Colon Cancer Clinical Trial

Clinical Trial Finder Colon Cancer Trials

Phase 3 Study of MRTX849 With Cetuximab vs Chemotherapy in Patients With Advanced Colorectal Cancer With KRAS G12C Mutation (KRYSTAL-10)

See Locations Near You

Summary

Study 849-010 is an open-label, randomized Phase 3 clinical trial comparing the efficacy of MRTX849 administered in combination with cetuximab versus chemotherapy in the second-line treatment setting in patients with CRC with KRAS G12C mutation.

View Eligibility Criteria

Eligibility Criteria

Inclusion Criteria:

Histologically confirmed diagnosis of colorectal carcinoma with KRAS G12C mutation in tumor tissue.
Prior receipt of 1st line treatment in advanced CRC with a fluoropyrimidine-based chemotherapy regimen containing either oxaliplatin or irinotecan, and radiographically documented progression of disease on or after treatment.

Exclusion Criteria:

Prior treatment with a therapy targeting KRAS G12C mutation (e.g., AMG 510).
Prior treatment with an anti-EGFR antibody (e.g., cetuximab or panitumumab).
Active brain metastasis

Study is for people with:

Colon Cancer

Phase:

Phase 3

Estimated Enrollment:

461

Study ID:

NCT04793958

Recruitment Status:

Active, not recruiting

Sponsor:

Mirati Therapeutics Inc.

Check Your Eligibility

Let’s see if you might be eligible for this study.

What is your age and gender ?

