Psoriasis Clinical Trial

A Study of JNJ-77242113 for the Treatment of Participants With Moderate to Severe Plaque Psoriasis

Summary

The purpose of the study is to see how effective JNJ-77242113 is in participants with moderate to severe plaque psoriasis compared to placebo and deucravacitinib.

View Eligibility Criteria

Eligibility Criteria

Inclusion Criteria:

Diagnosis of plaque psoriasis, with or without psoriatic arthritis (PsA), for at least 26 weeks prior to the first administration of study intervention
Total body surface area (BSA) greater than or equal to (>=)10 percent (%) at screening and baseline
Total psoriasis area and severity index (PASI) >=12 at screening and baseline
Total investigator global assessment (IGA) >=3 at screening and baseline
Candidate for phototherapy or systemic treatment for plaque psoriasis

Exclusion Criteria:

Nonplaque form of psoriasis (for example, erythrodermic, guttate, or pustular)
Current drug-induced psoriasis (for example, a new onset of psoriasis or an exacerbation of psoriasis from beta blockers, calcium channel blockers, or lithium)
A current diagnosis or signs or symptoms of severe, progressive, or uncontrolled renal, liver, cardiac, vascular, pulmonary, gastrointestinal, endocrine, neurologic, hematologic, rheumatologic, psychiatric, or metabolic disturbances
Known allergies, hypersensitivity, or intolerance to JNJ-77242113, deucravacitinib, or to any of the excipients or components of the study intervention
Major surgical procedure, (for example, requiring general anesthesia) within 8 weeks before screening, or will not have fully recovered from surgical procedure, or has a surgical procedure planned during the time the participant is expected to participate in the study

Study is for people with:

Psoriasis

Phase:

Phase 3

Estimated Enrollment:

750

Study ID:

NCT06143878

Recruitment Status:

Recruiting

Sponsor:

Janssen Research & Development, LLC

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There are 161 Locations for this study

