Comedian Amy Schumer, 42, Stopped Taking Ozempic After Side Effects Made Her Feel ‘So Sick’— What Is The Risk of New Blockbuster Weight Loss Drugs?

“Like a year ago, I tried it. I was one of those people that felt so sick and couldn’t play with my son. I was so skinny and he’s throwing a ball at me and [I couldn’t],” Schumer said, according to People.

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“You’re like, ‘OK this isn’t livable for me,’ but I immediately invested because I’m like, ‘Everyone and their mom is going to try it.'”

Referring to other celebrities, Schumer added, “Everybody (is) lying, everyone’s like, ‘Oh, smaller portions,’ like shut the f— up, you’re on Ozempic or one of those things. Just be real with the people.

“When I got lipo, I was like, ‘I got lipo, OK?'”

Schumer, who also previously opened up about undergoing liposuction on Chelsea Handler’s podcast “Dear Chelsea,” said she chose to have the surgery done after turning 40, following a C-section, and having her uterus and appendix removed to stop her endometriosis pain, according to People.

She said at the time, “I just wanted to say that, because if anybody sees me in pictures or anything and they’re like, she looks thinner, and whatever: it’s because I had a surgery. It’s too hard, and I just want to be real about it.”

As for the drug Schumer previously took for weight loss—highly popular drug Novo Nordisk’s semaglutide (known under the brand names Ozempic, Rybelsu, Wegovy)—healthcare company Lexicomp has reveals there are negative side effects of the medication, including an increased risk of cancer.

Lexicomp explains Ozempic as “an injectable prescription medicine for adults with type 2 diabetes mellitus that: along with diet and exercise may improve blood sugar (glucose),” noting it’s not the first choice of medicine for treating diabetes.

As for the most important information people should know before taking the drug, Lexicomp says Ozempic may cause serious side effects.

Some of the possible side effects include: inflammation of your pancreas (pancreatitis), changes in vision, low blood sugar, kidney problems, kidney failure, and serious allergic reactions.

“The most common side effects of OZEMPIC may include nausea, vomiting, diarrhea, stomach (abdominal) pain and constipation. Talk to your healthcare provider about any side effect that bothers you or does not go away,” Lexicomp states.

“These are not all the possible side effects of OZEMPIC. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.”

The Memorial Sloan Kettering Cancer Center explains, regarding Lexicomp’s warning, “This drug has been shown to cause thyroid cancer in some animals. It is not known if this happens in humans.

“If thyroid cancer happens, it may be deadly if not found and treated early. Call your doctor right away if you have a neck mass, trouble breathing, trouble swallowing, or have hoarseness that will not go away.

“Do not use this drug if you have a health problem called Multiple Endocrine Neoplasia syndrome type 2 (MEN 2), or if you or a family member have had thyroid cancer.”

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The side effects that call for immediate medical attention, in regard to all uses of the drug, the MSKCC lists as:

• Signs of an allergic reaction, like rash; hives; itching; red, swollen, blistered, or peeling skin with or without fever; wheezing; tightness in the chest or throat; trouble breathing, swallowing, or talking; unusual hoarseness; or swelling of the mouth, face, lips, tongue, or throat.
• Signs of kidney problems like unable to pass urine, change in how much urine is passed, blood in the urine, or a big weight gain.
• Signs of gallbladder problems like pain in the upper right belly area, right shoulder area, or between the shoulder blades; change in stools; dark urine or yellow skin or eyes; or fever with chills.
• Severe dizziness or passing out.
• A fast heartbeat.
• Change in eyesight.
• Low blood sugar can happen. The chance may be raised when this drug is used with other drugs for diabetes. Signs may be dizziness, headache, feeling sleepy or weak, shaking, fast heartbeat, confusion, hunger, or sweating. Call your doctor right away if you have any of these signs. Follow what you have been told to do for low blood sugar. This may include taking glucose tablets, liquid glucose, or some fruit juices.
• Severe and sometimes deadly pancreas problems (pancreatitis) have happened with this drug. Call your doctor right away if you have severe stomach pain, severe back pain, or severe upset stomach or throwing up.

