Melanoma Clinical Trial

A Study of Pembrolizumab (MK-3475) in Combination With Belzutifan (MK-6482) and Lenvatinib (MK-7902), or Pembrolizumab/Quavonlimab (MK-1308A) in Combination With Lenvatinib, Versus Pembrolizumab and Lenvatinib, for Treatment of Advanced Clear Cell Renal Cell Carcinoma (MK-6482-012)

Summary

The goal of this study is to evaluate the efficacy and safety of pembrolizumab plus belzutifan plus lenvatinib or pembrolizumab/quavonlimab plus lenvatinib versus pembrolizumab plus lenvatinib as first-line treatment in participants with advanced clear cell renal cell carcinoma (ccRCC).

The primary hypotheses are (1) pembrolizumab plus belzutifan plus lenvatinib is superior to pembrolizumab plus lenvatinib with respect to progression-free survival (PFS) and overall survival (OS), in advanced ccRCC participants; and (2) pembrolizumab/quavonlimab plus lenvatinib is superior to pembrolizumab plus lenvatinib with respect to PFS and OS, in advanced ccRCC participants.

View Eligibility Criteria

Eligibility Criteria

Inclusion Criteria:

Has histologically confirmed diagnosis of RCC with clear cell component.
Has received no prior systemic therapy for advanced ccRCC
Male participants are abstinent from heterosexual intercourse or agree to use contraception during and for at least 7 days after last dose of study intervention with belzutifan and lenvatinib.
Female participants are not pregnant or breastfeeding and are either not a woman of child-bearing potential (WOCBP) or use a contraceptive method that is highly effective or are abstinent from heterosexual intercourse during the intervention period and for at least 120 days after pembrolizumab or pembrolizumab/quavonlimab or for at least 30 days after last dose of lenvatinib or belzutifan, whichever occurs last
Has adequately controlled blood pressure with or without antihypertensive medications
Has adequate organ function.
Participants receiving bone resorptive therapy must have therapy initiated at least 2 weeks prior to randomization/allocation

Exclusion Criteria:

Has a known additional malignancy that is progressing or has required active treatment within the past 3 years
Has had major surgery, other than nephrectomy within 4 weeks prior to randomization
Has known central nervous system (CNS) metastases and/or carcinomatous meningitis
Has received prior radiotherapy within 2 weeks prior to first dose of study intervention
Has hypoxia or requires intermittent supplemental oxygen or requires chronic supplemental oxygen
Has clinically significant cardiac disease within 12 months from first dose of study intervention
Has a history of interstitial lung disease
Has symptomatic pleural effusion; a participant who is clinically stable following treatment of this condition is eligible
Has preexisting gastrointestinal or non-gastrointestinal fistula
Has a diagnosis of immunodeficiency or is receiving chronic systemic steroid therapy or any other form of immunosuppressive therapy within 7 days prior to the first dose of study treatment
Has a known psychiatric or substance abuse disorder that would interfere with requirements of the study
Has received a live or live-attenuated vaccine within 30 days before the first dose of study drug; killed vaccines are allowed
Has an active autoimmune disease that has required systemic treatment in the past 2 years
Has a history of noninfectious pneumonitis that required steroids or has current pneumonitis
Has an active infection requiring systemic therapy
Has a known history of human immunodeficiency virus (HIV) infection
Has a known history of Hepatitis B
Has radiographic evidence of intratumoral cavitation, encasement or invasion of a major blood vessel
Has clinically significant history of bleeding within 3 months prior to randomization
Has had an allogenic tissue/solid organ transplant

Study is for people with:

Melanoma

Phase:

Phase 3

Estimated Enrollment:

1653

Study ID:

NCT04736706

Recruitment Status:

Recruiting

Sponsor:

Merck Sharp & Dohme LLC

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There are 242 Locations for this study

