Chronic Lymphocytic Leukemia Clinical Trial
Ublituximab + TGR-1202 Compared to Obinutuzumab + Chlorambucil in Patients With Untreated and Previously Treated Chronic Lymphocytic Leukemia
Summary
This study evaluates the combination of ublituximab, a novel monoclonal antibody, and TGR-1202, a novel PI3K delta inhibitor compared to obinutuzumab and chlorambucil, and compared to ublituximab or TGR-1202 alone in Chronic Lymphocytic Leukemia (leukemia-cll/" >CLL) patients.
View Eligibility Criteria
Eligibility Criteria
Inclusion Criteria:
Treatment naïve or previously treated Chronic Lymphocytic Leukemia (CLL) requiring treatment
Eastern Cooperative Oncology Group (ECOG) score of 0 to 2
Exclusion Criteria:
Any major surgery, chemotherapy or immunotherapy within the last 21 days
Evidence of hepatitis B virus, hepatitis C virus or known HIV infection
Autologous hematologic stem cell transplant within 3 months of study entry. Prior Allogeneic hematologic stem cell transplant is excluded
Transformation of CLL to aggressive Non-Hodgkin's Lymphoma (NHL) (Richter's transformation)
Prior therapy with obinutuzumab and/or chlorambucil or a PI3K delta inhibitor
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There are 106 Locations for this study
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TG Therapeutics Investigational Trial Site
Huntsville Alabama, 35805, United States
Huntsville Alabama, 35805, United States
TG Therapeutics Investigational Trial Site
Mobile Alabama, 36604, United States
Mobile Alabama, 36604, United States
TG Therapeutics Investigational Trial Site
Chandler Arizona, 85224, United States
Chandler Arizona, 85224, United States
TG Therapeutics Investigational Trial Site
Phoenix Arizona, 85016, United States
Phoenix Arizona, 85016, United States
TG Therapeutics Investigational Trial Site
Tucson Arizona, 85711, United States
Tucson Arizona, 85711, United States
TG Therapeutics Investigational Trial Site
Fayetteville Arkansas, 72703, United States
Fayetteville Arkansas, 72703, United States
TG Therapeutics Investigational Trial Site
Concord California, 94520, United States
Concord California, 94520, United States
TG Therapeutics Investigational Trial Site
Duarte California, 91010, United States
Duarte California, 91010, United States
TG Therapeutics Investigational Trial Site
Greenbrae California, 94904, United States
Greenbrae California, 94904, United States
TG Therapeutics Investigational Trial Site
Pismo Beach California, 93449, United States
Pismo Beach California, 93449, United States
TG Therapeutics Investigational Trial Site
Pleasanton California, 94588, United States
Pleasanton California, 94588, United States
TG Therapeutics Investigational Trial Site
San Diego California, 92120, United States
San Diego California, 92120, United States
TG Therapeutics Investigational Trial Site
Santa Barbara California, 93105, United States
Santa Barbara California, 93105, United States
TG Therapeutics Investigational Trial Site
Whittier California, 90603, United States
Whittier California, 90603, United States
TG Therapeutics Investigational Trial Site
Aurora Colorado, 80012, United States
Aurora Colorado, 80012, United States
TG Therapeutics Investigational Trial Site
Denver Colorado, 80218, United States
Denver Colorado, 80218, United States
TG Therapeutics Investigational Trial Site
Bridgeport Connecticut, 06606, United States
Bridgeport Connecticut, 06606, United States
TG Therapeutics Investigational Trial Site
New Haven Connecticut, 06519, United States
New Haven Connecticut, 06519, United States
TG Therapeutics Investigational Trial Site
Stamford Connecticut, 06904, United States
Stamford Connecticut, 06904, United States
TG Therapeutics Investigational Trial Site
Newark Delaware, 19713, United States
Newark Delaware, 19713, United States
TG Therapeutics Investigational Trial Site
