New Discovery Explains Some Racial Disparities in Colon Cancer

Did you know that one side of your colon ages faster than the other? And if you’re African American, one side ages a lot faster than the other. Those were the results of a new study by researchers at the University of Virginia. The research could help explain some of disparities in the colon cancer rates among African American people and white people. But it leaves a lot unanswered, too.

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“This is an interesting study, but it doesn’t account for all the racial disparities in colon cancer,” Heather Yeo, MD, tells SurvivorNet. “It may help us understand why there is an increased risk of colon cancer in African Americans, but it doesn’t tell us why they do worse overall.” Yeo is a surgical oncologist who specializes in colon and rectal surgery at Weill Cornell Medicine.

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Colons Age at Different Rates

Researchers studied the DNA of cells from the colons of African American people and white people. Across the board, they found that the right side of the colon seems to age faster than the left. But, how much faster depended on race. The right side of the colons of African Americans seems to age fastest.

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This difference could contribute to the overall higher rates of colon cancer among African Americans compared to white people and the higher rates of cancers on the right side of the colon in African Americans. Also, because cancer in general is an age-related disease, this study could explain, at least in part, why African Americans may be more likely to get colon cancer at a younger age than white people do.

In partnership with NYU Langone and the Perlmutter Cancer Center, SurvivorNet is working to raise awareness about the huge disparities that exist for minorities when it comes to cancer care and survival rates.

But the study doesn’t explain all the biological differences in colon cancers between these two groups. It doesn’t, for example, offer any understanding as to why the gene mutations found in African American colon cancers tend to be different than those found in white cases of the disease, Yeo says.

Many Other Disparities to Consider

The speed at which the colon ages may be a factor in some race-based disparities in colon cancer. But, it doesn’t explain everything. It’s likely a combination of factors, including biology, lifestyle, access to care, and systemic racism that explains these differences.

Dr. Heather Yeo stresses the importance of colon cancer screening; breaks down the guidelines.

“It’s important to understand your risk of colon cancer,” Yeo says, “but it’s also important to work to minimize other healthcare disparities like access to screening and care, healthy foods, and awareness.”