See Locations Near You

The University of Alabama at Birmingham ( Site 0010)
Birmingham Alabama, 35294, United States More Info
Study Coordinator
Contact
205-934-3411
UC San Diego ( Site 0050)
La Jolla California, 92037, United States More Info
Study Coordinator
Contact
858-657-7516
Cedars Sinai Medical Center ( Site 0027)
Los Angeles California, 90048, United States More Info
Study Coordinator
Contact
310-423-3713
University of California Irvine ( Site 0029)
Orange California, 92868, United States More Info
Study Coordinator
Contact
714-456-8000
UCLA Hematology Oncology Santa Monica ( Site 0048)
Santa Monica California, 90404, United States More Info
Study Coordinator
Contact
310-633-8400
Hartford Hospital ( Site 0024)
Hartford Connecticut, 06102, United States More Info
Study Coordinator
Contact
860-972-4700
Advent Health Hematology & Oncology ( Site 0003)
Orlando Florida, 32804, United States More Info
Study Coordinator
Contact
407-303-2024
University Cancer & Blood Center, LLC ( Site 0057)
Athens Georgia, 30607, United States More Info
Study Coordinator
Contact
706-353-2990
Emory University Winship Cancer Institute ( Site 0012)
Atlanta Georgia, 30322, United States More Info
Study Coordinator
Contact
404-778-1900
Rush University Medical Center ( Site 0040)
Chicago Illinois, 60612, United States More Info
Study Coordinator
Contact
312-942-3732
Parkview Cancer Institute ( Site 0088)
Fort Wayne Indiana, 46845, United States More Info
Study Coordinator
Contact
833-724-8326
Norton Cancer Institute - St. Matthews ( Site 0065)
Louisville Kentucky, 40207, United States
Ochsner Medical Center ( Site 0049)
New Orleans Louisiana, 70121, United States More Info
Study Coordinator
Contact
504-842-3910
New England Cancer Specialists ( Site 0082)
Scarborough Maine, 04074, United States More Info
Study Coordinator
Contact
207-303-3300
Massachusetts General Hospital ( Site 0094)
Boston Massachusetts, 02114, United States More Info
Study Coordinator
Contact
617-724-4000
Beth Israel Deaconess Medical Center ( Site 0089)
Boston Massachusetts, 02215, United States More Info
Study Coordinator
Contact
617-667-7000
Dana Farber Cancer Institute ( Site 0093)
Boston Massachusetts, 02215, United States More Info
Study Coordinator
Contact
617-632-3000
Lahey Hospital & Medical Center ( Site 0090)
Burlington Massachusetts, 01805, United States More Info
Study Coordinator
Contact
781-744-8400
Henry Ford Hospital ( Site 0038)
Detroit Michigan, 48202, United States More Info
Study Coordinator
Contact
313-916-2600
Cancer & Hematology Centers of Western Michigan ( Site 0018)
Grand Rapids Michigan, 49503, United States More Info
Study Coordinator
Contact
616-885-1462
HealthPartners Cancer Research Center-HealthPartners Frauenshuh Cancer Center ( Site 0005)
Saint Louis Park Minnesota, 55426, United States More Info
Study Coordinator
Contact
952-993-6705
Regions Hospital ( Site 0095)
Saint Paul Minnesota, 55101, United States More Info
Study Coordinator
Contact
651-254-1517
University of Mississippi Medical Center ( Site 0037)
Jackson Mississippi, 39216, United States More Info
Study Coordinator
Contact
601-815-4540
Dartmouth Hitchcock Medical Center ( Site 0075)
Lebanon New Hampshire, 03756, United States More Info
Study Coordinator
Contact
603-650-4344
Roswell Park Cancer Institute ( Site 0032)
Buffalo New York, 14263, United States More Info
Study Coordinator
Contact
716-845-3159
Northwell Health- Monter Cancer Center ( Site 0013)
Lake Success New York, 11042, United States More Info
Study Coordinator
Contact
516-734-8919
Sidney Kimmel Center for Prostate and Urologic Cancers ( Site 0055)
New York New York, 10065, United States More Info
Study Coordinator
Contact
646-422-4524
Oregon Health & Science University ( Site 0071)
Portland Oregon, 97239, United States More Info
Study Coordinator
Contact
503-494-1080
Ralph H. Johnson VA Center ( Site 0073)
Charleston South Carolina, 29401, United States More Info
Study Coordinator
Contact
843-789-7816
University of Tennessee Medical Center Knoxville ( Site 0019)
Knoxville Tennessee, 37920, United States More Info
Study Coordinator
Contact
865-305-8780
Vanderbilt University Medical Center ( Site 0069)
Nashville Tennessee, 37232, United States More Info
Study Coordinator
Contact
615-936-8422
UTSW Medical Center ( Site 0015)
Dallas Texas, 75390, United States More Info
Study Coordinator
Contact
214-648-7097
Confluence Health | Wenatchee Valley Hospital & Clinics ( Site 0061)
Wenatchee Washington, 98801, United States More Info
Study Coordinator
Contact
509-436-6245
Liverpool Hospital ( Site 4006)
Liverpool New South Wales, 2170, Australia More Info
Study Coordinator
Contact
+61287389744
Macquarie University ( Site 4007)
