Isabella Strahan, Who Is In Remission From Brain Cancer, Is ‘Reminiscing’ On Modeling For Kenneth Cole’s Spring 2025 Collection

The college student and internet personality, who documented her cancer journey on YouTube, is seen in the brands ready-to-wear spring collection.

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A post shared by Isabella Strahan (@isabellastrahan)

In a video clip, also shared on her Instagram page, as well as by Kenneth Cole’s official account, Strahan is seen on the set of the photo shooting welcoming viewers behind the scenes to “raise awareness for mental health.”

Another clip shared on her account, showed her saying, “I am alive. Isn’t that a beautiful thing.”

Kenneth Cole’s official account wrote alongside the footage, “Our Spring 2025 collection, worn by @isabellastrahan.

“The day before her 19th birthday, Isabella was diagnosed with a cancerous brain tumor. Throughout her grueling treatment journey, she became a beacon of light for those in need. By documenting all of the ups and downs of her recovery on YouTube, she discovered the healing power of helping others.”

The post continued, “As she learned how to walk and talk again, she stepped up and used her voice to comfort, inspire, and give hope to others fighting to survive. Discover her story and shop her style at KennethCole.com.”

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A post shared by Kenneth Cole (@kennethcole)

After explaining her arduous cancer journey, which left her at one point unable to walk, she advised, “Something I would say to someone going through something similar is every day is a day closer to feeling better.

“So just look to the future, make goals for yourself. I think staying positive through the whole thing is key.”

Strahan continued, “There’s definitely points where I was feeling very awful, there was never points where I wanted to give up.

“I think my purpose going forward it to just be a voice in the cancer community. Kind of continue what I’ve been doing.”

The University of Southern California student concluded, “Just being alive and being able to experience human things is just so wonderful. Because like can change so quickly.”

Fans commented, “She’s an icon, she’s a legend, she is the moment” and “That is an extraordinarily beautiful thing!”

Another wrote, “You are amazing, you are strong, you are beautiful, you are smart, you are kind and i love you with my whole heart! So proud of you and how your year has changed soooo much.”

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A post shared by Kenneth Cole (@kennethcole)

Speaking to People about her experience modeling for Kenneth Cole, Strahan said, “Being on set for this campaign was amazing.

“I had the best time meeting everyone, and I was so comfortable. I went in the day before shooting the campaign for a fitting, and I was greeted with such kindness.”

She added, “It made me realize my words and actions do have power. I’m so honored to be a part of the campaign. I truly am inspired by all the work the brand does.”

Isabella’s Battle With Medulloblastoma

Isabella documented her journey in a series of video blogs, and she finally was dubbed “cancer-free” after having a clear scan in July 2024, she announced in a Vlog post.

Earlier in 2023, she revealed she was diagnosed with a malignant brain tumor after experiencing harsh headaches and nausea and had trouble walking.

More specifically, she had a medulloblastoma, which is a rare primary central nervous system tumor, the National Cancer Institute explains. This type of brain tumor is cancerous and grows quickly, making it more likely to spread to other parts of the body.

Common symptoms for this type of tumor may include:

• Difficulty walking or balancing
• Headaches
• Nausea
• Vomiting
• Difficulty with vision
• Seizures

She first underwent emergency surgery to remove most of the mass in her brain. Additional treatment includes radiation therapy, followed by chemotherapy, to try and get any remaining cancer cells left behind.

WATCH: Hair loss during chemo.

Strahan shared that she had a hellacious chemotherapy experience as she struggled with the grueling side effects of treatment.

Chemotherapy is an effective tool for oncologists to help treat cancer by stopping cancerous cells from growing, dividing, and spreading to other organs. Chemo works by traveling through the bloodstream, killing cancerous cells. However, the process also impacts healthy cells, leading to side effects.

Patients almost universally experience fatigue, often alongside gastrointestinal side effects, such as nausea. Doctors have many effective medications to combat chemo-induced nausea. “But mitigating that fatigue often depends on the patient,” says Dr. Renata Urban, a gynecologic oncologist at the University of Washington in Seattle.

Since reaching remission, Strahan said in one of her YouTube videos, “Ring the bell three times. It’s a toll to clearly say my treatment is done, this course is run, and I’m on my way.”

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A post shared by Isabella Strahan (@isabellastrahan)

Coping With Your New Body After Cancer Treatment

Cancer survivors often struggle with the changes others can see, whether temporary of permanent, like scarring, hair loss and weight gain. However, survivors also struggle with changes that may not be as obvious, such as infertility, and these can create body image issues and make survivors feel vulnerable.

One way to prepare yourself for possible body changes during cancer treatment is to understand that changes are possible but also, frequently temporary. This can also help build up your self-confidence. Your support group, filled with loved ones, can help you during this stage of your journey as well.

In a previous interview with SurvivorNet, psychologist Dr. Marianna Strongin shared some tips cancer survivors can explore to help manage the emotional toll body changes can have during treatment.

Dr. Strongin encourages survivors to take ownership of the part (or parts) of their body impacted mainly by cancer treatment. She says although they may represent “fear and pain,” they also represent “strength and courage.”