Boca Raton Florida, 33486, United States
Boca Raton Florida, 33486, United States
TG Therapeutics Investigational Trial Site
Fort Myers Florida, 33916, United States
Fort Myers Florida, 33916, United States
TG Therapeutics Investigational Trial Site
Jacksonville Florida, 32204, United States
Jacksonville Florida, 32204, United States
TG Therapeutics Investigational Trial Site
Jacksonville Florida, 32256, United States
Jacksonville Florida, 32256, United States
TG Therapeutics Investigational Trial Site
Ocala Florida, 34471, United States
Ocala Florida, 34471, United States
TG Therapeutics Investigational Trial Site
Pensacola Florida, 32504, United States
Pensacola Florida, 32504, United States
TG Therapeutics Investigational Trial Site
Saint Petersburg Florida, 33705, United States
Saint Petersburg Florida, 33705, United States
TG Therapeutics Investigational Trial Site
Tallahassee Florida, 32308, United States
Tallahassee Florida, 32308, United States
TG Therapeutics Investigational Trial Site
Tampa Florida, 33612, United States
Tampa Florida, 33612, United States
TG Therapeutics Investigational Trial Site
West Palm Beach Florida, 33407, United States
West Palm Beach Florida, 33407, United States
TG Therapeutics Investigational Trial Site
Albany Georgia, 31701, United States
Albany Georgia, 31701, United States
TG Therapeutics Investigational Trial Site
Macon Georgia, 31201, United States
Macon Georgia, 31201, United States
TG Therapeutics Investigational Trial Site
Chicago Illinois, 60612, United States
Chicago Illinois, 60612, United States
TG Therapeutics Investigational Trial Site
Decatur Illinois, 62526, United States
Decatur Illinois, 62526, United States
TG Therapeutics Investigational Trial Site
Maywood Illinois, 60153, United States
Maywood Illinois, 60153, United States
TG Therapeutics Investigational Trial Site
Niles Illinois, 60714, United States
Niles Illinois, 60714, United States
TG Therapeutics Investigational Trial Site
Peoria Illinois, 61615, United States
Peoria Illinois, 61615, United States
TG Therapeutics Investigational Trial Site
Swansea Illinois, , United States
Swansea Illinois, , United States
TG Therapeutics Investigational Trial Site
Urbana Illinois, 61801, United States
Urbana Illinois, 61801, United States
TG Therapeutics Investigational Trial Site
Fort Wayne Indiana, 46804, United States
Fort Wayne Indiana, 46804, United States
TG Therapeutics Investigational Trial Site
Indianapolis Indiana, 46237, United States
Indianapolis Indiana, 46237, United States
TG Therapeutics Investigational Trial Site
Ames Iowa, 50010, United States
Ames Iowa, 50010, United States
TG Therapeutics Investigational Trial Site
Cedar Rapids Iowa, 52403, United States
Cedar Rapids Iowa, 52403, United States
TG Therapeutics Investigational Trial Site
Kansas City Kansas, 64132, United States
Kansas City Kansas, 64132, United States
TG Therapeutics Investigational Trial Site
Westwood Kansas, 66210, United States
Westwood Kansas, 66210, United States
TG Therapeutics Investigational Trial Site
Louisville Kentucky, 40207, United States
Louisville Kentucky, 40207, United States
TG Therapeutics Investigational Trial Site
Baltimore Maryland, 21202, United States
Baltimore Maryland, 21202, United States
TG Therapeutics Investigational Trial Site
Baltimore Maryland, 21215, United States
Baltimore Maryland, 21215, United States
TG Therapeutics Investigational Trial Site
Bethesda Maryland, 20817, United States
Bethesda Maryland, 20817, United States
TG Therapeutics Investigational Trial Site
Columbia Maryland, 21044, United States
Columbia Maryland, 21044, United States
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Boston Massachusetts, 02111, United States
Boston Massachusetts, 02111, United States
TG Therapeutics Investigational Trial Site
