Lung Cancer Clinical Trial

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Skeletal Muscle Atrophy and Dysfunction in Human Cancer

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Summary

Cancer and its treatment can have profound effects on skeletal muscle, the most well-recognized being atrophy, weakness and diminished oxidative capacity. These adaptations negatively impact quality of life, treatment decisions and survival. Despite these consequences, the factors promoting these adaptations remain poorly defined and understudied in human patients. To address this gap in knowledge, our goal in this study is to examine the role of muscle disuse as a regulator of muscle size and function in human cancer patients

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Eligibility Criteria

Inclusion Criteria:

50-75 yrs of age
histologically-documented, stage III or IV non-small cell lung carcinoma (NSCLC)
estimated life expectancy >6 mos
Karnofsky's performance score of ≥70

Exclusion Criteria:

history, signs or symptoms of inflammatory or autoimmune disease
uncontrolled hypertension
heart or renal failure
exercise limitations from peripheral vascular disease or stroke
neuromuscular disease
knee/hip replacement
additional, actively-treated malignancy or history of malignancy, except non-melanoma skin cancer
taking medication that can have anti-coagulant effects that cannot be stopped prior to the muscle biopsy

Study is for people with:

Lung Cancer

Estimated Enrollment:

20

Study ID:

NCT02949076

Recruitment Status:

Recruiting

Sponsor:

University of Vermont

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There is 1 Location for this study

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University of Vermont College of Medicine
Burlington Vermont, 05405, United States More Info
Alexandraw Albertson
Contact
802-656-2178
[email protected]

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Study is for people with:

Lung Cancer

Estimated Enrollment:

20

Study ID:

NCT02949076

Recruitment Status:

Recruiting

Sponsor:


University of Vermont

How clear is this clinincal trial information?

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