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Medical Dermatology Specialists
Phoenix Arizona, 85006, United States
Center for Dermatology and Plastic Surgery
Scottsdale Arizona, 85260, United States
Johnson Dermatology
Fort Smith Arkansas, 72916, United States
First OC Dermatology
Fountain Valley California, 92708, United States
Center for Dermatology Clinical Research
Fremont California, 94538, United States
Integrative Skin Science and Research
Sacramento California, 95815, United States
Southern California Dermatology
Santa Ana California, 92701, United States
Clinical Science Institute
Santa Monica California, 90404, United States
Driven Research LLC
Coral Gables Florida, 33134, United States
Ziaderm Research, LLC
North Miami Beach Florida, 33162, United States
Renstar Medical Research
Ocala Florida, 34470, United States
Forcare Clinical Research Inc
Tampa Florida, 33613, United States
Hamilton Research, LLC.
Alpharetta Georgia, 30022, United States
Skin Care Physicians of Georgia
Macon Georgia, 31217, United States
Illinois Dermatology Institute - Chicago Loop Office
Chicago Illinois, 60602, United States
Arlington Dermatology
Rolling Meadows Illinois, 60008, United States
Northshore Medical Group
Skokie Illinois, 60077, United States
Dundee Dermatology
West Dundee Illinois, 60118, United States
Dawes Fretzin Clinical Research Group, LLC
Indianapolis Indiana, 46250, United States
Indiana Clinical Trial Center
Plainfield Indiana, 46168, United States
Dermatology Specialists
Louisville Kentucky, 40241, United States
Dermatology and Advanced Aesthetics
Lake Charles Louisiana, 70605, United States
Tufts Medical Center
Boston Massachusetts, 02111, United States
David Fivenson MD, Dermatology
Ann Arbor Michigan, 48103, United States
Michigan Center of Medical Research
Clarkston Michigan, 48346, United States
Henry Ford Medical Center
Detroit Michigan, 48202, United States
Hamzavi Dermatology
Fort Gratiot Michigan, 48059, United States
MediSearch Clinical Trials
Saint Joseph Missouri, 64506, United States
Skin Specialists
Omaha Nebraska, 68144, United States
Fife Dermatology
Las Vegas Nevada, 89119, United States
Allcutis Research
Portsmouth New Hampshire, 03801, United States
Windsor Dermatology
East Windsor New Jersey, 08520, United States
Schweiger Dermatology Group
Hackensack New Jersey, 07601, United States
Derm Research Center of New York, Inc.
Stony Brook New York, 11790, United States
Wilmington Dermatology Center
Wilmington North Carolina, 28405, United States
Oakview Dermatology
Athens Ohio, 45701, United States
Optima Research
Boardman Ohio, 44512, United States
Central Sooner Research
Oklahoma City Oklahoma, 73170, United States
Oregon Medical Research Center
Portland Oregon, 97201, United States
Health Concepts
Rapid City South Dakota, 57702, United States
Modern Research Associates
Dallas Texas, 75231, United States
Center for Clinical Studies
Houston Texas, 77004, United States
Austin Institute for Clinical Research
Houston Texas, 77056, United States
Austin Institute for Clinical Research
Pflugerville Texas, 78660, United States
Progressive Clinical Research
San Antonio Texas, 78213, United States
Texas Dermatology and Laser Specialists
San Antonio Texas, 78218, United States
Center for Clinical Studies
Webster Texas, 77598, United States
National Clinical Research
Richmond Virginia, 23294, United States
Frontier Derm Partners CRO, LLC
Mill Creek Washington, 98012, United States
Premier Clinical Research
Spokane Washington, 99202, United States
Instituto Medico De Alta Complejidad (IMAC)
Buenos Aires , B1643, Argentina
ARCIS Salud SRL Aprillus asistencia e investigacion
