33021, United States More Info
Site Public Contact
Contact
954-265-1847
[email protected]
Iftikhar Hanif
Principal Investigator
Nemours Children's Clinic-Jacksonville
Jacksonville Florida, 32207, United States More Info
Site Public Contact
Contact
302-651-5572
[email protected]
Scott M. Bradfield
Principal Investigator
University of Miami Miller School of Medicine-Sylvester Cancer Center
Miami Florida, 33136, United States More Info
Site Public Contact
Contact
305-243-2647
Julio C. Barredo
Principal Investigator
Nicklaus Children's Hospital
Miami Florida, 33155, United States More Info
Site Public Contact
Contact
888-624-2778
Ziad A. Khatib
Principal Investigator
Arnold Palmer Hospital for Children
Orlando Florida, 32806, United States More Info
Site Public Contact
Contact
321-841-5357
[email protected]
Amy A. Smith
Principal Investigator
Nemours Children's Hospital
Orlando Florida, 32827, United States More Info
Site Public Contact
Contact
302-651-5572
[email protected]
Scott M. Bradfield
Principal Investigator
Sacred Heart Hospital
Pensacola Florida, 32504, United States More Info
Site Public Contact
Contact
850-416-4611
[email protected]
Erlyn C. Smith
Principal Investigator
Tampa General Hospital
Tampa Florida, 33606, United States More Info
Site Public Contact
Contact
813-844-7829
[email protected]
Juan F. Rico
Principal Investigator
Saint Joseph's Hospital/Children's Hospital-Tampa
Tampa Florida, 33607, United States More Info
Site Public Contact
Contact
813-357-0849
[email protected]
Don E. Eslin
Principal Investigator
Saint Mary's Hospital
West Palm Beach Florida, 33407, United States More Info
Site Public Contact
Contact
561-881-2815
Narayana Gowda
Principal Investigator
Children's Healthcare of Atlanta - Egleston
Atlanta Georgia, 30322, United States More Info
Site Public Contact
Contact
404-785-2025
[email protected]
Daniel J. Bergsagel
Principal Investigator
Memorial Health University Medical Center
Savannah Georgia, 31404, United States More Info
Site Public Contact
Contact
912-350-7887
[email protected]
Andrew L. Pendleton
Principal Investigator
Kapiolani Medical Center for Women and Children
Honolulu Hawaii, 96826, United States More Info
Site Public Contact
Contact
808-983-6090
Wade T. Kyono
Principal Investigator
Saint Luke's Cancer Institute - Boise
Boise Idaho, 83712, United States More Info
Site Public Contact
Contact
208-381-2774
[email protected]
Eugenia Chang
Principal Investigator
Lurie Children's Hospital-Chicago
Chicago Illinois, 60611, United States More Info
Site Public Contact
Contact
773-880-4562
Jenna Rossoff
Principal Investigator
University of Illinois
Chicago Illinois, 60612, United States More Info
Site Public Contact
Contact
312-355-3046
Mary L. Schmidt
Principal Investigator
University of Chicago Comprehensive Cancer Center
Chicago Illinois, 60637, United States More Info
Site Public Contact
Contact
773-702-8222
[email protected]
Jennifer L. McNeer
Principal Investigator
Loyola University Medical Center
Maywood Illinois, 60153, United States More Info
Site Public Contact
Contact
708-226-4357
Eugene Suh
Principal Investigator
Advocate Children's Hospital-Oak Lawn
Oak Lawn Illinois, 60453, United States More Info
Site Public Contact
Contact
847-723-7570
Rebecca E. McFall
Principal Investigator
Advocate Children's Hospital-Park Ridge
Park Ridge Illinois, 60068, United States More Info
Site Public Contact
Contact
[email protected]
Rebecca E. McFall
Principal Investigator
Saint Jude Midwest Affiliate
Peoria Illinois, 61637, United States More Info
Site Public Contact
Contact
888-226-4343
Jaime M. Libes
Principal Investigator
Southern Illinois University School of Medicine
Springfield Illinois, 62702, United States More Info