Worcester Massachusetts, 01608, United States
Worcester Massachusetts, 01608, United States
TG Therapeutics Investigational Trial Site
Ann Arbor Michigan, 48106, United States
Ann Arbor Michigan, 48106, United States
TG Therapeutics Investigational Trial Site
Detroit Michigan, 48202, United States
Detroit Michigan, 48202, United States
TG Therapeutics Investigational Trial Site
Jackson Michigan, 49201, United States
Jackson Michigan, 49201, United States
TG Therapeutics Investigational Trial Site
Saint Louis Park Minnesota, 55416, United States
Saint Louis Park Minnesota, 55416, United States
TG Therapeutics Investigational Trial Site
Columbia Missouri, 65212, United States
Columbia Missouri, 65212, United States
TG Therapeutics Investigational Trial Site
Kansas City Missouri, , United States
Kansas City Missouri, , United States
TG Therapeutics Investigational Trial Site
Lincoln Nebraska, 68510, United States
Lincoln Nebraska, 68510, United States
TG Therapeutics Investigational Trial Site
Las Vegas Nevada, 89119, United States
Las Vegas Nevada, 89119, United States
TG Therapeutics Investigational Trial Site
Lebanon New Hampshire, 03756, United States
Lebanon New Hampshire, 03756, United States
TG Therapeutics Investigational Trial Site
Morristown New Jersey, 07962, United States
Morristown New Jersey, 07962, United States
TG Therapeutics Investigational Trial Site
Somerville New Jersey, 00876, United States
Somerville New Jersey, 00876, United States
TG Therapeutics Investigational Trial Site
East Setauket New York, 11733, United States
East Setauket New York, 11733, United States
TG Therapeutics Investigational Trial Site
Glens Falls New York, 12801, United States
Glens Falls New York, 12801, United States
TG Therapeutics Investigational Trial Site
Syracuse New York, 13210, United States
Syracuse New York, 13210, United States
TG Therapeutics Investigational Trial Site
Charlotte North Carolina, 28204, United States
Charlotte North Carolina, 28204, United States
TG Therapeutics Investigational Trial Site
Durham North Carolina, 27710, United States
Durham North Carolina, 27710, United States
TG Therapeutics Investigational Trial Site
Durham North Carolina, , United States
Durham North Carolina, , United States
TG Therapeutics Investigational Trial Site
Hickory North Carolina, 28602, United States
Hickory North Carolina, 28602, United States
TG Therapeutics Investigational Trial Site
Kinston North Carolina, 28501, United States
Kinston North Carolina, 28501, United States
TG Therapeutics Investigational Trial Site
Raleigh North Carolina, 27607, United States
Raleigh North Carolina, 27607, United States
TG Therapeutics Investigational Trial Site
Washington North Carolina, 27889, United States
Washington North Carolina, 27889, United States
TG Therapeutics Investigational Trial Site
Canton Ohio, 44718, United States
Canton Ohio, 44718, United States
TG Therapeutics Investigational Trial Site
Cincinnati Ohio, 45236, United States
Cincinnati Ohio, 45236, United States
TG Therapeutics Investigational Trial Site
Toledo Ohio, 43623, United States
Toledo Ohio, 43623, United States
TG Therapeutics Investigational Trial Site
Portland Oregon, 97227, United States
Portland Oregon, 97227, United States
TG Therapeutics Investigational Trial Site
Portland Oregon, 97239, United States
Portland Oregon, 97239, United States
TG Therapeutics Investigational Trial Site
Springfield Oregon, 97477, United States
Springfield Oregon, 97477, United States
TG Therapeutics Investigational Trial Site
Camp Hill Pennsylvania, 17011, United States
Camp Hill Pennsylvania, 17011, United States
TG Therapeutics Investigational Trial Site
Danville Pennsylvania, 17822, United States
Danville Pennsylvania, 17822, United States
TG Therapeutics Investigational Trial Site
Hershey Pennsylvania, 17033, United States