Buenos Aires , C1406, Argentina
Halitus Instituto Medico S.A. - Dermatologia y Estetica
Caba , C1122, Argentina
Hospital Italiano de Buenos Aires
Caba , C1199, Argentina
Instituto de Neumonologia y Dermatologia
Caba , C1425, Argentina
Hospital Italiano de La Plata
La Plata , B1900, Argentina
Instituto Caici Srl.
Rosario , S2000, Argentina
Centro de Investigaciones Medicas Tucuman
San Miguel De Tucuman , T4000, Argentina
North Eastern Health Specialists
Campbelltown , 5074, Australia
Sinclair Dermatology
East Melbourne , 3002, Australia
Skin Health Institute Inc.
Melbourne , 3053, Australia
Veracity Clinical Research
Woolloongabba , 4102, Australia
Fundacao do ABC - Centro Universitario FMABC
Santo Andre , 09060, Brazil
Enverus Medical
Surrey British Columbia, V3V 0, Canada
Karma Clinical Trials Inc.
St. John's Newfoundland and Labrador, A1A 4, Canada
CCA Medical Research Corporation
Ajax Ontario, L1S7K, Canada
SimcoDerm Medical and Surgical Dermatology Centre
Barrie Ontario, L4M 7, Canada
Dermatrials Research
Hamilton Ontario, L8N 1, Canada
York Dermatology Clinic and Research Centre
Richmond Hill Ontario, L4C 9, Canada
Alliance Clinical Trials
Waterloo Ontario, N2J 1, Canada
XLR8 Medical Research
Windsor Ontario, N8T 1, Canada
ISA - Interdisciplinary Study Association GmbH
Berlin , 10789, Germany
Hautarztpraxis
Bramsche , 49565, Germany
Klinische Forschung Dresden GmbH
Dresden , 01069, Germany
Praxis für Dermatologie und Venerologie
Dresden , 01097, Germany
Universitaetsklinikum Duesseldorf
Duesseldorf , 40225, Germany
Universitaetsklinikum Hamburg Eppendorf
Hamburg , 20246, Germany
MensingDerma research GmbH
Hamburg , 22391, Germany
Universitaetsklinikum Schleswig-Holstein Campus Kiel
Kiel , 24105, Germany
Studienzentrum Dr Schwarz Germany
Langenau , 89129, Germany
Universitätsklinikum Leipzig AÖR
Leipzig , 04103, Germany
Universitatsklinikum Schleswig Holstein Campus Lubeck
Lubeck , 23562, Germany
Universitaetsklinikum Mannheim
Mannheim , 68167, Germany
Klinik und Poliklinik fur Dermatologie und Allergologie am Biederstein
Munchen , 80802, Germany
Hautarztpraxis
Potsdam , 14467, Germany
Universitaetsmedizin Rostock
Rostock , 18057, Germany
Pecsi Tudomanyegyetem
Borgyogyaszati Klinika , 7632, Hungary
Obudai Egeszsegugyi Centrum Kft
Budapest , 1036, Hungary
Derma-B Kft
Debrecen , 4031, Hungary
Debreceni Egyetem Klinikai Kozpont
Debrecen , 4032, Hungary
Somogy Varmegyei Kaposi Mor Oktato Korhaz
Kaposvar , 7400, Hungary
SZTE AOK Szent-Gyorgyi Albert Klinikai Kozpont, Borgyogyaszati és Allergologiai Klinika
Szeged , 6720, Hungary
Allergo-Derm Bakos Kft.
Szolnok , 5000, Hungary
Medmare Egeszsegugyi Es Szolgaltato Bt.
Veszprem , 8200, Hungary
Fukuoka University Hospital
Fukuoka , 814-0, Japan
Hino Dermatology Clinic
Fukutsu , 811-3, Japan
Gifu University Hospital
Gifu , 501-1, Japan
Gunma University Hospital
Gunma , 371-8, Japan
JR Sapporo Hospital
Hokkaido , 060-0, Japan
Asahikawa Medical University Hospital
Hokkaido , 078-8, Japan
Tokai University Hospital
Isehara , 259-1, Japan
Teikyo University Hospital
Itabashi Ku , 173 8, Japan
St Marianna University Hospital
Kawasaki City , 216-8, Japan
Hospital of the University of Occupational and Environmental Health
Kitakyushu-shi , 807-8, Japan
Nagoya City University Hospital
Nagoya , 467 8, Japan
University of the Ryukyus Hospital
Nishihara , 903-0, Japan
Takagi Dermatology Clinic
Obihiro-shi , 080-0, Japan
Kindai University Hospital
Osaka-Sayama-shi , 589-8, Japan
Public Interest Incorporated Foundation Nipoon Life Saiseikai Nippon Life Hospital
Osaka , 550 0, Japan
Kume Clinic
Sakai-shi , 593-8, Japan
Sapporo Skin Clinic