Site Public Contact
Contact
217-545-7929
Gregory P. Brandt
Principal Investigator
Riley Hospital for Children
Indianapolis Indiana, 46202, United States More Info
Site Public Contact
Contact
800-248-1199
Sandeep Batra
Principal Investigator
Blank Children's Hospital
Des Moines Iowa, 50309, United States More Info
Site Public Contact
Contact
515-241-8912
[email protected]
Samantha L. Mallory
Principal Investigator
University of Iowa/Holden Comprehensive Cancer Center
Iowa City Iowa, 52242, United States More Info
Site Public Contact
Contact
800-237-1225
David S. Dickens
Principal Investigator
University of Kentucky/Markey Cancer Center
Lexington Kentucky, 40536, United States More Info
Site Public Contact
Contact
859-257-3379
James T. Badgett
Principal Investigator
Norton Children's Hospital
Louisville Kentucky, 40202, United States More Info
Site Public Contact
Contact
502-629-5500
[email protected]
Ashok B. Raj
Principal Investigator
Children's Hospital New Orleans
New Orleans Louisiana, 70118, United States More Info
Site Public Contact
Contact
[email protected]
Lolie C. Yu
Principal Investigator
Ochsner Medical Center Jefferson
New Orleans Louisiana, 70121, United States More Info
Site Public Contact
Contact
504-842-8084
[email protected]
Craig Lotterman
Principal Investigator
Eastern Maine Medical Center
Bangor Maine, 04401, United States More Info
Site Public Contact
Contact
207-973-4274
Nadine P. SantaCruz
Principal Investigator
Maine Children's Cancer Program
Scarborough Maine, 04074, United States More Info
Site Public Contact
Contact
207-396-7581
[email protected]
Eric C. Larsen
Principal Investigator
Sinai Hospital of Baltimore
Baltimore Maryland, 21215, United States More Info
Site Public Contact
Contact
410-601-6120
[email protected]
Jason M. Fixler
Principal Investigator
Johns Hopkins University/Sidney Kimmel Cancer Center
Baltimore Maryland, 21287, United States More Info
Site Public Contact
Contact
410-955-8804
[email protected]
Alan D. Friedman
Principal Investigator
Walter Reed National Military Medical Center
Bethesda Maryland, 20889, United States More Info
Site Public Contact
Contact
301-319-2100
Rebecca O. Clark
Principal Investigator
Tufts Children's Hospital
Boston Massachusetts, 02111, United States
Dana-Farber Cancer Institute
Boston Massachusetts, 02215, United States More Info
Site Public Contact
Contact
877-442-3324
Jessica A. Pollard
Principal Investigator
UMass Memorial Medical Center - University Campus
Worcester Massachusetts, 01655, United States More Info
Site Public Contact
Contact
508-856-3216
[email protected]
Stefanie R. Lowas
Principal Investigator
C S Mott Children's Hospital
Ann Arbor Michigan, 48109, United States More Info
Site Public Contact
Contact
800-865-1125
Rajen Mody
Principal Investigator
Children's Hospital of Michigan
Detroit Michigan, 48201, United States More Info
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Contact
[email protected]
Sureyya Savasan
Principal Investigator
Wayne State University/Karmanos Cancer Institute
Detroit Michigan, 48201, United States More Info
Site Public Contact
Contact
313-576-9790
[email protected]
Jeffrey W. Taub
Principal Investigator
Michigan State University Clinical Center
East Lansing Michigan, 48824, United States More Info
Site Public Contact
Contact
517-975-9547
Laura E. Agresta
Principal Investigator
Helen DeVos Children's Hospital at Spectrum Health
Grand Rapids Michigan, 49503, United States More Info
Site Public Contact
Contact
616-391-1230
[email protected]
Kathleen J. Yost
Principal Investigator
Bronson Methodist Hospital
Kalamazoo Michigan, 49007, United States More Info
Site Public Contact
Contact
616-391-1230
