Her experience shows what catching endometrial cancer early can mean: surgery, recovery, and moving forward.

However, not every woman’s story ends there. For women whose cancer returns or keeps growing after initial treatment such as chemotherapy and immunotherapy, options have been limited, but a new treatment now under review by the U.S. Food and Drug Administration may soon change that.

A Phase 3 clinical trial called TroFuse-005 is evaluating endometrial cancer patients who received the cancer drug Sacituzumab tirumotecan (Sac-TMT), an antibody-drug conjugate designed to find a protein on cancer cells. Patients treated with this experimental treatment lived a median of 19 months after beginning the trial, compared to patients receiving standard chemotherapy, who lived a median of 12.1 months. That’s nearly seven months of delayed cancer growth.

This promising treatment is not yet FDA-approved, but oncologists are optimistic about its future, as it could give doctors another option after platinum chemotherapy and immunotherapy stop controlling the cancer.

Dr. Sarah Lynam, a gynecologic oncologist at UH Seidman Cancer Center, said the treatment added: “almost 7 months of longevity to a population with historically poor prognosis.”

Dr. David G. Mutch, a WashU Medicine professor of obstetrics and gynecology at Siteman Cancer Center, called the findings a significant advance for patients previously treated with platinum chemotherapy and immunotherapy. In his view, sac-TMT “should be another treatment option in women who, heretofore, had none.”

Sac-TMT does come with possible side effects. During the clinical trial, the more common side effects patients experienced include:

• Anemia, meaning too few red blood cells
• Neutropenia, meaning low levels of infection-fighting white blood cells
• Painful sores or inflammation in the mouth
• Dry, irritated, or itchy eyes

Chamberlin’s Cancer Journey and Its Lasting Impact

Chamberlin was diagnosed last October with early-stage endometrial cancer.

Endometrial cancer begins when cancerous cells form in the tissues of the endometrium, or lining of the uterus. Symptoms typically associated with this type of cancer include vaginal bleeding and pelvic pain.

After a woman has been diagnosed with endometrial cancer, her doctor will stage the cancer based on its spread within the body. A pelvic exam and imaging tests help your doctor learn if the cancer has spread or metastasized.

Just weeks later, she underwent a complete hysterectomy.

A hysterectomy is a procedure that removes part or all of the uterus (or womb), often along with the cervix, according to the National Cancer Institute. Women who receive a diagnosis of uterine, ovarian, and cervical cancer may have their cancer treated with a hysterectomy.

Women may need a hysterectomy for a variety of reasons, and she and her doctor carefully review. Some examples may include endometrial cancer, ovarian cancer, endometriosis, chronic pelvic pain or vaginal bleeding, and uterine fibroids.

In a previous interview with SurvivorNet, Dr. Heidi Gray, a gynecologic oncologist, discussed open versus robotic surgery and how the two can be used to perform a hysterectomy.

“The most common procedure that we do robotically would be a hysterectomy, removal of the tubes and ovaries; you can also do more complicated omentectomy, removing the omentum [a fatty apron surrounding abdominal organs],” Dr. Gray explained.

WATCH: Staging Endometrial Cancer

The National Cancer Institute explains that there are different types of hysterectomy procedures.

• Total hysterectomy: Removal of the uterus and cervix, but the ovaries and fallopian tubes may also be removed.
• Supracervical hysterectomy: Removal of just the upper part of the uterus, but keeping the cervix. This may also be called a partial hysterectomy.
• Total hysterectomy with bilateral salpingo-oophorectomy: Removing the uterus, cervix, fallopian tubes (salpingectomy), and ovaries (oophorectomy).
• Radical hysterectomy with bilateral salpingo-oophorectomy: Removing the uterus, cervix, fallopian tubes, ovaries, the upper portion of the vagina, and some surrounding tissue and lymph nodes. This hysterectomy is done when cancer is involved.

As endometrial cancer patients are staged, Dr. BJ Rimel, a gynecologic oncologist at Cedars-Sinai Medical Center in Los Angeles, California, says the oncologist will explain the next steps.

“We’re going to talk about what that pathology shows and what the next steps in treatment would be. If the diagnosis has been made after a hysterectomy, then we’re going to talk a little bit about what that diagnosis shows and what the stage, grade, or extent of disease might be and how we proceed for treatment from there,” Dr. Rimel explained.