Macquarie University New South Wales, 2109, Australia More Info
Study Coordinator
Contact
+6129812 3526
Lyell McEwin Hospital ( Site 4004)
Elizabeth Vale South Australia, 5112, Australia More Info
Study Coordinator
Contact
+618 8282 0833
Monash Health ( Site 4008)
Clayton Victoria, 3168, Australia More Info
Study Coordinator
Contact
+61436387664
Fiona Stanley Hospital ( Site 4009)
Murdoch Western Australia, 6150, Australia More Info
Study Coordinator
Contact
+61298123526
Oncocentro Ceara ( Site 0309)
Fortaleza Ceara, 60135, Brazil More Info
Study Coordinator
Contact
+558532579408
Centro de Pesquisas Clinicas em Oncologia ( Site 0306)
Cachoeiro de Itapemirim Espirito Santo, 29308, Brazil More Info
Study Coordinator
Contact
+552835225095
Centro Avançado de Tratamento Oncológico- CENATRON-Clinical Research ( Site 0303)
Belo Horizonte Minas Gerais, 30130, Brazil More Info
Study Coordinator
Contact
+553136576864
Liga Norte Riograndense Contra o Cancer ( Site 0308)
Natal Rio Grande Do Norte, 59075, Brazil More Info
Study Coordinator
Contact
+558440095595
Hospital de Clinicas de Porto Alegre ( Site 0310)
Porto Alegre Rio Grande Do Sul, 90035, Brazil More Info
Study Coordinator
Contact
+555133598619
Instituto do Cancer do Estado de Sao Paulo - ICESP ( Site 0302)
Sao Paulo , 01246, Brazil More Info
Study Coordinator
Contact
55 11 38932645
BP - A Beneficencia Portuguesa de São Paulo-Medical Oncology ( Site 0300)
Sao Paulo , 01321, Brazil More Info
Study Coordinator
Contact
55 11 35056541
A.C. Camargo Cancer Center ( Site 0301)
Sao Paulo , 01525, Brazil More Info
Study Coordinator
Contact
+551121895138
Tom Baker Cancer Centre ( Site 0119)
Calgary Alberta, T4N 4, Canada More Info
Study Coordinator
Contact
4035213166
BC Cancer - Vancouver Center ( Site 0120)
Vancouver British Columbia, V5Z 4, Canada More Info
Study Coordinator
Contact
6048776000
Hamilton Health Sciences-Juravinski Cancer Centre ( Site 0117)
Hamilton Ontario, L8V 5, Canada More Info
Study Coordinator
Contact
9053879495 x63123
Sunnybrook Research Institute ( Site 0116)
Toronto Ontario, M4N 3, Canada More Info
Study Coordinator
Contact
4164805847
Centre intégré de cancérologie du CHU de Québec Université Laval, Hôpital de l'Enfant-Jésus ( Site 0
Quebec City Quebec, G1J 1, Canada More Info
Study Coordinator
Contact
4185254444
Centro Investigacion Cancer James Lind ( Site 0402)
Temuco Araucania, 48008, Chile More Info
Study Coordinator
Contact
+56452982404
IC La Serena Research ( Site 0403)
La Serena Coquimbo, 17204, Chile More Info
Study Coordinator
Contact
+56512386127
Servicios Medicos Urumed ( Site 0405)
Rancagua Lbtdr Gen Bernardo O Higgins, 28524, Chile More Info
Study Coordinator
Contact
56989022206
Fundacion Arturo Lopez Perez ( Site 0400)
Santiago Region M. De Santiago, 75009, Chile More Info
Study Coordinator
Contact
+569228205700
Bradfordhill-Clinical Area ( Site 0401)
Santiago Region M. De Santiago, 84203, Chile More Info
Study Coordinator
Contact
56229490970
Peking University First Hospital ( Site 6011)
Beijing Beijing, 10003, China More Info
Study Coordinator
Contact
13910688432
Beijing Cancer hospital-Renal carcinoma and melanoma ( Site 6000)
Beijing Beijing, 10014, China More Info
Study Coordinator
Contact
13911233048
Chongqing University Cancer Hospital ( Site 6009)
Chongqing Chongqing, 40003, China More Info
Study Coordinator
Contact
13883029913
SUN YAT-SEN UNIVERSITY CANCER CENTRE ( Site 6003)
Guangzhou Guangdong, 51006, China More Info
Study Coordinator
Contact
13922735659
The First Affiliated Hospital of Guangzhou Medical University-Urology ( Site 6036)
Guangzhou Guangdong, 51012, China More Info
Study Coordinator
Contact
0592-2132222
Guangzhou First People's Hospital ( Site 6007)
Guangzhou Guangdong, 51018, China More Info
Study Coordinator
Contact
13922231881
Henan Cancer Hospital-Urology ( Site 6006)
Zhengzhou Henan, 45000, China More Info
Study Coordinator
Contact
0371-65588237
Wuhan Union Hospital ( Site 6002)
Wuhan Hubei, 43002, China More Info
Study Coordinator
Contact
+86 027-85726300
Hunan Cancer Hospital ( Site 6020)
Changsha Hunan, 41001, China More Info
Study Coordinator
Contact
0731-89762271
Nanjing Drum Tower Hospital The Affiliated Hospital of Nanjing University Medical School-Urology ( S
Nanjing Jiangsu, 21000, China More Info
Study Coordinator
Contact
8613605171690
The Second Affiliated Hospital of Soochow University-Urology ( Site 6025)
Suzhou Jiangsu, 21500, China More Info
Study Coordinator
Contact
+86 18994392817
The First Affiliated Hospital of Nanchang University ( Site 6019)
Nanchang Jiangxi, 33000, China More Info
Study Coordinator
Contact
+86 13879103861
The First Affiliated Hospital of Xi'an Jiaotong University ( Site 6014)
Xi'an Shaanxi, 71006, China More Info
Study Coordinator
Contact
