Non Hodgkin Lymphoma Clinical Trial

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CAR T-cell Therapy in Patients With Renal Dysfunction

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Summary

This is a prospective, descriptive study designed to assess the feasibility of administering CAR T therapy among patients with moderate to severe renal impairment using dose adjusted lymphodepleting chemotherapy.

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Eligibility Criteria

Inclusion Criteria:

Receiving lymphodepleting chemotherapy prior to commercial CAR-T administration for multiple myeloma, leukemia, or lymphoma
Adequate bone marrow function to receive lymphodepleting chemotherapy
Renal function ECOG 0-2

Exclusion Criteria:

Relative CNS disorders
Active uncontrolled infection or any other concurrent disease or medical condition that was deemed to interfere with the conduct of the study as judged by the investigator
Use of therapeutic dose systemic corticosteroids (defined as >20mg/day prednisone or equivalent) within 72 hours of CAR-T administration

Study is for people with:

Non Hodgkin Lymphoma

Phase:

Phase 2

Estimated Enrollment:

20

Study ID:

NCT05909059

Recruitment Status:

Not yet recruiting

Sponsor:

Northside Hospital, Inc.

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There is 1 Location for this study

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Caitlin Guzowski
Atlanta Georgia, 30342, United States

How clear is this clinincal trial information?

Study is for people with:

Non Hodgkin Lymphoma

Phase:

Phase 2

Estimated Enrollment:

20

Study ID:

NCT05909059

Recruitment Status:

Not yet recruiting

Sponsor:


Northside Hospital, Inc.

How clear is this clinincal trial information?

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