For anyone using the drug for weight loss, they should speak with their doctor if they notice “new or worse behavior or mood changes like depression or thoughts of suicide.”

RELATED: What Are The New Weight Loss Drugs Everyone Is Talking About & What’s The Connection Between Weight And Cancer?

How Does Semaglutide Work?

Integral to blood sugar control, GLP-1 is a hormone released by the gut in response to food. It causes the pancreas to release insulin. A rising blood insulin level causes all the body tissues to start absorbing glucose (blood sugar) from the bloodstream, thereby lowering blood glucose levels. GLP-1 also prevents the release of glucagon, which is a hormone that raises blood sugar levels by stimulating liver cells to release glucose and helps people feel full for longer. These effects can also cause people to lose weight.

Modern studies on GLP-1 have shown that it has a role beyond glucose control. It modulates the immune system cells, including NK cells, in a way necessary for weight loss.

Semaglutide is a GLP-1 receptor agonist, meaning that it mimics the effects of GLP-1 in the body. Given as weekly subcutaneous injections It is normally prescribed to manage blood glucose levels in diabetic patients. It also leads to a significant amount of weight loss in these patients.

Semaglutide Communicates With The Immune System

In a recent study, researchers studied the interaction between semaglutide and NK cell function in 20 patients with obesity. They were started on semaglutide therapy, given weekly, for 6 months. NK cells were isolated from these patients before commencing therapy and after 6 months of therapy completion. Their number and their function were measured to see if it was influenced by semaglutide.

Patients had no significant change in NK cell numbers after receiving semaglutide for 6 months. NK cell function, however, was significantly improved by the drug. The researchers detected a measured increase in cytokines after semaglutide therapy. Cytokines are small molecules released by NK cells that are essential to their function. This includes enhancing their anti-cancer activity. Additionally, 9 out of 20 patients had a significant change in their body weight during the study period.

It should be noted that this was a relatively small study of 20 patients. It nonetheless highlights an important benefit of semaglutide that should be explored in larger future studies.

Is It Weight Loss Or Semaglutide That Improves Immune Function?

Since the patients in the study lost weight, it is fair to question whether it was the weight loss or semaglutide that improved the NK cell function.

The researchers anticipated this confusion and tested whether the observed weight loss was associated with changes in NF-associated cytokine production. They found no correlation between the two, thereby demonstrating that the improved NK cell function was indeed due to the medication use. They further cemented this association by exposing extracted NK cells to GLP-1 directly, which caused them to significantly increase their cytokine production.

Semaglutide Carries Side Effects

Semaglutide is an invaluable addition to the repertoire of drugs used to fight diabetes and obesity and strengthen the immune system, as demonstrated by the study. However, like all drugs, it carries side effects that must be considered by anyone contemplating treatment with semaglutide.

Side effects include:

• Nausea.
• Vomiting.
• Stomach Pain.
• Constipation or Diarrhea.
• Low blood sugar, which can cause dizziness, confusion, sweating, and headaches.

Most of these side effects can be managed with lifestyle modifications, such as eating more slowly and avoiding greasy and fried food.

Semaglutide can, occasionally, cause serious side effects, such as:

• Inflammation of the pancreas
• Gallbladder problems
• Kidney problems
• Allergic reactions

These side effects require prompt medical attention.

Can Semaglutide Be Used To Boost Immunity & Prevent Cancer?

Currently, semaglutide is approved for blood sugar control in people with type II diabetes, under the brand name Ozempic. Under the brand name Wegovy, it has also been approved for weight loss.

Semaglutide is, however, not approved for use as an immune booster and cancer preventative. Thus, it should not be prescribed for that purpose. Those taking it to control their diabetes or weight, however, can expect the additional benefit of improving their immunity and lowering their cancer risk.

