When Cancer Strikes Twice: A Mother and Son Battle Cancer Together

Here's what you should know about inherited risk for cancer.

Being a young mom who just got diagnosed with cancer is hard enough, but for one mother, it got harder when her son was diagnosed with leukemia just five months later. Vici Rugby had stage 4 colorectal cancer and her three-year-old son George was then told, in the same hospital, that he had acute lymphoblastic leukemia. Both Vici and George are now in remission—and while this type of story is not very common, we do know that in some cases, cancer risk is inherited in genes. Having a family member with cancer doesn’t necessarily mean you’re more likely to get the disease, but there is a genetic factor for some people.

 

According to the American Cancer Society, as many as 1 in 3 people will have some form of cancer in their lives, so it is very possible that two members of the same family may be diagnosed with different, unrelated types of cancer. However, there is something known as “Family Cancer Syndrome,” which means members of the same family have an increased risk of cancer because of certain gene:

“Cancers that run in families can be caused by an abnormal gene that is passed from generation to generation. Although this is often referred to as inherited cancer, what is inherited is the abnormal gene that can lead to cancer, not the cancer itself. Only about 5% to 10% of all cancers are thought to result directly from gene defects (called mutations) inherited from a parent.”

The gene mutation means that genes that would usually protect our bodies from cancer by “correcting DNA damage that naturally occurs when cells divide,” are not working properly. Since people get half of their genes from their mother and half from their father, children have a 50% chance of inheriting this type of gene mutation if one parent has it.

 

Certain cancers are more likely to be inherited through these types of genetic mutations. For example, Dr. Ophira Ginsberg, a medical oncologist and Director of the High-Risk Cancer Program at NYU Perlmutter Cancer Center, told SurvivorNet: “About 20% of people with colon cancer have a family history, and about half of those, we know the risks are based on specific genes.”

If you have a family history of cancer, it may be wise to look into genetic counseling, advises Rachel Webster, a Genetic Counselor at MD Anderson Cancer Center, which means discussing your history and risk for cancer with a specialist. “Genetic counselors have specialized training in order to figure out what genetic testing might be the most useful for you and your family,” she explains.

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