Colon Cancer Clinical Trial

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Phase 3 Study of MRTX849 With Cetuximab vs Chemotherapy in Patients With Advanced Colorectal Cancer With KRAS G12C Mutation (KRYSTAL-10)

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Summary

Study 849-010 is an open-label, randomized Phase 3 clinical trial comparing the efficacy of MRTX849 administered in combination with cetuximab versus chemotherapy in the second-line treatment setting in patients with CRC with KRAS G12C mutation.

View Eligibility Criteria

Eligibility Criteria

Inclusion Criteria:

Histologically confirmed diagnosis of colorectal carcinoma with KRAS G12C mutation in tumor tissue.
Prior receipt of 1st line treatment in advanced CRC with a fluoropyrimidine-based chemotherapy regimen containing either oxaliplatin or irinotecan, and radiographically documented progression of disease on or after treatment.

Exclusion Criteria:

Prior treatment with a therapy targeting KRAS G12C mutation (e.g., AMG 510).
Prior treatment with an anti-EGFR antibody (e.g., cetuximab or panitumumab).
Active brain metastasis

Study is for people with:

Colon Cancer

Phase:

Phase 3

Estimated Enrollment:

420

Study ID:

NCT04793958

Recruitment Status:

Recruiting

Sponsor:

Mirati Therapeutics Inc.

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There are 295 Locations for this study