18149480558
Shanghai Tenth People's Hospital ( Site 6023)
Shanghai Shanghai, 20007, China More Info
Study Coordinator
Contact
021-66300588
West China Hospital Sichuan University-Urology Surgery ( Site 6016)
Cheng Du Sichuan, 61004, China More Info
Study Coordinator
Contact
13881749152
Tianjin Medical University Cancer Institute and Hospital ( Site 6029)
Tianjin Tianjin, 30006, China More Info
Study Coordinator
Contact
022-23340123
The Second Hospital of Tianjin Medical University ( Site 6032)
Tianjin Tianjin, 30021, China More Info
Study Coordinator
Contact
022 6073 5857
The First Affiliated Hospital, Zhejiang University ( Site 6024)
Hangzhou Zhejiang, 31000, China More Info
Study Coordinator
Contact
8613957120101
The First Hospital of Jiaxing ( Site 6033)
Jiaxing Zhejiang, 31400, China More Info
Study Coordinator
Contact
13957391616
Ningbo First Hospital-Urology ( Site 6028)
Ningbo Zhejiang, 31501, China More Info
Study Coordinator
Contact
0574-87085146
The First Affiliated Hospital of Wenzhou Medical University-Urology Surgery ( Site 6021)
Wenzhou Zhejiang, 32500, China More Info
Study Coordinator
Contact
+86 13626582653
Instituto de Cancerología S.A Clínica de las Americas (ICCLA) ( Site 0500)
Medellin Antioquia, 05002, Colombia More Info
Study Coordinator
Contact
+5743423307
Clinica de la Costa S.A.S. ( Site 0502)
Barranquilla Atlantico, 08002, Colombia More Info
Study Coordinator
Contact
573008457996
Sociedad de Oncología Y Hematología del Cesar S.A.S. ( Site 0505)
Valledupar Cesar, 20000, Colombia More Info
Study Coordinator
Contact
+573128385292
Administradora Country SA - Clinica del Country ( Site 0504)
Bogota Distrito Capital De Bogota, 11022, Colombia More Info
Study Coordinator
Contact
3108627483
Instituto Nacional de Cancerología E.S.E. ( Site 0503)
Bogotá Distrito Capital De Bogota, 11151, Colombia More Info
Study Coordinator
Contact
+5714320160
Oncólogos del Occidente S.A ( Site 0501)
Pereira Risaralda, 66000, Colombia More Info
Study Coordinator
Contact
+573155313926
Fundacion Cardiovascular de Colombia ( Site 0506)
Piedecuesta Santander, 68101, Colombia More Info
Study Coordinator
Contact
+573215433439
Klinicki Bolnicki Centar Zagreb ( Site 3200)
Zagreb Grad Zagreb, 10000, Croatia More Info
Study Coordinator
Contact
+385915086676
Klinički Bolnički Centar Split ( Site 3202)
Split Splitsko-dalmatinska Zupanija, 21000, Croatia More Info
Study Coordinator
Contact
+38598448431
Klinicki bolnicki centar "Sestre milosrdnice" ( Site 3201)
Zagreb Zagrebacka Zupanija, 10000, Croatia More Info
Study Coordinator
Contact
+382 1 3787421
Masarykuv onkologicky ustav ( Site 2203)
Brno Brno-mesto, 656 5, Czechia More Info
Study Coordinator
Contact
+420543132216
Fakultni nemocnice u sv. Anny v Brne ( Site 2205)
Brno Jihomoravsky Kraj, 656 9, Czechia More Info
Study Coordinator
Contact
+420543183073
Nemocnice AGEL Novy Jicin a.s. ( Site 2202)
Novy Jicin Moravskoslezsky Kraj, 741 0, Czechia More Info
Study Coordinator
Contact
+420556416180
Fakultni nemocnice Ostrava ( Site 2208)
Ostrava Moravskoslezsky Kraj, 708 5, Czechia More Info
Study Coordinator
Contact
+420597372123
Fakultni nemocnice Olomouc ( Site 2200)
Olomouc , 775 2, Czechia More Info
Study Coordinator
Contact
+420588444295
Fakultni Thomayerova nemocnice ( Site 2201)
Praha 4 , 140 5, Czechia More Info
Study Coordinator
Contact
+420261082531
2 LF UK a FN Motol ( Site 2207)
Praha 5 , 150 0, Czechia More Info
Study Coordinator
Contact
+420224434700
Herlev Hospital ( Site 1700)
Herlev Hovedstaden, 2730, Denmark More Info
Study Coordinator
Contact
38683868
Odense University Hospital ( Site 1701)
Odense Syddanmark, 5000, Denmark More Info
Study Coordinator
Contact
+4566113333
TAYS ( Site 1801)
Tampere Pirkanmaa, 33520, Finland More Info
Study Coordinator
Contact
+358 3 31163082
Kuopion Yliopistollinen Sairaala ( Site 1803)
Kuopio Pohjois-Savo, 70210, Finland More Info
Study Coordinator
Contact
+358 44 717 2943
HYKS ( Site 1800)
Helsinki Uusimaa, 00290, Finland More Info
Study Coordinator
Contact
+358401440338
TYKS ( Site 1802)
Turku Varsinais-Suomi, 20520, Finland More Info
Study Coordinator
Contact
+35823130729
Institut Paoli Calmettes ( Site 1206)
Marseille Bouches-du-Rhone, 13009, France More Info
Study Coordinator
Contact
33491223760
CHU Jean Minjoz ( Site 1205)
Besancon Doubs, 25000, France More Info
Study Coordinator
Contact
+33370632403
Institut Claudius Regaud ( Site 1214)
Toulouse Haute-Garonne, 31059, France More Info
Study Coordinator
Contact
+33531155829
Clinique Francois Chenieux ( Site 1209)
Limoges Haute-Vienne, 87039, France More Info
Study Coordinator
Contact
33555454800
CHU Angers ( Site 1200)
Angers Maine-et-Loire, 49933, France More Info
Study Coordinator
Contact
33241355830
