Lung Cancer Clinical Trial

Liquid Biopsy With PET/CT Versus PET/CT Alone in Diagnosis of Small Lung Nodules

Summary

The purpose of this study is to determine if a liquid biopsy, a method of detecting cancer from a blood draw, combined with a PET/CT scan, a type of radiological scan, is better at determining whether a lung nodule is cancerous when compared to a PET/CT scan alone. A PET/CT scan is already used for diagnosis of lung nodules, but its efficacy is uncertain in nodules 6-20 mm in size. Therefore, the PET/CT will be evaluated for its diagnostic ability in lesions this size alone and in combination with a liquid biopsy. Secondarily, a machine learning model will be created to see if the combination of the PET/CT imaging data and the liquid biopsy data can predict the presence of cancer.

View Eligibility Criteria

Eligibility Criteria

Inclusion Criteria:

Over 18 years of age
ECOG performance status of 0,1, or 2

Newly discovered lung nodule with:

At least one solid lung nodule measuring 6 mm- 20 mm in greatest diameter detected on screening CT
No single lesion larger than 20 mm in greatest diameter when multiple nodules present
High- or intermediate-risk nodules per American College of Chest Physician (ACCP) guidelines
Able to provide informed consent

Exclusion Criteria:

Prior cancer of any type for the previous 3 years
Prior organ, bone marrow, of hematopoietic stem cell transplant
Contraindication to administration of [18F]FDG
Inability to undergo a PET/CT scan
Ongoing infection, either acute or subacute
Severe COPD or lung disease requiring home oxygen use
Pregnancy

Study is for people with:

Lung Cancer

Estimated Enrollment:

31

Study ID:

NCT05066776

Recruitment Status:

Terminated

Sponsor:

Palo Alto Veterans Institute for Research

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There is 1 Location for this study

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VA Palo Alto Health Care System
Palo Alto California, 94304, United States

How clear is this clinincal trial information?

Study is for people with:

Lung Cancer

Estimated Enrollment:

31

Study ID:

NCT05066776

Recruitment Status:

Terminated

Sponsor:


Palo Alto Veterans Institute for Research

How clear is this clinincal trial information?

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