Lung Cancer Clinical Trial
A Study of Prevalence of HER3 Expression in Non-Small Cell Lung Cancer
Summary
There is currently a lack of published HER3 expression prevalence data among non-small cell lung cancer (NSCLC) patients. The estimation of HER3 expression prevalence in this population using archival tissue samples and the assessment of associated patient characteristics in real world (RW) data will ultimately inform clinical strategy and increase awareness among health care providers (HCPs) and the greater medical community to improve patient care.
Full Description
The purpose of this study is to use archival tissue samples and RW data to generate HER3 expression prevalence data within the NSCLC population and by patient characteristics (e.g., ethnicity, histology, smoking status, age, prior treatment, etc.).
The primary objective of the study will analyze and assess archival tissue specimens and associated RW data to:
Increase the understanding of HER3 expression in NSCLC among HCPs and the medical community
Generate evidence to support future clinical strategies in this area
Eligibility Criteria
Inclusion Criteria:
Age ≥18 years in US
Histologically or cytologically documented advanced or metastatic NSCLC
At least one sample available and evaluable for HER3 expression
Additional population-specific inclusion criteria:
For Cohort 1:
Tissue sample collected on or after January 1, 2013
For Cohort 2:
EGFRm NSCLC previously treated with a 3rd generation EGFR TKI
2 samples are available and evaluable for HER3 expression at 2 timepoints: one pre-treatment and one post-treatment, where the treatment is a 3rd generation TKI (defined as Osimertinib, Aumolertinib [formerly Almonertinib])
For Cohort 3:
ALK+ NSCLC
2 samples are available and evaluable for HER3 expression at 2 timepoints: one pre-treatment and one post-treatment, where the treatment is a TKI
For Cohort 4:
NSCLC harboring a KRAS p.G12C mutation or EGFR exon 20 insertion
2 samples are available and evaluable for HER3 expression at 2 timepoints: one pre-treatment and one post-treatment
Exclusion Criteria:
Prior treatment with an anti-HER3 antibody or topoisomerase I inhibitor (single-agent or combination)
Prior treatment with an antibody drug conjugate (ADC) that contains a topoisomerase I inhibitor
Previous histologic or cytologic evidence of small cell or combined small cell/non-small cell disease
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There are 2 Locations for this study
Miami Florida, 33176, United States
Florence South Carolina, 29506, United States
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