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Birmingham Alabama, 35205, United States
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Gilbert Arizona, 85234, United States
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Goodyear Arizona, 85338, United States
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Phoenix Arizona, 85054, United States
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Springdale Arkansas, 72762, United States
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Bakersfield California, 93309, United States
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Clovis California, 93611, United States
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Fullerton California, 92835, United States
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Los Angeles California, 90033, United States
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Los Angeles California, 90048, United States
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Redlands California, 92373, United States
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San Diego California, 92123, United States
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San Francisco California, 94115, United States
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Sylmar California, 91342, United States
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Torrance California, 90505, United States
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Whittier California, 90602, United States
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Aurora Colorado, 80045, United States
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Denver Colorado, 80218, United States
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Norwich Connecticut, 06360, United States
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Fort Myers Florida, 33901, United States
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Jacksonville Florida, 32224, United States
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Miami Florida, 33136, United States
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Ocala Florida, 34471, United States
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Orlando Florida, 32804, United States
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Orlando Florida, 32806, United States
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Saint Petersburg Florida, 33705, United States
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Saint Petersburg Florida, 33709, United States
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Tallahassee Florida, 32308, United States
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West Palm Beach Florida, 33401, United States
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Weston Florida, 33331, United States
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Atlanta Georgia, 30322, United States
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Newnan Georgia, 30265, United States
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Naperville Illinois, 60540, United States
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Zion Illinois, 60099, United States
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Iowa City Iowa, 52242, United States
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Baton Rouge Louisiana, 70809, United States
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Baltimore Maryland, 21201, United States
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Boston Massachusetts, 02114, United States
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Detroit Michigan, 48202, United States
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Minneapolis Minnesota, 55404, United States
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Rochester Minnesota, 55905, United States
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Saint Paul Minnesota, 55101, United States
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Springfield Missouri, 65804, United States
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Lincoln Nebraska, 68510, United States
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Las Vegas Nevada, 89169, United States
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Belleville New Jersey, 07109, United States
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Florham Park New Jersey, 07932, United States
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New Brunswick New Jersey, 08903, United States
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Somerset New Jersey, 08873, United States
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New York New York, 10016, United States
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New York New York, 10029, United States
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New York New York, 10065, United States
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Port Jefferson Station New York, 11776, United States
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Jacksonville North Carolina, 28546, United States
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Sparta North Carolina, 28675, United States
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Cincinnati Ohio, 45211, United States
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Oklahoma City Oklahoma, 73104, United States
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Tulsa Oklahoma, 74146, United States
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Greenville South Carolina, 29607, United States
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Chattanooga Tennessee, 37404, United States
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Nashville Tennessee, 37203, United States
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Dallas Texas, 75216, United States
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Dallas Texas, 75246, United States
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Houston Texas, 77030, United States
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Houston Texas, 77090, United States
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Longview Texas, 75601, United States
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Temple Texas, 76508, United States
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Salt Lake City Utah, 84106, United States
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Fairfax Virginia, 22031, United States
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Fredericksburg Virginia, 24408, United States
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Richmond Virginia, 23230, United States
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Richmond Virginia, 23298, United States
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Everett Washington, 98201, United States
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Seattle Washington, 98109, United States
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Tacoma Washington, 98405, United States
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Vancouver Washington, 98684, United States
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Morgantown West Virginia, 26506, United States
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Milwaukee Wisconsin, 53226, United States
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Viedma Rio Negro, R8500, Argentina
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Buenos Aires , C1061, Argentina
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Buenos Aires , C1426, Argentina
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Buenos Aires , CI264, Argentina
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La Rioja , F5300, Argentina
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Waratah New South Wales, 2298, Australia
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Bedford Park South Australia, 5042, Australia
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Clayton Victoria, 3168, Australia
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Heidelberg Victoria, 3084, Australia
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Melbourne Victoria, 3004, Australia
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Garran , 2605, Australia
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Innsbruck Tyrol, 6020, Austria
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Wiener Neustadt , 2700, Austria
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Wien , 1090, Austria
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Edegem Antwerpen, 2650, Belgium
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Brussels , 1090, Belgium
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Gent , 9000, Belgium
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Yvoir , 5530, Belgium
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Blumenau Santa Catarina, 89010, Brazil
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Curitiba , 80520, Brazil
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Ijuí , 98700, Brazil
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Sao Paulo , 01509, Brazil
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São Paulo , 01246, Brazil
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São Paulo , 01323, Brazil
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São Paulo , 09060, Brazil
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São Paulo , 15090, Brazil
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Ottawa Ontario, K1H 8, Canada
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Toronto Ontario, M5B 1, Canada
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Montréal Quebec, H1T 2, Canada
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Toronto , M5G 2, Canada
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Bengbu Anhui, 23300, China
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Hefei Anhui, 23003, China
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Hefei Anhui, 23008, China
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Fuzhou Fujian, 35001, China
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Guangzhou Guang Dong, 51065, China
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Shenzhen Guang Dong, 51803, China
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Nanning Guangxi, 53000, China
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Harbin Heilongjiang, 15008, China
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Zhengzhou Henan, , China
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Wuhan Hubei, , China
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Changsha Hunan, 41000, China
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Changsha Hunan, 41001, China
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Nanjing Jiangsu, 21002, China
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Wuxi Jiangsu, 21440, China
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Nanchang Jiangxi, , China
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Changchun Jilin, 13000, China
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Changchun Jilin, 13001, China
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Shenyang Liaoning, 11004, China
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Shenyang Liaoning, 11010, China
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Shanghai Pudong, 20132, China
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Jinan Shandong, 25011, China
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Chengdu Sichuan, 61004, China
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Neijiang Sichuan, 64110, China
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Hangzhou Zhejiang, 31001, China
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Hangzhou Zhejiang, 31002, China
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Beijing , 10002, China
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Beijing , 10014, China
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Shanghai , 20002, China
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Shanghai , 20003, China
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Shanghai , 20012, China
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Shanghai , 20162, China
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Tianjin , 30006, China
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Xi'an , 71006, China
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Floridablanca Santander, 68100, Colombia
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Barranquilla , 08002, Colombia
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Bogotá , 11151, Colombia
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Medellín , 05003, Colombia
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Praha Prague, 150 0, Czechia
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Brno South Moravian, 656 5, Czechia