Sapporo shi , 060 0, Japan
Tohoku University Hospital
Sendai , 980-8, Japan
Osaka University Hospital
Suita-shi , 565-0, Japan
Jitaikai Tachikawa dermatology clinic
Tachikawa , 190 0, Japan
Shirasaki Dermatology Clinic
Takaoka-shi , 933-0, Japan
Tokyo Medical University Hospital
Tokyo , 160-0, Japan
Mie University Hospital
Tsu , 514 8, Japan
Pusan National University Hospital
Busan , 49241, Korea, Republic of
Seoul National University Bundang Hospital
Gyeonggi-do , 13620, Korea, Republic of
Seoul National University Hospital
Seoul , 03080, Korea, Republic of
Hanyang University Medical Center
Seoul , 04763, Korea, Republic of
Konkuk University Medical Center
Seoul , 05030, Korea, Republic of
The Catholic University of Korea Seoul St. Mary's Hospital
Seoul , 06591, Korea, Republic of
Kyung Hee University Hospital
Seoul , 130 0, Korea, Republic of
Specderm Poznanska sp j
Bialystok , 15 37, Poland
Osteo-Medic s.c A. Racewicz, J Supronik
Bialystok , 15-35, Poland
Centrum Kliniczno Badawcze J. Brzezicki, B. Gornikiewicz-Brzezicka Lekarze Spolka Partnerska
Elblag , 82-30, Poland
Specjalistyczny gabinet dermatologiczny Aplikacyjno Badawczy Marek Brzewski Pawel Brzewski Spolka Cywilna
Krakow , 30 00, Poland
Lidia Rajzer - Specjalistyczny Gabinet Dermatologiczno-Kosmetyczny
Krakow , 30-43, Poland
Centrum Medyczne Promed
Krakow , 31-41, Poland
Dermed Centrum Medyczne Sp z o o
Lodz , 90 26, Poland
Centrum Terapii Wspolczesnej J M Jasnorzewska Spolka Komandytowo Akcyjna
Lodz , 90-33, Poland
DermoDent Centrum Medyczne Aldona Czajkowska Rafał Czajkowski s.c.
Osielsko , 86031, Poland
SOLUMED Centrum Medyczne
Poznan , 60-52, Poland
Clinical Research Center sp z o o MEDIC R s k
Poznan , 61 73, Poland
Przychodnia Specjalistyczna High Med
Warszawa , 01 81, Poland
Klinika Ambroziak Dermatologia
Warszawa , 02-95, Poland
DERMMEDICA Sp.z o.o.
Wroclaw , 51 50, Poland
Centrum Medyczne Oporow
Wroclaw , 52-41, Poland
WroMedica I.Bielicka, A.Strzałkowska s.c.
Wrocław , 51-68, Poland
Hosp. Gral. Univ. Dr. Balmis
Alicante , 03010, Spain
Hosp. Univ. de Cruces
Barakaldo , 48902, Spain
Hosp. de La Santa Creu I Sant Pau
Barcelona , 08041, Spain
Hosp. Univ. San Cecilio
Granada , 18016, Spain
Hosp. Univ. de Bellvitge
L'Hospitalet de Llobregat , 08907, Spain
Hosp. Univ. de La Princesa
Madrid , 28006, Spain
Pedro Jaen Group
Madrid , 28006, Spain
Hosp. Gral. Univ. Gregorio Maranon
Madrid , 28007, Spain
Hosp. Univ. Infanta Leonor
Madrid , 28031, Spain
Hosp. Univ. 12 de Octubre
Madrid , 28041, Spain
Hosp. Univ. de La Paz
Madrid , 28046, Spain
Hosp. Univ. I Politecni La Fe
Valencia , 46026, Spain
National Taiwan University Hospital Hsin-Chu Branch
Hsin Chu , 30059, Taiwan
Chang Kung Memorial Hospital
Kaohsiung City , 833, Taiwan
Taipei Medical University Shuang Ho Hospital
New Taipei City , 235, Taiwan
National Taiwan University Hospital
Taipei , 10048, Taiwan
Taipei Mackay Memorial Hospital
Taipei , 10449, Taiwan
Taipei Veterans General Hospital
Taipei , 112, Taiwan
Linkou Chang Gung Memorial Hospital
Taoyuan , 33382, Taiwan
Guy's and St Thomas' NHS Foundation Trust
London , SE1 9, United Kingdom
Royal Berkshire Hospital
Reading , RG1 5, United Kingdom
Salford Royal Hospital
Salford , M6 8H, United Kingdom
University Hospital Southampton NHS Foundation Trust
Southampton , SO16 , United Kingdom

How clear is this clinincal trial information?

Study is for people with:

Psoriasis

Phase:

Phase 3

Estimated Enrollment:

750

Study ID:

NCT06143878

Recruitment Status:

Recruiting

Sponsor:


Janssen Research & Development, LLC

How clear is this clinincal trial information?

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