Heart Failure Clinical Trial

Gut Microbiome Profiling in Patients With Chronic Heart Failure

Summary

The goal of this observational study is to learn about the composition and function of the gut microbiome in adults with chronic heart failure with reduced ejection fraction. The main questions the study aims to answer are:

How does the gut microbiome and its interactions with the host change over time in adults with chronic heart failure?
How do these changes relate to heart failure disease severity and complications?

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Full Description

During this study, investigators will recruit adults diagnosed with chronic heart failure with reduced ejection fraction caused by non-ischemic cardiomyopathy. These individuals will undergo longitudinal profiling. This will include detailed profiling of their (1) gut microbiome, (2) blood metabolic and immune markers, and (3) heart failure clinical status. Integrated results will lead to deeper understanding of how gut microbiome interacts with and affects the host in chronic heart failure.

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Eligibility Criteria

Inclusion Criteria:

Heart failure with reduced ejection fraction (left ventricular ejection fraction less than 50%)
Non-ischemic cardiomyopathy
Body mass index (BMI) 18-40 kg/m2

Exclusion Criteria:

Treated diabetes
Advanced kidney disease
Cirrhosis
Significant gastrointestinal disease including any history of inflammatory bowel disease
History of extensive bowel resection
Active malignancy or systemic chemotherapy within the past 12 months
Active infection
Current or recent (within 4 weeks) use of systemic antibiotics, commercial probiotics, immunosuppressive or immunomodulatory medications
Pregnancy/lactation

Study is for people with:

Heart Failure

Estimated Enrollment:

150

Study ID:

NCT06361524

Recruitment Status:

Enrolling by invitation

Sponsor:

Stanford University

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There is 1 Location for this study

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Stanford University
Stanford California, 94305, United States

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Study is for people with:

Heart Failure

Estimated Enrollment:

150

Study ID:

NCT06361524

Recruitment Status:

Enrolling by invitation

Sponsor:


Stanford University

How clear is this clinincal trial information?

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