[email protected]
Kathleen J. Yost
Principal Investigator
Beaumont Children's Hospital-Royal Oak
Royal Oak Michigan, 48073, United States More Info
Site Public Contact
Contact
248-551-7695
Laura K. Gowans
Principal Investigator
Children's Hospitals and Clinics of Minnesota - Minneapolis
Minneapolis Minnesota, 55404, United States More Info
Site Public Contact
Contact
612-813-5193
Michael K. Richards
Principal Investigator
University of Mississippi Medical Center
Jackson Mississippi, 39216, United States More Info
Site Public Contact
Contact
601-815-6700
Anderson (Andy) B. Collier
Principal Investigator
Columbia Regional
Columbia Missouri, 65201, United States More Info
Site Public Contact
Contact
[email protected]
Barbara A. Gruner
Principal Investigator
Children's Mercy Hospitals and Clinics
Kansas City Missouri, 64108, United States More Info
Site Public Contact
Contact
816-302-6808
[email protected]
Keith J. August
Principal Investigator
Washington University School of Medicine
Saint Louis Missouri, 63110, United States More Info
Site Public Contact
Contact
800-600-3606
[email protected]
Robert J. Hayashi
Principal Investigator
Mercy Hospital Saint Louis
Saint Louis Missouri, 63141, United States More Info
Site Public Contact
Contact
314-251-7066
Robin D. Hanson
Principal Investigator
Children's Hospital and Medical Center of Omaha
Omaha Nebraska, 68114, United States More Info
Site Public Contact
Contact
402-955-3949
Jill C. Beck
Principal Investigator
University of Nebraska Medical Center
Omaha Nebraska, 68198, United States More Info
Site Public Contact
Contact
402-559-6941
[email protected]
Jill C. Beck
Principal Investigator
University Medical Center of Southern Nevada
Las Vegas Nevada, 89102, United States More Info
Site Public Contact
Contact
702-384-0013
[email protected]
Alan K. Ikeda
Principal Investigator
Sunrise Hospital and Medical Center
Las Vegas Nevada, 89109, United States More Info
Site Public Contact
Contact
702-384-0013
[email protected]
Alan K. Ikeda
Principal Investigator
Alliance for Childhood Diseases/Cure 4 the Kids Foundation
Las Vegas Nevada, 89135, United States More Info
Site Public Contact
Contact
702-384-0013
[email protected]
Alan K. Ikeda
Principal Investigator
Summerlin Hospital Medical Center
Las Vegas Nevada, 89144, United States More Info
Site Public Contact
Contact
702-384-0013
[email protected]
Alan K. Ikeda
Principal Investigator
Renown Regional Medical Center
Reno Nevada, 89502, United States More Info
Site Public Contact
Contact
702-384-0013
[email protected]
Alan K. Ikeda
Principal Investigator
Hackensack University Medical Center
Hackensack New Jersey, 07601, United States More Info
Site Public Contact
Contact
201-996-2879
Burton E. Appel
Principal Investigator
Morristown Medical Center
Morristown New Jersey, 07960, United States More Info
Site Public Contact
Contact
973-971-5900
Kathryn L. Laurie
Principal Investigator
Rutgers Cancer Institute of New Jersey-Robert Wood Johnson University Hospital
New Brunswick New Jersey, 08903, United States More Info
Site Public Contact
Contact
732-235-8675
Richard A. Drachtman
Principal Investigator
Saint Joseph's Regional Medical Center
Paterson New Jersey, 07503, United States More Info
Site Public Contact
Contact
973-754-2207
[email protected]
Alissa Kahn
Principal Investigator
Albany Medical Center
Albany New York, 12208, United States More Info
Site Public Contact
Contact
518-262-5513
Lauren R. Weintraub
Principal Investigator
Montefiore Medical Center - Moses Campus
Bronx New York, 10467, United States More Info
Site Public Contact
Contact
718-379-6866
[email protected]
Lisa Gennarini
Principal Investigator
Roswell Park Cancer Institute
