Multiple Myeloma Clinical Trial

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Minor Histocompatibility Vaccination After Allogeneic Stem Cell Transplantation for Advanced Hematologic Malignancies

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Summary

This is a clinical research study designed to evaluate whether the administration of a vaccine to patients after transplant consisting of a minor histocompatibility antigen (mHag peptide) mixed with G-CSF (a drug intended to stimulate the immune system) can stimulate increased graft versus leukemia (GVL) responses without causing graft-versus-host disease (GVHD).

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Eligibility Criteria

Inclusion Criteria:

Relapsed or refractory acute myelogenous or lymphoid leukemia.
Acute myeloid or lymphocytic leukemia in first remission at high-risk for recurrence.
Chronic myelogenous leukemia in accelerated phase or blast-crisis.
Chronic myelogenous leukemia in second or subsequent chronic phase
Recurrent or refractory malignant lymphoma or Hodgkin's disease
Multiple myeloma at high risk for disease recurrence.
Chronic lymphocytic leukemia, relapsed or with poor prognostic features.
Myeloproliferative disorder (polycythemia vera, myelofibrosis) with poor prognostic features.

Exclusion Criteria:

Clinical progression.
Contra-indications for vaccination.

Study is for people with:

Multiple Myeloma

Phase:

Phase 1

Estimated Enrollment:

1

Study ID:

NCT00943293

Recruitment Status:

Terminated

Sponsor:

University of Chicago

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There is 1 Location for this study

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The Uniiversity of Chicago
Chicago Illinois, 60637, United States

How clear is this clinincal trial information?

Study is for people with:

Multiple Myeloma

Phase:

Phase 1

Estimated Enrollment:

1

Study ID:

NCT00943293

Recruitment Status:

Terminated

Sponsor:


University of Chicago

How clear is this clinincal trial information?

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