Rimel adds that there are treatment options for every stage of the disease, with new options approved all the time.

“[I had] no spread, no further treatment necessary. I am lucky,” Chamberlin said.

How Chamberlin Approached Her Transformation Journey

“How I completed a transformation journey I was on… I’ve been thinking about how I’ve wanted more fulfillment and satisfaction in my life, and that started by getting on Instagram,” she told fans.

Social media, she said, became a tool to empower others to live healthier, more connected lives.

She hopes to speak directly to women in their 40s, 50s, 60s, 70s, and beyond because she feels these groups of women are often “overlooked.”

Her desire to uplift older women comes from lived experience. At 41, she received a call from “Guiding Light” producers telling her they wouldn’t be renewing her contract. The news hit hard.

“It really crashed my confidence because so much of my self-worth was connected to what I was doing for a living,” she said. Around the same time, the show was switching studios — and she learned she no longer had a dressing room, a moment that could have broken her. Instead, it became a turning point.

Rebuilding From the Inside Out

“When I was about 43, I started working out, and I tell people, it changed my body on the outside, and it changed me on the inside. It changed who I was,” Chamberlin explained.

The physical strength she gained translated into emotional strength. She marched into the producer’s office and demanded a dressing room — not just for herself, but for three other women she felt were slighted on the show.

Six months later, her character shifted from “grandmother” to “cougar,” a transformation she describes as validating.

“It felt like a real redemption, and I stopped looking for validation on the outside,” she said.

That shift inspired her to open her own gym since the powerful transformation she’s experienced positively impacted her mind and body. She hoped other women reaching middle-age can experience the same.

What Older Women Can Take Away From Her Message

Chamberlin’s story isn’t just about surviving cancer — it’s about reclaiming agency and control of your life – at any age. Her message to women navigating midlife, health challenges, or identity shifts is simple but powerful:

Transformation is not reserved for the young. Strength is something that can be improved upon both mentally and physically, and no matter your age, you’re allowed to reinvent yourself.

As she continues to recover from endometrial cancer surgery both physically and emotionally, Chamberlin is choosing to see 2026 not as a year defined by any diagnosis, but as a year defined by possibility and transformation.

Helping You Understand Endometrial Cancer

Endometrial cancer begins when cancerous cells form in the tissues of the endometrium, the inner lining of the uterus.

WATCH: Different Types of Endometrial Cancer

Some common risk factors for endometrial cancer include:

• Obesity
• Taking estrogen-only hormone replacement therapy after menopause
• Having never given birth or started menstruation at an early age
• Having a family history of endometrial cancer

Common symptoms of endometrial cancer may include:

• Pelvic pain: Some women may experience pain or discomfort in the pelvic area.
• Pain during intercourse: This symptom is less common but can occur in some cases.
• Unusual vaginal discharge: Watery or blood-tinged discharge may be a sign of endometrial cancer.
• Weight loss: Unexplained weight loss can sometimes be associated with cancer.
• Urinary problems: Difficulty or pain when urinating.

Endometrial Cancer Treatment Options

Treatment for endometrial cancer includes surgery, radiation, chemotherapy, hormone therapy, and targeted therapy. Surgery is the most common treatment method.

“There are a lot of new exciting treatments for advanced endometrial cancer that we’ve just discovered over the last couple of years,” Dr. Dana Chase, gynecologic oncologist at the David Geffen School of Medicine at UCLA, says.

“So even if you’re diagnosed with an advanced stage, ask your treating doctor what the latest treatments are, or even potentially, is there a clinical trial I can participate in for my endometrial cancer? … There’s a lot of research on new treatments for endometrial cancer, which is very exciting,” Dr. Chase continued.

The most common procedure is a hysterectomy, where the surgeon removes the uterus. They often also remove both ovaries and fallopian tubes in a bilateral salpingo-oophorectomy. This helps lower the risk of the cancer spreading or coming back.

WATCH: What to Know About Endometrial Cancer-Related Surgery

“Doctors usually treat early-stage endometrial cancer with surgery as the main approach,” Dr. Rimel explains. “During the surgery, doctors may also perform staging to see how far the cancer has spread. This involves taking out and examining nearby lymph nodes and tissues.”