Submit

There are 301 Locations for this study

See Locations Near You

Research Site
Birmingham Alabama, 35205, United States
Research Site
Gilbert Arizona, 85234, United States
Research Site
Goodyear Arizona, 85338, United States
Research Site
Phoenix Arizona, 85054, United States
Research Site
Springdale Arkansas, 72762, United States
Research Site
Bakersfield California, 93309, United States
Research Site
Clovis California, 93611, United States
Research Site
Fullerton California, 92835, United States
Research Site
Los Angeles California, 90033, United States
Research Site
Los Angeles California, 90048, United States
Research Site
Redlands California, 92373, United States
Research Site
San Diego California, 92123, United States
Research Site
San Francisco California, 94115, United States
Research Site
Sylmar California, 91342, United States
Research Site
Torrance California, 90505, United States
Research Site
Whittier California, 90602, United States
Research Site
Aurora Colorado, 80045, United States
Research Site
Denver Colorado, 80218, United States
Research Site
Norwich Connecticut, 06360, United States
Research Site
Fort Myers Florida, 33901, United States
Research Site
Jacksonville Florida, 32224, United States
Research Site
Miami Florida, 33136, United States
Research Site
Ocala Florida, 34471, United States
Research Site
Orlando Florida, 32804, United States
Research Site
Orlando Florida, 32806, United States
Research Site
Saint Petersburg Florida, 33705, United States
Research Site
Saint Petersburg Florida, 33709, United States
Research Site
Tallahassee Florida, 32308, United States
Research Site
West Palm Beach Florida, 33401, United States
Research Site
Weston Florida, 33331, United States
Research Site
Atlanta Georgia, 30322, United States
Research Site
Newnan Georgia, 30265, United States
Research Site
Naperville Illinois, 60540, United States
Research Site
Zion Illinois, 60099, United States
Research Site
Iowa City Iowa, 52242, United States
Research Site
Baton Rouge Louisiana, 70809, United States
Research Site
Baltimore Maryland, 21201, United States
Research Site
Boston Massachusetts, 02114, United States
Research Site
Detroit Michigan, 48202, United States
Research Site
Minneapolis Minnesota, 55404, United States
Research Site
Rochester Minnesota, 55905, United States
Research Site
Saint Paul Minnesota, 55101, United States
Research Site
Springfield Missouri, 65804, United States
Research Site
Lincoln Nebraska, 68510, United States
Research Site
Las Vegas Nevada, 89169, United States
Research Site
Belleville New Jersey, 07109, United States
Research Site
Florham Park New Jersey, 07932, United States
Research Site
New Brunswick New Jersey, 08903, United States
Research Site
Somerset New Jersey, 08873, United States
Research Site
New York New York, 10016, United States
Research Site
New York New York, 10029, United States
Research Site
New York New York, 10065, United States
Research Site
Port Jefferson Station New York, 11776, United States
Research Site
Jacksonville North Carolina, 28546, United States
Research Site
Sparta North Carolina, 28675, United States
Research Site
Cincinnati Ohio, 45211, United States
Research Site
Oklahoma City Oklahoma, 73104, United States
Research Site
Tulsa Oklahoma, 74146, United States
Research Site
Greenville South Carolina, 29607, United States
Research Site
Chattanooga Tennessee, 37404, United States
Research Site
Nashville Tennessee, 37203, United States
Research Site
Dallas Texas, 75216, United States
Research Site
Dallas Texas, 75246, United States
Research Site
Houston Texas, 77030, United States
Research Site
Houston Texas, 77090, United States
Research Site
Longview Texas, 75601, United States
Research Site
Temple Texas, 76508, United States
Research Site
Salt Lake City Utah, 84106, United States
Research Site
Fairfax Virginia, 22031, United States
Research Site
Fredericksburg Virginia, 24408, United States
Research Site
Richmond Virginia, 23230, United States
Research Site
Richmond Virginia, 23298, United States
Research Site
Everett Washington, 98201, United States
Research Site
Seattle Washington, 98109, United States
Research Site
Tacoma Washington, 98405, United States
Research Site
Vancouver Washington, 98684, United States
Research Site
Morgantown West Virginia, 26506, United States
Research Site
Milwaukee Wisconsin, 53226, United States
Research Site
Viedma Rio Negro, R8500, Argentina
Research Site
Buenos Aires , C1061, Argentina
Research Site
Buenos Aires , C1426, Argentina
Research Site
Buenos Aires , CI264, Argentina
Research Site
La Rioja , F5300, Argentina
Research Site
Waratah New South Wales, 2298, Australia
Research Site
Bedford Park South Australia, 5042, Australia
Research Site
Clayton Victoria, 3168, Australia
Research Site
Heidelberg Victoria, 3084, Australia
Research Site
Melbourne Victoria, 3004, Australia
