Ovarian Cancer Clinical Trial

Exercise Preconditioning in Ovarian Cancer

Summary

The purpose of this study is to determine if exercise preconditioning can mitigate the off target effects of chemotherapy treatment on measures of cardiovascular function, peripheral neuropathy, and quality of life.

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Full Description

While survivorship for those diagnosed with epithelial ovarian cancer has continued to improve, the significant off target effects of adjuvant and neoadjuvant chemotherapy have become more prominent. These off-target effects include increased risk of cardiovascular disease, neuropathy, and decreased quality of life. Exercise initiated prior to chemotherapy induction and continued through treatment has promise in terms of preserving VO2peak and potentially mitigating the negative cardiovascular and neuropathic effects of chemotherapy. The goal of this study is to examine the effects of initiating exercise prior to any oncologic therapy and sustaining this exercise paradigm in newly diagnosed women with ovarian cancer who are undergoing initial surgery and chemotherapy.

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Eligibility Criteria

Inclusion Criteria:

Age 18 years or over
Presumed diagnosis of ovarian cancer and a planned chemotherapy regimen of a taxane and carboplatin with or without VEGF inhibition
Physician clearance for exercise training

Exclusion Criteria:

Any patient unable/unwilling to cooperate with all study protocols
Cancer recurrence
Previous treatment with chemotherapy in the last 5-years
Medical/orthopedic co-morbidities that preclude exercise training
Significant heart, liver, kidney, blood, or respiratory disease precluding exercise participation
Peripheral vascular disease
Acute infectious disease or history of chronic infections

Study is for people with:

Ovarian Cancer

Estimated Enrollment:

27

Study ID:

NCT05029154

Recruitment Status:

Recruiting

Sponsor:

University of Virginia

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There is 1 Location for this study

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University of Virginia University Hospital
Charlottesville Virginia, 22903, United States More Info
Siddhartha S Angadi, PhD
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Susan Modesitt, MD
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How clear is this clinincal trial information?

Study is for people with:

Ovarian Cancer

Estimated Enrollment:

27

Study ID:

NCT05029154

Recruitment Status:

Recruiting

Sponsor:


University of Virginia

How clear is this clinincal trial information?

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