Heart Failure Clinical Trial

Sex and Obesity: Effects on Heart Failure Study

Summary

Sex has a major impact on myocardial metabolism and blood flow. In subjects without heart failure men's hearts tend to use proportionally more glucose and women's hearts use more fat and have higher blood flow.

Obesity is a major risk factor for Heart Failure. In subjects without heart failure, increasing body mass index is predictive of increased blood flow and fatty acid metabolism in women, but not men.

To measure blood flow and metabolism we will be using radioactive materials and a PET (positron emission Tomography)scan to study the metabolism of the heart.

Hypotheses: 1) Women with nonischemic heart failure will have higher levels of heart blood flow and fatty acid metabolism and lower glucose metabolism rates than men with nonischemic heart failure 2) Patients with obesity-related HF have a myocardial metabolic profile that is similar to that of obese subjects without heart failure and different (higher FA metabolism) from that of nonobese Heart failure patients.

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Eligibility Criteria

Inclusion Criteria: men and women

Non Ischemic Heart failure, ejection fraction <40%, age 20-65, non diabetic

Exclusion Criteria:

Pregnancy, lactating, actively losing weight, nonsedentary, greater than Class I hypertension,require alterations in heart medications, Diabetes, use of exogenous hormones.

Study is for people with:

Heart Failure

Estimated Enrollment:

10

Study ID:

NCT00776035

Recruitment Status:

Active, not recruiting

Sponsor:

Washington University School of Medicine

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There is 1 Location for this study

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Washington University School of Medicine
Saint Louis Missouri, 63110, United States

How clear is this clinincal trial information?

Study is for people with:

Heart Failure

Estimated Enrollment:

10

Study ID:

NCT00776035

Recruitment Status:

Active, not recruiting

Sponsor:


Washington University School of Medicine

How clear is this clinincal trial information?

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