Clinique Ambroise Pare Beuvry ( Site 1213)
Beuvry Nord-Pas-de-Calais, 62660, France More Info
Study Coordinator
Contact
+33321619283
CH Lyon Sud Hospices Civils de Lyon ( Site 1203)
Pierre Benite Rhone, 69310, France More Info
Study Coordinator
Contact
33478864324
Gustave Roussy ( Site 1207)
Villejuif Val-de-Marne, 94800, France More Info
Study Coordinator
Contact
+33142115252
Hopital Tenon ( Site 1212)
Paris , 75020, France More Info
Study Coordinator
Contact
+33156017110
Universitaetsklinik fuer Urologie ( Site 1300)
Tuebingen Baden-Wurttemberg, 72076, Germany More Info
Study Coordinator
Contact
'+49 7071 2985268
Helios Kliniken Schwerin GmbH ( Site 1302)
Schwerin Mecklenburg-Vorpommern, 19049, Germany More Info
Study Coordinator
Contact
493855202120
Charite Universitaetsmedizin Berlin ( Site 1301)
Berlin , 10117, Germany More Info
Study Coordinator
Contact
0049 30 450 615092
Centro Medico Integral de Cancerologia CEMIC ( Site 0701)
Salcaja Quetzaltenango, 09002, Guatemala More Info
Study Coordinator
Contact
+50259458053
Oncomedica ( Site 0700)
Guatemala , 01010, Guatemala More Info
Study Coordinator
Contact
+50222781269
Grupo Angeles SA ( Site 0705)
Guatemala , 01015, Guatemala More Info
Study Coordinator
Contact
+50223857572
Sanatorio Nuestra Senora del Pilar ( Site 0702)
Guatemala , 01015, Guatemala More Info
Study Coordinator
Contact
+50258190718
Medi-K Cayala ( Site 0703)
Guatemala , 01016, Guatemala More Info
Study Coordinator
Contact
+50222912323
Centro Regional de Sub Especialidades Medicas SA ( Site 0704)
Quetzaltenango , 09001, Guatemala More Info
Study Coordinator
Contact
+50277674235
Bacs-Kiskun Megyei Korhaz-Onkoradiologiai Kozpont ( Site 2308)
Kecskemét Bacs-Kiskun, 6000, Hungary More Info
Study Coordinator
Contact
+3676519853
Bekes Megyei Kozponti Korhaz - Pandy Kalman Tagkorhaza ( Site 2309)
Gyula Bekes, 5700, Hungary More Info
Study Coordinator
Contact
+36704397973
Jasz - Nagykun Szolnok megyei Hetenyi Geza Korhaz - Rendelointezet ( Site 2300)
Szolnok Jasz-Nagykun-Szolnok, 5004, Hungary More Info
Study Coordinator
Contact
+36209323256
Markusovszky Egyetemi Oktatokorhaz ( Site 2303)
Szombathely Vas, 9700, Hungary More Info
Study Coordinator
Contact
+3694515665
Orszagos Onkologiai Intezet ( Site 2304)
Budapest , 1122, Hungary More Info
Study Coordinator
Contact
+3612248600
Debreceni Egyetem Klinikai Kozpont ( Site 2301)
Debrecen , 4032, Hungary More Info
Study Coordinator
Contact
+3652255840
Beaumont Hospital ( Site 6101)
Dublin , D09 V, Ireland More Info
Study Coordinator
Contact
0035318092010
Tallaght University Hospital ( Site 6100)
Dublin , D24 N, Ireland More Info
Study Coordinator
Contact
+35314144299
Azienda Ospedaliero - Universitaria Policlinico di Modena ( Site 1404)
Modena Emilia-Romagna, , Italy More Info
Study Coordinator
Contact
+ 39 0594222648
Ospedale San Raffaele-Oncologia Medica ( Site 1417)
Milano Lombardia, 20132, Italy More Info
Study Coordinator
Contact
390226435789
Fondazione Policlinico Universitario A. Gemelli ( Site 1414)
Rome Roma, 00168, Italy More Info
Study Coordinator
Contact
+390630154953
Azienda Ospedaliera Policlinico di Bari ( Site 1411)
Bari , 70124, Italy More Info
Study Coordinator
Contact
+390805594167
Fondazione IRCCS Istituto Nazionale dei Tumori di Milano ( Site 1409)
Milano , 20133, Italy More Info
Study Coordinator
Contact
+390223904450
Istituto Nazionale Tumori Fondazione Pascale ( Site 1412)
Napoli , 80131, Italy More Info
Study Coordinator
Contact
+390815903637
Azienda Ospedaliera S. Maria di Terni ( Site 1410)
Terni , 05100, Italy More Info
Study Coordinator
Contact
+390744205410
Fujita Health University ( Site 5003)
Toyoake Aichi, 470-1, Japan More Info
Study Coordinator
Contact
+81-562-93-2111
Chiba cancer center ( Site 5021)
Chiba-shi Chiba, 260-8, Japan More Info
Study Coordinator
Contact
+81-43-264-5431
National Cancer Center Hospital East ( Site 5000)
Kashiwa Chiba, 277-8, Japan More Info
Study Coordinator
Contact
+81-4-7133-1111
Ehime University Hospital ( Site 5020)
Toon Ehime, 791-0, Japan More Info
Study Coordinator
Contact
+81-89-964-5111
Sapporo Medical University Hospital ( Site 5008)
Sapporo Hokkaido, 060-8, Japan More Info
Study Coordinator
Contact
+81-11-611-2111
Hokkaido University Hospital ( Site 5013)
Sapporo Hokkaido, 060-8, Japan More Info
Study Coordinator
Contact
+81-11-716-1161
Kanagawa cancer center ( Site 5016)
Yokohama Kanagawa, 241-8, Japan More Info
Study Coordinator
Contact
+81-45-520-2222
Nara Medical University Hospital ( Site 5002)
Kashihara Nara, 634-8, Japan More Info
Study Coordinator
Contact
+81-744-22-3051
Kindai University Hospital- Osakasayama Campus-Urology ( Site 5010)
Osakasayama Osaka, 589-8, Japan More Info
Study Coordinator
Contact
+81-72-366-0221