Buffalo New York, 14263, United States More Info
Site Public Contact
Contact
800-767-9355
[email protected]
Clare J. Twist
Principal Investigator
NYU Winthrop Hospital
Mineola New York, 11501, United States More Info
Site Public Contact
Contact
212-263-4432
[email protected]
Chana L. Glasser
Principal Investigator
The Steven and Alexandra Cohen Children's Medical Center of New York
New Hyde Park New York, 11040, United States More Info
Site Public Contact
Contact
718-470-3460
Arlene S. Redner
Principal Investigator
NYP/Columbia University Medical Center/Herbert Irving Comprehensive Cancer Center
New York New York, 10032, United States More Info
Site Public Contact
Contact
212-305-6361
[email protected]
Justine M. Kahn
Principal Investigator
Memorial Sloan Kettering Cancer Center
New York New York, 10065, United States More Info
Site Public Contact
Contact
212-639-7592
Christopher J. Forlenza
Principal Investigator
NYP/Weill Cornell Medical Center
New York New York, 10065, United States More Info
Site Public Contact
Contact
212-746-1848
Alexander J. Chou
Principal Investigator
University of Rochester
Rochester New York, 14642, United States
Stony Brook University Medical Center
Stony Brook New York, 11794, United States More Info
Site Public Contact
Contact
800-862-2215
Laura E. Hogan
Principal Investigator
State University of New York Upstate Medical University
Syracuse New York, 13210, United States More Info
Site Public Contact
Contact
315-464-5476
Philip M. Monteleone
Principal Investigator
New York Medical College
Valhalla New York, 10595, United States More Info
Site Public Contact
Contact
914-594-3794
Jessica C. Hochberg
Principal Investigator
Mission Hospital
Asheville North Carolina, 28801, United States More Info
Site Public Contact
Contact
828-213-7055
[email protected]
Douglas J. Scothorn
Principal Investigator
UNC Lineberger Comprehensive Cancer Center
Chapel Hill North Carolina, 27599, United States More Info
Site Public Contact
Contact
877-668-0683
[email protected]
Stuart H. Gold
Principal Investigator
Carolinas Medical Center/Levine Cancer Institute
Charlotte North Carolina, 28203, United States More Info
Site Public Contact
Contact
800-804-9376
Joel A. Kaplan
Principal Investigator
Novant Health Presbyterian Medical Center
Charlotte North Carolina, 28204, United States More Info
Site Public Contact
Contact
980-201-6360
[email protected]
Jessica A. Bell
Principal Investigator
East Carolina University
Greenville North Carolina, 27834, United States More Info
Site Public Contact
Contact
252-744-1015
[email protected]
Andrea R. Whitfield
Principal Investigator
Wake Forest University Health Sciences
Winston-Salem North Carolina, 27157, United States More Info
Site Public Contact
Contact
336-713-6771
Thomas W. McLean
Principal Investigator
Sanford Broadway Medical Center
Fargo North Dakota, 58122, United States More Info
Site Public Contact
Contact
701-323-5760
[email protected]
Samuel J. Milanovich
Principal Investigator
Children's Hospital Medical Center of Akron
Akron Ohio, 44308, United States More Info
Site Public Contact
Contact
330-543-3193
Erin Wright
Principal Investigator
Cincinnati Children's Hospital Medical Center
Cincinnati Ohio, 45229, United States More Info
Site Public Contact
Contact
513-636-2799
[email protected]
Benjamin E. Mizukawa
Principal Investigator
Rainbow Babies and Childrens Hospital
Cleveland Ohio, 44106, United States More Info
Site Public Contact
Contact
216-844-5437
Duncan S. Stearns
Principal Investigator
Cleveland Clinic Foundation
Cleveland Ohio, 44195, United States More Info
Site Public Contact
Contact
866-223-8100
[email protected]
Rabi Hanna
Principal Investigator
Nationwide Children's Hospital