Research Site
Garran , 2605, Australia
Research Site
Innsbruck Tyrol, 6020, Austria
Research Site
Wiener Neustadt , 2700, Austria
Research Site
Wien , 1090, Austria
Research Site
Edegem Antwerpen, 2650, Belgium
Research Site
Brussels , 1090, Belgium
Research Site
Gent , 9000, Belgium
Research Site
Yvoir , 5530, Belgium
Research Site
Blumenau Santa Catarina, 89010, Brazil
Research Site
Curitiba , 80520, Brazil
Research Site
Ijuí , 98700, Brazil
Research Site
Sao Paulo , 01509, Brazil
Research Site
São Paulo , 01246, Brazil
Research Site
São Paulo , 01323, Brazil
Research Site
São Paulo , 09060, Brazil
Research Site
São Paulo , 15090, Brazil
Research Site
Ottawa Ontario, K1H 8, Canada
Research Site
Toronto Ontario, M5B 1, Canada
Research Site
Montréal Quebec, H1T 2, Canada
Research Site
Toronto , M5G 2, Canada
Research Site
Bengbu Anhui, 23300, China
Research Site
Hefei Anhui, 23003, China
Research Site
Hefei Anhui, 23008, China
Research Site
Fuzhou Fujian, 35001, China
Research Site
Guangzhou Guang Dong, 51065, China
Research Site
Shenzhen Guang Dong, 51803, China
Research Site
Nanning Guangxi, 53000, China
Research Site
Harbin Heilongjiang, 15008, China
Research Site
Zhengzhou Henan, , China
Research Site
Wuhan Hubei, , China
Research Site
Changsha Hunan, 41000, China
Research Site
Changsha Hunan, 41001, China
Research Site
Nanjing Jiangsu, 21002, China
Research Site
Wuxi Jiangsu, 21440, China
Research Site
Nanchang Jiangxi, , China
Research Site
Changchun Jilin, 13000, China
Research Site
Changchun Jilin, 13001, China
Research Site
Shenyang Liaoning, 11004, China
Research Site
Shenyang Liaoning, 11010, China
Research Site
Shanghai Pudong, 20132, China
Research Site
Jinan Shandong, 25011, China
Research Site
Chengdu Sichuan, 61004, China
Research Site
Neijiang Sichuan, 64110, China
Research Site
Hangzhou Zhejiang, 31001, China
Research Site
Hangzhou Zhejiang, 31002, China
Research Site
Beijing , 10002, China
Research Site
Beijing , 10014, China
Research Site
Shanghai , 20002, China
Research Site
Shanghai , 20003, China
Research Site
Shanghai , 20012, China
Research Site
Shanghai , 20162, China
Research Site
Tianjin , 30006, China
Research Site
Xi'an , 71006, China
Research Site
Floridablanca Santander, 68100, Colombia
Research Site
Barranquilla , 08002, Colombia
Research Site
Bogotá , 11151, Colombia
Research Site
Medellín , 05003, Colombia
Research Site
Praha Prague, 150 0, Czechia
Research Site
Brno South Moravian, 656 5, Czechia
Research Site
Brno South Moravian, 656 9, Czechia
Research Site
Olomouc , 779 0, Czechia
Research Site
Prague , 128 0, Czechia
Research Site
Copenhagen , 2100, Denmark
Research Site
Odense , DK 50, Denmark
Research Site
Vejle , 7100, Denmark
Research Site
Helsinki , 00290, Finland
Research Site
Tampere , 33520, Finland
Research Site
Turku , 20520, Finland
Research Site
Dijon Bourgogne, 21079, France
Research Site
Brest Bretagne, 29200, France
Research Site
Besançon Doubs, 25000, France
Research Site
Lille Hauts-de-France, 59037, France
Research Site
Paris Ile-de-France, 75015, France
Research Site
Toulouse Midi-Pyrenees, 31059, France
Research Site
Avignon Provence Alpes Cote d'Azure, 84918, France
Research Site
Lyon Rhone-Alpes, 69008, France
Research Site
Bourdeaux Rhone, 33000, France
Research Site
Villejuif Val-de-Marne, 94805, France
Research Site
Marseille , 13005, France
Research Site
Paris , 75010, France
Research Site
Paris , 75012, France
Research Site
Paris , 75013, France
Research Site
Pessac , 33720, France
Research Site
Suresnes , 92150, France
Research Site
Tours , 37044, France
Research Site
Reutlingen Baden-Wurttemberg, , Germany
Research Site
München Bayern, 81737, Germany
Research Site
Frankfurt Hessen, 60488, Germany
Research Site
Bochum Nordrhein-Westfalen, 44791, Germany
Research Site
Dresden Sachsen, 01307, Germany
Research Site
Amberg , 92224, Germany
Research Site
Berlin , 10117, Germany
Research Site
Hamburg , 20246, Germany
Research Site
Herne , 44625, Germany
Research Site
Monchengladbach , 41063, Germany
Research Site
München , 81377, Germany
Research Site
Larissa Thessaly, 41110, Greece
Research Site
Athens , 11528, Greece
Research Site
Athens , 15562, Greece
Research Site
Heraklion , 71110, Greece
Research Site
Thessaloniki , 54645, Greece
Research Site
Thessaloníki , 57001, Greece
Research Site
Central , 1401-, Hong Kong
Research Site
Hong Kong , , Hong Kong
Research Site
Dublin , D04 Y, Ireland
Research Site
Dublin , D07 R, Ireland
Research Site
Dublin , D09V2, Ireland
Research Site
Dublin , D24 N, Ireland
Research Site
Lido Di Camaiore Lucca, 55041, Italy
Research Site
Candiolo Torino, 10060, Italy
Research Site
Avellino , 81300, Italy
Research Site
Biella , 13875, Italy
Research Site
Cagliari , 9042, Italy
Research Site
Milano , 20162, Italy
Research Site
Milan , 20141, Italy
Research Site
Naples , 80131, Italy
Research Site