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Brno South Moravian, 656 9, Czechia
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Olomouc , 779 0, Czechia
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Prague , 128 0, Czechia
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Copenhagen , 2100, Denmark
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Odense , DK 50, Denmark
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Vejle , 7100, Denmark
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Helsinki , 00290, Finland
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Tampere , 33520, Finland
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Turku , 20520, Finland
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Dijon Bourgogne, 21079, France
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Brest Bretagne, 29200, France
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Besançon Doubs, 25000, France
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Lille Hauts-de-France, 59037, France
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Paris Ile-de-France, 75015, France
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Toulouse Midi-Pyrenees, 31059, France
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Avignon Provence Alpes Cote d'Azure, 84918, France
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Lyon Rhone-Alpes, 69008, France
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Bourdeaux Rhone, 33000, France
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Villejuif Val-de-Marne, 94805, France
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Marseille , 13005, France
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Paris , 75010, France
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Paris , 75012, France
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Paris , 75013, France
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Pessac , 33720, France
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Suresnes , 92150, France
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Tours , 37044, France
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Reutlingen Baden-Wurttemberg, , Germany
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München Bayern, 81737, Germany
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Frankfurt Hessen, 60488, Germany
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Bochum Nordrhein-Westfalen, 44791, Germany
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Dresden Sachsen, 01307, Germany
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Amberg , 92224, Germany
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Berlin , 10117, Germany
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Hamburg , 20246, Germany
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Herne , 44625, Germany
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Monchengladbach , 41063, Germany
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München , 81377, Germany
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Larissa Thessaly, 41110, Greece
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Athens , 11528, Greece
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Athens , 15562, Greece
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Heraklion , 71110, Greece
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Thessaloniki , 54645, Greece
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Thessaloníki , 57001, Greece
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Central , 1401-, Hong Kong
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Hong Kong , , Hong Kong
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Dublin , D04 Y, Ireland
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Dublin , D07 R, Ireland
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Dublin , D09V2, Ireland
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Dublin , D24 N, Ireland
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Lido Di Camaiore Lucca, 55041, Italy
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Candiolo Torino, 10060, Italy
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Avellino , 81300, Italy
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Biella , 13875, Italy
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Cagliari , 9042, Italy
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Milano , 20162, Italy
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Milan , 20141, Italy
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Naples , 80131, Italy
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Padova , 35128, Italy
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Pisa , 56126, Italy
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Reggio Emilia , 42100, Italy
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Roma , 00144, Italy
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Turin , 10128, Italy
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Anyang-si Gyeonggi-do, 14068, Korea, Republic of
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Seongnam-si Gyeonggi-do, 13496, Korea, Republic of
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Yangsan Gyeongsangnam, 50612, Korea, Republic of
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Hwasun Jeollanam-do, 58128, Korea, Republic of
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Busan , 48108, Korea, Republic of
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Busan , 49201, Korea, Republic of
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Daejeon , 35015, Korea, Republic of
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Goyang-si , 10408, Korea, Republic of
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Seoul , 02841, Korea, Republic of
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Seoul , 03080, Korea, Republic of
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Seoul , 03772, Korea, Republic of
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Seoul , 05505, Korea, Republic of
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Seoul , 06351, Korea, Republic of
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Seoul , 06591, Korea, Republic of
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Sŏwŏn , 16247, Korea, Republic of
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Kota Kinabalu Sabah, 88996, Malaysia
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Kuala Lumpur Selangor, 50586, Malaysia
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Kuala Lumpur Selangor, 59100, Malaysia
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Petaling Jaya Selangor, 46050, Malaysia
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Johor Bahru , 81100, Malaysia
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Putrajaya , 62250, Malaysia
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Tuxtla Gutiérrez Chiapas, 29038, Mexico
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Guadalajara Jalisco, 44280, Mexico
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Guadalajara Jalisco, 44670, Mexico
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Cuernavaca Morelos, 62290, Mexico
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San Juan Del Río Queretaro, 76800, Mexico
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Mexico City , 14080, Mexico
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Veracruz , 94300, Mexico
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Nijmegen Gelderland, 6525 , Netherlands
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Amsterdam Noord-Holland, 1066 , Netherlands
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Nieuwegein Utrecht, 3435 , Netherlands
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Gdańsk , 80-21, Poland
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Otwock , 05-40, Poland
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Warsaw , 02-03, Poland
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Braga , 4710-, Portugal
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Lisboa , 1400-, Portugal
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Lisbon , 1649-, Portugal
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Porto , 4099-, Portugal
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Porto , 4200-, Portugal
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San Juan , 00935, Puerto Rico
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San Juan , , Puerto Rico
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Baia Mare , 43003, Romania
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Braşov , 50015, Romania
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Bucuresti , 02232, Romania
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Cluj-Napoca , 40001, Romania
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Cluj-Napoca , 40064, Romania
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Craiova , 20074, Romania
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Timişoara , 30023, Romania
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Singapore , 11907, Singapore
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Singapore , 16961, Singapore
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Singapore , 21756, Singapore
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Singapore , 25849, Singapore
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Badalona Barcelona, 08916, Spain
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A Coruña , 15006, Spain
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Barcelona , 08035, Spain
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Barcelona , 08036, Spain
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Barcelona , 08908, Spain
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Córdoba , 14004, Spain
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Madrid , 28007, Spain
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Madrid , 28040, Spain
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Madrid , 28041, Spain
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Madrid , 28046, Spain
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Pamplona , 31008, Spain
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Sabadell , 08208, Spain
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Santander , 39008, Spain
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Valencia , 46010, Spain
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Valencia , 46014, Spain
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Changhua , 500, Taiwan
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Kaohsiung , 807, Taiwan
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Taichung , 407, Taiwan
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Tainan , 704, Taiwan
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Tainan , 736, Taiwan
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Taipei , 100, Taiwan
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Taoyuan , 333, Taiwan
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Bangkok , 10110, Thailand
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Bangkok , 10400, Thailand
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Bangkok , 10700, Thailand
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Chiang Mai , 50200, Thailand
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Hat Yai , 90110, Thailand
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Bournemouth Dorset, BH7 7, United Kingdom
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Birmingham England, B91 2, United Kingdom
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Cambridge England, CB2 0, United Kingdom
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Leeds England, LS9 7, United Kingdom
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London England, NW1 2, United Kingdom
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London England, SW3 6, United Kingdom
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Maidstone England, ME16 , United Kingdom
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Manchester England, M20 4, United Kingdom
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Middlesex England, HA6 2, United Kingdom
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Sutton England, SM2 5, United Kingdom
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Aberdeen Scotland, AB25 , United Kingdom
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Glasgow Scotland, G12 0, United Kingdom
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How clear is this clinincal trial information?

Study is for people with:

Colon Cancer

Phase:

Phase 3

Estimated Enrollment:

420

Study ID:

NCT04793958

Recruitment Status:

Recruiting

Sponsor:


Mirati Therapeutics Inc.

How clear is this clinincal trial information?

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