Columbus Ohio, 43205, United States More Info
Site Public Contact
Contact
614-722-6039
[email protected]
Mark A. Ranalli
Principal Investigator
Dayton Children's Hospital
Dayton Ohio, 45404, United States More Info
Site Public Contact
Contact
800-228-4055
Mukund G. Dole
Principal Investigator
ProMedica Toledo Hospital/Russell J Ebeid Children's Hospital
Toledo Ohio, 43606, United States More Info
Site Public Contact
Contact
419-824-1842
[email protected]
Jamie L. Dargart
Principal Investigator
University of Oklahoma Health Sciences Center
Oklahoma City Oklahoma, 73104, United States More Info
Site Public Contact
Contact
405-271-8777
[email protected]
Rene Y. McNall-Knapp
Principal Investigator
Legacy Emanuel Children's Hospital
Portland Oregon, 97227, United States More Info
Site Public Contact
Contact
503-413-2560
Janice F. Olson
Principal Investigator
Oregon Health and Science University
Portland Oregon, 97239, United States More Info
Site Public Contact
Contact
503-494-1080
[email protected]
Bill H. Chang
Principal Investigator
Lehigh Valley Hospital-Cedar Crest
Allentown Pennsylvania, 18103, United States More Info
Site Public Contact
Contact
610-402-9543
[email protected]
Jacob A. Troutman
Principal Investigator
Geisinger Medical Center
Danville Pennsylvania, 17822, United States More Info
Site Public Contact
Contact
570-271-5251
[email protected]
Jagadeesh Ramdas
Principal Investigator
Penn State Children's Hospital
Hershey Pennsylvania, 17033, United States More Info
Site Public Contact
Contact
717-531-6012
Lisa M. McGregor
Principal Investigator
Children's Hospital of Philadelphia
Philadelphia Pennsylvania, 19104, United States More Info
Site Public Contact
Contact
267-425-5544
[email protected]
Richard Aplenc
Principal Investigator
Saint Christopher's Hospital for Children
Philadelphia Pennsylvania, 19134, United States More Info
Site Public Contact
Contact
215-427-8991
Gregory E. Halligan
Principal Investigator
Children's Hospital of Pittsburgh of UPMC
Pittsburgh Pennsylvania, 15224, United States More Info
Site Public Contact
Contact
412-692-8570
[email protected]
Jean M. Tersak
Principal Investigator
Rhode Island Hospital
Providence Rhode Island, 02903, United States More Info
Site Public Contact
Contact
401-444-1488
Jennifer J. Welch
Principal Investigator
Prisma Health Richland Hospital
Columbia South Carolina, 29203, United States More Info
Site Public Contact
Contact
864-241-6251
Stuart L. Cramer
Principal Investigator
BI-LO Charities Children's Cancer Center
Greenville South Carolina, 29605, United States More Info
Site Public Contact
Contact
864-241-6251
Aniket Saha
Principal Investigator
Sanford USD Medical Center - Sioux Falls
Sioux Falls South Dakota, 57117, United States More Info
Site Public Contact
Contact
605-312-3320
[email protected]
Kayelyn J. Wagner
Principal Investigator
T C Thompson Children's Hospital
Chattanooga Tennessee, 37403, United States
East Tennessee Childrens Hospital
Knoxville Tennessee, 37916, United States
Saint Jude Children's Research Hospital
Memphis Tennessee, 38105, United States More Info
Site Public Contact
Contact
888-226-4343
[email protected]
Raul C. Ribeiro
Principal Investigator
The Children's Hospital at TriStar Centennial
Nashville Tennessee, 37203, United States More Info
Site Public Contact
Contact
615-342-1919
Jennifer A. Domm
Principal Investigator
Vanderbilt University/Ingram Cancer Center
Nashville Tennessee, 37232, United States More Info
Site Public Contact
Contact
800-811-8480
Sara Zarnegar-Lumley
Principal Investigator
Texas Tech University Health Sciences Center-Amarillo
Amarillo Texas, 79106, United States More Info
Site Public Contact
Contact
806-354-5411
Samer Zaid Kaylani
