Psoriasis Clinical Trial

A Study of JNJ-77242113 for the Treatment of Participants With Moderate to Severe Plaque Psoriasis (ICONIC-ADVANCE 2)

Summary

The purpose of the study is to evaluate how effective JNJ-77242113 is in participants with moderate to severe plaque psoriasis compared to placebo and deucravacitinib.

View Eligibility Criteria

Eligibility Criteria

Inclusion Criteria:

Diagnosis of plaque psoriasis, with or without psoriatic arthritis (PsA), for at least 26 weeks prior to the first administration of study intervention
Total body surface area (BSA) greater than or equal to (>=)10 percent (%) at screening and baseline
Total psoriasis area and severity index (PASI) >=12 at screening and baseline
Total investigator global assessment (IGA) >=3 at screening and baseline
Candidate for phototherapy or systemic treatment for plaque psoriasis

Exclusion Criteria:

Nonplaque form of psoriasis (for example, erythrodermic, guttate, or pustular)
Current drug-induced psoriasis (for example, a new onset of psoriasis or an exacerbation of psoriasis from beta blockers, calcium channel blockers, or lithium)
A current diagnosis or signs or symptoms of severe, progressive, or uncontrolled renal, liver, cardiac, vascular, pulmonary, gastrointestinal, endocrine, neurologic, hematologic, rheumatologic, psychiatric, or metabolic disturbances
Known allergies, hypersensitivity, or intolerance to JNJ-77242113, deucravacitinib or to any of the excipients or components of the study intervention
Major surgical procedure, (for example, requiring general anesthesia) within 8 weeks before screening, or will not have fully recovered from surgical procedure, or has a surgical procedure planned during the time the participant is expected to participate in the study

Study is for people with:

Psoriasis

Phase:

Phase 3

Estimated Enrollment:

675

Study ID:

NCT06220604

Recruitment Status:

Recruiting

Sponsor:

Janssen Research & Development, LLC

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There are 123 Locations for this study