Osaka University Hospital ( Site 5012)
Suita Osaka, 565-0, Japan More Info
Study Coordinator
Contact
+81-6-6879-5111
Saitama Medical University International Medical Center ( Site 5015)
Hidaka-city Saitama, 350-1, Japan More Info
Study Coordinator
Contact
+81-42-984-4111
Hamamatsu University School of Medicine University Hospital ( Site 5004)
Hamamatsu Shizuoka, 431-3, Japan More Info
Study Coordinator
Contact
+81-53-435-2111
Tokyo Medical And Dental University Medical Hospital-Urology ( Site 5009)
Bunkyō Tokyo, 113-8, Japan More Info
Study Coordinator
Contact
+81-3-3813-6111
Toranomon Hospital ( Site 5001)
Minato-ku Tokyo, 10584, Japan More Info
Study Coordinator
Contact
+81-3-3588-1111
Toyama University Hospital ( Site 5014)
Toyoma Toyama, 930-0, Japan More Info
Study Coordinator
Contact
+81-76-434-2281
Kyushu University Hospital ( Site 5005)
Fukuoka , 812-8, Japan More Info
Study Coordinator
Contact
+81-92-641-1151
Kumamoto University ( Site 5022)
Kumamoto , 860-8, Japan More Info
Study Coordinator
Contact
+81-96-344-2111
Niigata University Medical & Dental Hospital ( Site 5024)
Niigata , 951-8, Japan More Info
Study Coordinator
Contact
025-223-6161
Okayama University Hospital ( Site 5017)
Okayama , 700-8, Japan More Info
Study Coordinator
Contact
+81-86-223-7151
Tokushima University Hospital-Department of Urology ( Site 5019)
Tokushima , 770-8, Japan More Info
Study Coordinator
Contact
+81-88-631-3111
Nippon Medical School Hospital ( Site 5006)
Tokyo , 113-8, Japan More Info
Study Coordinator
Contact
+81-3-3822-2131
Tokyo Women's Medical University Adachi Medical Center ( Site 5023)
Tokyo , 123-8, Japan More Info
Study Coordinator
Contact
+81-3-3857-0111
Keio university hospital ( Site 5011)
Tokyo , 160-8, Japan More Info
Study Coordinator
Contact
+81-3-3353-1211
National Cancer Center ( Site 4202)
Goyang-si Kyonggi-do, 10408, Korea, Republic of More Info
Study Coordinator
Contact
+82319201505
Chungnam National University Hospital ( Site 4205)
Daejeon Taejon-Kwangyokshi, 35015, Korea, Republic of More Info
Study Coordinator
Contact
+82422808369
Korea University Anam Hospital ( Site 4206)
Seoul , 02841, Korea, Republic of More Info
Study Coordinator
Contact
+8229206267
Seoul National University Hospital ( Site 4201)
Seoul , 03080, Korea, Republic of More Info
Study Coordinator
Contact
+82220721672
Severance Hospital Yonsei University Health System ( Site 4204)
Seoul , 03722, Korea, Republic of More Info
Study Coordinator
Contact
+82222288054
Asan Medical Center ( Site 4203)
Seoul , 05505, Korea, Republic of More Info
Study Coordinator
Contact
+82230106095
Samsung Medical Center ( Site 4200)
Seoul , 06351, Korea, Republic of More Info
Study Coordinator
Contact
+82234101767
Hospital Sultan Ismail ( Site 4303)
Johor Bahru Johor, 81100, Malaysia More Info
Study Coordinator
Contact
+6073565000
Institut Kanser Negara - National Cancer Institute ( Site 4302)
Putrajaya Wilayah Persekutuan Putrajaya, 62250, Malaysia More Info
Study Coordinator
Contact
60388925555
Hospital Kuala Lumpur ( Site 4301)
Kuala Lumpur , 50586, Malaysia More Info
Study Coordinator
Contact
60326155555
Universiti Malaya Medical Centre ( Site 4300)
Kuala Lumpur , 59100, Malaysia More Info
Study Coordinator
Contact
+60379492120
Hospital Civil de Guadalajara Fray Antonio Alcalde ( Site 0610)
Guadalajara Jalisco, 44280, Mexico More Info
Study Coordinator
Contact
+523315145351
I CAN Oncology SA de SV ( Site 0601)
Monterrey Nuevo Leon, 64710, Mexico More Info
Study Coordinator
Contact
+528125558165
Cuidados Oncologicos ( Site 0608)
Santiago De Quetaro Queretaro, 76000, Mexico More Info
Study Coordinator
Contact
+524421145730
Instituto Nacional de Cancerologia ( Site 0602)
Cdmx , 14080, Mexico More Info
Study Coordinator
Contact
+52 55 5628 0400 Ext. 37025
Centro de Investigacion Clinica de Oaxaca ( Site 0605)
Oaxaca , 68020, Mexico More Info
Study Coordinator
Contact
+52 951 547 3137
Akershus universitetssykehus ( Site 2000)
Lorenskog Akershus, 1478, Norway More Info
Study Coordinator
Contact
47 67 96 00 00
Soerlandet sykehus HF Kristiansand ( Site 2007)
Kristiansand Aust-Agder, 4615, Norway More Info
Study Coordinator
Contact
+4738146658
Helse Bergen HF - Haukeland Universitetssykehus ( Site 2002)
Bergen Hordaland, 5021, Norway More Info
Study Coordinator
Contact
47 55 97 50 00
Sykehuset Østfold HF Kalnes ( Site 2003)
Gralum Ostfold, 1714, Norway More Info
Study Coordinator
Contact
+4791508600
St. Olavs Hospital HF ( Site 2005)
Trondheim Sor-Trondelag, 7030, Norway More Info
Study Coordinator
Contact
47 72 57 30 00
Oslo Universitetssykehus Radiumhospitalet ( Site 2001)
Oslo , 0379, Norway More Info
Study Coordinator
Contact
+4797666192
Manila Doctors Hospital ( Site 4601)