Principal Investigator
Dell Children's Medical Center of Central Texas
Austin Texas, 78723, United States More Info
Site Public Contact
Contact
512-628-1902
[email protected]
Shannon M. Cohn
Principal Investigator
Driscoll Children's Hospital
Corpus Christi Texas, 78411, United States More Info
Site Public Contact
Contact
361-694-5311
[email protected]
Nkechi I. Mba
Principal Investigator
Medical City Dallas Hospital
Dallas Texas, 75230, United States More Info
Site Public Contact
Contact
972-566-5588
Stanton C. Goldman
Principal Investigator
UT Southwestern/Simmons Cancer Center-Dallas
Dallas Texas, 75390, United States More Info
Site Public Contact
Contact
214-648-7097
[email protected]
Tamra L. Slone
Principal Investigator
El Paso Children's Hospital
El Paso Texas, 79905, United States More Info
Site Public Contact
Contact
915-298-5444
[email protected]
Ranjan Bista
Principal Investigator
Baylor College of Medicine/Dan L Duncan Comprehensive Cancer Center
Houston Texas, 77030, United States More Info
Site Public Contact
Contact
713-798-1354
[email protected]
Michele S. Redell
Principal Investigator
M D Anderson Cancer Center
Houston Texas, 77030, United States More Info
Site Public Contact
Contact
877-632-6789
[email protected]
Najat C. Daw
Principal Investigator
Covenant Children's Hospital
Lubbock Texas, 79410, United States More Info
Site Public Contact
Contact
[email protected]
Kishor M. Bhende
Principal Investigator
UMC Cancer Center / UMC Health System
Lubbock Texas, 79415, United States More Info
Site Public Contact
Contact
806-775-8590
Erin K. Barr
Principal Investigator
Children's Hospital of San Antonio
San Antonio Texas, 78207, United States More Info
Site Public Contact
Contact
210-704-2894
[email protected]
Timothy C. Griffin
Principal Investigator
Methodist Children's Hospital of South Texas
San Antonio Texas, 78229, United States More Info
Site Public Contact
Contact
210-575-6240
[email protected]
Jose M. Esquilin
Principal Investigator
University of Texas Health Science Center at San Antonio
San Antonio Texas, 78229, United States More Info
Site Public Contact
Contact
210-450-3800
[email protected]
Anne-Marie R. Langevin
Principal Investigator
Primary Children's Hospital
Salt Lake City Utah, 84113, United States More Info
Site Public Contact
Contact
801-585-5270
Mallorie B. Heneghan
Principal Investigator
Inova Fairfax Hospital
Falls Church Virginia, 22042, United States More Info
Site Public Contact
Contact
703-208-6650
[email protected]
Robin Y. Dulman
Principal Investigator
Children's Hospital of The King's Daughters
Norfolk Virginia, 23507, United States More Info
Site Public Contact
Contact
757-668-7243
[email protected]
Eric J. Lowe
Principal Investigator
Virginia Commonwealth University/Massey Cancer Center
Richmond Virginia, 23298, United States More Info
Site Public Contact
Contact
[email protected]
Gita V. Massey
Principal Investigator
Carilion Children's
Roanoke Virginia, 24014, United States More Info
Site Public Contact
Contact
540-266-6238
[email protected]
Erwood G. Edwards
Principal Investigator
Seattle Children's Hospital
Seattle Washington, 98105, United States More Info
Site Public Contact
Contact
866-987-2000
Sarah E. Leary
Principal Investigator
Providence Sacred Heart Medical Center and Children's Hospital
Spokane Washington, 99204, United States More Info
Site Public Contact
Contact
800-228-6618
[email protected]
Judy L. Felgenhauer
Principal Investigator
Mary Bridge Children's Hospital and Health Center
Tacoma Washington, 98405, United States More Info
Site Public Contact
Contact
253-403-1461
[email protected]
Robert G. Irwin
Principal Investigator
Madigan Army Medical Center
