Bortezomib, Melphalan, and Dexamethasone in Treating Patients With Primary Amyloidosis or Light Chain Deposition Disease

DISEASE CHARACTERISTICS:

Biopsy-proven diagnosis of 1 of the following:

Primary systemic amyloidosis

Histochemical diagnosis of amyloidosis determined by polarizing microscopy of green bi-refringent material in Congo red-stained tissue specimens or characteristic electron microscopy appearance
Light chain deposition disease

Measurable disease as defined by one or more of the following:

Serum monoclonal protein ≥ 0.5 g/dL by serum electrophoresis
Urine monoclonal protein > 200 mg/tv in a 24 hr urine electrophoresis
Serum immunoglobulin free-light chain ≥ 10 mg/dL AND abnormal serum immunoglobulin kappa lambda free light chain ratio

Must meet 1 of the following criteria:

Clonal population of plasma cells in the bone marrow (≤ 30%)
Immunohistochemical stain with anti-light chain anti-sera of amyloid fibrils

Must not meet the following diagnostic criteria for symptomatic* multiple myeloma:

Lytic lesions on skeletal survey
Plasmacytoma
Increase in bone marrow plasma cells ≥ 30% NOTE: *Patients who meet the International Myeloma Working Group definition of symptomatic multiple myeloma with symptoms attributable only to associated amyloidosis and who do not otherwise meet the criteria for diagnosis of smoldering myeloma are potentially eligible upon approval of the principal investigator.

If not previously treated, patient is either not a candidate for autologous stem cell transplantation (ASCT) or has declined the option of ASCT

Patients who have undergone prior ASCT and have subsequently progressed are eligible, provided other eligibility criteria are met
No secondary or familial amyloidosis

PATIENT CHARACTERISTICS:

ECOG performance status 0-3
Creatinine < 5 mg/dL
Bilirubin < 2.5 times upper limit of normal (ULN)
ALT and AST < 3 times ULN
Absolute neutrophil count ≥ 1,000/mm³
Platelet count ≥ 80,000/mm³
Not pregnant or nursing
Negative pregnancy test
Fertile patients must use effective contraception
Peripheral sensory neuropathy < grade 3
No myocardial infarction within the past 6 months
No New York Heart Association class III or IV heart failure
No uncontrolled angina
No severe uncontrolled ventricular arrhythmias
No EKG* evidence of acute ischemia or active conduction system abnormalities (not including 1st degree AV-block, Wenckebach type 2nd degree heart block, or left bundle branch block) NOTE: *Prior to study entry, any EKG screening abnormality must be documented by the investigator as not medically relevant; there is no lower limit of LVEF below which patients are excluded from participation
No hypersensitivity to bortezomib, boron, or any of the other agents utilized in this study
No serious concurrent illness (e.g., stroke) within the past 30 days
No psychiatric illness likely to interfere with study participation

No untreated HIV infection

Patients with asymptomatic HIV infection on active antiretroviral therapy are potentially eligible
No diagnosis or treatment of another malignancy within the past 3 years, except completely resected basal cell or squamous cell carcinoma of the skin, an in situ malignancy, or low-risk prostate cancer after curative therapy

PRIOR CONCURRENT THERAPY:

See Disease Characteristics
No other investigational drugs within the past 14 days