Manila National Capital Region, 1000, Philippines More Info
Study Coordinator
Contact
+639189120812
The Medical City ( Site 4602)
Pasig City National Capital Region, 1605, Philippines More Info
Study Coordinator
Contact
+639178448605
Cardinal Santos Medical Center ( Site 4603)
San Juan National Capital Region, 1502, Philippines More Info
Study Coordinator
Contact
+639176227242
Centrum Onkologii im. Prof. Franciszka Lukaszczyka-Ambulatorium Chemioterapii ( Site 2420)
Bydgoszcz Kujawsko-pomorskie, 85796, Poland More Info
Study Coordinator
Contact
+48726990096
Radomskie Centrum Onkologii ( Site 2418)
Radom Mazowieckie, 26-60, Poland More Info
Study Coordinator
Contact
504057071
Luxmed Onkologia sp. z o. o. ( Site 2412)
Warszawa Mazowieckie, 01-74, Poland More Info
Study Coordinator
Contact
48691666578
Narodowy Instytut Onkologii im. Marii Sklodowskiej-Curie ( Site 2405)
Warszawa Mazowieckie, 02-78, Poland More Info
Study Coordinator
Contact
+4848225462331
Przychodnia Lekarska KOMED ( Site 2419)
Konin Wielkopolskie, 62-50, Poland
Szpital Kliniczny Przemienienia Panskiego UM im. K. Marcinkowskiego ( Site 2406)
Poznan Wielkopolskie, 60-56, Poland More Info
Study Coordinator
Contact
+48618549038
Szpital Wojewodzki im. Mikolaja Kopernika ( Site 2407)
Koszalin Zachodniopomorskie, 75-58, Poland More Info
Study Coordinator
Contact
48943488930
S.C.Focus Lab Plus S.R.L ( Site 2503)
Bucuresti , 02254, Romania More Info
Study Coordinator
Contact
+40721298677
Altay Regional Oncology Dispensary ( Site 2610)
Barnaul Altayskiy Kray, 65604, Russian Federation
Ivanovo Regional Oncology Dispensary ( Site 2615)
Ivanovo Ivanovskaya Oblast, 15304, Russian Federation
Krasnoyarsk Regional Clinical Oncological Dispensary ( Site 2609)
Krasnoyarsk Krasnoyarskiy Kray, 66013, Russian Federation
The Loginov Moscow Clinical Scientific Center ( Site 2604)
Moscow Moskva, 11112, Russian Federation
Moscow Oncological Clinical Dispensary #1 ( Site 2619)
Moscow Moskva, 12909, Russian Federation
Nizhniy Novgorod Region Oncology Dispensary ( Site 2621)
Nizhniy Novgorod Nizhegorodskaya Oblast, 60308, Russian Federation
FBHI Privolzhsky District Medical Center of the FMBA ( Site 2611)
Nizhny Novgorod Nizhegorodskaya Oblast, 60307, Russian Federation
Scientific Research Oncology Institute n.a. N.N.Petrov ( Site 2617)
Saint Petersburg Sankt-Peterburg, 19775, Russian Federation
City clinical oncological dispensary ( Site 2605)
Sankt-Petersburg Sankt-Peterburg, 19825, Russian Federation
Klinicki centar Srbije. ( Site 3333)
Belgrade Beograd, 11210, Serbia More Info
Study Coordinator
Contact
+381 641855999
Klinicki centar Nis ( Site 3322)
Nis Nisavski Okrug, 18000, Serbia More Info
Study Coordinator
Contact
+381631049653
Institut za onkologiju Vojvodine ( Site 3311)
Sremska Kamenica Sremski Okrug, 21204, Serbia More Info
Study Coordinator
Contact
+381638041910
Cancer Care Langenhoven Drive Oncology Centre ( Site 3009)
Port Elizabeth Eastern Cape, 6045, South Africa More Info
Study Coordinator
Contact
27413630581
Wits Clinical Research ( Site 3012)
Johannesburg Gauteng, 2193, South Africa More Info
Study Coordinator
Contact
+27113390600
Sandton Oncology Medical Group PTY LTD ( Site 3000)
Johannesburg Gauteng, 2196, South Africa More Info
Study Coordinator
Contact
+27118830900
Univ. Pretoria and Steve Biko Academic Hospitals ( Site 3002)
Pretoria Gauteng, 0002, South Africa More Info
Study Coordinator
Contact
012 354 2022
Life Wilgers Hospital ( Site 3004)
Pretoria Gauteng, 0040, South Africa More Info
Study Coordinator
Contact
+27128072744
Mary Potter Oncology Centre, Little Company of Mary Hospital ( Site 3001)
Pretoria Gauteng, 0181, South Africa More Info
Study Coordinator
Contact
+27123466701
Vaal Triangle Oncology Centre ( Site 3010)
Vereeniging Gauteng, 1939, South Africa More Info
Study Coordinator
Contact
+27164211778
Groote Schuur Hospital ( Site 3011)
Cape Town Western Cape, 7925, South Africa More Info
Study Coordinator
Contact
+27 (0)214044265
Cape Town Oncology Trials Pty Ltd ( Site 3006)
Kraaifontein Western Cape, 7570, South Africa More Info
Study Coordinator
Contact
+27219443832
Cancercare Rondebosch Oncology ( Site 3005)
Rondebosch Western Cape, 7700, South Africa More Info
Study Coordinator
Contact
+27861999914
Instituto Catalan de Oncologia - ICO ( Site 1502)
L Hospitalet De Llobregat Barcelona, 08908, Spain More Info
Study Coordinator
Contact
+34932607744
Hospital Universitario Marques de Valdecilla ( Site 1501)
Santander Cantabria, 39008, Spain More Info
Study Coordinator
Contact
+34942202525
Hospital Universitario de Girona Doctor Josep Trueta ( Site 1500)
Girona Gerona, 17007, Spain More Info
Study Coordinator
Contact
+34972225828
Hospital Clinico San Carlos ( Site 1503)
Madrid , 28040, Spain More Info
