Virtual Prostate Biopsy Protocol for Patients on Active Surveillance and at Risk of Prostate Cancer

Inclusion Criteria:

Biopsy-naive patients with a negative prostate MRI (PI-RADS score 1 or 2); or
Patients with a PI-RADS score of 3, 4, or 5 on MRI and a negative MR-targeted biopsy; or
Patients on active surveillance with a negative prostate MRI (PI-RADS 1 or 2).

Exclusion Criteria:

Positive DRE;
PSA > 10 ng/ml or unstable PSA (doubling time <3 years) during the last year prior to enrolling in this study;
PSAD > 0.15 (calculated using most recent PSA divided by MRI prostate volume);
First degree relative diagnosed with prostate cancer
First degree relative diagnosed with a BRCA2 or Lynch syndrome associated gene causing any cancer.
Patient carries a mutation on BRCA2 or a mismatch repair gene associated with Lynch syndrome (MLHl, MSH2, MSH6, PMS2); known BRCA2 or known mismatch repair gene mutation in the family (Lynch Syndrome) and patient has not had testing; or family history consistent with BRCA2 or Lynch syndrome and there is no known BRCA2 or mismatch repair gene in the family.