The current semaglutide landscape may change in the future as more and more studies discover its benefits beyond controlling diabetes and aiding in weight loss.

Weight and Cancer Risk

Being overweight or obese is clearly linked to an overall increased risk of cancer, according to the American Cancer Society. And in a 2022 study out of Brigham and Women’s Hospital, Boston, researchers found that childhood obesity may lead to an early cancer diagnosis.

In a previous interview with SurvivorNet, Dr. Andrea Tufano-Sugarman of NYU Langone Health talked about the importance of maintaining a healthy weight.

“While all cancers cannot be prevented, losing weight is a great way to reduce one’s risk,” she said.

Major Reduction in Cancer Risk by Following Old Standbys Diet and Exercise

Dr. Stephen Freedland of Cedars Sinai Medical Center also notes that obesity can affect a person’s prostate cancer risk and prognosis.

“Some of the best data we have is that obesity increases the risk of not just getting prostate cancer, but actually dying from prostate cancer,” Dr. Freeland previously told SurvivorNet. “Obese men are 35 percent more likely to die from prostate cancer.”

The Link Between Obesity and Prostate Cancer

Being overweight or obese is clearly linked with an increased risk of many types of cancer including the following:

• • • Breast cancer (in women past menopause)
    • Colon and rectal cancer
    • Endometrial cancer (cancer of the lining of the uterus)
    • Esophagus cancer
    • Gallbladder cancer
    • Kidney cancer
    • Liver cancer
    • Ovarian cancer
    • Pancreas cancer
    • Stomach cancer
    • Thyroid cancer
    • Multiple myeloma
    • Meningioma (a tumor of the lining of the brain and spinal cord)

Being overweight or obese might also raise the risk of other cancers such as:

• • • Non-Hodgkin lymphoma
    • Male breast cancer
    • Cancers of the mouth, throat, and voice box
    • Aggressive forms of prostate cancer

It’s also important to know that conditions caused or exasperated by obesity like diabetes and heart disease can pose problems for people who’ve already been diagnosed with cancer. They can lead to treatment complications, prevent people from receiving the recommended first-line therapies and even increase the risk of undergoing surgery. Overweight patients might not even have the option of surgery since removing the cancer could pose potential complications that could outweigh the benefits.

RELATED: 16 States Now Have Adult Obesity Rates At or Above 35%. What Does This Mean for Cancer Risk and Treatment?

Dr. Sairah Ahmed, associate professor in the division of cancer medicine at the University of Texas MD Anderson Cancer Center, previously said focusing on diet and exercise in a healthy way can help a person with cancer feel like they have more control.

“Diet, exercise and stress control are extremely important when going through cancer therapy, as well as once you’re done treating your cancer and trying to get back to the rest of your life,” she said.

Dr. Ahmed wants to remind people that none of the gimmicky diets are helpful for cancer-fighting. She says the main goal should be to simply consume nutritious foods.

What to Know about Diet and Exercise if You Have Cancer

“I’m asked about keto diets, alkaline diets, no-sugar diets,” she said. “Often I will tell patients there is not any one diet that has a better potential to keep their cancer away. There’s no data that shows that any of those help to treat cancer any better.

“You want to have a moderate diet where you’re including lots of fruits and vegetables, but you’re still eating fat and protein, and you want to maintain physical exercise,” she said

Dr. Ken Miller says a healthy diet and regular workout routine are important

Dr. Ken Miller, the director of outpatient oncology at the University of Maryland Greenebaum Cancer Center, recommends these four things for cancer survivors to do to try and avoid another cancer diagnosis:

• • • Exercise at least two hours a week, walking counts
    • Eat a low-fat diet
    • Eat a colorful diet with lots of fruits and vegetables, doctors recommend two to three cups a day
    • Maintain a healthy weight

Contributing: SurvivorNet Staff

Learn more about SurvivorNet's rigorous medical review process.

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