Multiple Sclerosis Clinical Trial

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Tecfidera and MRI for Brain Energy in MS

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Summary

The primary objective of this study is to test the hypothesis that DMF can improve mitochondrial function in the brain of people with MS. The investigators will assess mitochondrial function in the cerebral grey matter by measuring PCr and ATP by 31P magnetic resonance spectroscopy (MRS) and NAA in NAWM by 1H MRS.

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Eligibility Criteria

Inclusion Criteria:

Diagnosis of MS by 2010 McDonald criteria
Relapsing clinical course
Ages 18-55
Laboratory values that allow initiation of dimethyl fumarate (Tecfidera)

Exclusion Criteria:

Systemic disease associated with cerebrovascular disease (e.g. diabetes mellitus, hypertension, hyperlipidemia, coronary heart disease)
Treatment with corticosteroids or disease-modifying therapies (interferon beta, glatiramer acetate, natalizumab, fingolimod, teriflunomide) within 30 days of the first baseline MRI scan.
Treatment at any time with mitoxantrone, cyclophosphamide, or any other long acting immunosuppressant
Prior treatment of greater than 1 month at any time with DMF
Inability to tolerate MRI procedures
Pregnant/breastfeeding

Study is for people with:

Multiple Sclerosis

Estimated Enrollment:

4

Study ID:

NCT02644083

Recruitment Status:

Terminated

Sponsor:

Oregon Health and Science University

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There is 1 Location for this study

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Oregon Health & Science University
Portland Oregon, 97239, United States

How clear is this clinincal trial information?

Study is for people with:

Multiple Sclerosis

Estimated Enrollment:

4

Study ID:

NCT02644083

Recruitment Status:

Terminated

Sponsor:


Oregon Health and Science University

How clear is this clinincal trial information?

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