Hershey Pennsylvania, 17033, United States
TG Therapeutics Investigational Trial Site
Philadelphia Pennsylvania, 19106, United States
Philadelphia Pennsylvania, 19106, United States
TG Therapeutics Investigational Trial Site
Pittsburgh Pennsylvania, 15224, United States
Pittsburgh Pennsylvania, 15224, United States
TG Therapeutics Investigational Trial Site
Pittsburgh Pennsylvania, 15232, United States
Pittsburgh Pennsylvania, 15232, United States
TG Therapeutics Investigational Trial Site
Pawtucket Rhode Island, 00286, United States
Pawtucket Rhode Island, 00286, United States
TG Therapeutics Investigational Trial Site
Greenville South Carolina, 29615, United States
Greenville South Carolina, 29615, United States
TG Therapeutics Investigational Trial Site
Sioux Falls South Dakota, 57105, United States
Sioux Falls South Dakota, 57105, United States
TG Therapeutics Investigational Trial Site
Watertown South Dakota, 57201, United States
Watertown South Dakota, 57201, United States
TG Therapeutics Investigational Trial Site
Chattanooga Tennessee, 37404, United States
Chattanooga Tennessee, 37404, United States
TG Therapeutics Investigational Trial Site
Nashville Tennessee, 37203, United States
Nashville Tennessee, 37203, United States
TG Therapeutics Investigational Trial Site
Austin Texas, 78705, United States
Austin Texas, 78705, United States
TG Therapeutics Investigational Trial Site
Bedford Texas, 76022, United States
Bedford Texas, 76022, United States
TG Therapeutics Investigational Trial Site
Fort Worth Texas, 76104, United States
Fort Worth Texas, 76104, United States
TG Therapeutics Investigational Trial Site
Houston Texas, 77030, United States
Houston Texas, 77030, United States
TG Therapeutics Investigational Trial Site
San Antonio Texas, 78217, United States
San Antonio Texas, 78217, United States
TG Therapeutics Investigational Trial Site
San Antonio Texas, 78229, United States
San Antonio Texas, 78229, United States
TG Therapeutics Investigational Trial Site
Tyler Texas, 75702, United States
Tyler Texas, 75702, United States
TG Therapeutics Investigational Trial Site
Ogden Utah, 84405, United States
Ogden Utah, 84405, United States
TG Therapeutics Investigational Trial Site
Blacksburg Virginia, 24060, United States
Blacksburg Virginia, 24060, United States
TG Therapeutics Investigational Trial Site
Charlottesville Virginia, 22908, United States
Charlottesville Virginia, 22908, United States
TG Therapeutics Investigational Trial Site
Fort Belvoir Virginia, 22060, United States
Fort Belvoir Virginia, 22060, United States
TG Therapeutics Investigational Trial Site
Olympia Washington, 98502, United States
Olympia Washington, 98502, United States
TG Therapeutics Investigational Trial Site
Seattle Washington, 98104, United States
Seattle Washington, 98104, United States
TG Therapeutics Investigational Trial Site
Seattle Washington, 98109, United States
Seattle Washington, 98109, United States
TG Therapeutics Investigational Trial Site
Spokane Washington, 99216, United States
Spokane Washington, 99216, United States
TG Therapeutics Investigational Trial Site
Vancouver Washington, 98684, United States
Vancouver Washington, 98684, United States
TG Therapeutics Investigational Trial Site
Yakima Washington, 98902, United States
Yakima Washington, 98902, United States
TG Therapeutics Investigational Trial Site
Milwaukee Wisconsin, 53226, United States
Milwaukee Wisconsin, 53226, United States
TG Therapeutics Investigational Trial Site
Wauwatosa Wisconsin, 53226, United States
Wauwatosa Wisconsin, 53226, United States
TG Therapeutics Investigational Trial Site
Ashkelon , , Israel
Ashkelon , , Israel
TG Therapeutics Investigational Trial Site
Be'er Sheva , , Israel
Be'er Sheva , , Israel
TG Therapeutics Investigational Trial Site
Haifa , , Israel
Haifa , , Israel
TG Therapeutics Investigational Trial Site