Tacoma Washington, 98431, United States More Info
Site Public Contact
Contact
253-968-6144
[email protected]
Melissa A. Forouhar
Principal Investigator
West Virginia University Charleston Division
Charleston West Virginia, 25304, United States More Info
Site Public Contact
Contact
304-388-9944
Mohamad H. Badawi
Principal Investigator
University of Wisconsin Carbone Cancer Center
Madison Wisconsin, 53792, United States More Info
Site Public Contact
Contact
800-622-8922
Kenneth B. De Santes
Principal Investigator
Marshfield Medical Center-Marshfield
Marshfield Wisconsin, 54449, United States More Info
Site Public Contact
Contact
800-782-8581
[email protected]
Michelle A. Manalang
Principal Investigator
John Hunter Children's Hospital
Hunter Regional Mail Centre New South Wales, 2310, Australia More Info
Site Public Contact
Contact
(02) 4985 5180
Elizabeth L. Hesketh
Principal Investigator
The Children's Hospital at Westmead
Westmead New South Wales, 2145, Australia More Info
Site Public Contact
Contact
61-2-9845 1400
Marianne B. Phillips
Principal Investigator
Monash Medical Center-Clayton Campus
Clayton Victoria, 3168, Australia More Info
Site Public Contact
Contact
(03) 9928 8111
Paul J. Wood
Principal Investigator
Royal Children's Hospital
Parkville Victoria, 3052, Australia More Info
Site Public Contact
Contact
61 3 9345 5656
[email protected]
Diane Hanna
Principal Investigator
Perth Children's Hospital
Perth Western Australia, 6009, Australia More Info
Site Public Contact
Contact
[email protected]
Marianne B. Phillips
Principal Investigator
University of Alberta Hospital
Edmonton Alberta, T6G 2, Canada More Info
Site Public Contact
Contact
780-407-8798
[email protected]
Sarah J. McKillop
Principal Investigator
CancerCare Manitoba
Winnipeg Manitoba, R3E 0, Canada More Info
Site Public Contact
Contact
866-561-1026
[email protected]
Ashley Chopek
Principal Investigator
IWK Health Centre
Halifax Nova Scotia, B3K 6, Canada More Info
Site Public Contact
Contact
902-470-8520
[email protected]
Craig Erker
Principal Investigator
McMaster Children's Hospital at Hamilton Health Sciences
Hamilton Ontario, L8N 3, Canada More Info
Site Public Contact
Contact
905-521-2100
Uma H. Athale
Principal Investigator
Children's Hospital
London Ontario, N6A 5, Canada More Info
Site Public Contact
Contact
519-685-8306
Shayna M. Zelcer
Principal Investigator
Children's Hospital of Eastern Ontario
Ottawa Ontario, K1H 8, Canada More Info
Site Public Contact
Contact
613-737-7600
Donna L. Johnston
Principal Investigator
Hospital for Sick Children
Toronto Ontario, M5G 1, Canada More Info
Site Public Contact
Contact
416-813-7654
[email protected]
Oussama A. Abla
Principal Investigator
The Montreal Children's Hospital of the MUHC
Montreal Quebec, H3H 1, Canada More Info
Site Public Contact
Contact
514-412-4445
[email protected]
Sharon B. Abish
Principal Investigator
Centre Hospitalier Universitaire Sainte-Justine
Montreal Quebec, H3T 1, Canada More Info
Site Public Contact
Contact
514-345-4931
[email protected]
Yvan Samson
Principal Investigator
Centre Hospitalier Universitaire de Quebec
Quebec , G1V 4, Canada More Info
Site Public Contact
Contact
418-525-4444
Bruno Michon
Principal Investigator
HIMA San Pablo Oncologic Hospital
Caguas , 00726, Puerto Rico More Info
Site Public Contact
Contact
787-653-3434
Jhon A. Guerra
Principal Investigator

How clear is this clinincal trial information?

Study is for people with:

Myeloproliferative Neoplasms

Phase:

Phase 2

Estimated Enrollment:

110

Study ID:

NCT03817398

Recruitment Status:

Recruiting

Sponsor:


Children's Oncology Group

How clear is this clinincal trial information?

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