“Research has found that when looking in the mirror, we are more likely to focus on the parts of our body we are dissatisfied with, which causes us to have a negative self-view and lower self-esteem. Therefore, I would like you first to spend time gazing at the parts of your body you love, give them time, honor them, and then thank them,” Dr. Strongin said.

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Dr. Strongin then suggests looking at the part or parts of your body impacted by the cancer or cancer treatment. She recommends creating a regular practice of accepting your body image because it helps you accept your cancer journey emotionally and physically.

“As you allow yourself to spend more time looking at all of you, you will begin having a new relationship with your body. It may not happen immediately, but with time, you can begin honoring and thanking your new body,” Dr. Strongin added.

Protecting Your Inner Beauty and Self-Esteem

Dr. Strongin also previously explained to SurvivorNet, “Cancer changes who you are both physically and emotionally.” It’s important to understand that struggles with self-esteem can happen can take hold of anyone.

A study published in Frontiers in Psychology questioned how self-esteem should be considered in cancer patients. Researchers noted cancer patients’ framing of their diagnosis and how they cope with their diagnosis and subsequent treatment impacts their self-esteem throughout their cancer journeys.

“Adaptive adjustment strategies (positive reframing, use of emotional support, active coping, acceptance, and planning) in breast cancer patients were associated with high self-esteem. Social support also appears to be strongly related to self-esteem,” the study says.

If you find yourself wrestling with your emotions because of a diagnosis, remember you don’t have to go it alone. Your support group is filled with loved ones who are there to help you on your journey.

“The patient or person going through the stressful event should accept that emotions will be fluid. You may feel fine one day and then feel a massive stress wave the next. It’s also important for those you look to for support, whether that’s a therapist, friends, family, or both, to understand the fluidity of stress-related emotions,” psychiatrist Dr. Lori Plutchik says.

Understanding Brain Tumors

Brain tumors account for 85-90% of all primary central nervous system (CNS) tumors, according to the American Society of Clinical Oncology (ASCO). In 2023, the ASCO estimated that 24,810 adults (14,280 men and 10,530 women) in the United States would be diagnosed with primary cancerous tumors of the brain and spinal cord.

The central nervous system consists of the brain and spinal cord and acts as the main “processing center” for the body’s nervous system. The normal function of the brain and spinal cord can become difficult if there’s a tumor putting pressure on or spreading into normal tissue close by.

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There are many different types of brain and spinal cord tumors and some of which are more likely to spread into nearby parts of the brain or spinal cord than others. Slow-growing tumors may be considered benign, however, even these types of tumors can lead to serious problems.

Meanwhile, symptoms of brain tumors, as a whole, are usually caused by increased pressure in the skull. This pressure can stem from tumor growth, swelling in the brain, or blockage of cerebrospinal fluid (CSF), the American Cancer Society explains.

General symptoms may include:

• Headache
• Nausea
• Vomiting
• Blurred vision
• Balance problems
• Personality or behavior changes
• Seizures
• Drowsiness or even coma

Additionally, MD Anderson Cancer Center notes that changes in the ability to smell can also be a sign of brain tumors, and, more specifically, “strange smells” can be a symptom of seizures, which can result from brain tumors.

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It’s important to note that these symptoms are not exclusive to brain tumors. Still, you should always speak with your doctor if you’re experiencing any health problems.

Meanwhile, treatment options for brain cancer depend on a variety of factors, including the size and type of the tumor as well as the grade of the tumor.

Surgery, radiation, and chemotherapy are options doctors use to treat brain tumors. Cancer warriors are encouraged to talk to their doctor about their situation and the best treatment options.

Understanding Gliomas

There are various types of brain cancers and tumors that someone may be diagnosed with, so it’s important to understand that a glioma is a tumor originating in the central nervous system (CNS), specifically in the brain or spinal cord. A glioma originates in glial cells. Glial cells are supportive cells in the brain that protect and maintain the neurons. These types of tumors can either be benign (non-cancerous) or malignant (cancerous).

“Glioma is a broad term that refers to a whole range of different types of primary brain tumors,” Dr. Alexandra Miller, Director of the Neuro-Oncologist Division at NYU Langone Health, tells SurvivorNet.

“They’re tumors that originate in the brain and very rarely spread outside the brain to other parts of the body,” Dr. Miller continued.

Glioblastoma (GBM) is the most aggressive and lethal form of primary brain tumor. Classified as a Grade 4 glioma by the World Health Organization (WHO), glioblastoma presents significant challenges for treatment due to its highly invasive nature, rapid growth, and resistance to most conventional therapies.

WATCH: Understanding Gliomas

According to the National Cancer Institute, the average survival rate is 15 months with treatment and less than six if left untreated. While there is a five-year survival rate of averaging 6 percent, those individuals will never be cancer-free. They must continue receiving radiation and chemotherapy for the rest of their lives.

Clinical trials help doctors better understand cancer and discover more effective treatment methods. They also allow patients to try a treatment before it’s approved by the U.S. Food and Drug Administration (FDA), which can potentially be life-changing.