Jerusalem , , Israel
Jerusalem , , Israel
TG Therapeutics Investigational Trial Site
Nahariya , , Israel
Nahariya , , Israel
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Petah tikva , , Israel
Petah tikva , , Israel
TG Therapeutics Investigational Trial Site
Tel Aviv , , Israel
Tel Aviv , , Israel
TG Therapeutics Investigational Trial Site
Bologna , , Italy
Bologna , , Italy
TG Therapeutics Investigational Trial Site
Ferrara , , Italy
Ferrara , , Italy
TG Therapeutics Investigational Trial Site
Milan , , Italy
Milan , , Italy
TG Therapeutics Investigational Trial Site
Rome , , Italy
Rome , , Italy
TG Therapeutics Investigational Trial Site
Torino , , Italy
Torino , , Italy
TG Therapeutics Investigational Trial Site
Chorzów , , Poland
Chorzów , , Poland
TG Therapeutics Investigational Trial Site
Gdynia , , Poland
Gdynia , , Poland
TG Therapeutics Investigational Trial Site
Krakow , , Poland
Krakow , , Poland
TG Therapeutics Investigational Trial Site
Lublin , , Poland
Lublin , , Poland
TG Therapeutics Investigational Trial Site
Słupsk , , Poland
Słupsk , , Poland
TG Therapeutics Investigational Trial Site
Warszawa , , Poland
Warszawa , , Poland
TG Therapeutics Investigational Trial Site
Wroclaw , , Poland
Wroclaw , , Poland
TG Therapeutics Investigational Trial Site
Łódź , , Poland
Łódź , , Poland
TG Therapeutics Investigational Trial Site
Krasnozatonskiy , , Russian Federation
Krasnozatonskiy , , Russian Federation
TG Therapeutics Investigational Trial Site
Moscow , , Russian Federation
Moscow , , Russian Federation
TG Therapeutics Investigational Trial Site
Perm , , Russian Federation
Perm , , Russian Federation
TG Therapeutics Investigational Trial Site
Petrozavodsk , , Russian Federation
Petrozavodsk , , Russian Federation
TG Therapeutics Investigational Trial Site
Rodionova , , Russian Federation
Rodionova , , Russian Federation
TG Therapeutics Investigational Trial Site
Saint Petersburg , , Russian Federation
Saint Petersburg , , Russian Federation
TG Therapeutics Investigational Trial Site
Smolensk , , Russian Federation
Smolensk , , Russian Federation
TG Therapeutics Investigational Trial Site
Tula , , Russian Federation
Tula , , Russian Federation
TG Therapeutics Investigational Trial Site
Yaroslavl , , Russian Federation
Yaroslavl , , Russian Federation
TG Therapeutics Investigational Trial Site
Barcelona , , Spain
Barcelona , , Spain
TG Therapeutics Investigational Trial Site
Madrid , , Spain
Madrid , , Spain
TG Therapeutics Investigational Trial Site
Valencia , , Spain
Valencia , , Spain
TG Therapeutics Investigational Trial Site
Cambridge , , United Kingdom
Cambridge , , United Kingdom
TG Therapeutics Investigational Trial Site
Cumbria , , United Kingdom
Cumbria , , United Kingdom
TG Therapeutics Investigational Trial Site
Dudley West , , United Kingdom
Dudley West , , United Kingdom
TG Therapeutics Investigational Trial Site
London , , United Kingdom
London , , United Kingdom
TG Therapeutics Investigational Trial Site
Northbrook , , United Kingdom
Northbrook , , United Kingdom
TG Therapeutics Investigational Trial Site
Northumbria , , United Kingdom
Northumbria , , United Kingdom
TG Therapeutics Investigational Trial Site
Norwich , , United Kingdom
Norwich , , United Kingdom
TG Therapeutics Investigational Trial Site
Peterborough , , United Kingdom
Peterborough , , United Kingdom
TG Therapeutics Investigational Trial Site
Southampton , , United Kingdom
Southampton , , United Kingdom
TG Therapeutics Investigational Trial Site
St. James , , United Kingdom
St. James , , United Kingdom
TG Therapeutics Investigational Trial Site
Sunderland , , United Kingdom
Sunderland , , United Kingdom
TG Therapeutics Investigational Trial Site
Wolverhampton , , United Kingdom
Wolverhampton , , United Kingdom
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