PEAK: Panitumumab Plus mFOLFOX6 vs. Bevacizumab Plus mFOLFOX6 for First Line Treatment of Metastatic Colorectal Cancer (mCRC) Patients With Wild-Type Kirsten Rat Sarcoma-2 Virus (KRAS) Tumors

Inclusion Criteria:

Histologically or cytologically-confirmed adenocarcinoma of the colon or rectum in patients with unresectable metastatic (M1) disease
Patients with at least 1 uni-dimensionally measurable lesion of at least 10 mm per modified Response Evaluation Criteria in Solid Tumors (RECIST) guidelines
Wild-type KRAS tumor status confirmed by an Amgen approved central laboratory or an experienced laboratory (local laboratory) per local regulatory guidelines using a validated test method
Eastern Cooperative Oncology Group (ECOG) score of 0 or 1
Men or women 18 years of age or older
Adequate hematologic, renal, hepatic, metabolic, and coagulation function

Exclusion Criteria:

History of prior or concurrent central nervous system (CNS) metastases
Prior chemotherapy or other systemic anticancer therapy for treatment of metastatic colorectal carcinoma
Clinically significant cardiac disease
Clinically significant peripheral sensory neuropathy
Active inflammatory bowel disease
Recent gastroduodenal ulcer to be active or uncontrolled
History of interstitial lung disease
Recent pulmonary embolism, deep vein thrombosis, or other significant venous event
Pre-existing bleeding diathesis and/or coagulopathy with exception of well-controlled anticoagulation therapy
Recent major surgical procedure, open biopsy, or significant traumatic injury not yet recovered from prior major surgery.