See Locations Near You

Alliance Dermatology and MOHS Center P C
Phoenix Arizona, 85032, United States
California Dermatology & Clinical Research Institute
Encinitas California, 92024, United States
T Joseph Raoof Md Inc
Encino California, 91436, United States
University of California Los Angeles
Los Angeles California, 90024, United States
Wallace Medical Group, Inc.
Los Angeles California, 90056, United States
Dermatologist Medical Group of North County, Inc.
Oceanside California, 92056, United States
Bioclinical Research Alliance Inc.
Miami Florida, 33155, United States
Miami Dermatology And Laser Institute
Miami Florida, 33173, United States
Forcare Clinical Research Inc
Tampa Florida, 33613, United States
Southeast Dermatology Specialists
Douglasville Georgia, 30135, United States
Arlington Dermatology
Rolling Meadows Illinois, 60008, United States
Skin Sciences, PLLC
Louisville Kentucky, 40217, United States
Qualmedica Research
Owensboro Kentucky, 42301, United States
DermAssociates, PC
Rockville Maryland, 20850, United States
Metro Boston Clinical Partners
Brighton Massachusetts, 02135, United States
ActivMed Practices and Research
Methuen Massachusetts, 01844, United States
Great Lakes Research Group
Bay City Michigan, 48706, United States
The Derm Institute of West Michigan
Caledonia Michigan, 49316, United States
Hamzavi Dermatology
Canton Michigan, 48187, United States
Somerset Skin Centre
Troy Michigan, 48084, United States
Cleaver Dermatology
Kirksville Missouri, 63501, United States
Bexley dermatology research
Bexley Ohio, 43209, United States
Essential Medical Research
Tulsa Oklahoma, 74137, United States
Oregon Dermatology & Research Center
Portland Oregon, 97210, United States
Paddington Testing Co, Inc.
Philadelphia Pennsylvania, 19103, United States
Clinical Research Center of the Carolinas LLC
Charleston South Carolina, 29407, United States
Palmetto Clinical Trial Services, LLC
Greenville South Carolina, 29615, United States
Arlington Research Center, Inc.
Arlington Texas, 76011, United States
UT Southwestern Medical Center
Dallas Texas, 75390, United States
Dermatology Clinical Research Center of San Antonio
San Antonio Texas, 78229, United States
Center for Clinical Studies
Webster Texas, 77598, United States
Cope Family Medicine - Ogden Clinic
Bountiful Utah, 84010, United States
Springville Dermatology CCT Research
Springville Utah, 84663, United States
Kalo Clinical Research
West Valley City Utah, 84120, United States
Virginia Dermatology Skin Cancer Center Pllc
Norfolk Virginia, 23502, United States
The Skin Centre
Benowa , 4217, Australia
Premier Specialists
Kogarah , 2217, Australia
The Alfred Hospital
Melbourne , 3004, Australia
ISHI dermatology
Mitcham , 3132, Australia
Royal Melbourne Hospital
Parkville , 3050, Australia
UNESP - Faculdade de Medicina da Universidade Estadual Paulista - Campus Botucatu
Botucatu , 18618, Brazil
Chronos Clinica Medica LTDA - Chronos Pesquisa Clinica
Brasilia , 72.14, Brazil
Hospital Das Clinicas Da Faculdade De Medicina De RPUSP HCRP
Ribeirao Preto , 14048, Brazil
Fundacao do ABC - Centro Universitario FMABC
Santo Andre , 09060, Brazil
Hospital Das Clinicas Da Faculdade De Medicina Da USP
Sao Paulo , 05403, Brazil
Dr. Chih-ho Hong Medical
Surrey British Columbia, V3R 6, Canada
Wiseman Dermatology Research Inc.
Winnipeg Manitoba, R3M 3, Canada
Lovegrove Dermatology
London Ontario, N6A 5, Canada
Lynderm Research Inc.
Markham Ontario, L3P 1, Canada
DermEdge Research
Mississauga Ontario, L4Y 4, Canada
Skin Centre for Dermatology
Peterborough Ontario, K9J 5, Canada
North York Research Inc
Toronto Ontario, M2N 3, Canada
Toronto Research Centre
Toronto Ontario, M3H 5, Canada
XLR8 Medical Research
Windsor Ontario, N8T 1, Canada
Innovaderm Research Inc.
Montreal Quebec, H2X 2, Canada
Centre De Recherche Dermatologique Du Quebec Metropolitain
Quebec , G1V 4, Canada
Hautarztpraxis Dr. Mihaescu
Augsburg , 86150, Germany
Fachklinik Bad Bentheim
Bad Bentheim , 48455, Germany
CRS Clinical Research Services Berlin GmbH