Study Coordinator
Contact
+34913303000 x3133
Hospital Universitario 12 de Octubre ( Site 1505)
Madrid , 28041, Spain More Info
Study Coordinator
Contact
+34913908339
Hospital Universitario Virgen de la Victoria ( Site 1504)
Malaga , 29016, Spain More Info
Study Coordinator
Contact
+34951032508
Lanssjukhuset Ryhov ( Site 2103)
Jonkoping Jonkopings Lan, 551 8, Sweden More Info
Study Coordinator
Contact
+46102425942
Karolinska Universitetssjukhuset Solna ( Site 2100)
Stockholm Stockholms Lan, 171 7, Sweden More Info
Study Coordinator
Contact
+46851770000
Akademiska Sjukhuset ( Site 2105)
Uppsala Uppsala Lan, 751 8, Sweden More Info
Study Coordinator
Contact
+46186110000
Norrlands Universitetssjukhus ( Site 2106)
Umea Vasterbottens Lan, 901 8, Sweden More Info
Study Coordinator
Contact
+46907850000
Sahlgrenska Universitetssjukhuset ( Site 2102)
Goteborg Vastra Gotalands Lan, 413 4, Sweden More Info
Study Coordinator
Contact
+46313421000
Chang Gung Medical Foundation. Kaohsiung Branch ( Site 4405)
Kaohsiung , 833, Taiwan More Info
Study Coordinator
Contact
+886773171233267
Taichung Veterans General Hospital ( Site 4403)
Taichung , 40705, Taiwan More Info
Study Coordinator
Contact
+886 4 23592525 ext.5121
National Cheng Kung University Hospital ( Site 4404)
Tainan , 704, Taiwan More Info
Study Coordinator
Contact
+88662353535
National Taiwan University Hospital ( Site 4401)
Taipei , 100, Taiwan More Info
Study Coordinator
Contact
+88623123456
Taipei Veterans General Hospital ( Site 4402)
Taipei , 11217, Taiwan More Info
Study Coordinator
Contact
+886228757519 ext. 306
Chang Gung Medical Foundation-Linkou Branch-Urology ( Site 4406)
Taoyuan , 333, Taiwan More Info
Study Coordinator
Contact
886-3-3281200-2103
Ramathibodi Hospital. ( Site 4500)
Bangkok Krung Thep Maha Nakhon, 10400, Thailand More Info
Study Coordinator
Contact
+6622011000
Siriraj Hospital ( Site 4501)
Bangkok Krung Thep Maha Nakhon, 10700, Thailand More Info
Study Coordinator
Contact
+6624191000
Ankara Universitesi Tip Fakultesi ( Site 2902)
Ankara , 06100, Turkey More Info
Study Coordinator
Contact
0903125957112
Hacettepe Universitesi Tıp Fakultesi ( Site 2903)
Ankara , 06100, Turkey More Info
Study Coordinator
Contact
+903123055000
Trakya University Medical Faculty Balkan Oncology Hospital ( Site 2906)
Edirne , 22030, Turkey More Info
Study Coordinator
Contact
+905322480988
Istanbul Universitesi Cerrahpasa Tip Fakultesi ( Site 2900)
Istanbul , 34098, Turkey More Info
Study Coordinator
Contact
+905324167355
TC Saglik Bakanligi Goztepe Prof. Dr. Suleyman Yalcin Sehir Hastanesi-oncology ( Site 2901)
Istanbul , 34722, Turkey More Info
Study Coordinator
Contact
+905063509061
Ege Universitesi Tip Fakultesi Hastanesi ( Site 2904)
Izmir , 35040, Turkey More Info
Study Coordinator
Contact
+902323904387
Dokuz Eylul Universitesi Tip Fakultesi Hastanesi ( Site 2905)
Izmir , 35340, Turkey More Info
Study Coordinator
Contact
+902324122222
Cherkasy Regional Oncology Dispensary ( Site 2704)
Cherkasy Cherkaska Oblast, 18009, Ukraine
Chernihiv Medical Center of Modern Oncology ( Site 2709)
Chernihiv Chernihivska Oblast, 14029, Ukraine
MI Dnipr Regional Clinical Hospital named after I.I. Mechnikov ( Site 2710)
Dnipropetrovsk Dnipropetrovska Oblast, 49005, Ukraine
Clinical oncology dispensary of Dnipro ( Site 2700)
Dnipro Dnipropetrovska Oblast, 49055, Ukraine
Ivano-Frankivsk Regional Hospital-Urology department ( Site 2707)
Ivano-Frankivsk Ivano-Frankivska Oblast, 76008, Ukraine
Ivano-Frankivsk Regional Oncology Clinical Dispensary ( Site 2711)
Ivano-Frankivsk Ivano-Frankivska Oblast, 76018, Ukraine
Regional Oncology Center of Kharkiv ( Site 2708)
Kharkiv Kharkivska Oblast, 61000, Ukraine
Reg. Clinical Center of Urology and Nephrology n.a. V. I. Shapoval ( Site 2715)
Kharkiv Kharkivska Oblast, 61037, Ukraine
Kyiv City Clinical Oncology Center ( Site 2706)
Kyiv Kyivska Oblast, 03115, Ukraine
Lviv State Regional Oncological Center ( Site 2712)
Lviv Lvivska Oblast, 79031, Ukraine
Addenbrookes Hospital ( Site 3110)
Cambridge Cambridgeshire, CB2 2, United Kingdom More Info
Study Coordinator
Contact
01223 216083
Barts Health NHS Trust - St Bartholomew s Hospital ( Site 3116)
London England, EC1A , United Kingdom More Info
Study Coordinator
Contact
00442078828505
Mount Vernon Cancer Centre ( Site 3101)
Northwood London, City Of, HA6 2, United Kingdom More Info
Study Coordinator
Contact
+442038262020

How clear is this clinincal trial information?

Study is for people with:

Melanoma

Phase:

Phase 3

Estimated Enrollment:

1653

Study ID:

NCT04736706

Recruitment Status:

Recruiting

Sponsor:


Merck Sharp & Dohme LLC

How clear is this clinincal trial information?

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