WATCH: Clinical Trials can be Life-Saving

Within the U.S., all new drugs must go through clinical trials before the FDA approves them. Although the rewards of clinical trials can be great, they also come with risks. Talking to your doctor about this before enrolling in a trial is important.

Glioblastoma Risk Factors and Symptoms

Glioblastoma risk factors can include:

• Prior radiation exposure
• Gender: men are more likely to get glioblastoma than women
• Age: people 50 years or older
• Certain genetic syndromes, including neurofibromatosis, tuberous sclerosis, von Hippel-Lindau disease

Common symptoms of glioblastoma can include:

• Headaches
• Seizures
• Changes in mental function, mood, or personality
• Changes in speech
• Sensory changes in hearing, smell, and sight
• Loss of balance
• Changes in your pulse and breathing rate

Treatment Options for Gliomas

“The first step is always the neurosurgery. How much can you take out? Is it safe to do surgery? Do you have to rely on a biopsy? Can you even do a biopsy?” Dr. Henry Friedman, Deputy Director of the Preston Robert Tisch Brain Tumor Center at Duke, tells SurvivorNet.

WATCH: Glioma Treatment Options

The main treatment options are:

• Observation—Some benign, small, and without symptoms of gliomas or tumors located in inoperable locations can be recommended for observation.
• Surgery is often the first-line treatment for gliomas, with the goal of achieving maximal safe resection, where the largest amount of tumor is removed without causing significant neurologic deficits. For low-grade gliomas, surgery alone can sometimes be curative.

After surgery, pathologists examine the tumor tissue to understand its features and molecular makeup. This added step helps doctors outline an appropriate treatment.

“We go through a very elaborate process of diagnostics, which includes looking at it under the microscope through our pathology team,” Dr. Friedman explained to SurvivorNet.

WATCH: The Role of Surgery in Treating Gliomas

Radiation and chemotherapy are often needed after surgery because removing the tumor completely is usually not possible due to the tumor’s ability to spread into surrounding brain tissue.

• Radiation therapy uses high–energy X–rays to target and kill tumor cells. It is often used after surgery to target residual tumor cells.
• Chemotherapy – These medications kill or slow the growth of cancer cells. Chemotherapy can be used alongside radiation or following radiation and is often used in higher-grade tumors.

The Food and Drug Administration (FDA) has approved some drug treatments, including temozolomide (Temodar), to help patients with this aggressive disease. Temozolomide is a chemotherapy drug patients can take after surgery and radiation therapy.

• Targeted therapy and immunotherapy are newer treatments designed to target specific genetic mutations in the tumor or to stimulate the immune system to fight the cancer. Their role in the treatment of gliomas is continuing to evolve.

Other FDA-approved drugs for treating glioblastoma include lomustine (Gleostine), intravenous carmustine (Bicnu), carmustine wafer implants, and Avastin (bevacizumab).

Avastin is a targeted drug therapy that blocks glioblastoma cells from requesting new blood vessels that feed and allow the tumor to grow.

The FDA approved Vorasidenib, an IDH inhibitor. It works by blocking the mutated enzyme, slowing tumor growth, and extending the time before disease progression. IDH mutant gliomas tend to grow more slowly and have a better prognosis than IDH wild-type gliomas.

Dr. Alexandra Miller, Director of the Neuro-Oncology Division at NYU Langone Health, tells SurvivorNet that Vorasidenib is a “huge breakthrough for people with IDH mutant tumors.”

WATCH: Vorasidenib for IDH Mutant Gliomas

“What I tell my patients is that we have these effective treatments, but what they do is they delay the time to when this tumor comes back. Only in exceptional circumstances would we ever talk about getting rid of one of these cancers a few,” Dr. Daniel Wahl, professor of radiation and oncology at the University of Michigan, tells SurvivorNet.

Ongoing Research Offers Hope

Fortunately, research is ongoing to improve the prognosis for people battling glioblastoma. One area of promise is tumor-treating fields, which can help extend patients’ lives by two years on average, giving them hope.

Optune, the brand name for the tumor-treating field delivery device, was launched in 2011 and approved by the FDA in 2015. It is a wearable and portable device for glioblastoma treatment for adult patients aged 22 years or older.

“There’s been a very exciting development of tumor treating fields, which are electrical fields that have been applied to the brain,” Dr. Suriya Jeyapalan, a neurologist at Tufts Medical Center, previously told Survivor Net.

TTFields use low-intensity electric fields to disrupt the cell division process, making it harder for cancerous cells to multiply.

WATCH: Using electric sources to improve glioblastoma treatment.

Despite Optune’s hope, not all cancer experts agree with its approach, including Dr. Friedman.

“Although the National Comprehensive Cancer Network (NCCN) recognizes Optune within its guidelines as a therapy for glioblastoma, many people don’t believe it adds value. At Duke, for example, we don’t consider it a mainstay of therapy,” Dr. Friedman said.

Contributing: SurvivorNet Staff

Learn more about SurvivorNet's rigorous medical review process.

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