Berlin , 13627, Germany
Niesmann & Othlinghaus GbR
Bochum , 44793, Germany
Klinikum Darmstadt GmbH - Hautklinik
Darmstadt , 64283, Germany
Medizinische Fakultat Carl Gustav Carus Technische Universitat Dresden
Dresden , 01307, Germany
Hautzentrum Dulmen
Dulmen , 48249, Germany
Privatpraxis Dr. Hilton & Partner
Dusseldorf , 40212, Germany
Derma-Study-Center Friedrichshafen GmbH
Friedrichshafen , 88045, Germany
Eurofins bioskin GmbH
Hamburg , 20095, Germany
Universitaetsklinikum Heidelberg
Heidelberg , 69120, Germany
Hautarztpraxis
Mahlow , 15831, Germany
Universitätsmedizin der Johannes Gutenberg-Universität Mainz
Mainz , 55131, Germany
Hautmedizin Saar
Merzig , 66663, Germany
Universitaetsklinikum Muenster
Muenster , 48149, Germany
Klinikum Oldenburg
Oldenburg , 26133, Germany
Hautarztpraxis
Witten , 58453, Germany
CentroDerm GmbH
Wuppertal , 42287, Germany
Uno Medical Trials Ltd.
Budapest , 1152, Hungary
Bugat Pal Korhaz
Gyongyos , 3200, Hungary
Synexus Magyarorszag Kft
Gyula , 5700, Hungary
Bacs Kiskun Varmegyei Oktatokorhaz
Kecskemet , 6000, Hungary
Synexus Magyarorszag Kft
Zalaegerszeg , H-890, Hungary
Korea University Ansan Hospital
Ansan-si , 15355, Korea, Republic of
Hallym University Sacred Heart Hospital
Anyang-si , 14068, Korea, Republic of
The Catholic University of Korea Bucheon St Mary s Hospital
Bucheon si , 14647, Korea, Republic of
Chosun university hospital
Gwangju , 61453, Korea, Republic of
CHA Bundang Medical Center, CHA University
Seongnam , 13496, Korea, Republic of
Asan Medical Center
Seoul , 05505, Korea, Republic of
Korea University Guro Hospital
Seoul , 8308, Korea, Republic of
Renew Clinic
Bialystok , 15 79, Poland
Care Clinic
Katowice , 40-56, Poland
Centrum Medyczne Angelius Provita
Katowice , 40-61, Poland
Prywatny Gabinet Dermatologiczny Elzbieta Klujszo
Kielce , 25-31, Poland
SGD s.c.
Krakow , 30-00, Poland
Krakowskie Centrum Badan Klinicznych
Krakow , 30-30, Poland
Jagiellonskie Centrum Innowacji
Krakow , 30-34, Poland
Diamond Clinic
Krakow , 31-55, Poland
Etyka Osrodek Badan Klinicznych
Olsztyn , 10 11, Poland
Royalderm Agnieszka Nawrocka
Warsaw , 02-96, Poland
Synexus Polska Sp z o o Oddzial w Warszawie
Warszawa , 02 67, Poland
Carpe Diem Centrum Medycyny Estetycznej
Warszawa , 02-66, Poland
WroMedica I.Bielicka, A.Strzałkowska s.c.
Wrocław , 51-68, Poland
Cabinet Medical Dermato-Venerologie
Cluj-Napoca , 40010, Romania
Centrul Medical Vitaplus
Craiova , 20054, Romania
Spitalul Clinic Judetean de Urgenta
Craiova , 20064, Romania
Sc Iasiprest Srl
Iasi , 70038, Romania
Spitalul Clinic Judetean de Urgenta Bihor
Oradea , 41016, Romania
New Derm Clinic
Timisoara , 30075, Romania
Hosp. Univ. Fundacion Alcorcon
Alcorcon , 28922, Spain
Hosp. Univ. Germans Trias I Pujol
Badalona , 08916, Spain
Hosp. Clinic de Barcelona
Barcelona , 08036, Spain
Hosp. de Manises
Manises , 46940, Spain
Hosp. Clinico Univ. de Salamanca
Salamanca , 37007, Spain
Clinica Gaias
Santiago de Compostela , 15702, Spain
Hosp. Clinico Univ. de Santiago
Santiago de Compostela , 15706, Spain
Hosp. Virgen Macarena
Sevilla , 41009, Spain
Hosp. Ntra. Sra. de Valme
Sevilla , 41014, Spain
Hosp. de La Marina Baixa
Villajoyosa , 03570, Spain
Hosp. Clinico Univ. Lozano Blesa
Zaragoza , 50009, Spain
Kaohsiung Medical University Chung-Ho Memorial Hospital
Kaohsiung , 80756, Taiwan
Kaohsiung Veterans General Hospital
Kaohsiung , 81362, Taiwan
Chung Shan Medical University Hospital
Taichung , 40201, Taiwan
Taichung Veterans General Hospital
Taichung , 40705, Taiwan
National Cheng Kung University Hospital
Tainan , 710, Taiwan
Taipei Medical University
Taipei , 110, Taiwan
Taipei Municipal Wanfang Hospital
Taipei , 116, Taiwan

How clear is this clinincal trial information?

Study is for people with:

Psoriasis

Phase:

Phase 3

Estimated Enrollment:

675

Study ID:

NCT06220604

Recruitment Status:

Recruiting

Sponsor:


Janssen Research & Development, LLC

How clear is this clinincal trial information?

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