Padova , 35128, Italy
Research Site
Pisa , 56126, Italy
Research Site
Reggio Emilia , 42100, Italy
Research Site
Roma , 00144, Italy
Research Site
Turin , 10128, Italy
Research Site
Anyang-si Gyeonggi-do, 14068, Korea, Republic of
Research Site
Seongnam-si Gyeonggi-do, 13496, Korea, Republic of
Research Site
Yangsan Gyeongsangnam, 50612, Korea, Republic of
Research Site
Hwasun Jeollanam-do, 58128, Korea, Republic of
Research Site
Busan , 48108, Korea, Republic of
Research Site
Busan , 49201, Korea, Republic of
Research Site
Daejeon , 35015, Korea, Republic of
Research Site
Goyang-si , 10408, Korea, Republic of
Research Site
Seoul , 02841, Korea, Republic of
Research Site
Seoul , 03080, Korea, Republic of
Research Site
Seoul , 03772, Korea, Republic of
Research Site
Seoul , 05505, Korea, Republic of
Research Site
Seoul , 06351, Korea, Republic of
Research Site
Seoul , 06591, Korea, Republic of
Research Site
Sŏwŏn , 16247, Korea, Republic of
Research Site
Kota Kinabalu Sabah, 88996, Malaysia
Research Site
Kuala Lumpur Selangor, 50586, Malaysia
Research Site
Kuala Lumpur Selangor, 59100, Malaysia
Research Site
Petaling Jaya Selangor, 46050, Malaysia
Research Site
Johor Bahru , 81100, Malaysia
Research Site
Putrajaya , 62250, Malaysia
Research Site
Tuxtla Gutiérrez Chiapas, 29038, Mexico
Research Site
Guadalajara Jalisco, 44280, Mexico
Research Site
Guadalajara Jalisco, 44670, Mexico
Research Site
Cuernavaca Morelos, 62290, Mexico
Research Site
San Juan Del Río Queretaro, 76800, Mexico
Research Site
Mexico City , 14080, Mexico
Research Site
Veracruz , 94300, Mexico
Research Site
Nijmegen Gelderland, 6525 , Netherlands
Research Site
Amsterdam Noord-Holland, 1066 , Netherlands
Research Site
Nieuwegein Utrecht, 3435 , Netherlands
Research Site
Gdańsk , 80-21, Poland
Research Site
Otwock , 05-40, Poland
Research Site
Warsaw , 02-03, Poland
Research Site
Braga , 4710-, Portugal
Research Site
Lisboa , 1400-, Portugal
Research Site
Lisbon , 1649-, Portugal
Research Site
Porto , 4099-, Portugal
Research Site
Porto , 4200-, Portugal
Research Site
San Juan , 00935, Puerto Rico
Research Site
San Juan , , Puerto Rico
Research Site
Baia Mare , 43003, Romania
Research Site
BraÅŸov , 50015, Romania
Research Site
Bucuresti , 02232, Romania
Research Site
Cluj-Napoca , 40001, Romania
Research Site
Cluj-Napoca , 40064, Romania
Research Site
Craiova , 20074, Romania
Research Site
TimiÅŸoara , 30023, Romania
Research Site
Singapore , 11907, Singapore
Research Site
Singapore , 16961, Singapore
Research Site
Singapore , 21756, Singapore
Research Site
Singapore , 25849, Singapore
Research Site
Badalona Barcelona, 08916, Spain
Research Site
A Coruña , 15006, Spain
Research Site
Barcelona , 08035, Spain
Research Site
Barcelona , 08036, Spain
Research Site
Barcelona , 08908, Spain
Research Site
Córdoba , 14004, Spain
Research Site
Madrid , 28007, Spain
Research Site
Madrid , 28040, Spain
Research Site
Madrid , 28041, Spain
Research Site
Madrid , 28046, Spain
Research Site
Pamplona , 31008, Spain
Research Site
Sabadell , 08208, Spain
Research Site
Santander , 39008, Spain
Research Site
Valencia , 46010, Spain
Research Site
Valencia , 46014, Spain
Research Site
Changhua , 500, Taiwan
Research Site
Kaohsiung , 807, Taiwan
Research Site
Taichung , 407, Taiwan
Research Site
Tainan , 704, Taiwan
Research Site
Tainan , 736, Taiwan
Research Site
Taipei , 100, Taiwan
Research Site
Taoyuan , 333, Taiwan
Research Site
Bangkok , 10110, Thailand
Research Site
Bangkok , 10400, Thailand
Research Site
Bangkok , 10700, Thailand
Research Site
Chiang Mai , 50200, Thailand
Research Site
Hat Yai , 90110, Thailand
Research Site
Bournemouth Dorset, BH7 7, United Kingdom
Research Site
Birmingham England, B91 2, United Kingdom
Research Site
Cambridge England, CB2 0, United Kingdom
Research Site
Leeds England, LS9 7, United Kingdom
Research Site
London England, NW1 2, United Kingdom
Research Site
London England, SW3 6, United Kingdom
Research Site
Maidstone England, ME16 , United Kingdom
Research Site
Manchester England, M20 4, United Kingdom
Research Site
Middlesex England, HA6 2, United Kingdom
Research Site
Sutton England, SM2 5, United Kingdom
Research Site
Aberdeen Scotland, AB25 , United Kingdom
Research Site
Glasgow Scotland, G12 0, United Kingdom
Load More

How clear is this clinincal trial information?

Study is for people with:

Colon Cancer

Phase:

Phase 3

Estimated Enrollment:

461

Study ID:

NCT04793958

Recruitment Status:

Active, not recruiting

Sponsor:


Mirati Therapeutics Inc.

How clear is this clinincal trial information?

Clinical Trial Resources

Why I’d Choose a Clinical Trial For Myself
SurvivorNet’s Guide To Clinical Trials: What Are They And Are They Right for You?
Clinical Trials Can be Life-Saving for Some
×

Introducing, the Journey Bar

Use this bar to access information about the steps in your cancer journey.