Prostate Cancer Clinical Trial

Comparison of High-Dose Rate Brachytherapy and Stereotactic Ablative Radiotherapy as Monotherapy for the Treatment of Localized Prostate Cancer

Summary

This phase II trial compares high-dose rate brachytherapy and stereotactic ablative radiotherapy as monotherapy in treating patients with prostate cancer that has not spread to other parts of the body (localized). High-dose rate brachytherapy delivers radiation directly into the prostate within a few minutes by a single radioactive seed through temporarily placed plastic catheters inside the prostate gland. Stereotactic ablative radiotherapy is an external beam radiation method that delivers large doses of radiation to the cancer in a short period of time, usually 5 treatments. This trial aims to find which of these two approaches is better in terms of patient-reported quality of life.

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Full Description

PRIMARY OBJECTIVE:

I. To assess feasibility of a pilot non-randomized trial evaluating stereotactic ablative radiotherapy (SABR) and high-dose rate brachytherapy for localized prostate cancer.

OUTLINE: Patients elect to participate in arms 1 or 2.

ARM I: Patients undergo high-dose rate brachytherapy (HDR).

ARM II: Patients undergo SABR every other day for 5 treatments.

After completion of study treatment, patients are followed up periodically.

View Eligibility Criteria

Eligibility Criteria

Inclusion Criteria:

Histologically confirmed adenocarcinoma of the prostate diagnosed within the last 9 months. Patients on active surveillance with evidence of disease progression are eligible to the protocol as long as they meet the eligibility criteria and have a recent prostate biopsy (within 9 months)

Low-risk and intermediate-risk patients are eligible according to the following guidelines:

Low and intermediate-risk disease defined as:

Clinical stage T1-T2 and Gleason =< 7 and prostate specific antigen (PSA) < 15 ng/ml
Lymph node evaluation by either computed tomography (CT) or magnetic resonance imaging (MRI) and bone scan are optional and are left at the discretion of the treating physician
Prostate MRI is recommended by not mandatory
No alpha reductase inhibitors use within 2 weeks of randomization. A washout period of 2 weeks is required prior to randomization
Eastern Cooperative Oncology Group status 0-1
Judged to be medically fit for brachytherapy by a radiation oncologist
Concurrent, neoadjuvant and/or adjuvant androgen deprivation therapy (ADT) is not permitted
Prostate volume by trans-rectal ultrasound (TRUS) =< 60 cc
International Prognostic Scoring System (IPSS) =< 20 (alpha blockers allowed)
Patients must sign a study specific informed consent form prior to study entry
Patients must by accessible for treatment and follow-up. Patients registered on this trial must be treated and followed at the participating center. Investigators must assure themselves that patients enrolled in this trial will be available for complete documentation of the treatment, adverse events, and follow up
Protocol treatment is to begin within 4 weeks of patient randomization

Exclusion Criteria:

Patients with a history of other malignancies, except: adequately treated non-melanoma skin cancer, or other solid tumors curatively treated with no evidence of disease for >= 5 years
Prior or current bleeding diathesis
Radical surgery for carcinoma of the prostate, prior pelvic radiation, prior chemotherapy for prostate cancer, prior transurethral resection of the prostate (TURP), prior cryosurgery of the prostate
Stage T3b and evidence of nodal or distant metastatic disease on diagnostic CT, MRI or bone scan
Subjects who have plans to receive other concomitant or post treatment adjuvant antineoplastic therapy while on this protocol including surgery, cryotherapy, conventionally fractionated radiotherapy, hormonal therapy, or chemotherapy given as part of the treatment of prostate cancer

Severe, active co-morbidity, defined as follows:

Unstable angina and/or congestive heart failure requiring hospitalization within the last 6 months
Transmural myocardial infarction within the last 6 months
Acute bacterial for fungal infection requiring intravenous antibiotics at the time of registration
Chronic obstructive pulmonary disease exacerbation or other respiratory illness requiring hospitalization or precluding study therapy within 30 days before registration
Hepatic insufficiency resulting in clinical jaundice and/or coagulations defects; note, however, that laboratory tests for liver function and coagulation parameters are not required for entry into this protocol
Acquired immune deficiency syndrome (AIDS) based upon current Centers for Disease Control and Prevention (CDC) definition; note, however, that human immunodeficiency virus (HIV) testing is not required for entry into this protocol. The need to exclude patients with AIDS from this protocol is necessary because the treatments involved in this protocol may be significantly immunosuppressive. Protocol-specific requirements may also exclude immumo-compromised patients
Patients with history of inflammatory colitis (including Crohn's disease and ulcerative colitis) or collagen vascular diseases including rheumatoid arthritis and lupus are not eligible
Subjects who have a history of significant psychiatric illness
Men of reproductive potential who do not agree that they or their partner will use an effective contraceptive method such as condom/diaphragm and spermicidal foam, intrauterine device (IUD), or prescription birth control pills

Study is for people with:

Prostate Cancer

Phase:

Phase 2

Estimated Enrollment:

10

Study ID:

NCT04253483

Recruitment Status:

Recruiting

Sponsor:

Rutgers, The State University of New Jersey

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There are 3 Locations for this study

See Locations Near You

RWJBarnabas Health - Saint Barnabas Medical Center, Livingston
Livingston New Jersey, 07039, United States More Info
Lara Hathout
Contact
732-253-3954
[email protected]
Rutgers Cancer Institute of New Jersey
New Brunswick New Jersey, 08903, United States More Info
Lara Hathout
Contact
732-253-3954
[email protected]
Lara Hathout
Principal Investigator
Rutgers New Jersey Medical School
Newark New Jersey, 07101, United States More Info
Lara Hathout
Contact
732-253-3954
[email protected]
Lara Hathout
Principal Investigator

How clear is this clinincal trial information?

Study is for people with:

Prostate Cancer

Phase:

Phase 2

Estimated Enrollment:

10

Study ID:

NCT04253483

Recruitment Status:

Recruiting

Sponsor:


Rutgers, The State University of New Jersey

How clear is this clinincal trial information?

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