Bladder Cancer Clinical Trial

HIPEC After Radical Cystectomy for High Risk Bladder Cancer

Summary

This is a non-randomized, non-blinded, pilot study administering hyperthermic intraperitoneal chemotherapy with Mitomycin-C in 10 men and women with muscle-invasive urothelial carcinoma of the bladder undergoing radical cystectomy with pelvic lymph node dissection who have risk factors for tumor recurrence.

View Eligibility Criteria

Eligibility Criteria

Inclusion Criteria:

Primary urothelial cell carcinoma of the bladder
Patient's aged 45-85, both genders.
ECOG performance status < 1
Hematology: ANC > 1.5x109/L; Platelets > 100x109/L
Women with child bearing potential who are negative for pregnancy test (urine or blood) and who agree to use effective contraceptive method. Reliable contraception should be used from trial screening and must be continued throughout the study. A woman of childbearing potential is defined as one who is biologically capable of becoming pregnant.

Signed and dated written informed consent to participate in this clinical trial must be obtained prior to any study procedure.

Either any of the following preoperative factors for increased risk of recurrence:

Lymphovascular invasion
Variant histology in the background of primary urothelial (notably plasmacytoid)
Clinical T3 or greater
Clinical N+

No prior neoadjuvant chemotherapy (NAC) or lack of response to NAC

Or any of the following perioperative factors for increased risk of recurrence:

Palpable concern for extravesical disease
Tumor spillage/bladder entry
Suspicious nodes or positive intraoperative frozen sections

Exclusion Criteria:

Subjects who have previously undergone intraperitoneal chemotherapy.
Subjects with tumor histology other than urothelial cell carcinoma.
Patients on concurrent anti-cancer therapy other than that allowed in the study.
Other prior malignancies, except for cured non-melanoma skin cancer or curatively treated in situ carcinoma of the cervix or adequately treated malignancies for which there has been no evidence of activity for more than 3 years.
Subjects with renal insufficiency defined as creatinine > 1.5x the upper limit of normal or a calculated creatinine clearance of < 50 cc/min.
Subjects with a condition which may interfere with the subjects' ability to understand the requirements of the study.
Known HIV, Hepatitis B or Hepatitis C positive.
Subjects with uncontrolled concurrent illness including, but not limited to, ongoing or severe infection requiring antibiotics, symptomatic congestive heart failure, unstable angina pectoris, acute gastrointestinal bleeding, psychiatric illness or other condition which in the opinion of the investigator, places the patient at an unacceptable risk for participation in the study.
Any condition that would preclude the ability to deliver appropriate IP therapy.

Study is for people with:

Bladder Cancer

Estimated Enrollment:

7

Study ID:

NCT03514888

Recruitment Status:

Completed

Sponsor:

Weill Medical College of Cornell University

Check Your Eligibility

Let’s see if you might be eligible for this study.

What is your age and gender ?

Submit

There is 1 Location for this study

See Locations Near You

Weill Cornell Medicine - New York Presbyterian Hospital
New York New York, 10065, United States

How clear is this clinincal trial information?

Study is for people with:

Bladder Cancer

Estimated Enrollment:

7

Study ID:

NCT03514888

Recruitment Status:

Completed

Sponsor:


Weill Medical College of Cornell University

How clear is this clinincal trial information?

×

Introducing, the Journey Bar

Use this bar to access information about the steps in your cancer journey.