Chemotherapy and radiation are options, particularly when the cancer is in more advanced stages.

Treating endometrial cancer with hormone therapy involves removing hormones or blocking their ability to help cancer cells grow. Targeted therapy uses drugs designed to target specific cancer cells.

“Hormonal therapy commonly works because most endometrial cancers are estrogen receptor-positive,” Dr. Michael Toboni, an assistant professor in the division of gynecologic oncology at the University of Alabama at Birmingham, tells SurvivorNet.

“So if you give progesterone, it can counteract the estrogen feeding the cancer. This is commonly given with multiple anti-estrogen medications or an anti-estrogen medication in combination with another medication that inhibits a common pathway in endometrial cancer.”

Each treatment method can have side effects, and the impact on the body may vary depending on the type of treatment. If you are undergoing treatment for endometrial cancer, discussing potential side effects with your doctor and strategies to minimize their impact is crucial.

Additional Endometrial Cancer Treatment Options

In recent years, endometrial cancer patients have seen an increasing number of treatment options emerge to make battling the disease more manageable.

WATCH: New Combination Therapy for Advanced Endometrial Cancer Patients

The impact of new combination therapies on advanced endometrial cancer – a type of cancer that affects the lining of the uterus – is a significant advance for treating the disease. Patients are living longer, healthier lives.

Durvalumab (brand name IMFINZI) is an immunotherapy drug that’s often used alongside chemotherapy.

Olaparib (brand name LYNPARZA) is a PARP inhibitor, a type of drug that helps treat some cancers by blocking an enzyme called PARP that helps repair damaged DNA in cells. Olaparib destroys cancer cells, especially cells that already have trouble repairing their DNA. Sometimes, it’s used as an add-on to durvalumab.

“For a long time, patients with early-stage endometrial cancer generally do very well with a combination of surgery, maybe some radiotherapy,” says Dr. Shannon Westin, a professor in the Department of Gynecologic Oncology and Reproductive Medicine at the University of Texas MD Anderson Cancer Center in Houston, TX.

“However, there’s a population of patients who are diagnosed at a later stage, stage three or four, or who have their cancer come back after initial therapy. And those patients have had a really hard time,” she adds.

According to Westin, the latest treatments combine immunotherapy with standard chemotherapy plus a drug that prevents cancer cells from fixing their own DNA.

The results are encouraging, especially for patients who have late-stage endometrial cancer or whose disease has come back.

Some known side effects of durvalumab and Olaparib include:

Durvalumab can cause inflammation in various parts of the body, which can lead to:

• Skin rashes
• Diarrhea
• Liver inflammation

Olaparib may lead to side effects such as:

• Fatigue
• Nausea
• Blood-related issues such as anemia
• Increased risk of developing certain other cancers due to the DNA repair inhibition.

Another U.S. Food and Drug Administration (FDA) approved combination therapy for advanced or recurrent endometrial cancer to be used with traditional chemotherapy is dostarlimab-gxly (brand name Jemperli). It is an immune checkpoint inhibitor, a type of immunotherapy that helps reinvigorate the body’s immune system to fight cancer.

WATCH: Treatment for Advanced or Recurrent Endometrial Cancer

Dostarlimab-gxly was already approved for metastatic and recurrent endometrial cancer in cases where chemotherapy did not work. Now, dostarlimab-gxly is approved as part of the first treatment for patients who have a specific set of genetic mutations called mismatch repair deficiency (dMMR) or microsatellite instability-high (MSI-H). These genetic factors are associated with a much greater response to the checkpoint inhibitor class of drugs.

Questions for Your Doctor

If you have been diagnosed with endometrial cancer, you may want to ask your doctor a few questions to ensure you are well-informed about your diagnosis and the treatment journey that awaits.

• What stage is my endometrial cancer?
• What are the treatment options available for my specific type and stage of endometrial cancer?
• What are the potential side effects of each treatment option, and how can they be managed?
• What is the expected prognosis for my condition?
• Are there any clinical trials or experimental treatments that I may be eligible for?
• How often will I need follow-up appointments and tests to monitor my condition?
• Are there any lifestyle changes or dietary recommendations that can help improve my prognosis or manage side effects?
• What support services are available to help me cope emotionally?

Learn more about SurvivorNet's rigorous medical review process.

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