The purpose of this study is to see if propranolol and etodolac along with mind-body resilience training/MBRT and music therapy help participants who are experiencing physiological stress before, during, and after primary debulking surgery/PDS and also if it's better than the standard-of-care approach (no intervention for reducing stress).
Advanced (stage II-IV) epithelial ovarian, fallopian tube, or primary peritoneal carcinoma diagnosed on the basis of imaging, CA125, and clinical assessment Scheduled to undergo exploratory laparotomy and PDS or IDS Scheduled for surgery with at least 10 days of lead time, to allow the participant to take the β-blocker and COX2 inhibitor 7 days preoperatively Age ≥18 years ASA score of 1 to 3 Ability to understand the study objectives and procedures, comply with the protocol, and provide informed consent
Exclusion Criteria:
Chronic treatment with any β-blocker or COX inhibitor Contraindication for β-blocker therapy (asthma, second- or third-degree atrioventricular block, sinus bradycardia, sick sinus syndrome, right-sided heart failure, pheochromocytoma, peripheral vascular disease) Contraindication for COX2 inhibitor therapy (renal failure [creatinine level >1.5 mg/dL], significant liver failure [known cirrhosis, bilirubin level >2], active peptic disease), or current use of oral anticoagulant) Contraindication for regional epidural anesthesia Chronic autoimmune disease Active infection Pregnant Minimally invasive procedure Participation in another clinical trial that interferes with this study
